Developing an adaptive paediatric intensive care unit platform trial with key stakeholders: a qualitative study by Kerry Woolfall, Mark J Peters, Padmanabhan Ramnarayan, Elizabeth Deja, Jennifer Preston, Paul R Mouncey, Julie C Menzies, Doug William Gould, Tracy Karen Mitchell, Shelley Marsh, Jennifer Ainsworth, Hannah Sedgwick, Carly Tibbins

“…Objectives Platform trials were used successfully in adult populations during the COVID-19 pandemic. By testing multiple treatments within a single trial, platform trials can help identify the most effective treatments (and any interactions between treatments) for patients more quickly and with less burden for patients and their families. …”
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Prevalence, Treatment, and Unmet Needs of Migraine in the Middle East: A Systematic Review by Taoufik Alsaadi, AbuBakar Al Madani, Mohammed Alhatou, Mona Nada, Abdulrazaq Albilali, Ahmed Al-Qassabi, Hegab Mohamed, Haytham Mohamed, Rowan El Masry, Ghaidaa Ahmed Saifuddin, Suhail Abdullah AlRukn

“…Despite the high disease burden, there is a scarcity of data on migraines within the Middle East (ME) region. …”
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Pneumonia among Under-Five Children in Northwest Ethiopia: Prevalence and Predictors—A Community-Based Cross-Sectional Study by Zewudu Andualem, Tsegaye Adane, Abiye Tigabu, Walelign Worku Yallew, Sintayehu Daba Wami, Henok Dagne, Jember Azanaw, Gebisa Guyasa, Zelalem Nigussie Azene, Mastewal Endalew

“…As such, enhancing strategies that would address unpaved roads within 100 m of the house, living within 100 m of heavy traffic, the habit of not opening doors while cooking, cockroach infestation, and new carpet in the house to reduce the burden of childhood pneumonia needs to be advocated.…”
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Investigating shared risk variants and genetic etiology between Alzheimer’s disease and three stress-related psychiatric disorders: a large-scale genome-wide cross-trait analysis by Weijia Dang, Tianqi Hao, Ning Li, Hualin Zhang, Ziqi Li, Hongmei Yu, Yalu Wen, Deqiang Zheng, Long Liu

“…IntroductionObservational studies have reported that patients with Alzheimer’s disease (AD) have a greater burden of comorbidities typically associated with stress-related psychiatric disorders. …”
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The prevalence of malaria in the five districts of Limpopo Province, South Africa, 2015 - 2017 by M T Lamola, A Musekiwa, A de Voux, C Reddy, M Morifi, P C Mutevedzi

“…In South Africa (SA), malaria is endemic in three of nine provinces – KwaZulu-Natal, Mpumalanga and Limpopo. During 2010 - 2014, SA reported that ~47.6% of all malaria cases were imported. …”
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Deletion of pagL and arnT genes involved in LPS structure and charge modulation in the Salmonella genome confer reduced endotoxicity and retained efficient protection against wild-... by Ram Prasad Aganja, Jun Kwon, Amal Senevirathne, John Hwa Lee

“…Histopathological evaluations revealed substantial protection in the immunised birds, with minimal tissue damage and inflammatory responses, thus reducing the in vivo bacterial burden. Furthermore, none of the immunised birds died. …”
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Primary cerebral cystic echinococcosis in a child from Roman countryside: Source attribution and scoping review of cases from the literature. by Adriano Casulli, Stefania Pane, Franco Randi, Paola Scaramozzino, Andrea Carvelli, Carlo Efisio Marras, Andrea Carai, Azzurra Santoro, Federica Santolamazza, Francesca Tamarozzi, Lorenza Putignani

“…The proportions of CE cases with uncommon localizations and with high impact on patients' lives have been globally neglected and should be included in the computation of the global burden of CE.…”
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Limited restoration of T cell subset distribution and immune function in older people living with HIV-1 receiving HAART by Na Li, Hong-Yi Zheng, Wei Li, Xiao-Yan He, Mi Zhang, Xia Li, Ren-Rong Tian, Xing-Qi Dong, Zhi-Qiang Shen, Yong-Tang Zheng

“…Abstract Background Older people living with HIV-1 (PLWH) experience a dual burden from the combined effects of aging and HIV-1 infection, resulting in significant immune dysfunction. …”
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Anti-vascular Endothelial Growth Factor Outpatient Treatment Patterns in Patients with Exudative Age-related Macular Degeneration from a Japanese Hospital Claims Database by Tomohiro Iida, Aya Narimatsu, Kenji Adachi, Edward CY Wang

“…Nonetheless, patients still visit the hospital frequently, which can significantly burden patients, caregivers, and healthcare providers.…”
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A Deep Learning Enabled Chest X-Ray Abnormality Detection Model for Radiology Assistance. by Ssempeebwa, Phillip, Ainembabazi, Patience

“…By doing so, this research seeks to prevent the burden on radiologists and enhance patient outcomes by providing timely and accurate diagnoses. …”
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Prevalence of Trypanosoma congolense and Trypanosoma vivax in Lira District, Uganda by Aziz, Katabazi, Adamu, Almustapha Aliero, Sarah, Gift Witto, Martin, Odoki, Simon Peter, Musinguzi

