Fibrocyte enrichment and myofibroblastic adaptation causes nucleus pulposus fibrosis and associates with disc degeneration severity by Yi Sun, Yan Peng, Zezhuo Su, Kyle, K. H. So, Qiuji Lu, Maojiang Lyu, Jianwei Zuo, Yongcan Huang, Zhiping Guan, Kenneth M. C. Cheung, Zhaomin Zheng, Xintao Zhang, Victor Y. L. Leung

“…Refined clustering and classification distinguished the fibrocyte-like populations as subtypes in the NP cells - and immunocytes-clusters, expressing disc degeneration markers HTRA1 and ANGPTL4 and genes related to response to TGF-β. In injury-induced mouse disc degeneration model, fibrocytes were found recruited into the NP undergoing fibrosis and adopted a myofibroblast phenotype. …”
Get full text

Etiologic Causes and Epidemiological Characteristics of Patients with Intraocular Foreign Bodies: Retrospective Analysis of 1340 Cases over Ten Years by Lin Li, Hai Lu, Kai Ma, Yun-Yun Li, Hai-Yan Wang, Ning-Pu Liu

“…More males than females were injured by SFB (59.4% versus 44.3%, P=0.009). Firework injury was the commonest (41.6% versus 3.1%–15.3%, P<0.05) in patients under nine. …”
Get full text

Multi-trace elements-enriched functional drink accelerates gastric ulcer repair via the HGF/c-Met/STAT3 pathway by Yongnan Piao, Nuoya Wang, Mingji Jin, Jianyu Piao, Mingfeng Han, Zifei Wang, Chunhua Quan, Jishan Yin, Zhonggao Gao, Wenxiang Cui, Shuangqing Wang, Xiuquan Quan

“…Finally, FD reduced the severity of gastric mucosal injury caused by invasive factors, improved the morphological structure of gastric mucosal cells, enhanced the ability of oxidative stress, and inhibited excessive inflammatory response. …”
Get full text

Anti-Apoptosis Effects of Green Tea in Diagnostic and Therapeutic Doses of Ionizing Radiation by Najmeh Anbiaee, Mohammad Taghi Bahreyni Toossi, Hosein Azimian, Zoha Sahebnasagh, Sepideh Abdollahi Dehkordi, Majid Kianmehr, samaneh soudmand salarabadi, Maryam Najafi Amiri

“…The aim of the present study is assessing the protective effect of green tea on lymphocytes affected by radiation injury.Material and Methods: Blood samples was obtained from four adults healthy human and lymphocytes were extracted. …”
Get full text

Ex vivo delivery of recombinant IL-10 to human donor lungs by Jonathan C. Yeung, Terumoto Koike, Dirk Wagnetz, Tiago N. Machuca, Riccardo Bonato, Mingyao Liu, Stephen Juvet, Marcelo Cypel, Shaf Keshavjee

“…Background: The immunoregulatory cytokine interleukin-10 (IL-10) has been shown to be a promising therapy for donor lung injuries before transplantation. However, the very short half-life of IL-10 in vivo (∼2 hours) has necessitated the use of gene therapy in almost all animal models of lung transplantation. …”
Get full text

Lipopolysaccharide-Binding Protein Downregulates Fractalkine through Activation of p38 MAPK and NF-κB by Xia Huang, Yi Zeng, Yujie Jiang, Yueqiu Qin, Weigui Luo, Shulin Xiang, Suren R. Sooranna, Liao Pinhu

“…LBPK95A, SB203580, and SC-514 ameliorated LPS-induced rat lung injury and suppressed LPS-induced downregulation of fractalkine by decreasing phospho-p38 MAPK and p65 NF-κB. …”
Get full text

The evaluation of safe zones for the corona mortis using a cadaver simulation of the Modified Stoppa approach by Jade Naicker, Zithulele Nkosinathi Tshabalala, Andries Masenge, Obakeng Modisane, Steven Matshidza, Nkhensani Mogale

