Hydrolysis and Oxidation of Recalcitrant Substrates by Microbial Isolates from Hot Springs by Anastasiya I. Dmitrieva, Elizaveta R. Faskhutdinova, Timothy A. Larichev, Natalia S. Velichkovich, Veronika Yu. Boger, Larisa M. Aksenova

“…Microbial fuel cells are an alternative energy source that can reduce the environmental burden. Microbial fuel cells also remove recalcitrant wastes from wastewater. …”
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Sex-specific prevalence, inequality and associated predictors of hypertension, diabetes, and comorbidity among Bangladeshi adults: results from a nationwide cross-sectional demogra... by Abdur Razzaque Sarker, Raisul Akram, Nausad Ali, Marufa Sultana, Nurnabi Sheikh

“…A joint effort involving public, private and non-governmental organisations is necessary to ensure improved accessibility in service utilisation and to reduce the disease burden.…”
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Assessing a clinical vital sign in severe mental illness: validation study of the 5 sit-to-stand test for monitoring muscle strength – The PsychiActive Project by Alvaro Lopez-Moral, Diego Munguia-Izquierdo, Javier Bueno-Antequera

“…Routine muscle strength assessments could identify vulnerabilities, thereby reducing the growing burden associated with SMI. However, integration into clinical settings faces obstacles because of limited resources and inadequate healthcare staff training. …”
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Yoga: As a Transformative Approach to Addressing Male Infertility and Enhancing Reproductive Health in Men: A Narrative Review by Anjali Yadav, Prabhakar Tiwari, Rima Dada

“…Infertility presents multifaceted challenges that encompass both physical and emotional burdens. Yoga, as a comprehensive system of mind–body medicine, serves as an effective intervention for managing male factor infertility, a complex lifestyle disorder with significant psychosomatic elements. …”
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Comprehensive Analysis of Differentially Expressed miRNAs and mRNAs Reveals That miR-181a-5p Plays a Key Role in Diabetic Dermal Fibroblasts by Peng Liu, Yi Zhu, Qin Li, Biao Cheng

“…A diabetic nonhealing wound causes heavy economic burden and compromised quality of life in patients. …”
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The Accuracy of the Clinical Carpal Tunnel Syndrome Diagnosis before the Nerve Conduction Studies by A. Atkočiūnas, A. Šimkutė, Rasa Mameniškienė

“…CTS affects middle-aged active workers and is associated with high healthcare costs and a hefty economic burden. It is thus essential to diagnose CTS early and refer the patient to further investigation and treatment. …”
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Use of Healthcare Claims Data to Generate Real-World Evidence on Patients With Drug-Resistant Epilepsy: Practical Considerations for Research by Nicole Stamas, Tom Vincent, Kathryn Evans, Qian Li, Vanessa Danielson, Reginald Lassagne, Ariel Berger

“…**Objectives:** Regulatory bodies, health technology assessment agencies, payers, physicians, and other decision-makers increasingly recognize the importance of real-world evidence (RWE) to provide important and relevant insights on treatment patterns, burden/cost of illness, product safety, and long-term and comparative effectiveness. …”
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Oral health status, behavior and impact profile among naval personnel in the Malaysian naval armed forces by Nik Madihah Nik Azis, Raja Noreihan Raja Abdullah, Mohamad Nur Adzmi Mohamad Ayub, Badiah Baharin

“…The DMFT index highlighted a substantial burden of dental caries with a mean score of 4.59 ± 4.24, including untreated decay (1.15 ± 1.63). …”
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Epigenome-wide DNA methylation profiling in septic and non-septic patients with similar infections: potential use as sepsis biomarkers by Ian López-Cruz, Ian López-Cruz, José Luis García-Giménez, José Luis García-Giménez, José Luis García-Giménez, Manuel Madrazo, Manuel Madrazo, Judit García-Guallarte, Laura Piles, Federico V. Pallardó, Federico V. Pallardó, Federico V. Pallardó, Arturo Artero, Arturo Artero

