Real-world clinical multi-omics analyses reveal bifurcation of ER-independent and ER-dependent drug resistance to CDK4/6 inhibitors by Zhengyan Kan, Ji Wen, Vinicius Bonato, Jennifer Webster, Wenjing Yang, Vladimir Ivanov, Kimberly Hyunjung Kim, Whijae Roh, Chaoting Liu, Xinmeng Jasmine Mu, Jennifer Lapira-Miller, Jon Oyer, Todd VanArsdale, Paul A. Rejto, Jadwiga Bienkowska

“…The ER independent subgroup, growing from 5% pre-treatment to 21% post-progression, is characterized by down-regulated estrogen signaling and enrichment of resistance markers including TP53 mutations, CCNE1 over-expression and Her2/Basal subtypes. Trajectory inference analyses identify a pseudotime variable strongly correlated with ER independence and disease progression; and revealed bifurcated evolutionary trajectories for ER-independent vs. …”
Get full text

Study on Deformation and Stability of Rock-Like Materials Retaining Structure during Collaborative Construction of Super-Adjacent Underground Project by Hongfu Qu, Lihua Wang, Chunlei Feng, Hualao Wang, Xuan Zhang

“…Then, the calculation formula for the against basal heave stability covering different adjacent degrees was established. …”
Get full text

Th17 Cell Response in SOD1G93A Mice following Motor Nerve Injury by Allen Ni, Tao Yang, Nichole A. Mesnard-Hoaglin, Rafael Gutierrez, Evan B. Stubbs, Susan O. McGuire, Virginia M. Sanders, Kathryn J. Jones, Eileen M. Foecking, Junping Xin

“…SOD1G93A mice, compared with WT mice, displayed an increase in the basal activation state of CD4+ T cells and higher frequency of Th17 cells, which were further enhanced by FNA. …”
Get full text

PROWADZENIE BIZNESU Z PERSPEKTYWY TAOIZMU by Julitta Koćwin

“…W artykule starano się znaleźć odpowiedź na pytanie jaka jest rola wartości taoizmu w biznesie i jaki mają one wpływ na rozwój przedsiębiorstwa i gospodarki? …”
Get full text

Study of the Potential Endocrine-Disrupting Effects of Phenylurea Compounds on Neurohypophysis Cells In Vitro by Krisztián Sepp, Zsolt Molnár, Anna M. László, Tünde Alapi, László Tóth, Andrea Serester, Zsuzsanna Valkusz, Márta Gálfi, Marianna Radács

“…In the experimental protocol, the basal levels of OT and AVP were determined as controls. …”
Get full text

Discursos pedagógicos sobre el valor formativo de la enseñanza histórica. Perspectiva de los formadores de docentes by Omar Turra Díaz, Juan Mansilla Sepúlveda

“…El estudio se realizó desde una metodología cualitativa, utilizándose como epistemología basal la fenomenología hermenéutica y como técnica de producción de información la entrevista en profundidad. …”
Get full text

Vermicomposting of cow dung amended with eggshell powder: Possible roles of eggshell powder on the growth models of Serendipita indica, wheat growth and performances and soil enzym... by Mohammad Zarea, Nasrin Karimi

“…CDES vermicompost caused the increase in soil basal respiration and soil enzymatic activities.Conclusion Eggshell powder growth promoting effect can be attributed to the biologically active compound that exists in eggshell extract.…”
Get full text

Baza noclegowa i towarzysząca – wybrane elementy infrastruktury polskich parków narodowych w latach 2005‒2015 by Milena Bera, Aneta Zaremba

“…Analiza porównawcza wykazała zróżnicowanie badanych parków w omawianym zakresie. Z przeprowadzonych badań wynika, że największy udział w bazie noclegowej w parkach narodowych miały kempingi i biwaki, z zauważalną tendencją spadkową w każdym analizowanym roku. …”
Get full text

Types of Digital Presence among Seniors by Agnieszka Iwanicka

“…Formy aktywności cyfrowej seniorów Artykuł ma charakter przeglądowy i stanowi podsumowanie wiedzy w zaprezentowanym obszarze badawczym, integruje też i interpretuje dotychczasowe wyniki badań naukowych. Jego celem jest diagnoza zakresu udziału seniorów w korzystaniu z mediów cyfrowych. …”
Get full text

Hydrogen Peroxide-Induced DNA Damage and Repair through the Differentiation of Human Adipose-Derived Mesenchymal Stem Cells by Mahara Valverde, Jonathan Lozano-Salgado, Paola Fortini, Maria Alexandra Rodriguez-Sastre, Emilio Rojas, Eugenia Dogliotti

“…DNA repair capacity of hADMSCs was affected in cells exposed to 150 and 200 μM of hydrogen peroxide. An increase in the basal levels of DNA breaks and oxidative DNA lesions was observed through adipocyte differentiation. …”
Get full text

