Transcriptome analysis of novel B16 melanoma metastatic variants generated by serial intracarotid artery injection by Jenny C. Kienzler, Erick M. Contreras, Janet Treger, Linda M. Liau, Geoffrey C. Owens, Robert M. Prins

“…Cells were injected into the right carotid artery and recovered from the brain after the mice had reached the study endpoint due to tumor burden, then expanded in vitro and reinjected. We compared the transcriptomes of 4th generation B16 cell populations from separate lineages with the founder B16-F0 cells. …”
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A scoping review on the health effects of smoke haze from vegetation and peatland fires in Southeast Asia: Issues with study approaches and interpretation. by Vera Ling Hui Phung, Attica Uttajug, Kayo Ueda, Nina Yulianti, Mohd Talib Latif, Daisuke Naito

“…In this scoping review, we addressed issues related to the application of epidemiology (EPI), health burden estimation (HBE), and health risk assessment (HRA) approaches, and discussed the interpretation of findings, and current research gaps. …”
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Efficacy of Chinese traditional quadruple single pill combination versus valsartan/hydrochlorothiazide for the treatment of hypertension (COSPQ-BP): study protocol for randomised c... by Kai Liu, Yu Yan, Xin Zhang, Yanan Li, Yuanyuan Yao, Lu Liu, Runyu Ye, Si Wang, Xiangyu Yang, Xiaoping Chen, Shanshan Jia, Qingtao Meng, Xianghao Zuo

“…Introduction Hypertension constitutes the primary health burden of cardiovascular diseases, and the global control of blood pressure (BP) remains insufficient. …”
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Quality of life prognosis in patients with somatoform disorders with sleep disorders by V.V. Ogorenko, I.I. Makarova, A.V. Shornikov

“…Patients with somatoform disorders place a significant burden on the healthcare system. Depending on the diagnostic approach, the prevalence of somatoform disorders ranges from 0.8% to 34%, with nearly half of the patients experiencing sleep disorders. …”
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Use of iStent as a Standalone Operation in Patients with Open-Angle Glaucoma by Yu-Yen Chen, Yun-Ju Lai, Yung-Feng Yen, Li-Ying Huang

“…The subgroup analysis revealed a reduction in IOP and medication burden in each category of iStent generation, follow-up duration of up to 42 months, and iStent numbers. …”
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Multilevel analysis of factors associated with suicide attempts: Evidence from 2022/2023 Mozambique Demographic and Health Survey. by Angwach Abrham Asnake, Beminate Lemma Seifu, Bezawit Melak Fente, Hiwot Altaye Asebe, Meklit Melaku Bezie, Yohannes Mekuria Negussie, Zufan Alamrie Asmare, Mamaru Melkam

“…Despite Mozambique having the 9th highest suicide rate in the world and the highest in Africa, there is no national data quantifying the burden of suicide attempts. Therefore, this study aimed to assess the prevalence of suicide attempts and identify individual and community-level factors associated with them using mixed-effects logistic regression. …”
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Listeria monocytogenes use multiple mechanisms to disseminate from the intestinal lamina propria to the mesenteric lymph nodes by Joshua S. Nowacki, Grant S. Jones, Sarah E. F. D'Orazio

“…We show here that CCR2−/− mice had a significant reduction in Ly6Chi monocytes in the MLN but no change in bacterial burden following foodborne infection; thus, dissemination of L. monocytogenes associated with monocytes is not required for colonization of the MLN. …”
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Methicillin-Resistant <i>Staphylococcus aureus</i>: The Shifting Landscape in the United Arab Emirates by Syrine Boucherabine, Rania Nassar, Lobna Mohamed, Maya Habous, Anju Nabi, Riyaz Amirali Husain, Mubarak Alfaresi, Seema Oommen, Hamda Hassan Khansaheb, Mouza Al Sharhan, Handan Celiloglu, Mubarak Hussain Raja, Eman Abdelkarim, Nishi Ali, Salman Tausif, Victory Olowoyeye, Nelson Cruz Soares, Mahmood Hachim, Danesh Moradigaravand, Dean Everett, Elke Mueller, Stefan Monecke, Ralf Ehricht, Abiola Senok

“…Background: Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) is a significant burden globally, particularly in the Arabian Gulf region. …”
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Bidimensionally partitioned online sequential broad learning system for large-scale data stream modeling by Wei Guo, Jianjiang Yu, Caigen Zhou, Xiaofeng Yuan, Zhanxiu Wang

“…Firstly, IBLS needs to retain all historical data and perform associated calculations in the incremental learning process, which causes its computational overhead and storage burden to increase over time and as such puts the efficacy of the algorithm at risk for massive or unlimited data streams. …”
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Seasonal Profile and Five-Year Trend Analysis of Malaria Prevalence in Maygaba Health Center, Welkait District, Northwest Ethiopia by Fitsum Tigu, Tsegay Gebremaryam, Asnake Desalegn

“…Malaria is a serious public health problem of most developing countries, including Ethiopia. The burden of malaria is severely affecting the economy and lives of people, particularly among the productive ages of rural society. …”
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Anemia during pregnancy and adverse maternal outcomes in Georgia-A birth registry-based cohort study. by Natia Skhvitaridze, Amiran Gamkrelidze, Tinatin Manjavidze, Tormod Brenn, Erik Eik Anda, Charlotta Rylander