“…Methods: The current study aimed to create and validate clinically significant safe zones to avoid injury to these anomalous vessels during the Modified Stoppa approach. …”
Get full text

Expert-Performed Endotracheal Intubation-Related Complications in Trauma Patients: Incidence, Possible Risk Factors, and Outcomes in the Prehospital Setting and Emergency Departmen... by Yuko Ono, Takeyasu Kakamu, Hiroaki Kikuchi, Yusuke Mori, Yui Watanabe, Kazuaki Shinohara

“…We also found that ETI-related complications decreased the likelihood of survival of trauma patients (AOR, 0.60; 95% CI, 0.38–0.95), independently of age, male sex, Injury Severity Score, Glasgow Coma Scale Score, and off-hours presentation. …”
Get full text

The Manufacture of GMP-Grade Bone Marrow Stromal Cells with Validated In Vivo Bone-Forming Potential in an Orthopedic Clinical Center in Brazil by Rhayra B. Dias, João A. M. Guimarães, Marco B. Cury, Leonardo R. Rocha, Elaine S. da Costa, Liebert P. Nogueira, Camila Hochman-Mendez, Anneliese Fortuna-Costa, Anna Karoline F. Silva, Karin S. Cunha, Sergio A. L. de Souza, Maria Eugênia L. Duarte, Rafaela C. Sartore, Danielle C. Bonfim

“…In vitro-expanded bone marrow stromal cells (BMSCs) have long been proposed for the treatment of complex bone-related injuries because of their inherent potential to differentiate into multiple skeletal cell types, modulate inflammatory responses, and support angiogenesis. …”
Get full text

Gait-Specific Optimization of Composite Footwear Midsole Systems, Facilitated through Dynamic Finite Element Modelling by Dimitris Drougkas, Evagelos Karatsis, Maria Papagiannaki, Serafeim Chatzimoisiadis, Fotini Arabatzi, Stergios Maropoulos, Alexander Tsouknidas

“…During the last century, running shoes have been subject to drastic changes with incremental however improvements as to injury prevention. This may be, among others, due to the limited insight that experimental methodologies can provide on their 3D in situ response. …”
Get full text

Increasing incidences and changes in treatment trends of clavicle fractures in adults during 2 decades in Denmark: a nationwide study on data from the Danish National Patient Regis... by Ida Tryggedsson, Bjarke Viberg, Per Hviid Gundtoft, Ilija Ban, Søren Overgaard, Tazio Maleitzke, Arvind von Keudell

“… Background and purpose: Clavicle fractures are common shoulder injuries, but treatment strategies are debated. While a non-surgical approach has been preferred historically, recent studies suggest surgical intervention may reduce non-union rates and improve outcomes for displaced fractures. …”
Get full text

Serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) in HCV-Positive Egyptian Patients Treated with Sofosbuvir by Ali Nada, Mohamed Abbasy, Aliaa Sabry, Azza Mohamed Abdu Allah, Somaia Shehab-Eldeen, Nada Elnaidany, Hanan Elimam, Kawthar Ibraheem Mohamed Ibraheem, Abdallah Essa

“…Neutrophil gelatinase-associated lipocalin (NGAL) has been proven as a predictor of renal tubular injury. Hence, the aim of this work was to assess serum neutrophil gelatinase-associated lipocalin (NGAL) in HCV-positive patients before and after treatment with the sofosbuvir-based antiviral regimen. …”
Get full text

Suppressing GDF15 enhances the chemotherapeutic effect of 5 FU on MSI-H CRC by regulating the ferroptosis pathway SLC7A11/GSH/GPX4 by Zhi min Huang Fu, Ming Xiao, Hailun Xie, Shuxian Zhang, Tang Yi, Qingshu Li, Ming Li, Yalan Wang

