Association between cardiovascular health and metabolic dysfunction-associated steatotic liver disease: a nationwide cross-sectional study by Lian-Zhen Huang, Ze-Bin Ni, Wei-Feng Huang, Li-Ping Sheng, Yan-Qing Wang, Jin-Yan Zhang

“…Encouraging adherence to optimal CVH levels may help mitigate the burden of MASLD.…”
Get full text

Prevalence, Intensity, and Associated Factors of Schistosoma mansoni among School Children in Northwest Ethiopia by Ayalew Jejaw Zeleke, Ayenew Addisu, Yalewayker Tegegne

“…Schistosomiasis is one of the Neglected Tropical Diseases in Ethiopia, and its burden may show variations from time to time across different regions. …”
Get full text

Morbidity and Mortality of Premature Birth at Ramadi Teaching Hospital for Maternity and Children/West of Iraq by Sabah M Ali, Rana F Shitran

“…With improvement of neonatal care facilities, it still comprises a burden on health care centers, with a lot of costs and increasing mortality. …”
Get full text

Protocol for the enhanced management of multimorbid patients with COPD and severe asthma: role of indoor air quality by Emili Vela, Isaac Cano, Josep Roca, Antoni Sisó-Almirall, Carme Hernandez, Ebymar Arismendi, Ramon Farré, Alba Gómez-López, María Figols, Antonio Montilla-Ibarra, Núria Sánchez-Ruano, Benigno Sánchez, Marta Sorribes, Jordi Piera-Jiménez, Jaume Benavent, Jose Fermoso, Rubèn González-Colom

“…Each cycle involves a targeted cocreation process following a mixed-methods approach with the active participation of patients, health professionals, managers and digital experts.Ethics and dissemination The Ethics Committee for Human Research at Hospital Clinic de Barcelona approved the protocol on 29 June 2023 (HCB/2023/0126). Before any procedure, all patients in the study must sign an informed consent form.Trial registration number NCT06421402.…”
Get full text

Immunopathology of Airway Surface Liquid Dehydration Disease by Brandon W. Lewis, Sonika Patial, Yogesh Saini

“…However, a plethora of abiotic insults and airborne pathogens present in the environment are occasionally introduced into the airspaces during inhalation, which could be detrimental to the structural integrity and functioning of the respiratory system. …”
Get full text

Blood-based biomarkers in patients with non-small cell lung cancer treated with immune checkpoint blockade by Yo-Ting Tsai, Jeffrey Schlom, Renee N. Donahue

“…In response, there has been a growing emphasis on the development of “liquid biopsy”‒ derived biomarkers, which offer a minimally invasive means to dynamically monitor the immune status of NSCLC patients either before and/or during the course of treatment. Here we review studies in which multiple blood-based biomarkers encompassing circulating soluble analytes, immune cell subsets, circulating tumor DNA, blood-based tumor mutational burden, and circulating tumor cells have shown promising associations with the clinical response of NSCLC patients to ICI therapy. …”
Get full text

Neoadjuvant apatinib addition to sintilimab and carboplatin-taxane based chemotherapy in patients with early triple-negative breast cancer: the phase 2 NeoSAC trial by Guoshuang Shen, Zhilin Liu, Miaozhou Wang, Yi Zhao, Xinlan Liu, Yujin Hou, Wenbiao Ma, Jingqi Han, Xiaofeng Zhou, Dengfeng Ren, Fuxing Zhao, Zitao Li, Shifen Huang, Yongzhi Chen, Yingjian He, Yan Liu, Zijun Zhu, Yongxin Li, Jinming Li, Mengting Da, Hongnan Mo, Feng Du, Liang Cui, Jing Bai, Zhen Liu, Fei Ma, Jiuda Zhao

“…Among 34 enrolled patients, 24 achieved pCR (70.6%; 95% confidence interval (CI), 53.0-85.3), and 79.4% (95% CI, 65.1-93.7) had residual cancer burden 0-I. Imaging evaluation showed 21 complete responses (61.8%) and 13 partial responses (38.2%). …”
Get full text

