Research hotspots and frontiers in the tumor microenvironment of colorectal cancer: a bibliometric study from 2014 to 2024 by Xinran He, Tingyi Xie, Li Shi, Xuyi Kuang, Lei Li, Xingyu Shang, Bo Fu

“…BackgroundColorectal cancer (CRC) is the second leading cause of cancer deaths globally, which poses a heavy burden on our healthcare and economy. In recent years, increasing researches suggest that the tumor microenvironment (TME) influences cancer onset, progression, metastasis, and treatment. …”
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A Principal Component Analysis of Metabolome and Cognitive Decline Among Japanese Older Adults: Cross-sectional Analysis Using Tohoku Medical Megabank Cohort Study Data by Sakura Kiuchi, Kumi Nakaya, Upul Cooray, Kenji Takeuchi, Ikuko N. Motoike, Naoki Nakaya, Yasuyuki Taki, Seizo Koshiba, Shunji Mugikura, Ken Osaka, Atsushi Hozawa

“…Background: Dementia is the leading cause of disability and imposes a significant burden on society. Previous studies have suggested an association between metabolites and cognitive decline. …”
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The In Vitro Antioxidant and Antiadipogenic Properties of Pigmented Flower Extracts of Geraniaceae and Lamiaceae Plant Families by Anton Venter, Hennie Fisher, Gary I. Stafford, June C. Serem, Megan J. Bester, Kwaku G. Duodu

“…This study investigated the potential health-promoting properties of new sources of natural food colorants, namely pigmented flower extracts from Geraniaceae (Pelargonium grandiflorum, Pelargonium × hortorum, Pelargonium zonale hybrid) and Lamiaceae (Salvia aurea × dolomitica, Salvia dolomitica and Plectranthus zuluensis). …”
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Effects of perioperative treatment of resectable adenocarcinoma of esophagogastric junction by immunotherapy (Adebrelimab) combined with chemotherapy (XELOX): protocol for a single... by Yingyi Li, Yuqin Cao, Xipeng Wang, Chengqiang Li, Liqin Zhao, Hecheng Li

“…The exploratory outcomes are the biomarkers related to therapeutic efficacy, such as PD-L1 expression, microsatellite instability (MSI), tumor mutational burden(TMB), Epstein-Barr virus(EBV) infection, and circulating tumor DNA(ctDNA). …”
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Modeling optimal combination of breast and cervical cancer screening strategies in China by Xuewei Liu, Yanbo Wang, Bei Gao, Xinlin Lu, Yuan Wang, Wenli Lu

“…Secondary prevention of cancer through screening minimizes disease burden and improves survival outcomes. Optimizing screening strategies for breast and cervical cancers is a challenge in resource-limited settings with a high population density such as China. …”
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The Impact of the 2020 Medicaid Expansion in a Community Clinic Serving the Marshallese Population in a Rural State by Robert Brand, Samantha Robinson, Mohammod Mahmudur Rahman, Alshaimaa Hazaa, Sheena CarlLee, Hanna Jensen

“…Analyses of comorbidities indicated similar disease burden in both pre and post cohorts.  Conclusion The study’s findings suggest an increase in the use of healthcare services following the expansion of Medicaid services to previously uninsured patients. …”
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Indoor Air Quality and Indoor Environmental Quality: The role of occupational health surveillance and the cooperation between public and occupational health stakeholders by Francesco Chirico, Gaetano Settimo, Nicola Magnavita

“…The viewpoint discusses the severe implications of IAQ, especially in developing countries, where it contributes significantly to the global disease burden. It introduces the concept of Indoor Environmental Quality (IEQ), expanding the focus from just air quality to encompass lighting, acoustics, thermal comfort, and water quality. …”
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Experiences and Perceptions on Community Client-Led ART Delivery (CCLADS) Model of Antiretroviral (ART) Delivery: Patients’ and Providers’ Perspectives in South Western Uganda. by Kasande, Meble, Tusimiirwe, Happiness, Taremwa, Michael, Lamulatu, Kabiite, Amanyire, Mark, Nakidde, Gladys, Kabami, Jane

“…Purpose: Community Client-Led ART Delivery groups (CCLADS) were introduced as part of the differentiated service delivery models in 2017 to better serve the growing number of HIV patients and reduce unnecessary burden on the HIV care delivery system. However, there is limited evidence on the exact experiences and perceptions of patients and care providers regarding the CCLADS model of ART delivery. …”
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Effect of Single Parenting on Children’s Social Welfare in Chahi Sub-County Kisoro District. by Nyiraneza, Gloria

“…The economic strain leads to inadequate educational resources, poor housing conditions, and malnutrition, which in turn affect children’s academic performance and psychological well-being. …”
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Fruit and vegetable intake and mental health among family caregivers of people with dementia in Uganda by Herbert, E. Ainamani, Wilson, M. Bamwerinde, Godfrey, Z. Rukundo, Sam, Tumwesigire, Valence, Mfitumukiza, Everd, Bikaitwoha Maniple, Alexander, C. Tsai

“…Multivariable regression models were used to estimate the associations between fruits and vegetable consumption and depression and anxiety, adjusting for caregiving burden and other potential confounders. Depression symptom severity was negatively associated with consumption of jackfruits (b =-4.68; 95% confidence interval [CI], -8.96 to -0.39), green leafy vegetables (b =-14.1; 95% CI, -18.0 to -10.1), root vegetables (b =-14.0; 95% CI, -19.5 to -8.63), and other vegetables (b =-14.8; 95% CI, -19.3 to -10.3), and frequent consumption of vegetables (b =-1.91; 95% CI, -3.77 to -0.04). …”
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Association of inflammation cytokines with cognitive function in first-episode major depressive disorder by Yan Qing Xi, Yan Qing Xi, Yan Qing Xi, Zong Qi Wang, Zong Qi Wang, Zong Qi Wang, Guo Juan Li, Guo Juan Li, Guo Juan Li, Zhuo Qun Hao, Zhuo Qun Hao, Zhuo Qun Hao, Jia Hui Nie, Jin Xiang Li, Yu Ting Tan, Xiao Dong Hu, Xiao Dong Hu, Gen Wei Wang, Sha Liu, Sha Liu, Yan Fang Wang, Yan Fang Wang, Yan Fang Wang