HOW TO SEARCH THE PLACE BRAND IDENTITY DISTINGUISHED FEATURES? THE LOCAL STAKEHOLDERS' PERSPECTIVE by Ewa Glińska

“…Celem niniejszego artykułu jest zaprezentowanie kategorii wyróżników tożsamości marki miasta zidentyfikowanych poprzez lokalnych interesariuszy. Wyniki badań zaprezentowane w opracowaniu zawierają sugestie dotyczące sposobu selekcji atrybutów tożsamości miejskiej, w relacji do zarządzania wizerunkiem zwłaszcza małych miast. …”
Get full text

Fluid Retention over the Menstrual Cycle: 1-Year Data from the Prospective Ovulation Cohort by Colin P. White, Christine L. Hitchcock, Yvette M. Vigna, Jerilynn C. Prior

“…Ovulation was documented by quantitative basal temperature analysis, and serum estradiol and progesterone levels were available from initial and final cycles. …”
Get full text

Cardiovascular rehabilitation. Results in the cardiology service. by Juan José Navarro López, Roberto S. Vega Hernández., Claudio González Rodríguez., Teresa Rodríguez Rodríguez

“…In a significant way p &lt; 0,001 varied the double product of the ergometric test and the units of the basal metabolism. <strong><br />Conclusions:</strong> For the clinical changes, ergometrics and psychological evaluated in those patients we can consider them integrally rehabilitated with this group of exercises.…”
Get full text

Kurs, Nilai Ekspor, dan Cadangan Devisa di Indonesia (Tinjauan Empiris Tahun 2013 - 2022) by Laila Maghfiroh, Anggraeni

“…Penelitian ini di olah menggunakan program SPSS versi 25 dengan menggunakan analisis regresi linear berganda. data penelitian ini di kumpulkan melalui observasi dan dokumentasi terhadap data yang ada pada Badan Pusat Statistik (BPS) dan Bank Indonesia (BI). …”
Get full text

Relationship Between Physical Activity Levels and Body Compositions of University Students by Şükran Arıkan, Serkan Revan

“…There was a significant relationship between the total score of high intensity physical activity and body weight (r = 0.21), body fat percentage (r = -0.21), lean body mass (r = 0.24), basal metabolic rate (r = 0.23), body mass index (r = 0.17) and waist / hip ratio (r = 0.24). …”
Get full text

A Case of Hepatic Malignant Solitary Fibrous Tumor: A Case Report and Review of the Literature by Zhiyan Fu, Evita B. Henderson-Jackson, Barbara A. Centeno, Gregory Y. Lauwers, Mihaela Druta, Daniel A. Anaya, Yukihiro Nakanishi

“…A 73-year-old man with a history of atrial myxoma and basal cell carcinoma presented with unexplained fever. …”
Get full text

Rola historii nauki w działalności naukowej, dydaktycznej i filozoficznej Mariana Smoluchowskiego by Paweł Polak

“…Jego krótka praca o historii fizyki w Polsce stanowi pionierskie opracowanie tego zagadnienia, była cytowana wiele razy, tworząc punkt wyjścia do dalszych badań nad historią fizyki w Polsce. Należy jednakże podkreślić, że nigdy nie poddano systematycznej analizie zagadnienia roli historii nauki w działalności naukowej Smoluchowskiego. …”
Get full text

Renal and Hematological Effects of CLCF-1, a B-Cell-Stimulating Cytokine of the IL-6 Family by Virginia J. Savin, Mukut Sharma, Jianping Zhou, David Gennochi, Timothy Fields, Ram Sharma, Ellen T. McCarthy, Tarak Srivastava, Jos Domen, Aurélie Tormo, Jean-François Gauchat

“…CLCF-1 increased phosphorylation of STAT3 in multiple cell types, activated podocytes leading to formation of lamellipodia and decrease in basal stress fibers, increased glomerular albumin permeability, and increased STAT3 phosphorylation of peripheral blood cells and renal cortex. …”
Get full text

Loss of Cochlear Ribbon Synapse Is a Critical Contributor to Chronic Salicylate Sodium Treatment-Induced Tinnitus without Change Hearing Threshold by Wei Zhang, Zhe Peng, ShuKui Yu, Qing-Ling Song, Teng-Fei Qu, Lu He, Ke Liu, Shu-Sheng Gong

“…A immunostaining study showed that there is significant loss of anti-CtBP2 puncta (a marker of cochlear inner hair cell (HC) ribbon synapses) in treated animals in apical, middle, and basal turns (all p<0.05). The ABR wave I amplitudes were significantly reduced at 4, 8, 12, 14, 16, and 20 kHz (all p<0.05). …”
Get full text

A Case of Left Retroexternal Iliac Artery Megaureter Associated with Additional Renal and Vascular Congenital Anomalies by Amin A. Karadaghy, Matthew T. Bell, Daniel T. Daly, Yun Tan

“…A number of rare anatomical anomalies, including retroexternal iliac ureter, extrarenal calyces (ERCs), and vascular anomalies, were observed in a 96-year-old female cadaver during a routine dissection. Description. …”
Get full text