Study protocol for a stepped-wedge implementation study investigating the intersectoral collaboration of implementing the TREAT INTERACT intervention for primary school teachers an... by Ane-Marthe Solheim Skar, Ingunn Marie S. Engebretsen, Nora Braathu, Harriet Aber, Harald Bækkelund, Melf-Jakob Kühl, Marjorie Mukisa, Joyce Sserunjogi Nalugya, Norbert Skokauskas, Vilde Skylstad, Tore Wentzel-Larsen, TREAT research consortium, Juliet Ndimwibo Babirye

“…Abstract Background Mental and neuropsychological disorders make up approximately 14% of the total health burden globally, with 80% of the affected living in low- and middle-income countries (LMICs) of whom 90% cannot access mental health services. …”
Get full text

Testing the Psychometric Properties of a Chinese Version of the Level of Expressed Emotion Scale by Wai Tong Chien, Zenobia Chung-Yee Chan, Sally Wai-Chi Chan

“…The four-factor Chinese version also indicated a good concurrent validity with significant correlations with family functioning (r = −0.54) and family burden (r = 0.49) and a satisfactory reproducibility over six months (intraclass correlation coefficient of 0.90). …”
Get full text

Iron⁃calcium⁃biochar enhanced sludge deep dewatering and sludge⁃based biochar preparation by JIAO Hongming, FU Liang*, ZHOU Yingying, WANG Xurong, ZHANG Leilei, Gao Yonglin, ZHOU Dandan

“…Furthermore, the pH of the filtrate remained close to neutral, thus avoiding additional burden on the filtrate treatment process. The dehydrated sludge cake containing Fe and Ca elements were utilized to produce high-performance sludge-based biochar under 400 ℃. …”
Get full text

Unveiling the psychosocial and academic implications of living with sickle cell disease among undergraduates in a private university in Nigeria by Olumide T. Adeleke, Olufemi Folaranmi, Yetunde Olasinde, Larry Ayuba, Oludamola V. Adeleke, Modupe M. Ojo-Rufai, Efeturi Agelebe, Oyelola E. Adeoye, Aderemi T. Olabode, Dolapo E. Ajala, Titilola S. Akingbola

“…Conversely, some SCD patients enjoy some social support from colleagues and family members which gives hope and succor to them during difficult times.ConclusionThis study reveals that undergraduates with SCD face various academic and psychosocial challenges that affect their overall performance. …”
Get full text

Effectiveness of an intensive outpatient treatment programme combining prolonged exposure and EMDR therapy for adolescents and young adults with PTSD in a naturalistic setting by Elvira M. Rentinck, Rosa van Mourik, Ad de Jongh, Suzy J. M. A. Matthijssen

“…PTSD symptoms, depressive symptoms, and the perceived burden of trauma symptoms were assessed before treatment, at the start and one month after treatment.Results: Patients showed a significant reduction in PTSD symptoms from pre-treatment to one month after treatment (Cohen’s d = 1.66). …”
Get full text

Delving into female breast cancer: Distinct disease-specific survival outcomes between invasive lobular and ductal carcinomas revealed by propensity score matching. by Wu Zhang, Yuquan Huang, Ye Zhou, Jiaojiao Xue, Shan Gao, Lin Kang, Jian Shi, Tao Zhou, Yalong Duan, Sihan Guo, Qingxia Li

“…Resolving this controversy can help to more accurately determine patients' prognosis, provide further personalized treatment, alleviate unnecessary psychological burden for some patients, and provide direction for further fundamental research.…”
Get full text

A study on beneficial impact of the use of medium-molecular-weight hydroxyethyl starch in granulocyte apheresis using continuous-flow cell separator Spectra Optia: A retrospective... by Amardeep Pathak, Devasis Panda, Narender Tejwani, Anurag Mehta

“…This strategy can also have no or minimal extra cost burden to patients.…”
Get full text

Nonsevere Hypoglycemia Episode Clinical and Economic Outcomes: A Comparison between Sulfonylurea and Sodium-Glucose Cotransporter 2 Inhibitor as Add-On to Metformin from a Canadian... by Pendar Farahani

“…Nonsevere hypoglycemia episodes (NSHEs) are associated with clinically adverse outcomes, lower health-related quality of life, increased burden of disease, and reduced work productivity. …”
Get full text

Prevalence of Hepatic Encephalopathy from a Commercial Medical Claims Database in the United States by Aniruddha Potnis, Susan VanMeter, Jan Stange

“…In this longitudinal cohort–based study, it was estimated that ≈202,000 patients had HE in the United States in 2018, representing a considerable burden to society and payers.…”
Get full text

Potential biomarkers for cerebral small vessel disease with cognitive impairment: a systematic review and meta-analysis by Libin Liao, Weiquan Huang, Rongchao Ma, Xuan He, Xuan He, Moxi Su, Dujuan Sha, Dujuan Sha, Dujuan Sha

“…CSVD-related cognitive impairment (CSVD-CI) affects more and more elderly people, resulting in economic losses and burdens on families and society. In recent years, circulating biomarkers have made breakthroughs and played an increasingly important role in the diagnosis, progression, and prognosis of CSVD-associated cognitive impairment, and are expected to be applied to the early clinical detection, diagnosis, and treatment of patients with cerebral small vessel disease. …”
Get full text

