Stem Cells from Human Exfoliated Deciduous Teeth Ameliorate Diabetic Nephropathy In Vivo and In Vitro by Inhibiting Advanced Glycation End Product-Activated Epithelial-Mesenchymal... by Nanquan Rao, Xiaotong Wang, Jing Xie, Jingzhi Li, Yue Zhai, Xiaoxia Li, Tengjiaozi Fang, Yuanyuan Wang, Yuming Zhao, Lihong Ge

“…At 8 weeks after administration, renal injury, including hyperglycemia, hyperlipidemia, increased urinary albumin excretion, ECM accumulation, and a fractional mesangial area, was dramatically attenuated. …”
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Shorter Digestion Times of Donor Islets Is Associated With Better Islet Graft Function After Islet Transplantation by Chia-Hao Wang, Christopher Orr, Jeannette Hacker-Stratton, Mohamed El-Shahawy, Keiko Omori, Meirigeng Qi, Fouad Kandeel

“…Shorter digestion time of isolated donor islets were associated with lower PIR ( P = 0.014) and a higher GFI ( P = 0.027) after transplantation. Islet injury related to digestion enzyme exposure influenced islet function as estimated using PIR and GFI post-transplantation.…”
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Bone-patellar tendon-bone vs hamstring tendon autograft for anatomical anterior cruciate ligament reconstruction: outcomes at a mean follow-up of 8 years by Thatchinamoorthy Santhamoorthy, Anish Anto Xavier, Lalithambigai Chellamuthu, Arun Kaliaperumal, Dharamveer Kumar Dubey

“…Anterior cruciate ligament (ACL) tear is a common ligament injury of the knee joint. Anterior cruciate ligament reconstruction (ACLR) using autografts or allografts is the standard of treatment for complete ACL tear. …”
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Enhanced Activity by NKCC1 and Slc26a6 Mediates Acidic pH and Cl− Movement after Cardioplegia-Induced Arrest of db/db Diabetic Heart by Minjeong Ji, Seok In Lee, Sang Ah Lee, Kuk Hui Son, Jeong Hee Hong

“…These transporters should be considered as potential therapeutic targets to develop the next generation of cardioplegia solution for protection against ischemia-reperfusion injury in diabetic hearts.…”
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Burden of NASH related liver cancer from 1990 to 2021 at the global, regional, and national levels by Shuang Li, Shuang Li, Shuangjiang Li, Linjing Guan, Mingjuan Li, Jiahui Zhao, Min Wu, Qiuyun Li, Hui Li, Guoqing Ouyang, Guangdong Pan, Guangdong Pan

“…This study presents a comprehensive analysis of NRLC burden at the global, regional, and national levels, further categorized by age, sex, and sociodemographic index (SDI).MethodData on NRLC from the Global Burden of Disease, Injuries, and Risk Factors (GBD) study 2021 were downloaded at global, regional, and national levels. …”
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HGF-Modified Dental Pulp Stem Cells Mitigate the Inflammatory and Fibrotic Responses in Paraquat-Induced Acute Respiratory Distress Syndrome by Panpan Geng, Yuning Zhang, Huan Zhang, Xiwen Dong, Yuefeng Yang, XiaoNa Zhu, Chu-Tse Wu, Hua Wang

“…Paraquat (PQ) poisoning can cause acute lung injury and progress to pulmonary fibrosis and eventually death without effective therapy. …”
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Sepsis in Internal Medicine: blood culture-based subtypes, hospital outcomes, and predictive biomarkers by Gaetano Zizzo, Gabriele Guazzardi, Daniela Bompane, Francesco Di Terlizzi, Giorgio Rotola, Ilario Stefani, Michela Medugno, Mario Bucalo, Antonino Mazzone

“…Blood culture-negative sepses showed shorter stays and higher mortality (acute kidney injury and fast deterioration) compared to culture-positive ones; polymicrobial sepses showed higher ICU transfer rates (acute respiratory distress); while multidrug-resistant (MDR+) and/or polymicrobial sepses showed longer stays and higher mortality (complicated course) compared to drug-sensitive or monomicrobial ones. …”
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Skin graft take rate among minor burns – A cohort study to investigate the effect of factors such as burn depth, burn size, and timing of the operation by Sinan Dogan, Arina Mahmoud, Ingrid Steinvall, Elin Albertsson, Elina Bergman, Jamila Halimi, Moustafa Elmasry

“…Methods: This retrospective study included patients with thermal injury, a burn size smaller than 11 % total body surface area (TBSA), and who were treated with a skin graft operation. …”
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Prognostic Value of the Tricuspid Regurgitation Impact on Outcomes (TRIO) Score in Patients Undergoing Transcatheter Aortic Valve Implantation by Jizhong Wang, Yuanwei Chen, Xuxing Zhang, Songyuan Luo, Jie Li, Fang Pei, Jianfang Luo

“…Patients with a higher TRIO score also had significantly higher rates of stroke (3.1% vs. 0.5%, p = 0.028), acute kidney injury (10.1% vs. 4.3%, p = 0.011), and MACEs (14.9% vs. 3.6%, p < 0.001) within 30 days after TAVI. …”
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Machine learning-based identification and validation of amino acid metabolism related genes as novel biomarkers in chronic kidney disease by Guoqing Zhang, Hongyan Luo, Xiaohua Lu, Yonghua Liu, Mei Wang, Bo Li, Haixia Lu, Yali Zheng

