Self-management of non-communicable diseases in low- and middle-income countries: A scoping review. by Jason Hearn, Isaac Ssinabulya, Jeremy I Schwartz, Ann R Akiteng, Heather J Ross, Joseph A Cafazzo

“…Self-management, which enables patients to better manage their health, presents a potentially-scalable means of mitigating the growing burden of NCDs in LMICs. Though the effectiveness of self-management interventions in high-income countries is well-documented, the use of these strategies in LMICs has yet to be thoroughly summarized.…”
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A Network Pharmacology-Based Strategy for Unveiling the Mechanisms of Tripterygium Wilfordii Hook F against Diabetic Kidney Disease by Yuyang Wang, Tongtong Liu, Fang Ma, Xiaoguang Lu, Huimin Mao, Weie Zhou, Liping Yang, Ping Li, Yongli Zhan

“…Diabetic kidney disease (DKD) poses a major public-health burden globally. Tripterygium wilfordii Hook F (TwHF) is a widely employed herbal medicine in decreasing albuminuria among diabetic patients. …”
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Factors influencing access, quality and utilisation of primary healthcare for patients living with hypertension in West Africa: a scoping review by Tolib Mirzoev, Pablo Perel, Irene Akua Agyepong, Evelyn K Ansah, Kezia Naa Amerley Akosua Amarteyfio, Eugene Paa Kofi Bondzie, Veronika Reichenberger, Nana Efua Enyimayew Afun, Albert Kofi Mensah Cofie, Mary Pomaa Agyekum, Paul Lamptey

“…These factors are interconnected and complex and should be addressed as a whole to reduce the burden of hypertension in West Africa.Conclusion Multiple complex and interrelated factors at contextual, health systems, community and patient levels act as barriers and enablers to access, utilisation and quality of primary care for hypertension in West Africa. …”
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Genomic Insights into Blood Pressure Regulation: Exploring Ion Channel and Transporter Gene Variations in Jordanian Hypertensive Individuals by Mansour Abdullah Alghamdi, Laith AL-Eitan, Rasheed Ibdah, Islam Bani Khalid, Salma Darabseh, Maryam Alasmar, Asaad Ataa

“…<i>Background and Objectives</i>: Hypertension (HTN) constitutes a significant global health burden, yet the specific genetic variant responsible for blood pressure regulation remains elusive. …”
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A systematic review of interventions targeting Anopheles stephensi [version 1; peer review: 2 approved] by Alison M Reynolds, Patricia Doumbe Belisse, Martin J Donnelly, Anne L Wilson, David Weetman

“…The invasion of this species into sub-Saharan Africa is of particular concern given its potential to increase malaria burden, especially in urban environments where An. stephensi thrives. …”
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High Expression of UPK3A Promotes the Progression of Gastric Cancer Cells by Inactivating p53 Pathway by Deliang Xu, Jing Guo, Hongwei Xu

“…Gastric cancer is a common gastrointestinal tract cancer and is a considerable health burden worldwide. TCGA analysis found Uroplakin 3A (UPK3A) was upregulated in gastric cancer tissues. …”
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Factors associated with multidrug-resistant organism (MDRO) mortality: an analysis from the national surveillance of multidrug-resistant organism, 2018-2022 by Sharifa Ezat WP, M Norhidayah, Muhammad Nur Amir AR

“…Improved surveillance and reporting mechanisms are necessary to better understand the burden of MDRO infections and guide research funding allocation.…”
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Health and tuberculosis systems resilience, the role of the private sector and pandemic preparedness: insights from a cross-country qualitative study with policy-makers in India, I... by Madhukar Pai, Poshan Thapa, Charity Oga-Omenka, Angelina Sassi, Vijayashree Yellappa, Petra Heitkamp, Bony Wiem Lestari, Surbhi Sheokand, Nathaly Aguilera Vasquez, Laura Jane Brubacher, Bolanle Olusola-Faleye, Joel Shyam Klinton

“…India, Indonesia and Nigeria are high TB-burden countries where the majority of initial care-seeking happens in the private health sector. …”
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Exploring the Chemopreventive Potential of <i>Artemisia annua</i> Methanolic Extract in Colorectal Cancer Induced by Azoxymethane in Mice by Faris Alrumaihi

“…<b>Background/Objectives:</b> Colorectal cancer (CRC) remains a major global health burden, necessitating innovative preventive approaches. …”
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Obesity phenotypes and dyslipidemia in adults from four African countries: An H3Africa AWI-Gen study. by Engelbert A Nonterah, Godfred Agongo, Nigel J Crowther, Shukri F Mohamed, Lisa K Micklesfield, Palwendé Romuald Boua, Alisha N Wade, Solomon S R Choma, Hermann Sorgho, Isaac Kissiangani, Gershim Asiki, Patrick Ansah, Abraham R Oduro, Shane A Norris, Stephen M Tollman, Frederick J Raal, Marianne Alberts, Michele Ramsay, as members of AWI-Gen and the H3Africa Consortium

“…We characterized lipid levels and investigated their relation with the growing burden of obesity in SSA countries.<h4>Methods</h4>A cross-sectional study was conducted in Burkina Faso, Ghana, Kenya and South Africa. …”
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Perceived stress and family adaptability in head and neck cancer patients receiving radiotherapy: the chain-mediated effect of social support and family resilience by Xiaoru Li, Xiaoru Li, Xiaoru Li, Yu Zhu, Yu Zhu, Yu Zhu, Hongwei Wan, Hongwei Wan, Hongwei Wan

