The Clinical Outcome of Transforaminal Lumbar Interbody Fusion and Laminectomy for Single-level Lumbar Canal Stenosis with Grade 1 and 2 Spondylolisthesis by Ashok Sharma, Tarachand Suthar, Mudit Mathur, Vishnu Mittal, Shiv Bhagwan Sharma, Gaurav Mehta

“…Laminectomy procedures are associated with lesser economic burden, lesser hospital stays, lesser blood loss, and shorten surgical duration compared to TLIF.…”
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A 10-year review of isoniazid-resistant TB management in Uzbekistan 2009-2020 by M.L. Rekart, P. Thit, M. Oluya, S. Moe, T. Hasan, N. Parpieva, K. Safaev, A. Khristusev, T. Zinaida, J. Singh, S. Allamuratova, I. Azamat, C.G. Restrepo, N. Sitali, J. Achar, J.L. Alvaraez, A. Sinha

“…Uzbekistan has a high burden of TB (62/100,000 population) and multidrug-resistant TB (12/100,000 population). …”
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Acute Stroke in northern Portugal: outcomes and characteristics of patients in a Medical-Surgical Emergency Department by Sandra Domingues, Tiago Barros, João Correia, Arlindo Cruz, Nuno Araújo, Liliana Silva

“…Disparities in European access to stroke care suggest an increased burden on individuals and society. Effective management of acute stroke in emergency departments is critical, requiring a rapid and coordinated response to optimize clinical outcomes. …”
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Intra-Cardiac Kinetic Energy and Ventricular Flow Analysis in Bicuspid Aortic Valve: Impact on Left Ventricular Function, Dilation Severity, and Surgical Referral by Ali Fatehi Hassanabad, Julio Garcia

“…Intra-cardiac kinetic energy (KE) and ventricular flow analysis (VFA), as derived from 4D-flow MRI, can be used to understand the physiological burden placed on the left ventricle (LV) due to bicuspid aortic valve (BAV). …”
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Real-World Effectiveness and Safety of Isavuconazole Versus Amphotericin B for Patients with Invasive Mucormycosis by Jiayuan Qin, Hongxia Bi, Guangmin Tang, Xinyao Liu, Junyan Qu, Xiaoju Lv, Yanbin Liu

“…Background: Invasive mucormycosis (IM) poses a substantial morbidity and mortality burden among immunocompromised patients. Objectives: We aim to compare the real-world effectiveness and safety of isavuconazole with those of amphotericin B in patients with IM. …”
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A Profile and Three-Year Follow-Up of Patients with Basal Cell Carcinoma in the Western Cape, South Africa by J. C. Gallo, J. W. Schneider, J. de Wet, K. Moxley, H. F. Jordaan, W. I. Visser, B. Tod

“…BCC represents a high burden of disease in our setting. Compared to existing studies, the BCCs in this study are clinically and histologically similar to international reports.…”
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Co-design and content validation of psychosis care assessment material for medical, pharmacy, nursing, and occupational therapy curricula by Jenny Chen, Jack Charles Collins, Justin Newton Scanlan, Andrea McCloughen, Rosa Howard, Claire Ashton-James, Claire L. O’Reilly, Rebekah J. Moles, Tina X. Ung, Carl R. Schneider, Bandana Saini, Jennifer Ong, Paul Beckett, Karen Watson, Margaret McGrath, Timothy F. Chen, Sarira El-Den

“…Abstract Background Despite high disease burden and heightened suicide risk associated with psychosis, psychosis education is lacking in healthcare curricula, potentially hindering students’ willingness, and confidence to provide psychosis care as future healthcare professionals. …”
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Combination of ataxia telangiectasia and Rad3-related inhibition with ablative radiotherapy remodels the tumor microenvironment and enhances immunotherapy response in lung cancer by Jenny Ling-Yu Chen, Chun-Kai Pan, Li-Cheng Lin, Yu-Sen Huang, Tsung-Hsuan Huang, Shu-Jyuan Yang, Sung-Hsin Kuo, Yu-Li Lin

