Surgical site infections post-ventriculoperitoneal shunting: A matched healthcare cost and length of stay study: Empirical research quantitative by Issa M. Hweidi, Saba W. Al-Ibraheem, Omar H. Jebreel

“…Impact: There are significant associations of SSI post neurosurgery with increased financial burden and wastage of healthcare resources. The findings of this study can be utilized as a standard source for national benchmarking to evaluate the quality of care delivered to likewise patients and promote their infection control measures. …”
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Deciphering sepsis: transforming diagnosis and treatment through systems immunology by Robert E. W. Hancock, Andy An, Claudia C. dos Santos, Amy H. Y. Lee

“…This should be prioritized in multistakeholder collaborations involving research communities, healthcare providers/systems, patients, and governments to reduce the current high disease burden from sepsis and to mitigate against future pandemics.…”
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Tumor Markers in Pleural Fluid: A Comprehensive Study on Diagnostic Accuracy by Vladimir Aleksiev, Daniel Markov, Kristian Bechev

“…<b>Background/Objectives</b>: Malignant pleural effusions (MPEs) pose a significant challenge in clinical practice and exert a considerable socio-economic burden on the healthcare system, affecting approximately 1 million individuals annually. …”
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Classifying strategies for building community health movements: a guide for implementers by Felicia Jia Hui Chan, Alyssa Yenyi Chan, Wen Xi Zhuang, Priyanka Rajendram, Joseph Jie Hui Quek, Weng Mooi Tan, Yoek Ling Yong, Clarice Liying Song, Zoe Jane-Lara Hildon

“…Abstract Background Enabling community-led health initiatives will contribute to reducing the burdens on the healthcare system. Implementing such initiatives successfully in high and upper-middle income Asian countries is poorly understood and documented. …”
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Study on the Therapeutic Effects of Bisdemethoxycurcumin on a Cerebral Amyloid Angiopathy Mouse Model Established via Chronic Treatment With Five Vascular Risk Factors by Shudong Lin, Guanghua Zhu, Juan Xie, Xuanwei Wen, Limin Deng, Sijing Li, Guozhi Liu, Feiyan Wang, Shuangxi Chen, Zijian Xiao

“…Result The therapeutic administration of BDMC demonstrates a pronounced efficacy in alleviating Aβ burden and cerebral microbleeding in CAA mice, concurrently enhancing learning and memory capabilities. …”
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Impact of tiered restrictions in December 2020 on COVID-19 hospitalisations in England: a synthetic control study by Daniel Hungerford, Benjamin Barr, Mark Green, Marta García-Fiñana, Iain Buchan, Xingna Zhang

“…The impact did not exacerbate socioeconomic inequalities during the pandemic. Our findings suggest that regionally targeted restrictions can be effective in managing infectious diseases.…”
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Research Progress on the Relationship between Ischemic Stroke and Immunoinflammatory Factors by Qiang TANG, Huilin HUANG, Luwen ZHU, Hongyu LI, Jiyao ZHANG, Ping QIN, Xia YIN, Jiashuai LI

“…China is facing an increasingly severe situation of prevention and treatment, and the disease has brought a heavy burden to patients, families and even the whole society, which has become one of the focuses and difficulties of modern medical research. …”
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Unmet Medical Needs in the Management of Ulcerative Colitis: Results of an Italian Delphi Consensus by Marco Daperno, Alessandro Armuzzi, Silvio Danese, Walter Fries, Giuseppina Liguori, Ambrogio Orlando, Claudio Papi, Mariabeatrice Principi, Fernando Rizzello, Angelo Viscido, Paolo Gionchetti

“…Although considerable progress in understanding the molecular pathways involved in ulcerative colitis has led to improved treatment options, there is currently no definitive cure for ulcerative colitis, there remain considerable unmet needs in terms of long-term efficacy and safety, and there are many patients who continue to be burdened by physical and psychological symptoms. …”
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Racial disparities in acute care utilization among individuals with myasthenia gravis by Cynthia Qi, Pushpa Narayanaswami, Ashley E. L. Anderson, Deborah Gelinas, Yuebing Li, Jeffrey T. Guptill, Dakshinamoorthy Amirthaganesan, Charlotte Ward, Rupesh Panchal, Amit Goyal, Glenn Phillips

“…ObjectiveIn myasthenia gravis (MG), evidence on the impact of social determinants of health on disparities in disease burden and healthcare resource utilization is limited. …”
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Neuroimaging stratification reveals the striatal vulnerability to stress as a risk for schizophrenia by Xiaoqian Ma, Nana Feng, Lena Palaniyappan, Luolong Cao, Zixin Gu, Jujiao Kang, Liu Yuan, Lijun Ouyang, Yujue Wang, Chunwang Li, Ke Jin, Xiaogang Chen, Jianfeng Feng, Ying He, Qiang Luo

“…This caudate-SLE association was replicated in two independent large-scale cohorts, when individuals were stratified by both a higher polygenic burden for schizophrenia and smaller right putamen. …”
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Enhancing diagnostic outcomes in kidney genetic disorders: the KidGen national kidney genomics study protocol by Amali Mallawaarachchi, Hugh McCarthy, Thomas A. Forbes, Kushani Jayasinghe, Chirag Patel, Stephen I. Alexander, Tiffany Boughtwood, Jeffrey Braithwaite, Aron Chakera, Sam Crafter, Ira W. Deveson, Randall Faull, Trudie Harris, Lilian Johnstone, Matthew Jose, Anna Leaver, Melissa H. Little, Daniel MacArthur, Tessa Mattiske, Christine Mincham, Kathy Nicholls, Catherine Quinlan, Michael C. J. Quinn, Gopala Rangan, Jessica Ryan, Cas Simons, Ian Smyth, Madhivanan Sundaram, Peter Trnka, Laura Wedd, Erik Biros, Zornitza Stark, Andrew Mallett

