Insulin resistance and β-cell dysfunction in individuals with normal glucose tolerance but elevated 1-h post-load plasma glucose by Qianwen Nie, Xue Jin, Yahui Mu, Youyuan Huang, Aimei Dong

“…ObjectiveDiabetes and its complications impose a significant burden on public health, necessitating early identification and intervention, yet current prediabetes diagnostic criteria may not fully capture all high-risk individuals. …”
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miRNA-451a and miRNA-125a Expression Levels in Ankylosing Spondylitis: Impact on Disease Diagnosis, Prognosis, and Outcomes by Dina Salem Fotoh, Rasha Ibrahim Noreldin, Mohamed Soliman Rizk, Maha Mohamed Elsabaawy, Heba Ahmed Esaily

“…Both miRNA-451a and miRNA-125a were found to be of great value as sensitive noninvasive diagnostic, prognostic, and disease burden biomarker of AS patients in Egypt with suggested further studies for future therapeutic implications.…”
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Predominance of OXA-48 Carbapenemase-Producing Enterobacterales in a Moroccan Hospital by El Mehdi Belouad, Elmostafa Benaissa, Nadia El Mrimar, Fatna Bssaibis, Adil Maleb, Mostafa Elouennass

“…Enterobacterales strains from March to June 2018 were collected from different clinical samples. …”
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Associations between specific and cumulative adverse childhood experiences, childhood obesity, and obesogenic behaviours by Ladan Hashemi, Maryam Ghasemi, Brooklyn Mellar, Pauline Gulliver, Barry Milne, Fiona Langridge, Tracey McIntosh, Christa Fouche, Boyd Swinburn

“…Background: Individuals impacted by adverse childhood experiences (ACEs) are at greater risk of developing obesity, however, few studies have prospectively measured ACEs and obesity during childhood. Associations with the adoption of obesogenic behaviours during childhood, which directly contribute to obesity are also understudied.Objective: To examine associations between individual and cumulative ACEs, obesity, and obesogenic behaviours during childhood.Methods: Data came from Growing Up in New Zealand. …”
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“…They were just treating her Symptom by Symptom”: maternal experiences of having a child with spinal muscular atrophy in Ghana by Esther Doe-Yo Tawiah, Jacob Owusu Sarfo

“…It was also found that mothers tend to have a deep connection to their faith and a sense of closeness to God during challenging times, which provides them with strength and comfort. …”
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Prevalence of hemoglobinopathies using high-performance liquid chromatography as diagnostic tool in anemic patients of tertiary care center of Western India by Virender Singh, Amit Kumar Biswas, Ajay Kumar Baranwal, Bhushan Asthana, Tejpal Dahiya

“…India is developing country and many studies show a significant burden of hemoglobinopathies in India. AIMS: The aim of the present study was to check the prevalence of various hemoglobinopathies in anemic subjects using high-performance liquid chromatography (HPLC) method in Pune region which has multiple ethnic population groups from all parts of India. …”
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Adult HIV/AIDS patients are more likely to experience anxiety symptoms by Zakir Abdu, Wondwossen Belayneh, Aman Dule, Solomon Seyife Alemu, Lema Fikadu Wedajo, Mohammedamin Hajure, Gebremeskel Mulatu Tesfaye, Yadeta Alemayehu Workneh, Wubishet Gezimu, Mustefa Adem Hussen, Bilisumamulifna Tefera, Sadik Habib

“…Based on these findings, timely intervention is recommended to enhance the overall well-being and quality of life for people living with HIV (PLWH), leading to better health outcomes, reducing the burden of mental health issues, and supporting more holistic, patient-centered care.…”
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Navigating DR-TB Treatment care: a qualitative exploration of barriers and facilitators to retention in care among people with history of early disengagement from drug-resistant tu... by Ndiviwe Mphothulo, Sindisiwe Hlangu, Jennifer Furin, Mosa Moshabela, Marian Loveday

“…Barriers to optimal retention in care included a limited understanding of DR-TB disease and treatment, transport challenges, side effects of the medication, pill burden, stigma and discrimination experienced at health care facilities other than DR-TB facilities, food insecurity, and financial difficulties, which included loss of income and a lack of transport money and mental health challenges such as fear, anxiety and feeling lonely and unsupported. …”
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Measures of Counteracting Domestic Violence Committed by Children: Problematic Aspects by A. S. Bakhaieva

