输注陈旧红细胞对肝细胞癌切除术后病人预后的影响 by 薛瑞峰, 赵崇希, 王培宗, 陈东泰, 陈晓辉, 曾维安, 李强

“…Kaplan–Meier生存分析显示输血组的总生存时间，肝内无复发生存时间，肝外无转移生存时间都更差（<italic>P</italic>&lt;0.001），Cox多因素回归分析进一步提示输注陈旧红细胞是总生存时间（HR<italic>=</italic>1.417， <italic>P</italic>=0.049）和肝内无复发生存时间（HR<italic>=</italic>1.519， <italic>P</italic>=0.013）的独立影响因素，新鲜红细胞却不是。…”
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布鲁菌病67例临床特征 by 曾国芬, 庄江锋, 高亮, 沈堃宇, 张杨, 苏桂华, 高志良, 舒欣

“…喀地一院、中山三院分别有39例（73.6%）、11例（78.6%）患者发生并发症，院间发生率无统计学差异（<italic>P</italic>=0.971），且均以肝炎和骨骼损害最常见。中山三院患者脊柱炎（<italic>P</italic>=0.042）及神经型布病（<italic>P</italic>=0.041）的发生率高于喀地一院，其余并发症分布无明显统计学差异。…”
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Effect of Bloodletting Therapy on Patients with Spastic Wrist Dorsiflexion Dysfunction after Stroke by LIN Wanqing, XIE Xuemin, CHEN Bin, ZHENG Xinyi

“…Compared with the control group, the MAS grade, iEMG and RMS of the experimental group were significantly lower, and the PROM score, FMA-UE score were significantly higher (<italic>P</italic>&lt;0.05). There was no significant difference in the total effective rate between two groups (<italic>P</italic>&gt;0.05), while the obvious effective rate of the experimental group was significantly higher than the control group (<italic>P</italic>&lt;0.05).ConclusionBloodletting therapy can improve the spasticity of wrist flexor muscle in patients with spastic wrist dorsiflexion dysfunction after stroke, reduce the abnormal muscle contraction, and improve the passive range of motion of wrist joint and limb motor function. …”
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胸骨后重建路径联合术后辅助放疗在微创Mckeown食管癌切除术近期并发症与安全性分析 by 田界勇, 梅新宇, 张天赐, 徐广文, 熊燃

“…方法回顾性分析2020年1月至2021年6月期间在中国科学技术大学附属第一医院胸外科行微创Mckeown食管癌切除术89例，部分患者接受术后辅助放疗，根据管状胃上提途径分为胸骨后路径及后纵隔路径两组，其中胸骨后路径组39例，后纵隔路径组50例，比较两组患者临床特征及围手术期并发症情况。结果两组患者临床特征差异无统计学意义（<italic>P</italic>＞0.05）；两组患者在手术时间，术中出血，术后引流情况，术后住院时间等方面差异无统计学意义（<italic>P</italic>＞0.05）。…”
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SDF-1/CXCR4激活ERK和PI3K/AKT通路介导髓核致炎根性疼痛 by 魏明, 高凤娇, 杨琳, 孙来保, 邹学农, 黄文起

“…③ 18只大鼠随机分为溶剂组、U0126组、LY294002组，鞘内注射相应药物，测量大鼠PWT的变化。结果① 髓核自体移植使大鼠PWT下降（<italic>P</italic>＜0.001），脊髓中SDF-1、CXCR4、pERK，pAKT表达上调（<italic>P</italic>＜0.05），SDF-1主要与脊髓中神经元共表达，CXCR4 与神经元和星形胶质细胞共表达。…”
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Effect of Tiaoxin Recipe on Memory Learning and Synaptic Plasticity in APP/PS1 Double Transgenic Alzheimer's Disease Mice based on αCaMKⅡ-CREB-BDNF Signal Pathway by Xiaowen WANG, Hong QIAN, Chunjuan SHEN, Yanjun LI, Haixin YUAN, Jian WANG