“…It was thus important to estimate the burden of trypanosomiasis in the region. This study was designed to compare the prevalence of animal African trypanosomes in cattle in Lira District using microscopy and polymerase chain reaction amplification (PCR) methods. …”
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Prevalence of Trypanosoma congolense and Trypanosoma vivax in Lira District, Uganda by Aziz, Katabazi, Adamu, Almustapha Aliero, Simon Peter, Musinguzi

“…It was thus important to estimate the burden of trypanosomiasis in the region. This study was designed to compare the prevalence of animal African trypanosomes in cattle in Lira District using microscopy and polymerase chain reaction amplification (PCR) methods. …”
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Factors influencing childbirth fear among Asian women: a scoping review by Aida Kalok, Aida Kalok, Ixora Kamisan Atan, Shalisah Sharip, Nazarudin Safian, Shamsul Azhar Shah

“…Fear of childbirth (FOC) or tokophobia adversely affects women during pregnancy, delivery, and postpartum. Childbirth fear may differ across regions and cultures. …”
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Oral Hygiene Practices and Associated Factors among Patients Visiting Private Dental Clinics at Hawassa City, Southern Ethiopia, 2018 by Desalegn Humna Beyene, Bereket Beyene Shashamo, Lankamo Ena Digesa, Eshetu Zerihun Tariku

“…African regions carry a major burden of oral health problems. However, very few studies highlighted about oral hygiene practices and there is also paucity of information in Ethiopia. …”
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FEATURES OF THE FUNCTIONING OF THE NATIONAL LABOR MARKET IN CONDITIONS OF MILITARY THREAT AND INTERNAL POPULATION DISPLACEMENT by Liudmyla Akimova, Gаlina Urchik

“…The results of the analysis demonstrate that the Ukrainian labour market has undergone significant transformations during the war compared to peacetime. These include: 1) A notable decrease in the number of registered unemployed individuals. 2) A reduction in the proportion of unemployed individuals receiving unemployment benefits. 3) A sharp decline in the number of vacant jobs and employers informing the State Employment Service (SES) about available vacancies. 4) A high burden on vacant jobs. …”
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Longitudinal changes in the 6-minute walk test and the Glittre-activities of daily living test in adults with cystic fibrosis by Vera Lucia Barros Abelenda, Cláudia Henrique da Costa, Mônica de Cássia Firmida, Raphael Freitas Jaber de Oliveira, Rogério Rufino, Agnaldo José Lopes

“…In relation to the group that did not undergo CP, individuals undergoing CP showed an increase in the 'treatment burden'–CFQ-R between T1 and T2 [16.1 (-3-18) vs. -11.2 (-28-1) points, p=0.049]. …”
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Whole-genome sequencing identifies novel loci for keratoconus and facilitates risk stratification in a Han Chinese population by Yinghao Yao, Xingyong Li, Lan Wu, Jia Zhang, Yuanyuan Gui, Xiangyi Yu, Yang Zhou, Xuefei Li, Xinyu Liu, Shilai Xing, Gang An, Zhenlin Du, Hui Liu, Shasha Li, Xiaoguang Yu, Myopia Associated Genetics Intervention and Consortiums, Hua Chen, Jianzhong Su, Shihao Chen

“…Common and rare variants were respectively subjected to single variant association analysis and gene-based burden analysis. Polygenic risk score (PRS) models were developed using top single-nucleotide polymorphisms (SNPs) identified from a multi-ethnic meta-analysis and then evaluated in the Chinese cohort. …”
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Central Aortic Pressure and Arterial Stiffness in Parkinson’s Disease: A Comparative Study by Mehmet Balal, Meltem Demirkiran, Saime Paydas

“…After LD intake, most of these parameters decreased, which might have a positive effect on the vascular burden.…”
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Incidence and prevalence of traumatic and non-traumatic wounds and burns and access to wound care in Sierra Leone; data from a nationwide household survey (PRESSCO) 2020 by Jonathan H. Vas Nunes, Alex J. van Duinen, Daniel Boateng, Amidu J. Tommy, Osman Sankoh, Martin P. Grobusch, Håkon A. Bolkan

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Repurposing the prostaglandin analogue treprostinil and the calcium-sensing receptor modulator cinacalcet to revive cord blood as an alternate source of hematopoietic stem and prog... by Michaela Prchal-Murphy, Julia Zehenter, Marlene Fischer, Anita Pirabe, Madeleine Themanns, Behnaz Afrashteh, Eva Maria Putz, Karoline Kollmann, José Basílio, José Basílio, Manuel Salzmann, Wolfgang Strohmaier, Günther Krumpl, Alex Farr, Veronika Sexl, Michael Freissmuth, Eva Zebedin-Brandl

“…Furthermore, enhancing the potency of HSPCs has the potential to alleviate the burden and risks associated with HSPC donation, as it would reduce the number of cells needed for collection.…”
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