Effects of Stromal Cell-Derived Factor-1α Secreted in Degenerative Intervertebral Disc on Activation and Recruitment of Nucleus Pulposus-Derived Stem Cells by Jinwei Ying, Zhihua Han, Shishen Pei, Linghao Su, Dike Ruan

“…Stromal cell-derived factor-1α (SDF-1α) plays a significant role in mobilizing and recruiting mesenchymal stem cells (MSCs) to the sites of injury. This study investigated the potential of SDF-1α released in the degenerative intervertebral disc (IVD) to activate and recruit endogenous nucleus pulposus-derived stem cells (NPSCs) for regeneration in situ. …”
Get full text

Risk of infection and conversion time from external to definitive fixation in open tibial fracture by Wazzan S. Aljuhani, Yasir A. Alshabi, Abdullah M. Alanazi, Meshal A. Alothri, Saleh A. Almutairi, Ziad A. Aljaafri, Abdullah M. Alzahrani

“…In the management of these injuries, the primary focus is on reducing the infection rate, as this is crucial for achieving the best clinical outcomes. …”
Get full text

Flood Risk Assessment and Zoning for Niamey and Lokoja Metropolises in Niger and Nigeria by Youssoufa Doulla Nouhou, Martins Yusuf Otache, Salamatou Abdourahamane Illiassou, Olasunkanmi Habeeb Okunola, Appollonia Aimiosino Okhimamhe, Thanh Thi Nguyen

“…Communities in flood-prone areas experience heightened insecurity, loss of property, and, in some cases, serious injuries or fatalities. Consequently, flood risk assessment and mitigation have become essential. …”
Get full text

Poly-L-Arginine Induces Apoptosis of NCI-H292 Cells via ERK1/2 Signaling Pathway by Ya-Ni Wang, Ling-Ling Zhang, Xiao-Yun Fan, Sha-Sha Wu, Sheng-Quan Zhang

“…Besides, inhibition of cationic protein-induced apoptotic death in airway epithelial cells could be considered as a potential target of anti-injury or antiremodeling in asthmatics.…”
Get full text

Comparison of Atypical and Osteoporotic Femoral Shaft Fractures in the Elderly: A Multicenter Study by Takanori Miura, Hiroaki Kijima, Noriyuki Ishikawa, Toshihito Ebina, Takayuki Tani, Shuichi Chida, Tetsuya Suzuki, Satoshi Yumto, Hiroshi Tazawa, Naohisa Miyakoshi, Yoichi Shimada

“…We identified 65 patients and excluded 37 among these due to high-energy injuries or being younger than 65 years. Among the remaining patients, we identified 17 and 11 women with atypical (AFF group) and osteoporotic femoral shaft fractures (OP group), respectively. …”
Get full text

Modulation of biological activities in adipose derived stem cells by histone deacetylation by Sallam Abdallah, Mouna Tabebi, Sawsan Qanadilo, Neserin Ali, Jing Wang, Pádraig D’Arcy, Wen Zhong, Folke Sjoberg, Moustafa Elmasry, Ahmed El-Serafi

“…Exploring epigenetic regulation in adipose-derived stem cells (ADSCs) holds promise for improving skin injury treatments. We investigated the effects of histone deacetylase inhibitor (SAHA) on ADSCs to better understand its cellular and molecular impacts. …”
Get full text

Occupational Risks in Occupational Therapy Service Learning: A Single-Site “Fear Factor” Study in South Africa by Deshini Naidoo, Pragashnie Govender, Stephanie Nicole Naidoo, Naledi Ngubane, Zamankosi Nkosi, Aziza Mulla

“…Several concerns over potential occupational risks were reported, namely, anxiety over contracting infectious diseases, concerns around musculoskeletal injuries due to manual handling requirements, and inappropriate behaviour of clients, which made the students feel unsafe. …”
Get full text