Influence of Overweight and Obesity on Morbidity and Mortality among Hospitalized Patients in Sri Lanka: A Single-Center Analysis by M. D. S. A. Dilrukshi, V. Thotamuna, D. J. Senarath Yapa, L. De Silva, P. Ranasinghe, P. Katulanda

“…Conclusion. A double burden of malnutrition and diseases were noted among hospital admissions, with obesity being a risk factor for in-hospital all-cause mortality and AKI. …”
Get full text

Analysis of differentially expressed genes in hypertension and hypertensive cerebral hemorrhage via RNA-sequencing by Hongwu Qi, Min Qiao, Yansong Liu, Weijun Zeng, Lizhao Zhang, Hongjun Guo

“…Hypertension (HT) is a major cause of intracerebral hemorrhage (ICH), and hypertensive cerebral hemorrhage (HCH) has a serious impact on life quality of patients and gives society a heavy burden. This study investigated the key genes involved in HT and HCH. …”
Get full text

Anti-SARS-CoV-2 Antibody Screening in Healthcare Workers and Its Correlation with Clinical Presentation in Tertiary Care Hospital, Kathmandu, Nepal, from November 2020 to January 2... by Suraj Aryal, Sanskriti Pandit, Sushant Pokhrel, Mandira Chhusyabaga, Pabitra Bista, Mahendra Psd. Bhatt, Dharma Datta Subedi, Basista Psd. Rijal

“…Healthcare workers carry a high burden of SARS-CoV-2 infection and are at risk of acquiring infection from their workplace. …”
Get full text

Enhanced AC/DC optimal power flow via nested distributed optimization for AC/VSC-MTDC hybrid power systems by Haixiao Li, Pedro P. Vergara, Robert Dimitrovski, Hongjin Du, Aleksandra Lekić

“…One of the most critical issues is how to achieve the optimal operation of such wide-area systems involving several power entities with as minimal communication burden as possible. To address this issue, an enhanced AC/DC optimal power flow (OPF) is specifically proposed. …”
Get full text

Diet management of older subjects with Oropharyngeal Dysphagia: The efficacy of ready-made texture-modified and fortified meals by Nikolina Jukic Peladic, Paolo Orlandoni, Laura Bartoloni, Giulia Giulioni, Claudia Venturini, Alessia Fumagalli

“…Difficulties with their preparation and administration aggravate also the burden of caregivers. This study investigated whether the ready-made texture-modified meals, fortified with amino acids and Vitamin D, may guarantee safe and efficient management of meals in older subjects with OD and facilitate patient management. …”
Get full text

IMMUnity Unveiled: A Translational NETwork for tackling PARKinson's Disease – IMMUPARKNET [version 2; peer review: 2 approved] by Tamara Saksida, Alessia di Flora, Marina Romero-Ramos, Vladimirs Pilipenko, Laura Muñoz Delgado, Franca Marino, Yasemin Gursoy Ozdemir, Neda Nikolovski, Cristoforo Comi, Dale Lawson, Inês Figueira, Mitilda Gugu, Simona Poletti, Shubhra Acharya, Dogukan Pira

“…It currently has no definitive cure, meaning that patients rely only on symptomatic treatments, which themselves are burdened by side effects. …”
Get full text

Timp2 loss-of-function mutation and TIMP2 treatment in a murine model of NSCLC: Modulation of immunosuppression and oncogenic signaling by David Peeney, Sarvesh Kumar, Tej Pratap Singh, Yueqin Liu, Sandra M. Jensen, Ananda Chowdhury, Sasha Coates-Park, Joshua Rich, Sadeechya Gurung, Yu Fan, Daoud Meerzaman, William G. Stetler-Stevenson

“…Mounting evidence suggests that the tissue inhibitor of metalloproteinases-2 (TIMP2) can reduce tumor burden and metastasis. However, the demonstration of such anti-tumor activity and associated mechanisms using in vivo tumor models is lacking. …”
Get full text

Russia and Poland: Problems of Inevitable Coexistence by D. V. Ofitserov-Belskiy

“…Over the last quarter of the century relations between Russia and Poland are balancing between trying to understand the burden of mutual guilt and a desire to construct non-emotional pragmatic relations. …”
Get full text

BMI trajectories are associated with NAFLD and advanced fibrosis via aging-inflammation mediation by Haiyang Peng, Zhibo Zhao, Jianping Gong, Kun He

“…Abstract Background As the global epidemic of obesity fuels metabolic conditions, the burden of nonalcoholic fatty liver disease (NAFLD) will become enormous. …”
Get full text

The Effect of Community Based Intervention on People with Type 2 Diabetes Mellitus: Systematic Review by M Agung Akbar, Junaiti Sahar, Etty Rekawati, Ratu Ayu Dewi Sartika, Prateek Gupta

“… Background:The rising prevalence of Type 2 Diabetes Mellitus (T2D) has become a significant global health burden, with profound implications for healthcare systems and affected individuals. …”
Get full text