“…ObjectivePatients with head and neck tumors undergoing radiotherapy are burdened with a variety of disease-related stressors that may affect their family adaptability. …”
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Global research trends on gastrointestinal cancer and mental health (2004–2024): a bibliographic study by Wenjin Han, Tianmeng Wang, Zhiqiang He, Caihua Wang, Zhaozhao Hui, Shuangyan Lei, Nan Hao, Ning Li, Xiaoqin Wang, Xiaoqin Wang

“…BackgroundGastrointestinal (GI) cancers impose a significant burden on global public health. Patients often experience mental health challenges due to physical changes and treatment-related symptoms, which can worsen their condition or delay recovery. …”
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Population impact of malaria control interventions in the health district of Kati, Mali. by Abdoulaye Katile, Issaka Sagara, Mady Cissoko, Cédric Stéphane Bationo, Mathias Dolo, Pascal Dembélé, Bourama Kamate, Ismaila Simaga, Mahamadou Soumana Sissoko, Jordi Landier, Jean Gaudart

“…To further reduce the burden of malaria, sustained efforts and new interventions are needed, including improving access to rapid diagnosis and treatment in communities by developing community health workers and locally tailored mass drug administration.…”
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Diabetes and tuberculosis: a systematic review and meta-analyis of mendelian randomization evidence by Ivaan Pitua, Raafidha Raizudheen, Mark Muyanja, Joseph Nyero, Morrish Okello Obol

“…Conclusion This review highlights a causal association between DM and TB, emphasizing the need for integrated screening and management of DM within TB control programs, particularly in high-burden regions. Future MR studies should include diverse populations to enhance generalizability and explore genetic mechanisms underlying this association.…”
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Lifecycle environmental benefits of integrated rational fertilization, biochar, and constructed wetland in mitigating nutrient loading by Yu-Ning Chen, Chihhao Fan, Michal Šereš, Markéta Šerešová, Jan Vymazal, Shu-Yuan Pan

“…Agricultural activities due to fertilization contribute significantly to nutrient loadings and other environmental burdens, posing a severe threat to ecosystems. Although a portfolio of green agricultural practices is recommended, few studies address the environmental benefits from a life-cycle perspective. …”
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Real-world clinical utility of Xpert MTB/RIF Ultra in the assessment of tuberculosis in a low-TB-incidence, high-resource setting by Robert C Free, Manish Pareek, Hemu Patel, Pranabashis Haldar, Jee Whang Kim, Richard Halliwell, Nelun Perera, Gerrit Woltmann, Alison Glimour-Caunt, Raman Verma

“…However, Xpert-Ultra had a higher negative predictive value than smear (QFT-positive contacts 6.7% vs 17.7%).Conclusion In low-TB-burden settings, systematic adoption of Xpert-Ultra for clinical assessment of suspected TB can improve the proportion of microbiologically verified diagnoses and improve the stratification of transmission risk.…”
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Spatio-temporal risk prediction of leptospirosis: A machine-learning-based approach. by Rodrigue Govan, Romane Scherrer, Baptiste Fougeron, Christine Laporte-Magoni, Roman Thibeaux, Pierre Genthon, Philippe Fournier-Viger, Cyrille Goarant, Nazha Selmaoui-Folcher

“…The Pacific islands bear a high burden of leptospirosis, making it crucial to identify key factors influencing its distribution. …”
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Atherogenic index of plasma and cardiovascular disease risk in cardiovascular-kidney-metabolic syndrome stage 1 to 3: a longitudinal study by Yu Zhang, Yue Song, Yinfei Lu, Tao Liu, Ping Yin

“…BackgroundCardiovascular disease (CVD) remains a major contributor to the global disease burden. Previous studies have established a link between the atherogenic index of plasma (AIP) and CVD. …”
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Prevalence of childhood mental disorders in high-income countries: a systematic review and meta-analysis to inform policymaking by Charlotte Waddell, Christine Schwartz, Jenny Lou Barican, Donna Yung, Yufei Zheng, Katholiki Georgiades

“…Question Mental disorders typically start in childhood and persist, causing high individual and collective burdens. To inform policymaking to address children’s mental health in high-income countries we aimed to identify updated data on disorder prevalence.Methods We identified epidemiological studies reporting mental disorder prevalence in representative samples of children aged 18 years or younger—including a range of disorders and ages and assessing impairment (searching January 1990 through February 2021). …”
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Neuropsychological outcome of indoor rehabilitation in post-COVID-19 condition—results of the PoCoRe study by Michael Jöbges, Melanie Tempfli, Melanie Tempfli, Christoph Kohl, Christoph Herrmann, Stefan Kelm, Alexa Kupferschmitt, Alexa Kupferschmitt, Alexa Kupferschmitt, Ida Montanari, Nike Walter, Gerhard Suetfels, Thomas Loew, Volker Köllner, Volker Köllner, Thilo Hinterberger

“…Furthermore, of the 27% of participants with pathological MoCA scores at admission, 63% improved to normative levels during rehabilitation, indicating a significant treatment effect (p ≤ 0.001). …”
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