“…Abstract Growth differentiation factor 15 (GDF15) is a member of the transforming growth factor beta (TGF-β) superfamily and is related to metabolism, injury, and aging. GDF15 has both tumor-promoting and tumor-suppressing effects. …”
Get full text

Cerebellar-cerebral circuits functional connectivity in patients with cognitive impairment after basal ganglia stroke: a pilot study by Lijun Zuo, Xinlong Lan, Yijun Zhou, Hao Liu, Yang Hu, Yongjun Wang, Yongjun Wang, Tao Liu, Zixiao Li, Zixiao Li

“…These changes may represent compensatory mechanisms of the cerebellum in response to stroke injury.…”
Get full text

Pluripotency of Dental Pulp Cells and Periodontal Ligament Cells Was Enhanced through Cell-Cell Communication via STAT3/Oct-4/Sox2 Signaling by Zhengjun Peng, Lu Liu, Wenyu Zhang, Xi Wei

“…PCR arrays were constructed to identify genes that were differentially expressed, and the results were confirmed by a rat model with injury. Further research on the mechanism of the related signaling pathways was investigated by overexpression/silence of STAT3, ChIP, the dual-luciferase reporter assay, and EMSA. …”
Get full text

Sex-specific differences in fit between two different types of body armour: A pilot study by Buttner Claire, Tiller Sharne-Louise, Vollenweider Nash, Canetti Elisa, Schram Ben, Dawes Jay, Lockie Robert, Orr Robin

“…Body armour, whilst improving wearer survivability, can negatively impact physical performance and increase injury risk. These impacts may differ between male and female personnel due to the generic design of armour systems. …”
Get full text

Serum Levels of IL-1β, IL-6, TGF-β, and MMP-9 in Patients Undergoing Carotid Artery Stenting and Regulation of MMP-9 in a New In Vitro Model of THP-1 Cells Activated by Stenting by Rongrong Zhang, Fan Jiang, Cindy Si Chen, Tianzhu Wang, Jinzhou Feng, Tao Tao, Xinyue Qin

“…Second, we established a new in vitro model, where THP-1 monocytes were treated with the supernatants of human umbilical vein endothelial cells (HUVECs) that were scratched by pipette tips, which mimics monocytes activated by mechanical injury of stenting. The treatment enhanced THP-1 cell adhesion, migration and invasion ability, and the phosphorylation of ERK1/2 and Elk-1 and MMP-9 expression were significantly increased. …”
Get full text

The pro-inflammatory cytokine Tumor Necrosis Factor alpha (TNF-α) in Diabetic Nephropathy by Alia KH Mahmoud, Muhammed Ahmed Abd El Moety, Amal Khalifa Ahmed, Samer A. El-Sawy

“…Regretfully, we still don't fully understand the mechanisms underlying the onset and progression of renal injury in diabetes. There is now proof that inflammation and activated innate immunity play important roles in the etiology of problems with diabetes. …”
Get full text

Remote Limb Ischemic Postconditioning Protects against Ischemic Stroke via Modulating Microglia/Macrophage Polarization in Mice by Dong Han, Jue Wang, Lulu Wen, Miao Sun, Hang Liu, Yan Gao

“…The protection against ischemia/reperfusion injury mediated by remote limb ischemic postconditioning (RIPC) shows great clinical value in ischemic stroke therapy, but the particular mechanism of RIPC remains unclear. …”
Get full text

Neutrophil Gelatinase-Associated Lipocalin in Kidney Transplantation Is an Early Marker of Graft Dysfunction and Is Associated with One-Year Renal Function by Isabel Fonseca, José Carlos Oliveira, Manuela Almeida, Madalena Cruz, Anabela Malho, La Salete Martins, Leonídio Dias, Sofia Pedroso, Josefina Santos, Luísa Lobato, António Castro Henriques, Denisa Mendonça

“…Urinary NGAL is an early marker of graft injury and is independently associated with dialysis requirement within one week after KTx and one-year graft function.…”
Get full text