“…Adding ICI therapy further enhanced local antitumor effects, reducing the metastatic lung tumor burden and remodeling the tumor microenvironment through immunogenic cell death induction and enhanced immune cell infiltration. …”
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Prior immunity to Ureaplasma urealyticum protects against respiratory infection in immunosuppressed mice by Maha Y. Al-Jabri, Robin Patel, Derek Fleming

“…U. urealyticum and U. parvum lung burden was reduced in immunized compared with control mice (~6 log10 reduction for U. urealyticum and <1 log10 reduction for U. parvum; P = 0.008 and 0.046, respectively). …”
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Spray vaccination with a safe and bivalent H9N2 recombinant chimeric NDV vector vaccine elicits complete protection against NDV and H9N2 AIV challenge by Xiaoquan Wang, Jing Dai, Wenhao Yang, Yao Yao, Jin Zhang, Kaituo Liu, Xiaolong Lu, Ruyi Gao, Yu Chen, Jiao Hu, Min Gu, Shunlin Hu, Xiufan Liu, Xiaowen Liu

“…Vaccination is a widely used preventive measure against these pathogens, yet the lack of a live bivalent vaccine targeting NDV and H9N2 AIV imposes a heavy vaccination burden. Previously, we constructed a genotype-matched chimeric NDV vector, LX-OAI4S, in which the genotype I NDV backbone was replaced with the ectodomain of haemagglutinin-neuraminidase (HN) and modified using the attenuated F gene from the genotype VII vaccine strain A-VII. …”
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The high-resolution map of Oxia Planum, Mars; the landing site of the ExoMars Rosalind Franklin rover mission by Peter Fawdon, Csilla Orgel, Solmaz Adeli, Matt Balme, Fred J. Calef, Joel M. Davis, Alessandro Frigeri, Peter Grindrod, Ernst Hauber, Laetitia Le Deit, Damien Loizeau, Andrea Nass, Cathy Quantin-Nataf, Elliot Sefton-Nash, Nick Thomas, Ines Torres, Jorge L. Vago, Matthieu Volat, Sander De Witte, Francesca Altieri, Andrea Apuzzo, Julene Aramendia, Gorka Arana, Rickbir Singh Bahia, Steven G. Banham, Robert Barnes, Alexander M. Barrett, Wolf-Stefan Benedix, Anshuman Bhardwaj, Sarah Jane Boazman, Tomaso R. R. Bontognali, John Bridges, Benjamin Bultel, Valérie Ciarletti, Maria Cristina De Sanctis, Zach Dickeson, Elena A. Favaro, Marco Ferrari, Frédéric Foucher, Walter Goetz, Albert F. C. Haldemann, Elise Harrington, Angeliki Kapatza, Detlef Koschny, Agata M. Krzesinska, Alice Le Gall, Stephen R. Lewis, Tanya Lim, Juan Manuel Madariaga, Benjamin James Man, Lucia Mandon, Nicolas Mangold, Javier Martin-Torres, Joseph D. McNeil, Antonio Molina, Andoni G. Moral, Sara Motaghian, Sergei Nikiforov, Nicolas Oudart, Andrea Pacifici, Adam Parkes Bowen, Dirk Plettemeier, Pantelis Poulakis, Alfiah Rizky Diana Putri, Ottaviano Ruesch, Lydia Sam, Christian Schröder, Christoph Statz, Rebecca Thomas, Daniela Tirsch, Zsuzsanna Toth, Stuart Turner, Martin Voelker, Stephanie C. Werner, Frances Westall, Barry J. Whiteside, Adam Williams, Rebecca M. E. Williams, Jack Wright, Maria-Paz Zorzano

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Subclinical Plasmodium spp. Infections in a Community Setting in Bangui, Central African Republic by Nzoumbou-Boko R, Denissio Morissi Nalingbo MCI, Yambiyo BM, Detol R, Moussa ERF, Nalinga D, Namsenei-Dankpea LJVDLG, Manirakiza A, Ayong L, Boum II Y

