Effectiveness of interventions for dry eye: a protocol for an overview of systematic reviews by Tianjing Li, Paul McCann, Riaz Qureshi, Zanna Kruoch

“…Introduction Dry eye is a leading cause of ocular morbidity and economic and societal burden for patients and healthcare systems. There are several treatment options available for dry eye and high-quality systematic reviews synthesise the evidence for their effectiveness and potential harms.Methods and analysis We will search the Cochrane Eyes and Vision US satellite (CEV@US) database of eyes and vision systematic reviews for systematic reviews on interventions for dry eye. …”
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In silico design of an epitope-based vaccine ensemble for fasliolopsiasis by Ruchishree Konhar, Ruchishree Konhar, Kanhu Charan Das, Kanhu Charan Das, Aiboklang Nongrum, Rohan Raj Samal, Shailesh Kumar Sarangi, Devendra Kumar Biswal, Devendra Kumar Biswal

“…It predominates in school-age children, and significant worm burdens are not uncommon. The causal organism is Fasciolopsis buski, a giant intestinal fluke that infects humans and causes diarrhoea, fever, ascites, and intestinal blockage. …”
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The effect of triple CFTR modulator therapy and azithromycin on ion channels and inflammation in cystic fibrosis by Suhad Bani Melhim, Lisa E.J. Douglas, James A. Reihill, Damian G. Downey, S. Lorraine Martin

“…Conclusions Incorporating ETI into the standard of CF care provides an opportunity to re-evaluate therapeutic regimens to reduce treatment burden and safely discontinue chronic treatments such as AZ, without loss of clinical benefit. …”
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Clinical presentation and predictors of hospital mortality of diphtheria in Nigeria, July 2023 to April 2024: a single-center study by Abdurrazzaq Alege, Olayinka Rasheed Ibrahim, Rasheedat Mobolaji Ibraheem, Olajide Aladesua, Abubakar Sani Lugga, Yunusa Yusuf Yahaya, Abdallah Sanda, Bello Muhammed Suleiman

“…Herein, we describe the sociodemographic, clinical, and laboratory features associated with hospitalization outcomes (defined as death or discharge) during the recent diphtheria outbreak in Nigeria. …”
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Effects of acteoside from Cistanche tubulosa on the plasma metabolome of cancer-related fatigue mice inoculated with colon cancer cells by Shilei Zhang, Fukai Gong, Jiali Liu, Shuping You, Tao Liu, Jianhua Yang, Junping Hu

“…Administration of ACT ameliorated both tumor burden and PTX-induced muscle fatigue-like behavior. …”
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A Method for Quantifying Mung Bean Field Planting Layouts Using UAV Images and an Improved YOLOv8-obb Model by Kun Yang, Xiaohua Sun, Ruofan Li, Zhenxue He, Xinxin Wang, Chao Wang, Bin Wang, Fushun Wang, Hongquan Liu

“…Quantifying planting layouts during the seedling stage of mung beans (<i>Vigna radiata</i> L.) is crucial for assessing cultivation conditions and providing support for precise management. …”
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The liminal space between hope and grief: The phenomenon of uncertainty as experienced by people living with relapsing-remitting multiple sclerosis. by Eva C van Reenen, Inge A M van Nistelrooij, Leo H Visser, Janet W K de Beukelaar, Stephan T F M Frequin, Alistair R Niemeijer

“…In comparison, existential uncertainty has been under-researched, even though it might pose a greater burden to those experiencing it.<h4>Objective</h4>To understand the lived experience of uncertainty for people living with relapsing-remitting Multiple Sclerosis.…”
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Gastrostomy uptake in motor neurone disease: a mixed-methods study of patients’ decision making by Natalie James, Emma Power, Anne Hogden, Julie Labra, Victoria M Flood

“…Other reported factors included: reducing carer burden, improving quality of life, increasing independence, continuing participation in social outings and gaining control.Conclusions Future research may give greater insight into how healthcare organisations can better facilitate gastrostomy decision making, to meet the needs of people living with MND. …”
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Biological subphenotypes in patients hospitalized with suspected infection in Thailand: a secondary analysis of a prospective observational studyResearch in context by Prapassorn Poolchanuan, Taylor D. Coston, Viriya Hantrakun, Parinya Chamnan, Gumphol Wongsuvan, Pavan K. Bhatraju, Narisara Chantratita, Direk Limmathurotsakul, T. Eoin West, Shelton W. Wright

“…Interpretation: We identified three biological subphenotypes of patients with suspected infection in rural Thailand, where the burden of infection is high but understudied. Patient subphenotype assignment was characterized by distinct clinical outcomes and biological profiles which could inform contextualized future study design. …”
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Dynamic interplay of autophagy and membrane repair during Mycobacterium tuberculosis Infection. by Jacques Augenstreich, Anna T Phan, Charles N S Allen, Anushka Poddar, Hanzhang Chen, Lalitha Srinivasan, Volker Briken