“…Domestic violence is a heavy burden both for the victim and for society in the whole. …”
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Prevalence, Risk Factors, and Antimicrobial Resistance Profiles of Thermophilic Campylobacter Species in Humans and Animals in Sub-Saharan Africa: A Systematic Review by Noel Gahamanyi, Leonard E. G. Mboera, Mecky I. Matee, Dieudonné Mutangana, Erick V. G. Komba

“…The present review provides evidence of thermophilic Campylobacter occurrence in humans and animals and high levels of AMR in SSA, emphasizing the need for strengthening both national and regional multisectoral antimicrobial resistance standard surveillance protocols to curb both the campylobacteriosis burden and increase of antimicrobial resistance in the region.…”
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A qualitative study assessing acceptability and appropriateness of a technology-assisted mental health intervention by community frontline workers: mPareshan implementation researc... by Samina Akhtar, Fauziah Rabbani, Javeria Nafis, Amna Siddiqui, Zul Merali

“…All participants had realization of rising burden of mental illnesses and identified key determinants for mental ill-health. …”
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Epidemiology of endometriosis in Kazakhstan: a national population-based cohort analysis (2014–2019) using data from the national electronic healthcare system by Gulzhanat Aimagambetova, Yesbolat Sakko, Talshyn Ukybassova, Milan Terzic, Milan Terzic, Aizada Marat, Nazira Kamzayeva, Arnur Gusmanov, Gulnur Zhakhina, Sauran Yerdessov, Kamilla Mussina, Dmitriy Syssoyev, Abduzhappar Gaipov, Abduzhappar Gaipov

“…However, the analysis of the UNEHS records on endometriosis reveals incomplete and inconsistent registration of the disease, which results in the underestimation of the disease’s real burden. Clinical specialist and health authorities in Kazakhstan must work to ensure the endometriosis proper diagnosis end registration to improve the disease management and outcomes.…”
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Review of potential simultaneous operations for the surgical rehabilitation of patients with thyroid eye disease by D.S. Atarshchikov, E.Yu. Korchemkina

“…Korchemkina² </p> <p> ¹Central Clinical Hospital and Polyclinic of the Department for Presidential Affairs, Moscow, Russian Federation </p> <p> ²Academy of Postgraduate Education of the Federal Scientific and Clinical Center of the Federal Medical Biological Agency of Russian Federation, Moscow, Russian Federation </p> <p> The importance of revising the traditional multi-stage approach to the surgical rehabilitation of patients with thyroid eye disease is supported by multiple reasons, such as high operation costs, anesthesia-related increase in a burden for patients, and repeated surgical incisions associated with a delayed healing of surgical wounds. …”
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Understanding experiences of neglected tropical diseases of the skin: a mixed-methods study to inform intervention development in Ethiopia by Michael Marks, David Mabey, Ruth Canter, Elizabeth Allen, Charles Opondo, Jennifer Palmer, Iris Mosweu, Jacob Novignon, Sinéad Langan, Maria Zuurmond, Catherine Pitt, Stephen L Walker, Dorothy Yeboah-Manu, Tara Mtuy, Rachel L Pullan, Richard Phillips, Daniel Okyere, Anthony Ablordey, Samantha Owen, Portia Boakye Okyere, Kidist Bobosha, Katherine Halliday, Steve Walker, Galana Mamo Ayana, Rachel Pullan, Mirgissa Kaba, Tara B Mtuy, Yaw Amoako, Adwoa Asante-Poku, Abigail Agbanyo, Eric Koka, Joseph Timothy, Yohannes Hailemichael, Abebaw Yeshambel Alemu, Teklu Cherkose, Getachew Kebebew, Fikregabrail Aberra Kassa, Tedros Nigusse, Kibur Engedawork, Zenebu Begna, Abay Waday, Saba Lambert, Katherine Elizabeth Halliday, Endalamaw Gadisa, Vanessa Yardley, Collins Ahorlu, Anita Achiaa Gyekye, Emmanuel Afreh, Esther Amon, Abraham Kwabena Anang, Ruth Dede Tuwor, Giulia D’Odorico, Kibur Engidawork, Mehari Getaneh, Bernadette Morkporkpor, Emmanuel Narh, Dorcas Opai-Tetteh, Yohannes Michael, Amel Mohammed, Fewzia Shikur Mohammed, Shimelis Doni Nigusse, Maja Niksic, Edmond Okloo, Michael Oppong, Lucy Owusu, Ishaque Siam, Ingrid Sobel, Feleke Tilahum, Joseph Tuffour, Abay Woday, Abebaw Yeshambel, Adelaide Forkuo- Boadu, Derrick Kontoh, Jojo Cobbinah