“…Compared with the model group, the expressions of αCaMKⅡ, CREB, BDNF and PSD-95mRNA in the hippocampus of the Tiaoxin recipe group were significantly higher, and the difference was statistically significant (<italic>P</italic>&lt;0.05).③Western blot assay results: Compared with the normal group, the expressions of p-αCaMKⅡ, p-CREB, BDNF and PSD-95 protein in the hippocampus of the model group were significantly lower, and the difference was statistically significant (<italic>P</italic>&lt;0.05). compared with the model group, the expressions of p-αCaMKⅡ, p-CREB, BDNF and PSD-95 prote in in the hippocampus of mice in Tiaoxin recipe group were significantly increased, and the difference was statistically significant (<italic>P</italic>&lt;0.05).Conclusion:Tiaoxin recipe can improve the LTP of hippocampal CA1 region of APP/PS1 double transgenic AD mice, increase the expression of PSD-95mRNA and protein, improve the memory learning function and synaptic plasticity of APP/PS1 double transgenic AD mice, and its mechanism may be related to its up-regulation of hippocampal αCaMKⅡ-CREB-BDNF signal pathway.…”
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Determinants of 5-year survival in patients with advanced NSCLC with PD-L1≥50% treated with first-line pembrolizumab outside of clinical trials: results from the Pembro-real 5Y glo... by Mieke Van Hemelrijck, Salvatore Grisanti, Avinash Aujayeb, Martin Forster, Giannis Mountzios, Andrea Napolitano, Bruno Vincenzi, Joachim G J V Aerts, Marina Garassino, Valter Torri, Solange Peters, Alex Friedlaender, Alfredo Addeo, Giuseppe Lo Russo, Roberto Ferrara, Diego Signorelli, Alessandro Russo, So Yeon Kim, Jarushka Naidoo, Scott Gettinger, Heather Wakelee, Martin Sebastian, Mark Awad, Abdul Rafeh Naqash, Alessio Cortellini, Raffaele Giusti, Michele De Tursi, Federica Zoratto, Marco Russano, Rita Chiari, Biagio Ricciuti, Andrea De Giglio, Alain Gelibter, Giuseppe Tonini, Amin H Nassar, Alessandra Curioni-Fontecedro, Eleni Karapanagiotou, Emilio Bria, Jack Bell, Paolo Bironzo, Joao V Alessi, Alessandro Morabito, David J Pinato, Francesco Passiglia, Carlo Genova, Francesca Mazzoni, Alessandro Inno, Francesco Grossi, Luca Cantini, Lorenza Landi, Luigi Della Gravara, Margarita Majem, Uma Mukherjee, Federica Biello, Alessandro Leonetti, Annalisa Guida, Marianna Macerelli, Gabriele Minuti, Giulio Metro, Thomas Newsom-Davis, Eleni Josephides, Andrea Camerini, Elisa Roca, David O’Reilly, Mingjia Li, Laura Mezquita, Teresa Gorría, Claudia A M Fulgenzi, Lauren Young, Joel W Neal, Javier Baena, Francesco Pantano, Jacobo Rogado, Mary Jo Fidler, Teresa Beninato, Federica Pecci, Alessandro Di Federico, Kazuki Takada, Leonardo Brunetti, Talal El Zarif, Laura Moliner, Alberto Servetto, Sukumar Kalvapudi, Sai Yendamuri, Edoardo Garbo, Giuseppina Rita Di Fazio, Monica Loza, Ritujith Jayakrishnan, Michele Montrone, Nichola O Awosika, Bartlomiej Tomasik, Maximilian Rost, Isabelle Monnet, Francesco Agustoni, Artur Katz, Dwight Hall Owen, Michele Ghidini, Armida D’Incecco, Gianpaolo Spinelli, Monica Verrico, Manuel Dupont, Rafael Di Marco Barros, Diego Luigi Cortinovis, Chiara Bennati, Frank Aboubakar Nana, Anne-Marie Dingemans, Taher Abu Hejleh

“…However, real-world data on its long-term efficacy remains sparse.Methods This study assessed 5-year outcomes of first-line pembrolizumab monotherapy in a large, multicenter, real-world cohort of patients with advanced NSCLC and PD-L1 TPS≥50%, referred to as Pembro-real 5Y. …”
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Clinical Observation on Basal Ganglia Aphasia after Stroke Treated by Donepezil by Xi CHENG, Jinghui LAI, Zhifeng WANG, Yanling GAO, Xiaofeng CHEN, Ling LIN

“…Objective:To evaluate the curative effect of donepezil on basal ganglia aphasia after stroke.Methods:A total of 37 patients with basal ganglia aphasia after stroke were randomly assigned to donepezil group (<italic>n</italic>=19) and control group (<italic>n</italic>=18). …”
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Structural and Passability Analysis of Pipeline Robot by Zhiqiang Li, Weiguo Li, Zhicheng Feng, Lili Wang, Wen'gang Yan, Shijie Guo

“…Experimental results show that the structure design and calculation of the robot are reasonable，the size and motion constraint analysis of the robot in the bend pipe are correct，the robot can successfully pass the bend pipe with <italic>R</italic>≥1.5<italic>D</italic>. The research results provide a reference for the follow-up robot simulation experiment and prototype manufacture.…”
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Error Analysis and Compensation of a Three-degree-of-freedom Cervical Traction Rehabilitation Mechanisms by Hong Li, Qingfeng Wang, Xinyu Wang, Weixiao Lu