“…All key genes correlated significantly with markers of kidney injury, such as eGFR and serum creatinine. The expression of ALDH18A1, CENPF were increased while CSAD, CTH and CYP27B1 were decreased in HK-2 cells cultured with indole sulfate. …”
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Mitochondria-targeted photothermal-chemodynamic therapy enhances checkpoint blockade immunotherapy on colon cancer by Benchao Zheng, Hongbo Wang, Shiyi Zhai, Jiangsheng Li, Kuangda Lu

“…This effect has been attributed in several studies to the release of damage-associated molecular patterns (DAMPs) triggered by mitochondrial injury. We propose that mitochondria-targeted PTT may better synergize with immunotherapy. …”
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Global burden and cross-country inequalities of nutritional deficiencies in adults aged 65 years and older, 1990–2021: population-based study using the GBD 2021 by Shuang Liang, Shao-Zhi Xi, Jia-Yi Liu, Gui-Chun Tang, Wei-Guang Zhang, Xin-Ru Guo, Chen Yang, Chun Zhang, Guang-Yan Cai

“…Methods Age-standardised prevalence, disability-adjusted life years (DALYs), and average annual percentage changes (AAPCs) of these deficiencies in people aged ≥ 65 years at global, regional, and national levels were estimated from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021. Cross-country inequalities in disease burden were quantified using the slope index and concentration index, standard health equity methods recommended by the World Health Organization. …”
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Adipose-derived stem cells promote the recovery of intestinal barrier function by inhibiting the p38 MAPK signaling pathway by Mei Yang, Wangbin Xu, Chaofu Yue, Rong Li, Xian Huang, Yongjun Yan, Qinyong Yan, Shisheng Liu, Yuan Liu, Qiaolin Li

“…This study provides novel insights into the treatment of intestinal injury. …”
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Predictors of direct oral anticoagulant concentrations in the trauma population by Laura Adams, Alan M Smith, Louis Perkins, Dmitri Lerner, Jarrett Santorelli, Leslie Kobayashi

“…The population was 53% woman, with median age of 78 years, and median Injury Severity Score of 5. In total, 39% of patients had therapeutic and 20% had supratherapeutic anti-Xa levels. …”
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A qualitative study of community perceptions and practices relating to blood donation in Cameroon by Solange Dabou, Wilfred Ngwa, Ngo Valery Ngo, Constantine T Asahngwa, Ghyslaine Bruna Djeunang Dongho, Regina Sinsai, Evrard Kepgang, Odette D Kibu, Ronald Mbua Gobina, Denis Alemka Foretia

“…Introduction Blood and blood products are essential for patients in need of transfusion therapy, especially those undergoing surgical procedures, childbirth and other injuries. In Cameroon, there is an annual deficit of over 270 000 pints of blood, with a coverage rate of only 17%. …”
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The ameliorative effects of melatonin against BDE-47-induced hippocampal neuronal ferroptosis and cognitive dysfunction through Nrf2-Chaperone-mediated autophagy of ACSL4 degradati... by Quan Yuan, Mingwei Wang, Zhaoxiang Zhang, Ruofei Wang, Dechao Wang, Zichun Sang, Pu Zhao, Xiaoli Liu, Xiaoying Zhu, Gaofeng Liang, Hua Fan, Dongmei Wang

“…Importantly, melatonin, CMA activator CA77.1, and ACSL4 inhibitor rosiglitazone (RSG) administration substantially attenuated neuronal/synaptic injury and cognitive deficits following BDE-47 exposure. …”
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Frailty Is Associated With Decreased Survival in Adult Patients With Nonoperative and Operative Traumatic Subdural Hemorrhage: A Retrospective Cohort Study of 381,754 Patients by Evan N. Courville, MD, Oluwafemi P. Owodunni, MD, MPH, Jordyn T. Courville, BS, Syed F. Kazim, MD, PhD, Alexander J. Kassicieh, BS, Allyson M. Hynes, MD, Meic H. Schmidt, MD, MBA, Christian A. Bowers, MD

“…A retrospective study examining tSDH patients ≥18 years and assigned an abbreviated injury scale score ≥3, and entered into ACS-TQIP between 2007 and 2020. …”
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Evaluations of Morphometric Traits and Body Conformation Indices of Horse Ecotypes Reared in the Highlands of Bale Eco‐Region, Ethiopia by Mesay Guyo, Melaku Tareke, Andualem Tonamo, Diriba Bediye, Girma Defar

“…It also determines the design of harnessing implements, physical injury level and working performance of the native horses. …”
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Pyogenic Granuloma of the Larynx: A Case Report by Moallim Hussein AA, Sheikh OA, Mukhtar AA, Abdi IA, Ahmed NM, Mohamed SS, Kahiye MA, Nur MA, Asseyr AF

“…Predisposing factors for pyogenic granuloma of the larynx have been linked to prior traumatic injuries, such as intubation, previous surgeries, or laryngopharyngeal reflux.Case Presentation: A 33-year-old male visited our clinic with complaints of progressive dysphonia and choking for two months. …”
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Returning to the emergency department: a retrospective analysis of mental health re-presentations among young people in New South Wales, Australia by Rebecca Ivers, Michael Dinh, Patricia Cullen, Bette Liu, Katharine Steinbeck, Natasha Walker, Robert Neil Leong

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