“…To progress toward sustainable development goals and alleviate the public health burden of anemia, it is essential to not only identify and manage anemia during pregnancy but also address underlying factors with a multifaceted response.…”
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Ambient Air Pollution and Chronic kidney disease risk in Deltan communities: A Policy Brief, 2023 [version 3; peer review: 1 approved, 2 approved with reservations, 1 not approved] by Luca Mora, Elaine Carnegie, Ogochukwu Okoye

“…The traditional risk factors for CKD, such as hypertension and diabetes have received relatively ample attention but do not sufficiently explain the high burden of CKD. Ambient air pollution is an emerging environmental risk factor for CKD; however, epidemiological data and evidence are lacking for susceptible populations in developing countries. …”
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Effectiveness of ‘Tackle Your Tics’, a brief, intensive group-based exposure therapy programme for children with tic disorders: study protocol of a randomised controlled trial by Danielle Cath, Annet Heijerman-Holtgrefe, Chaim Huyser, Cara Verdellen, Jolande van de Griendt, Laura Beljaars, Kees-Jan Kan, Ramón Lindauer, Pieter Hoekstra, Lisbeth Utens

“…Tourette syndrome and chronic tic disorders are prevalent neurodevelopmental disorders, placing considerable burden on youth and their families. Behavioural treatment is the first-line, evidence-based intervention for tic disorders, but tic reduction and availability remain relatively low. …”
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Zoonotic Parasites and Their Association With Human Activities in Northern Tanzania: An Integrated Ecosystem Approach for One Health by Barakaeli Abdieli Ndossi, Eblate Ernest Mjingo, Hansol Park, Dongmin Lee, Mohammed Mebarek Bia, Heejae Yang, Sungbo Seo, Keeseon S. Eom

“…Prioritizing education and promoting awareness along with implementing comprehensive strategies are essential steps to effectively tackle the problems linked to STH infections and substantially lessen the public health burden caused by zoonotic diseases.…”
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Applying implementation science frameworks to understand why fisherfolk continue or discontinue pre-exposure prophylaxis for HIV prevention in Uganda: a qualitative analysis by Simon Mwima, Rhoda Kitti Wanyenze, Rose Naigino, Laura M Bogart, William Musoke, Semei C Mukama, Stella Allupo, Herbert Kadama, Barbara Mukasa

“…Intervention characteristics such as side effects and the pill burden were significant barriers, particularly for women who reported nausea and stomach issues. …”
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AI predicting recurrence in non-muscle-invasive bladder cancer: systematic review with study strengths and weaknesses by Saram Abbas, Rishad Shafik, Naeem Soomro, Rakesh Heer, Rakesh Heer, Kabita Adhikari

“…BackgroundNon-muscle-invasive Bladder Cancer (NMIBC) is notorious for its high recurrence rate of 70-80%, imposing a significant human burden and making it one of the costliest cancers to manage. …”
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Cardiovascular risk and mortality in men receiving testosterone replacement therapy for Klinefelter syndrome in Denmark: a retrospective cohort studyResearch in context by Simon Chang, Lars Pedersen, Anne Skakkebæk, Agnethe Berglund, Claus H. Gravholt

“…Testosterone replacement therapy (TRT) has the potential to alleviate this burden. We assessed the risk of major cardiovascular events (MACE) and mortality in KS according to TRT exposure. …”
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Changing role of security alliances in the post-Cold War era by I. A. Istomin, A. V. Levchenko

“…Firstly, the authors highlight the waning interest of the leading powers towards formalized allied relations, since they increasingly perceive the latter as an unnecessary burden. At the same time, the researchers note that the leading powers adhered to different approaches to alliance and coalition building in the post-bipolar period. …”
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Biochar effects on durum wheat (Triticum durum) under ambient and elevated atmospheric CO2 by Lorenzo Brilli, Franz-Werner Badeck, Lorenzo Genesio, Silvia Baronti, Fulvia Rizza, Clara Fares, Luigi Cattivelli, Franco Miglietta, Anita Maienza, Alessandro Zaldei, Federica Camin, Rosella Motzo, Piero Toscano

“…Results indicated that biochar increased soil temperatures by +1 °C during winter, thus favouring an earlier phenology and average biomass (+10 % and +7.2 %) and yield (+13.2 % and +8.5 %) increase in both a[CO2] and e[CO2] treatments compared to the no biochar [B0] treatments. …”
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Changes in faecal haemoglobin values over sequential rounds of faecal immunochemical tests (FIT) in a surveillance population by Amanda J Cross, Kate Wooldrage, Gemma Mortell, Gwen A Murphy

“…Less invasive faecal immunochemical tests (FIT) could reduce the burden of surveillance colonoscopy. We investigated whether changes in FIT values over multiple rounds were associated with advanced colorectal neoplasia (ACN) detection.Methods A cohort of men and women aged 60–72 years deemed intermediate risk by the 2002 UK adenoma surveillance guidelines and scheduled for three yearly colonoscopies were recruited (January 2012–December 2013) within the English Bowel Cancer Screening Programme and offered a quantitative FIT at 1, 2 and 3 years post-baseline colonoscopy for a prospective analysis within a diagnostic accuracy study. …”
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