“…Current studies suggest that the occurrence of MDD may be related to oxidative stress-induced inflammation, hypothalamic-pituitary-adrenal axis disorders, diminished monoamine function and microbe-brain-gut axis, among other pathways. …”
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Identification and validation of occupational stress factors for employees of the electricity distribution company of Ilam province by Ardeshir Shiri

“…Role burden is the origin of many organizational problems, including job stress (Abbasi, 2015). …”
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The Predictive Role of Lactate in the Emergency Department in Patients with Severe Dyspnea by Maciej Niczewski, Szymon Gawęda, Paulina Kluszczyk, Mikołaj Rycerski, Daria Syguła, Anna Danel, Szymon Szmigiel, Konrad Mendrala, Aleksandra Oraczewska, Czarosław Kijonka, Monika Nowicka, Michał Wita, Tomasz Cyzowski, Grzegorz Brożek, Maciej Dyrbuś, Szymon Skoczyński

“…The primary endpoint was short-term, all-cause mortality during the follow-up of median (quartile 1–quartile 3) 2 (1–4) months. …”
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The impact of biofeedback in enhancing chronic pain rehabilitation: A systematic review of mechanisms and outcomes by Andrea Calderone, Vincenza Maura Mazzurco Masi, Rosaria De Luca, Antonio Gangemi, Mirjam Bonanno, Daniela Floridia, Francesco Corallo, Giovanni Morone, Angelo Quartarone, Maria Grazia Maggio, Rocco Salvatore Calabrò

“…Background and objectives: Chronic pain (CP), affecting approximately 20 % of adults globally, imposes a profound burden on individuals and healthcare systems. This condition, characterized by persistent pain, muscle stiffness, and emotional distress, often results in a complex interplay of physical and psychological factors that exacerbate symptoms and hinder recovery. …”
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User-centred design of ChestCare: mHealth app for pulmonary rehabilitation for patients with COPD; a mixed-methods sequential approach by Suad J. Ghaben, Arimi Fitri Mat Ludin, Nazlena Mohamad Ali, Devinder Kaur Ajit Singh

“…Background The increasing prevalence and burden of chronic obstructive pulmonary disorder (COPD), the challenges in implementing pulmonary rehabilitation (PR) programs and the limited availability of alternatives and supportive programs to serve patients with COPD necessitate the development of pulmonary telerehabilitation (PTR) systems to provide patients with COPD with PR programs. …”
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Population travel increases the risk of Plasmodium falciparum infection in the highland population of Gardula Zone, South Ethiopia: A longitudinal study. by Muluken Assefa, Fekadu Massebo, Temesgen Ashine, Teklu Wegayehu

“…Hence, malaria interventions targeting travelers should be implemented to reduce the imported malaria burden in highlands.…”
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Efficacy and safety of neoadjuvant therapy with tislelizumab plus axitinib for nonmetastatic renal cell carcinoma with inferior vena cava tumor thrombus: a retrospective study by Zhongjie Zhao, Zhengsheng Liu, Kaiyan Zhang, Wei Li, Lijian Zhang, Bingliang Jiang, Bin Chen, Jinchun Xing, Xuegang Wang

“…Abstract In renal cell carcinoma (RCC) patients with inferior vena cava (IVC) tumor thrombus, neoadjuvant therapy could alleviate the burden of tumor thrombus, enhance the safety and feasibility of surgical resection, and improve patient prognosis. …”
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A review of conceptual changes and perception studies of autism and related terminologies by LAO Uchong, ZHU Huilin

“…The medical terms “孤独症” （gūdú zhèng） and “自闭症” （zìbì zhèng） carry stigmatizing connotations， especially “zìbì zhèng，” which， due to its negative association with self-imposed isolation， is often linked with negative labels such as “dangers” or “burdens.” Terms like “星星的孩子” （xīngxīng de háizi） and “闭娃” （bì wá）， despite their popularity， are criticized by the autistic community for their romanticized and demeaning connotations， and for overlooking adult autistic individuals. …”
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Kinetic-pharmacodynamic model to predict post-rituximab B-cell repletion as a predictor of relapse in pediatric idiopathic nephrotic syndrome by Ziwei Li, Qian Shen, Hong Xu, Zhiping Li

“…Monte Carlo simulation was conducted to explore a mini-dose regimen with larger intervals.ResultsNomogram contained 7 predictors of relapse including neutrophil-to-lymphocyte ratio, duration of B-cell depletion, duration of disease, urine immunoglobulin G to creatinine ratio, urine transferrin, duration of maintenance immunosuppressant and hemoglobin. …”
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Synthesis and characterization of innovative GA@Ag-CuO nanocomposite with potent antimicrobial and anticancer properties by Amr H. Hashem, Mostafa A. Abdel-Maksoud, Sabiha Fatima, Saeedah M. Almutairi, Mohamed A. Ghorab, Ahmed I. El-Batal, Gharieb S. El-Sayyad

“…Abstract Cancer and microbial infections place a significant burden on the world’s health systems and can increase the rate of disease and mortality. …”
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