“…Firstly， the error modeling is based on the closed vector method， and 11 important errors are identified according to the global error sensitivity； then， based on the given error range， global pose errors and local errors of the moving platform when <italic>z</italic>=600 mm and <italic>z</italic>=650 mm are analyzed； finally， based on the particle swarm algorithm， the optimal solutions for the four sets of error compensation are derived， and the joint experimental simulation analysis is carried out by Matlab and Adams software. …”
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Bootstrap Statistical Model of Tooth Surface Deviation of Heat Treatment Deformation of Batch Spiral Bevel Gears by Weihao Sun, Jubo Li, Tianxing Li, Chuang Jiang, Songlin Wang, Jianxin Su

“…Aiming at the same batch of spiral bevel gears with the same gear material， NC milling method and heat treatment specification， a bootstrap resampling is carried out on a small number of tooth surface deviation sample data based on the bootstrap method， a large number of sample data are obtained and a bootstrap statistical model of batch spiral bevel gear tooth surface deviation is established； the probability characteristic value of the sequential points of tooth surface measurement is calculated， and whether they conform to the normal distribution is tested by <italic>k</italic>-<italic>s</italic>； the estimated true value， estimated interval and other parameters are selected to describe their statistical laws and results； through the cubic NURBS surface fitting method， the variation law of the tooth surface deviation of the whole batch is obtained， and the effective evaluation of the tooth surface accuracy of the whole batch is realized. …”
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Exploration of Melodic Intonation Therapy on Nonfluent Aphasia by Jie ZHU, Lingyu LIANG, Jingbo LI, Kanglun YU, Jiamin ZHANG

“…Western aphasia battery (WAB) were obtained before and after treatment to record improvement in language tasks.Results:After blocks of MIT, the table showed that patients had significantly improved WAB scores (<italic>P</italic>&lt;0.05) in Information tasks, Fluency tasks, Auditory Comprehension tasks, Commands tasks, Repetition tasks, Naming tasks and Responsive Speech tasks. …”
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Fault Feature Extraction of Gearbox based on Adaptive VMD by Wenyao Li, Wengang Yang

“…The VMD is widely used in gearbox fault diagnosis， but it is a parametric decomposition method. If <italic>K</italic> is too large or too small， it will lead to over-decomposition or under-decomposition. …”
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Evaluation of the Motor Function of Sling Exercise Therapy in Children with Cerebral Palsy by Chuntao ZHANG, Zhenhuan LIU, Shangsheng DONG

“…Gross motor assessment scale (GMFM-88), Beijing Gesell scale (Gesell) and Berg balance scale were used to evaluate the motor function before and after trial.Results:The scores of GMFM-88, Gesell and Berg balance scale were improved after trial than those before treatment (<italic>P</italic>&lt;0.05). After treatment, the scores of the observation group were improved significantly compared to those in the control group (<italic>P</italic>&lt;0.05).Conclusion:The sling exercise therapy can effectively improve the level of the motor and balance ability of children with cerebral palsy.…”
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RESEARCH ON BENDING⁃TORSION COUPLING VIBRATION CHARACTERISTIC OF COMPRESSOR SHAFT SYSTEM CONSIDERING HARD STIFFNESS CHARACTERISTIC by ZHANG Hao, ZHAO Xiang, ZHANG DongMei, ZUO Song

“…The degree of phase space fluctuation decreases with the reduction of the axial tile clearance， and the area of the non⁃contacting region in the <italic>x</italic> and <italic>y</italic> directions shows a decreasing trend. …”
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Effect of Acupotomy Intervention on Fibrosis of Rectus Femoris in Rabbits with Knee Osteoarthritis by LIU Jing, ZENG Weiquan, LIN Qiaoxuan, LU Liming, GUO Zexing, LIU Hong, ZHANG Liangzhi, XIU Zhongbiao

“…Compared with the blank group, the collagen volume fraction of rectus femoris muscle in the model group increased, and the difference was statistically significant (<italic>P</italic>&lt;0.01). Compared with the model group, the acupotomy group had decreased collagen volume fraction of rectus femoris muscle, and the difference was statistically significant (<italic>P</italic>&lt;0.01). 2) RT-PCR results showed that the mRNA expressions of ColⅠ, VIM and α-SMA in the model group were significantly higher than those in the blank group (<italic>P</italic>&lt;0.01), while those in the acupotomy group were significantly lower than those in the model group, and the difference was statistically significant (<italic>P</italic>&lt;0.01). 3) Western blot results showed that the proteins expressions of ColⅠ, VIM and α-SMA in the model group were significantly higher than those in the blank group (<italic>P</italic>&lt;0.01), while those in the acupotomy group were significantly lower than those in the model group, and the difference was statistically significant (<italic>P</italic>&lt;0.01).ConclusionBased on the Jingjin theory, the release of quadriceps femoris' transfascial focal point by acupotomy can down-regulate the expression levels of mRNA and protein of ColⅠ, VIM, α-SMA, and reduce the degree on fibrosis of rectus femoris muscle, which may be one of the mechanisms of acupotomy for KOA.…”
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血浆游离甲氧基肾上腺类物质对嗜铬细胞瘤和副神经节瘤的诊断价值 by 姚瑶, 冯绮玲, 李永洁, 张小云, 唐菊英, 郭颖, 张少玲, 严励