“…Proportions of positives were 32.45% by PCR, 27.59% by mRDT, and 23.51% by Giemsa-based thick blood smear microscopy, representing the burden of subclinical malaria. In addition, a 9.56% prevalence of submicroscopic infections was observed. …”
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Examining the impact of implementing routine rotavirus vaccination on the number of paediatric admissions due to diarrhoea and dehydration in Kenyan hospitals: A study using interr... by Samuel Akech, Lucas Malla, Daisy Chelangat, Reuben C. Langat

“…We used a segmented mixed effects model to assess changes in the burden of diarrhoea and dehydration after introduction of rotavirus vaccine. …”
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Otolaryngology needs among an adult homeless population: a prospective study by Vincent Wu, Christopher W. Noel, David Forner, Florence Mok, Molly Zirkle, Antoine Eskander, Vincent Lin, John M. Lee

“…Abstract Background Homeless individuals frequently experience poor access to healthcare, delayed clinical presentation, and higher disease burden. Providing subspecialty otolaryngology care to this population can be challenging. …”
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Surfactin alleviated hyperglycaemia in mice with type 2 diabetes induced by a high-fat diet and streptozotocin by Xiaoyu Chen, Hongyuan Zhao, Fanqiang Meng, Libang Zhou, Zhaoxin Lu, Yingjian Lu

“…In addition, the increased Bifidobacterium abundance indirectly reduced the liver burden of the metabolic products indole, cresol and amine produced by saprophytic bacteria. …”
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Mapping the association between mental health and people's perceived and actual ability to practice hygiene-related behaviours in humanitarian and pandemic crises: A scoping review... by Emily Yasmin Ghassemi, Astrid Hasund Thorseth, Karine Le Roch, Thomas Heath, Sian White

“…Here, they often reside in areas with poor environmental health conditions leading to an increased burden of infectious diseases such as gastrointestinal and respiratory infections. …”
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Effect of atrial high-rate episodes (AHREs) on functional status and quality of life (QoL) in heart failure—cardiac resynchronization therapy population by Lamyaa Elsayed Allam, Youssef Abdel Moneim, Hayam Mohammad Eldamanhoury, Sherif Mohammad Aziz Eltoukhy

“…There was a significant correlation between AHRE and the distance walked during 6MWT when compared to the distance expected for an equivalent healthy individual (82.02 ± 17.22% in the non-AHRE group vs. 75.15 ± 15.78% in the AHRE group, P < 0.001). …”
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The well-being of Polish general practitioners during the COVID-19 pandemic-cross-sectional questionnaire-based study by Katarzyna Nessler, Krzysztof Studziński, Esther Van Poel, Sara Willems, Ewa Wójtowicz, Elżbieta Kryj – Radziszewska, Adam Windak

“…Results A vast majority (80%) of respondents were considered at risk of distress during the COVID-19 outbreak, with an eWBI score of 2 or more. …”
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Sociodemographic Characteristics, Dietary Practices, and Nutritional Status of Adults with Hypertension in a Semi-Rural Community in the Eastern Region of Ghana by Esi K. Colecraft, Matilda Asante, Aaron K. Christian, Seth Adu-Afarwuah

“…Hypertension is a major contributor to the global disease burden and mortality. Evidence suggests increasing hypertension prevalence in Ghana but there is limited public awareness and information on the characteristics of those with the disease. …”
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Interpretable machine learning-based prediction of 28-day mortality in ICU patients with sepsis: a multicenter retrospective study by Li Shen, Li Shen, Jiaqiang Wu, Jianger Lan, Chao Chen, Yi Wang, Zhiping Li

“…BackgroundSepsis is a major cause of mortality in intensive care units (ICUs) and continues to pose a significant global health challenge, with sepsis-related deaths contributing substantially to the overall burden on healthcare systems worldwide. The primary objective was to construct and evaluate a machine learning (ML) model for forecasting 28-day all-cause mortality among ICU sepsis patients.MethodsData for the study was sourced from the eICU Collaborative Research Database (eICU-CRD) (version 2.0). …”
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