“…The LC3 recruitment to MCVs displayed a high variability in timing that was independent of the size of the MCV or the bacterial burden. Most notably, the LC3-positive MCVs did not acidify, indicating that LC3 recruitment does not necessarily lead to the formation of mature autophagolysosomes. …”
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Pediatric Sleep Quality and Parental Stress in Neuromuscular Disorders: Descriptive Analytical Study by Sajjad Khaksar, Mehdi Jafari-Oori, Forogh Sarhangi, Malihe Sadat Moayed

“…These conditions significantly affect patients’ quality of life and impose a substantial burden on caregivers. Spinal muscular atrophy (SMA) is a relatively common NMD in children that presents in various types with varying degrees of severity. …”
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Assessment of prognosis and responsiveness to immunotherapy in colorectal cancer patients based on the level of immune cell infiltration by Kaili Liao, Minqi Zhu, Lei Guo, Zijun Gao, Jinting Cheng, Bing Sun, Yihui Qian, Bingying Lin, Jingyan Zhang, Tingyi Qian, Yixin Jiang, Yanmei Xu, Qionghui Zhong, Xiaozhong Wang

“…The high-risk subgroup in our model exhibited elevated immune cell infiltration coupled with a higher tumor mutation burden, but the difference in response to immunotherapy was not significant compared to the low-risk group. …”
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Iconography of abnormal non-neuronal cells in pediatric focal cortical dysplasia type IIb and tuberous sclerosis complex by Joyce Zhang, Deneen Argueta, Xiaoping Tong, Harry V. Vinters, Gary W. Mathern, Carlos Cepeda

“…These abnormal cells emerge during early brain development as a result of a hyperactive mTOR pathway and may express both neuronal and glial markers. …”
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Prevalence of intestinal parasitic contamination in fresh vegetables in Bangkok, Thailand, and surrounding areas: A cross-sectional survey by Pokkamol Laoraksawong, Uthaitip Bunkasem, Anunya Pradidthaprecha

“…Public health education campaigns on the risks of consuming contaminated vegetables should also be implemented to reduce the burden of intestinal parasitic infections in Thailand.…”
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Prevalence and demographic distribution of anaemia among those visiting a teaching hospital located in tribal predominant block of Jharkhand: Retrospective record based analysis by Vasanth Chellamuthu, Srinivasan Chelladurai, Vinayagamoorthy Venogopal, Bhagyasri Ray, S Sharanabasappa, Vasantha C. Kalyani, Satya Patra

“…Conclusion: This study shows that half of the patients attending hospital are anaemic and the burden increases as the age increases and highest among elderly >60 years. …”
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Reconstruction for Time-Domain In Vivo EPR 3D Multigradient Oximetric Imaging—A Parallel Processing Perspective by Christopher D. Dharmaraj, Kishan Thadikonda, Anthony R. Fletcher, Phuc N. Doan, Nallathamby Devasahayam, Shingo Matsumoto, Calvin A. Johnson, John A. Cook, James B. Mitchell, Sankaran Subramanian, Murali C. Krishna

“…Speedup factors of 4.57 and 4.25 have been achieved during the reconstruction process and oximetry computation, for a data set with 23×23×23 gradient steps. …”
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Prevalence and risk factors of gastroesophageal reflux disease among adults attending primary healthcare in Bahrain by Dhuha F. Alqassab, Maryam J. Hasan, Ayman M. AlSaadoon, Aysha J. AlMuqahwi, Farah A. AlAwadhi, Samya A. Bahram, Adel S. Alsayyad

“…However, there are no published previous studies to determine such disease and its burden in Bahrain. Hence, this study aims to estimate the prevalence and evaluate the risk factors associated with GERD among adults attending primary care in Bahrain. …”
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Identification of β-globin gene mutations among transfusion-dependent β-thalassemia patients by Haidar Hussein Al-Fatlawi, Bassam Mahammad Hameed

“…The detection of the most frequent mutations is significant to the implementation of an effective preventive program in this area because of the significant burden it places on the local health authorities, patients, and their families. …”
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Evaluation of Sociodemographic Factors among Diabetic Patients with Urinary Tract Infections in Kisii Referral Hospital, Kenya by Vincent M. Mageto, Oliver W. Mbuthia, Caroline J. Ngetsa, Dinah O. Moraa, Erick O. Okoyo, Scholastica G. Mathenge, Wachuka G. Njoroge

“…Clean-catch midstream urine was collected from all participants and cultured in cysteine lactose electrolyte deficient agar for bacterial isolation. …”
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Associations between inflammation and striatal dopamine D2-receptor availability in aging by Vanessa Crine, Goran Papenberg, Jarkko Johansson, Carl-Johan Boraxbekk, Anders Wåhlin, Ulman Lindenberger, Martin Lövdén, Katrine Riklund, Lars Bäckman, Lars Nyberg, Nina Karalija

“…No significant association was found between DNA methylation scores and white-matter lesions, but higher scores as well as higher lesion burden were independently associated with reduced striatal DRD2 availability in men. …”
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