Biogenic silver nanoparticles produced by Trichoderma reesei inhibit SARS-CoV-2 infection, reduce lung viral load and ameliorate acute pulmonary inflammation by Marcus V.M.V. Amaral, Cláudia B. Carraro, Amanda C.C. Antoniêto, Mariana N. Costa, Thais F.C. Fraga-Silva, Ualter G. Cipriano, Rodrigo P.F. Abuná, Tamara S. Rodrigues, Ronaldo B. Martins, Andreia M. Luzenti, Glaucia R. Caruso, Priscyla D. Marcato, Vania L.D. Bonato, Dario S. Zamboni, Bergman M. Ribeiro, Sônia N. Báo, Joao S. da Silva, Flávio P. Veras, Roberto N. Silva

“…Moreover, our study reveals that AgNPs treatment significantly alleviated acute lung injury induced by SARS-CoV-2 infection in Syrian hamsters. …”
Get full text

Regeneration of Tracheal Tissue in Partial Defects Using Porcine Small Intestinal Submucosa by Nelson Bergonse Neto, Lianna Ferrari Jorge, Julio C. Francisco, Bruna Olandoski Erbano, Barbara Evelin Gonçalves Barboza, Larissa Luvison Gomes da Silva, Marcia Olandoski, Katherine Athayde Teixeira de Carvalho, Luiz Felipe Pinho Moreira, Jose Rocha Faria Neto, Eltyeb Abdelwahid, Luiz Cesar Guarita-Souza

“…Although tracheal SIS engraftment could not prevent stenosis in a rabbit model of tracheal injury, it produced some remarkable changes, efficiently facilitating neovascularization, reepithelialization, and neoformation of immature cartilage.…”
Get full text

Selenoprotein S Attenuates Tumor Necrosis Factor-α-Induced Dysfunction in Endothelial Cells by Siyuan Cui, Lili Men, Yu Li, Yingshuo Zhong, Shanshan Yu, Fang Li, Jianling Du

“…Conversely, the knockdown of SelS with siRNA results in an enhancement of TNF-α-induced injury in HUVECs. These findings suggest that SelS protects endothelial cells against TNF-α-induced dysfunction by inhibiting the activation of p38 MAPK and NF-κB pathways and implicates it as a possible modulator of vascular inflammatory diseases.…”
Get full text

Beetroot (Beta vulgaris L.) Extract Ameliorates Gentamicin-Induced Nephrotoxicity Associated Oxidative Stress, Inflammation, and Apoptosis in Rodent Model by Ali A. El Gamal, Mansour S. AlSaid, Mohammad Raish, Mohammed Al-Sohaibani, Shaza M. Al-Massarani, Ajaz Ahmad, Mohamed Hefnawy, Mohammed Al-Yahya, Omer A. Basoudan, Syed Rafatullah

“…BVEE treatment also ameliorated the extent of histologic injury and reduced inflammatory infiltration in renal tubules. …”
Get full text

Blood-brain barrier breakdown in brain ischemia: Insights from MRI perfusion imaging by Sarvin Sasannia, Richard Leigh, Pouya B. Bastani, Hyeong-Geol Shin, Peter van Zijl, Linda Knutsson, Paul Nyquist

“…Hence, understanding the mechanisms of BBB breakdown and white matter injury across various ischemic conditions is critical for developing effective interventions and improving patient outcomes. …”
Get full text

Spinal Reflex Recovery after Dorsal Rhizotomy and Repair with Platelet-Rich Plasma (PRP) Gel Combined with Bioengineered Human Embryonic Stem Cells (hESCs) by Mateus Vidigal de Castro, Moníze Valéria Ramos da Silva, Gabriela Bortolança Chiarotto, Maria Helena Andrade Santana, Ângela Cristina Malheiros Luzo, Sergiy Kyrylenko, Alexandre Leite Rodrigues de Oliveira

“…Dorsal root rhizotomy (DRZ) is currently considered an untreatable injury, resulting in the loss of sensitive function and usually leading to neuropathic pain. …”
Get full text

Evaluating Forelimb and Hindlimb Joint Conformation of Morna Racehorses (<i>Equus caballus</i>) by Israr Ahmad, Sahar Ijaz, Mirza M. Usman, Ayesha Safdar, Imdad U. Khan, Muhammad Zeeshan, Syed S. U. H. Bukhari