“…两组病人血浆MN中位数［0.54（0.17~4.48） nmol/L <italic>vs.</italic> 0.15（0.11~0.21） nmol/L， <italic>P</italic>&lt;0.001］， NMN中位数［7.48（2.12~15.01） nmol/L <italic>vs.…”
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乔木层植被结构对印支灰叶猴夜宿地选择的影响 by 陆瑞, 杨云飞, 范琳琳, 范朋飞, 马驰

“…为了评估濒危灵长类印支灰叶猴（<italic>Trachypithecus crepusculus</italic>）现有分布区的夜宿地质量，并为亚洲疣猴栖息地植被的保护提供具体意见，于2010年1月—2022年 12月对云南无量山印支灰叶猴夜宿地选择策略进行研究。…”
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磷酸二酯酶5在肾脏纤维化中的保护作用 by 翟庆娴, 李蒙, 隆罗莎, 梁柏恩, 王蔚东

“…方法C57BL/6雄性小鼠被随机分为假手术Sham（<italic>n</italic>=6）、7UUO（<italic>n</italic>=6）、7UUO+SIL（<italic>n</italic>=6）或7UUO+LW1646（<italic>n</italic>=6）组，术前1h给予SIL或LW1646、或溶剂灌胃给药，连续给药7 d后处死小鼠，收集梗阻侧肾脏标本。…”
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Effect of Aerobic Treadmill Exercise Regulating Glucose Transporter 9 on Renal Function in Hyperuricemia Rats by LIANG Jiarong, YANG Huan, CUN Yongdan, WANG Lihuan, LI Yijie, YE Bin

“…Hematoxylin-eosin (HE) was used to stain the renal histopathological section, and the microscope (×400) was used to observe the structural changes of renal tubules and glomerulus; the peroxidase method was used to detect the renal function indexes such as uric acid (UA), creatinine (Cre) and urea nitrogen (BUN); enzyme-linked immunosorbent assay (ELISA) method was used to determine the contents of interleukin-1β (IL-1β) in serum and kidney tissues; Western blot was used to detect the expressions of Caspase-1, IL-1β and glucose transporter 9 (GLUT-9) in the kidney tissues.Results① Pathological examination results: there was not obvious pathological changes were observed in the kidney tissues of the Control group; in the Model group, the renal tissue capsule was incomplete, the glomerulus was deformed and atrophic, and the renal tubules were disordered; in the Exercise group, the number of inflammatory cell infiltration was significantly decreased, the renal tubular structure was relatively intact, and the pathological changes such as cytoplasmic vacuolation of renal tubular epithelial cells were significantly decreased. ② UA, Cre and BUN content of serum: compared with the Control group, UA, BUN and Cre content in serum of the Model group and Exercise group was significantly increased (<italic>P</italic>&lt;0.05); compared with the Model group, UA, BUN and Cre content in serum of the Exercise group were significantly decreased (<italic>P</italic>&lt;0.05). ③ Serum and kidney IL-1β content: compared with the Control group, the expression of IL-1β in serum and kidney of the Model group and the Exercise group were significantly increased (<italic>P</italic>&lt;0.05); compared with the Model group, the expression of IL-1β in serum and kidney of the Exercise group was significantly decreased (<italic>P</italic>&lt;0.05). ④ Expressions of Caspase-1, IL-1β and GLUT-9 protein: compared with the Control group, the expressions of Caspase-1, IL-1β and GLUT-9 protein in kidney tissues of the Model group and the Exercise group were significantly increased (<italic>P</italic>&lt;0.05); compared with the Model group, the expressions of Caspase-1, IL-1β, and GLUT-9 protein in kidney tissues of the Exercise group were significantly decreased (<italic>P</italic>&lt;0.05).ConclusionAerobic treadmill exercise can effectively reduce the level of uric acid and inflammatory response of hyperuricemia rats, and improve renal function, which may be related to the regulation of GLUT-9 protein expression.…”
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