Social participation challenges and facilitators among Chinese stroke survivors: a qualitative descriptive study by Xiaojuan Wan, Dorothy Ngo Sheung Chan, Janita Pak Chun Chau, Yu Zhang, Zhi’e Gu, Limei Xu

“…These values included family-oriented beliefs regarding responsibility towards their children, struggles with societal expectations, and perceptions of social participation being a burden on others. Conclusions Stroke survivors perceived varying degrees of changes in their social participation. …”
Get full text

Identifying biomarkers for epilepsy after cerebral malaria in Zambian children: rationale and design of a prospective observational study by Bo Zhang, Archana A Patel, Gretchen L Birbeck, Maitreyi Mazumdar, Suzanna Mwanza, Rosemary Nyirongo, Dixon Berejena, Joseph Kasolo, Tina Mwale, Violet Nambeye, Kafula Lisa Nkole, Nfwama Kawatu, Alexander Rotenberg

“…Outcome measures will include qualitative and quantitative analysis of routine EEG recordings, as well as clinical metrics in the acute and subacute period, including histidine-rich protein 2 levels of parasite burden, depth and length of coma, presence and severity of acute seizures, presence of hypoglycaemia, maximum temperature and 1-month post-CM neurodevelopmental assessment scores. …”
Get full text

Recovery from Liver Failure and Fibrosis in a Rat Portacaval Anastomosis Model after Neurointermediate Pituitary Lobectomy by Martín Muñoz-Ortega, Noé Macías-Segura, Javier Ventura-Juárez, Manuel Enrique Ávila-Blanco, Leonardo D. Ponce-Damian, Daniel González-Blas, Esperanza Sánchez-Alemán, Andrés Quintanar-Stephano

“…Liver diseases, including cirrhosis, viral hepatitis, and hepatocellular carcinoma, account for approximately two million annual deaths worldwide. They place a huge burden on the global healthcare systems, compelling researchers to find effective treatment for liver fibrosis-cirrhosis. …”
Get full text

Potential for eliminating COVID-19 in Thailand through third-dose vaccination: A modeling approach by Pannathon Kreabkhontho, Watchara Teparos, Thitiya Theparod

“…Simulation results demonstrated that the optimal vaccination rate led to a substantial decrease in the number of infections, with the epidemic projected to be completely eradicated from the population by June 19, 2022. These findings underscore the importance of targeted vaccination efforts and proactive public health interventions in mitigating the spread of COVID-19 and minimizing the burden on healthcare systems. …”
Get full text

Implicit bias in referrals to relational psychological therapies: review and recommendations for mental health services by Chenai Mandangu, Anne Millicent Ramos, Mohona Sengupta, Rosslyn Bender, Reem El-Hayani, Ifrah Hasan, Hannah Okechukwu, Shafeena Anas, Dominik Havsteen-Franklin

“…IntroductionTimely and appropriate psychological treatment is an essential element required to address the growing burden of mental health issues, which has significant implications for individuals, society, and healthcare systems. …”
Get full text

Examining the relationship between incidence and mortality for commonly diagnosed cancers in the USA: an observational study using population-based SEER database by H Gilbert Welch, Adewole S Adamson, Vishal R Patel

“…Objective Incidence and mortality are fundamental epidemiologic measures of cancer burden, yet few studies have examined individual cancers to determine how these measures correlate across place. …”
Get full text

Assessing the diagnostic accuracy of radiological and histological findings in the diagnosis of non-alcoholic fatty liver disease stages among patients in a tertiary hospital by Ekpe Edemekong L, Emanghe U, Ekpe EL, Obiora IC, Yemiode Itam, Akinmola OO

“…Background: Early screening, detection, and early intervention are life-saving modalities to lessen the impact and burden of non-communicable diseases. Aim and Objectives: To evaluate the diagnostic strength of ultrasound in the diagnosis of Non-alcoholic Fatty Liver Disease (NAFLD) stages. …”
Get full text