“…Measuring limb joint angles is crucial for understanding horse conformation, performance, injury diagnosis, and prevention. While Thoroughbred horses have been extensively studied, local Pakistani breeds (e.g., Morna racehorse) have not received scientific attention. …”
Get full text

Paracrine Mechanisms of Mesenchymal Stromal Cells in Angiogenesis by Selma Maacha, Heba Sidahmed, Shana Jacob, Giusy Gentilcore, Rita Calzone, Jean-Charles Grivel, Chiara Cugno

“…MSC-derived secretome mediates beneficial angiogenic effects in a variety of tissue injury-related diseases. This supports the current effort to develop cell-free therapeutic products that bring both clinical benefits (reduced immunogenicity, persistence in vivo, and no genotoxicity associated with long-term cell cultures) and manufacturing advantages (reduced costs, availability of large quantities of off-the-shelf products, and lower regulatory burden). …”
Get full text

Intraoperative sensitization in trigeminal region caused by postherpetic neuralgia: a case report by Gangwen Guo, Dan Li, Hongyan Li, Rong Hu, Haocheng Zhou

“…It is essential to monitor and prevent hypersensitivity to both innoxious and noxious stimuli in patients with neuropathic pain syndrome, especially at surgical sites close to the area of nerve injury.…”
Get full text

Intravenous Transplantation of Mesenchymal Stem Cells Reduces the Number of Infiltrated Ly6C+ Cells but Enhances the Proportions Positive for BDNF, TNF-1α, and IL-1β in the Infarct... by Yunqian Guan, Xiaobo Li, Wenxiu Yu, Zhaohui Liang, Min Huang, Renchao Zhao, Chunsong Zhao, Yao Liu, Haiqiang Zou, Yanli Hao, Zhiguo Chen

“…The present study is aimed at differentiating the neurotrophic and inflammatory roles played by microglial vs. infiltrating circulation-derived cells in the acute phase in rat ischemic brains and explore the influences of intravenously infused allogeneic MSCs. The ischemic brain injury was induced by distal middle cerebral artery occlusion (dMCAO) in SD rats, with or without MSC infusion in the same day following dMCAO. …”
Get full text

Mouse Umbilical Cord Mesenchymal Stem Cell Paracrine Alleviates Renal Fibrosis in Diabetic Nephropathy by Reducing Myofibroblast Transdifferentiation and Cell Proliferation and Upr... by Hongde Li, Pengfei Rong, Xiaoqian Ma, Wei Nie, Yan Chen, Juan Zhang, Qiong Dong, Min Yang, Wei Wang

“…We found that the repeated injection with mUC-MSCs alleviates albuminuria, glomerulus injury, and fibrosis in DN mouse models. Next, mesangial cells were exposed to 5.6 mM glucose, 30 mM glucose, or mUC-MSC-conditioned medium, and then we performed western blotting, immunofluorescence, wound healing assay, and cell proliferation assay to measure extracellular matrix (ECM) proteins and matrix metalloproteinases (MMPs), myofibroblast transdifferentiation (MFT), and cell proliferation. …”
Get full text

Improved Outcome of Severe Acute Pancreatitis in the Intensive Care Unit by Polychronis Pavlidis, Siobhan Crichton, Joanna Lemmich Smith, David Morrison, Simon Atkinson, Duncan Wyncoll, Marlies Ostermann

“…Forty patients (80%) tolerated enteral nutrition, and 46% received antibiotics for non-SAP reasons. Acute kidney injury was significantly more common among hospital nonsurvivors compared to survivors (100% versus 42%, ). …”
Get full text

Three-Dimensional Shapes and Cell Deformability of Rat Red Blood Cells during and after Asphyxial Cardiac Arrest by Hui Jai Lee, SangYun Lee, HyunJoo Park, YongKeun Park, Jonghwan Shin

“…In particular, rheological changes in red blood cells (RBCs) have been observed during and after ischemic-reperfusion injury. Employing three-dimensional laser interferometric microscopy, we investigated three-dimensional shapes and deformability of RBCs during and after asphyxial cardiac arrest in rats at the individual cell level. …”
Get full text