“…Despite its significant global burden, the underlying mechanisms of immune dysfunction in sepsis remain incompletely understood. …”
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Association between exposure to environmental pollutants and increased oral health risks, a comprehensive review by Li Zhu, Mengchen Tang, Yinyin Cai, Yinyin Cai, Panpan Wang, Panpan Wang

“…The burden of disease and death attributable to environmental pollution is a growing public health challenge worldwide, particularly in developing countries. …”
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Renal Dysfunction among Ghanaians Living with Clinically Diagnosed Hypertension in the Asutifi-South District: A Cross-Sectional Descriptive Study at the St. Elizabeth Hospital, Hw... by Sylvester Yao Lokpo, James Osei-Yeboah, William K. B. A. Owiredu, Francis Abeku Ussher, Verner Ndudiri Orish, Felix Gadzeto, Paul Ntiamoah, Felix Botchway, Ivan Muanah, Romeo Asumbasiya Aduko

“…This study aimed at evaluating the burden of renal dysfunction among people living with hypertension in the Asutifi-South District of the Brong Ahafo Region, who were attending clinic at the St. …”
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Scutellarin combined with lidocaine exerts antineoplastic effect in human glioma associated with repression of epidermal growth factor receptor signaling. by Xiu-Ying He, Yui-Si Yang, Yue-Xiang Zheng, Qing-Jie Xia, Hong-Zhou Yu, Xiao-Ming Zhao, Ting-Hua Wang

“…Although great achievements have been made in the treatment, the efficacy is still unsatisfactory, which imposes a hefty burden on patients and society. Therefore, the exploration of new and effective anti-glioma drugs is urgent.…”
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Multicentre study conducted across centres in the USA, Europe and Australia to assess the safety and effectiveness of a bilateral hypoglossal nerve stimulation system for the treat... by B Tucker Woodson, Maria V Suurna, M Boyd Gillespie, Tod C Huntley, Melyssa Hancock, Angela Santos, Jeyakumar Subbaroyan, Fatima Makori, Grégoire Fesneau, Clemens Heiser, David T Kent

“…Secondary effectiveness endpoints include mean changes in quality-of-life assessments (daytime sleepiness and its effect on activities of daily living, OSA-specific quality of life, daytime sleepiness), levels of intermittent hypoxia, change in hypoxaemic burden and OSA severity.Ethics and dissemination The Food and Drug Administration, Advarra Institutional Review Board (IRB), University of Tennessee HSC IRB, University of Pennsylvania IRB, Weill Cornell Medicine IRB, Medical College of Wisconsin/Froedert Hospital, Human Research Protections Programme Vanderbilt University, St. …”
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Evaluation of Real-Life Investigational Use of Enoximone in Asthma, the Third Step in Drug Repurposing: A Preliminary Report by Jan Beute, Pieter Boermans, Alex KleinJan

“…The population of uncontrolled asthma patients represents a large therapeutic burden. The PDE3-inhibitor enoximone is a strong and quick bronchodilator and is known to successfully treat life-threatening bronchial asthma (status asthmaticus). …”
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SAlexNet: Superimposed AlexNet using residual attention mechanism for accurate and efficient automatic primary brain tumor detection and classification by Qurat-ul-ain Chaudhary, Shahzad Ahmad Qureshi, Touseef Sadiq, Anila Usman, Ambreen Khawar, Syed Taimoor Hussain Shah, Aziz ul Rehman