Efficient and secure attribute-based heterogeneous online/offline signcryption for body sensor networks based on blockchain by Jawaid Iqbal, Arif Iqbal Umar, Noorul Amin, Abdul Waheed

“…Furthermore, we design an online/offline signcryption method to overcome the burden on biosensor nodes. We split the signcryption process into two phases: offline phase and online phase. …”
Get full text

'We don't have the right to get sick': A qualitative study of gaps in public health insurance among Im/migrant women in British Columbia, Canada. by Shira M Goldenberg, Shaina Schafers, Maggie Hamel-Smith Grassby, Stefanie Machado, Ruth Lavergne, Mei-Ling Wiedmeyer, IRIS Study Team

“…Participants also described ineligibility for public health insurance as resulting in a high economic burden, and that exclusion from public health insurance perpetuated experiences of discrimination, invisibility, and exclusion from systems of care amongst im/migrant participants. …”
Get full text

The association Malnutrition-Inflammation Score with chronic kidney disease-associated pruritus and quality of life in hemodialysis patients: a multicenter cross-sectional study by Hossein Bavi Behbahani, Meysam Alipour, Ahmad Zare Javid, Hamidreza Razmi, Pardis Tofighzadeh, Fatemeh Fayazfar, Sara Keramatzadeh, Shiva Shokri, Haleh Soltaniyan Dehkordi, Kian Khosravi, Siavash Babajafari Esfandabad, Shokouh Shayanpour

“…Moreover, the pruritus VAS score, as well as the burden of kidney disease and mental component, had a significant negative association with MIS after adjusting for confounders (p < 0.05 for all). …”
Get full text

Backtranslation of human RNA biosignatures of tuberculosis disease risk into the preclinical pipeline is condition dependent by Hannah Painter, Sasha E. Larsen, Brittany D. Williams, Hazem F. M. Abdelaal, Susan L. Baldwin, Helen A. Fletcher, Andrew Fiore-Gartland, Rhea N. Coler

“…These data suggest that in certain experimental designs and in several tissue types, human COR signatures correlate with disease progression as measured by the bacterial burden in the preclinical TB model pipeline. We observed the best performance when the model most closely reflected human infection or disease conditions. …”
Get full text

Dogmatic Construction of Universal Legal Succession in the Field of Inheritance Law by O. Ye. Kukharyev

“…The integrity of the construction of universal hereditary legal succession is ensured by a set of the following factors: 1) the succession passes to lawful heirs unchanged as a cohesive whole, with all the methods of provision and the burdens imposed on it; 2) immediacy, which is manifested in the fact that the lawful heir acquires the succession directly from the ancestor without prior transfer to third parties; 3) the uniqueness of the transfer of the succession to lawful heirs from the time of its opening, regardless of the time of acceptance and state registration; 4) the rights and obligations that belonged to the ancestor are transferred to lawful heirs in the same form in the composition, volume and value, which existed at the time of the opening of the succession; 5) conclusiveness and unconditionalness of the acts of the succession’s acceptance and refusal of its acceptance. …”
Get full text

Protocol for a nested case-control study: identifying neuroimaging biomarkers for the progression of subclinical depression and qi-stagnation constitution to major depressive disor... by Jing Wang, Chengfeng Zhang, Yueqi Zhang, Yuanyuan Liu, Jingli Zhang, Xingwei Fang, Wangyang Xia, Yanzhao Xie, Zhongli Lan, Jinhui Wang, Jinhui Wang, Jinhui Wang, Jinhui Wang, Min Lu, Jun Chen, Jun Chen

“…BackgroundMajor depressive disorder (MDD) frequently results in suboptimal treatment outcomes and elevated recurrence rate, with patients frequently engaging in self-harm and suicidal behavior, thereby placing a heavy burden on families and society. Specifically, MDD in adolescents is linked to an elevated suicide risk. …”
Get full text