“…Precise genetic diagnosis in GKD promises to improve patient outcomes, provide access to targeted treatments, and reduce the disease burden for individuals, families, and healthcare systems. …”
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Patterns and trends of heat and wildfire smoke indicators across rural–urban and social vulnerability gradients in Idaho by Seyd Teymoor Seydi, Jennifer Pierce, John T Abatzoglou, Anna Radin, Ethan Sims, Hilary Flint, Stephanie Wicks, Eric Henderson, Bhaskar Chittoori, Mojtaba Sadegh

“…While populations with high social vulnerability generally bear a larger burden of exposure to and impact from environmental hazards; such patterns and trends are less explored at the confluence of social vulnerability and rural–urban gradients. …”
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Spatiotemporal Traffic Density Estimation Based on ADAS Probe Data by Donghyun Lim, Younghoon Seo, Eunjeong Ko, Jaehyun(Jason) So, Hyungjoo Kim

“…Therefore, this practical approach is expected to mitigate the burden of density estimation, particularly in future road systems in which ADAS and autonomous vehicles are prevalent.…”
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Schizophrenia spectrum disorders in India: A population-based study by Prakyath Ravindranath Hegde, Lakshmi P. Nirisha, Chethan Basavarajappa, Satish Suhas, Channaveerachari Naveen Kumar, Vivek Benegal, Girish N. Rao, Mathew Varghese, Gopalkrishna Gururaj, NMHS National Collaborators Group

“…Introduction: Schizophrenia spectrum disorders represent a significant global health concern, contributing significantly to the global burden of disease. The National Mental Health Survey (NMHS) of India, conducted between 2015 and 2016, investigated the prevalence and epidemiological correlates of schizophrenia spectrum disorders in India. …”
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Prevalence and clinical profile of hepatitis C virus infections in multitransfused thalassemic patients in the capital twin cities of Pakistan by Z. Z. Piracha, U. Saeed, R. Uppal, M. R. Uppal, A. Ahmad Khan, M. Abdullah, K. Mari, A. Basra, S. S. Gilani, M. N. Tariq, D. U. Ozsahin, B. Uzun, I. Ozsahin

“…Consequently, there is a compelling need for rigorous screening of blood products prior to transfusion to mitigate the future burden of HCV in Pakistan.…”
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Service delivery and the role of clinical pharmacists in UK primary care for older people, including people with dementia: a scoping review by Alice Burnand, Abi Woodward, Vladimir Kolodin, Jill Manthorpe, Yogini Jani, Mine Orlu, Cini Bhanu, Kritika Samsi, Victoria Vickerstaff, Jane Wilcock, Jane Ward, Greta Rait, Nathan Davies

“…Abstract Objective As populations age globally, there is increasing prevalence of multiple long-term conditions, such as dementia, leading to many challenges. The burden on health and care services, economic pressures, and the necessity for innovative policies to better support older people and people with dementia becomes paramount. …”
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Local application of sodium thiosulfate as an otoprotectant for cisplatin-exposed patients – A narrative literature review to explore the potential benefit for children with cancer... by Nienke Streefkerk, Amirhossein Masroor, James I. Geller, Martine van Grotel, Marc Ansari, Eric Bouffet, Archie Bleyer, Brice Fresnau, Michael Sullivan, Alwin D.R. Huitema, Alexander E. Hoetink, Per Kogner, Rudolf Maibach, Allison F. O’Neill, Vassilios Papadakis, Kaukab M. Rajput, Gareth J. Veal, Penelope R. Brock, Annelot J.M. Meijer, Marry M. van den Heuvel-Eibrink

“…Interpretation: Preclinical studies suggest a potential benefit of locally administered STS, however clinical evidence for a significant otoprotective effect is not yet available. The burden and potential sequalae of repeated intratympanic procedures in children, together with the low level of evidence of efficacy, currently limited to pre-clinical data, suggests that further study and potentially improved technology to apply local STS is required for childhood cancer patients receiving cisplatin.…”
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The modern use of hydroxyurea for children with sickle cell anemia by Charles T. Quinn, Russell E. Ware

“…Although transformative and even curative therapies for SCA are emerging, hydroxyurea is the only available and accessible disease-modifying treatment that can address the global burden of disease, especially in low-resource settings within sub-Saharan Africa. …”
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Pretreatment Fatigue in Breast Cancer Patients: Comparison With Healthy Controls and Associations With Biopsychosocial Variables by Patricia Blickle, Martina E. Schmidt, Karen Steindorf

“…ABSTRACT Objective Cancer‐related fatigue is one of the most common burdens of cancer patients. To date, most studies focused on fatigue during or after treatment. …”
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Injury mortality in South Africa: a 2009 and 2017 comparison to track progress to meeting sustainable development goal targets by Megan Prinsloo, Shibe Mhlongo, Rifqah A. Roomaney, Lea Marineau, Thakadu A. Mamashela, Bianca Dekel, Debbie Bradshaw, Lorna J. Martin, Carl Lombard, Rachel Jewkes, Naeemah Abrahams, Richard Matzopoulos

“…Objective Two nationally representative surveys for 2009 and 2017 are utilised to assess SA’s progress towards SDG targets for violence and road traffic injuries, alongside changes in suicide and under-5 mortality rates for childhood injuries, and compare these estimates with those of the Global Burden of Disease for SA. Methods The surveys utilised multi-stage, stratified cluster sampling from eight provinces, with mortuaries as primary sampling units. …”
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