“…In this work, we propose Superimposed AlexNet (SAlexNet-1 and its extension SAlexNet-2) to detect the malignancy of primary brain tumors (Glioma, Meningioma, and Pituitary) by incorporating three enhancements: (1) fusing Hybrid Attention Mechanism (HAM), (2) dense feature extraction by replacing initial convolution 11 × 11 layer with multiple convolution 3 × 3 layers for extra non-linearity alleviating parameter burden, and (3) pretraining the encoder path on a correlated dataset via semi-transfer learning (STL) enhancing model performance. …”
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Inverse relationship of oxidative balance score with hyperuricemia among Chinese adults: a population-based cross-sectional study by Hewei Peng, Ying Han, Jingru Huang, Wenxin Qiu, Huajing Chang, Jiangwang Fang, Xian-E Peng

“…Abstract Background The oxidative balance score (OBS) is a composite metric highlights pro-oxidants and antioxidants balance, representing the overall burden of oxidative stress. This study aims to examine the association between OBS and hyperuricemia in a Chinese population. …”
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Long-term ambient air pollution and the risk of major mental disorder: A prospective cohort study by Chuyu Pan, Bolun Cheng, Shiqiang Cheng, Li Liu, Xuena Yang, Peilin Meng, Xin Qi, Na Zhang, Xiaoyue Qin, Dan He, Wenming Wei, Jingni Hui, Yan Wen, Yumeng Jia, Huan Liu, Feng Zhang

“…Conclusions Our findings highlight the importance of air pollution control in alleviating the burden of MD. …”
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Does semaglutide reduce alcohol intake in Danish patients with alcohol use disorder and comorbid obesity? Trial protocol of a randomised, double-blinded, placebo-controlled clinica... by Jens Juul Holst, Tina Vilsbøll, Claus Thorn Ekstrøm, Helene Benveniste, Nora D Volkow, Anders Fink-Jensen, Gitte M Knudsen, Mette Kruse Klausen, Tugba Kuzey, Julie Niemann Pedersen, Signe Keller Justesen, Line Rasmussen, Ulla B Knorr, Graeme Mason, George Koob

“…Introduction Alcohol use disorder (AUD) is a massive burden for the individual, relatives and society. …”
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Fractures in sub-Saharan Africa: epidemiology, economic impact and ethnography (Fractures-E3): study protocol [version 1; peer review: 2 approved] by Christopher Grundy, Simon Matthew Graham, Hannah Wilson, Samuel Hawley, Kebba Marenah, Tadios Manyanga, James Masters, Bintou Trawally, Munyardardzi Ndekwere, Prudance Mushayavanhu, Mkhululi Lukhele, Rachael Gooberman-Hill, Farhanah Paruk, Kate A. Ward, Matthew Costa, Celia L. Gregson, Rashida A. Ferrand, Sarah Drew, Anya Burton, Landing M. Jarjou, Bilkish Cassim, Nyashadzaishe Mafirakureva, Sian Noble

“…Conclusions: Greater understanding of current and expected fracture burdens, fracture risk factors, and existing fracture care provision, is intended to inform national clinical guidelines, health service policy and planning and future health service development in sub-Saharan Africa.…”
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Neoandrographolide inhibits mature osteoclast differentiation to alleviate bone loss and treat osteoporosis by Kai Tang, Kai Tang, Kai Tang, Wei Deng, Wei Deng, Wei Deng, Wei Deng, Zhiying Huang, Zhiying Huang, Zhiying Huang, Simin Chen, Simin Chen, Simin Chen, Zilin Zhu, Zilin Zhu, Shukun Lin, Shukun Lin, Lubin Zhong, Lubin Zhong, Quanxin Zheng, Quanxin Zheng, Wenhua Zhao, Wenhua Zhao, Zhida Zhang, Zhida Zhang, Ling Mo, Ling Mo, Ling Mo

“…The clinical discomfort and complications associated with OP impose a significant burden on patients. Therefore, finding more effective treatments for OP remains an urgent challenge.MethodWe first conducted in vitro experiments to determine whether Neoandrographolide (NEO) exhibits cytotoxic or proliferative effects on bone marrow macrophages (BMMs) and to explore the specific timeframe during which NEO exerts its inhibitory action on osteoclast (OC) differentiation. …”
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