“…Transmission discourses shaped different understandings of who was affected by leprosy and CL and expectations of behaviour during and after treatment. Many policy actors felt that existing supply chain interventions, decentralised treatment approaches and community engagement initiatives for leprosy could also benefit CL, but others also warned against increasing care-seeking unless CL treatment could be provided on a scale commensurate with the large burden they perceived.Conclusion Our findings demonstrate significant gaps in the provision of care for skin NTDs within primary healthcare, very different health-seeking patterns for leprosy and CL, and a need to develop new models of care, especially for CL.…”
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Perforin-2 is dispensable for host defense against Aspergillus fumigatus and Candida albicans by Mariano A. Aufiero, Li-Yin Hung, De'Broski R. Herbert, Tobias M. Hohl

“…We found that Mpeg1−/− mice generated on a mixed C57BL/6J-DBA/2 background exhibited enhanced survival, reduced lung fungal burden, and greater neutrophil fungal killing activity compared to wild-type C57BL/6J (B6) mice, suggesting that Perforin-2 may impair antifungal immune responses. …”
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Diabetes Fact Sheets in Korea 2024 by Se Eun Park, Seung-Hyun Ko, Ji Yoon Kim, Kyuho Kim, Joon Ho Moon, Nam Hoon Kim, Kyung Do Han, Sung Hee Choi, Bong Soo Cha

“…Young adults with diabetes bear a significant burden of obesity and comorbidities, alongside low awareness and treatment rates. …”
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Overview of cultivated and wild species of the Bignoniaceae family in the Emirate of Fujairah (United Arab Emirates) by Byalt Vyacheslav Vyacheslavovich, Korshunov Mikhail Vladimirovich

“…Mattos, <em><strong>Radermachera sinica</strong></em> (Hance) Hemsley, <em><strong>Tabebuia aurea</strong></em> (Silva Manso) Benth. &amp; Hook. f. ex S. …”
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Effects of Production System With or Without Growth-Promoting Technologies on Growth and Blood Expression of (Cyto)Chemokines and Heat Shock and Tight Junction Proteins in <i>Bos taurus</i> and <i>indicus</i> Breeds During Summer Season by Mark Branine, Ashley K. Schilling-Hazlett, Pedro H. V. Carvalho, Kim R. Stackhouse-Lawson, Edilane C. Martins, Julia T. da Silva, Laura Amundson, Chris Ashworth, Mike Socha, Sami Dridi

“…Heat stress (HS) induced by global warming is a real welfare, productivity, and economic burden of cattle production. However, some cattle breeds have superior physiological adaptive traits to others, yet the underlying molecular mechanisms are not fully defined. …”
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Prevalence, predictors and selected outcomes of early sexual initiation among adolescents in secondary schools in Lugbe, Abuja, Nigeria: a mixed methods study by Uchechi Grace Okonta

“…Despite many negative effects of early sexual initiation, its prevalence has kept increasing globally over the past decades.Objective This study aims to determine the burden, identify risk factors and examine the selected outcomes of early sexual initiation among secondary school adolescents.Design The study was a school-based descriptive cross-sectional survey which employed quantitative and qualitative methods.Method A descriptive cross-sectional survey was conducted among 300 in-school adolescents aged 15–19 in Lugbe, Abuja. …”
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Psilocybin-assisted therapy for reducing alcohol intake in patients with alcohol use disorder: protocol for a randomised, double-blinded, placebo-controlled 12-week clinical trial... by Claus Thorn Ekstrøm, Patrick MacDonald Fisher, Gitte Moos Knudsen, Dea Siggaard Stenbæk, Anders Fink-Jensen, Mathias Ebbesen Jensen, Tobias Søgaard Juul

“…Introduction Alcohol use disorder is a difficult-to-treat psychiatric disorder and a major burden on public health. Existing treatment efficacy is moderate, and relapse rates are high. …”
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