瑞芬太尼下调大鼠背根神经节和脊髓背角GIRK2的表达 by 罗国娅, 王晓娥, 李林芝, 王文慧, 杨翘睿, 陈元, 肖力, 崔宇

“…免疫印迹结果显示，静脉输注瑞芬太尼1 d后，与对照组相比，背根神经节 GIRK2总蛋白（0.47 ± 0.10 <italic>vs.</italic> 1.01 ± 0.17，<italic>P &lt; </italic>0.001）和膜蛋白（0.47 ± 0.11 <italic>vs.…”
Get full text

二甲双胍和孟鲁司特在急性和慢性过敏性哮喘小鼠模型中的作用 by 郭妍蓉, 严彦

“…各实验组小鼠处死后苏木素-伊红染色和马松染色分析小鼠的肺部病理特征；采用Image J软件进行气道炎症细胞浸润评分和胶原沉积评分，以及分析支气管形态参数，包括支气管壁厚度和支气管平滑肌厚度；采用ELISA方法检测小鼠血清总IgE水平，qRT-PCR检测炎症因子<italic>IL-4</italic>、<italic>IL-5</italic>、<italic>IL-13</italic> mRNA转录水平。…”
Get full text

Effect of Pien Tze Huang on Lymphangiogenesis Mediated by LncRNA-ANRIL in Colorectal Cancer by Yao LU, Min ZHANG, Jie LIU, Qianqian MAO, Zhiyun CAO, Jiumao LIN

Subjects: Get full text

Effect and Mechanism of Catalpol on Behavior in Rats with Post-stroke Depression by WANG Xiangyu, ZHOU Xia, LIU Ju, LIU Fuhong, ZHANG Jiale, SUN Liping, LI Wanbin

“…TTC staining showed that the volume of cerebral infarction in the catalpol intervention group was significantly reduced compared with model group (<italic>P</italic>&lt;0.05). In the ELISA experiment, compared with the model group, 5-HT and BDNF in the catalpol intervention group were significantly increased on the 4th and 7th day after intervention, and the difference was significant (<italic>P</italic>&lt;0.05); there was no significant difference in NE content in the catalpol intervention group on the 4th and 7th day after intervention (<italic>P</italic>&gt;0.05); compared with the model group, the hippocampal 5-HT and BDNF in the catalpol intervention group increased significantly (<italic>P</italic>&lt;0.05); there was no significant difference in the content of NE in hippocampus between the catalpol intervention group and the model group (<italic>P</italic>&gt;0.05), indicating that catalpol could increase 5-HT and BDNF levels in rats with post-stroke depression, but did not significantly improve NE.ConclusionCatalpol can improve post-stroke depression, promote the recovery of neurological function, regulate the function of central serotonin system and promote the secretion of BDNF.…”
Get full text

Clinical Study of Repetitive Transcranial Direct Current Stimulation Combined with Rehabilitation Therapy for Patients with Consciousness Disorder by CHENG Xiaorong, SUN Dengjuan, ZHANG Yibao, MA Yumei, MA Rui, BAO Yingcun, LI Qun

“…In the control group，there were 2 （9.50%） patients with responded and 19 （90.50%） patients who did not respond，the difference between the two groups was significant difference （<italic>P</italic>&lt;0.05）. As for MAS score，there was no significant difference in MAS score of right flexor elbow muscle between the two groups before treatment （<italic>P</italic>＞0.05）; There was no significant difference in MAS score of bilateral flexor elbow muscle in the control group before and after treatment （<italic>P</italic>＞0.05），but there was significant difference in the observation group before and after treatment （<italic>P</italic>&lt;0.05）. …”
Get full text

基于集成磁共振成像的正常儿童及青年人脑体积测量 by 戴艳, 陈颖茜, 苏舒, 钱龙, 吴柳晖, 张洪宇, 范淼, 杨智云

“…结果在儿童组及青年组中通过配对<italic>t</italic>检验显示两种方法所得的GMV、WMV、BPV、ICV的值虽具有差异（<italic>P＜</italic>0.05），但均具有较好的相关性（Pearson相关分析儿童组中<italic>r</italic>值分别为0.691、0.577、0.938、0.796，<italic>P＜</italic>0.001；青年组中<italic>r</italic>值分别为0.657、0.623、0.933、0.881，<italic>P</italic>＜0.001）及一致性［儿童组ICC95%CI分别为0.816（0.647，0.905），0.732（0.484，0.861），0.968（0.938，0.983），及0.880（0.770，0.938），青年组ICC95%CI分别为0.751（0.476，0.881），0.760（0.496，0.886），0.962（0.920，0.982），及0.936（0.866，0.970）］。…”
Get full text

基于生物信息学途径筛选缺血性脑卒中关键基因及药物预测 by 于瑜, 王钟兴

“…用R语言的Limma包对数据进行差异表达分析，<italic>P</italic>&lt;0.05且|log₂FC|&gt;0.6的基因为差异表达基因。…”
Get full text

超声对乳腺单纯黏液癌与纤维腺瘤鉴别诊断的价值 by 王红莉, 胡越, 谭翠, 顾然, 梅静思, 余玥幸, 陈丽莉, 龚畅

“…结果PMC患者中位年龄为47岁，而FA为33岁，PMC患者年龄较FA偏大，两者差异具有统计学意义（<italic>P</italic>&lt;0.001）。PMC患者病变中位长径2.4 cm大于FA的1.8 cm，差异有统计学意义（<italic>P</italic>=0.001）。…”
Get full text

我国华南中麝鼩分子系统地理学分析 by 栾天琪, 郭秋颖, 高艺, 韩美凤, 张春凤, 陈欢, 蔡赫, 金志民, 张隽晟, 刘铸

“…华南中麝鼩（<italic>Crocidura rapax</italic>）亚种分化存在异议。为了明确我国华南中麝鼩的分子系统地理格局，为其分类学提供进一步分子生物学证据，测定了我国贵州华南中麝鼩20个样本的<italic>Cyt b</italic>基因序列，并结合GenBank下载的19个华南中麝鼩<italic>Cyt b</italic>基因序列进行一并分析。…”
Get full text

Correlation Between Learning and Memory Impairment and Changes in Cerebral White Matter Nerve Fibers and Pericytes in Rats with Chronic Cerebral Ischemia by HUANG Jia, WANG Mengxue, NI Jinglei, LIANG Shengxiang, LIN Bingbing

“…At 28 d and 56 d after operation, morris water maze was used to detect spatial learning and memory ability; diffusion tensor imaging was used to observe the fractional anisotropy (FA) and mean diffusivity (MD) rate of white matter nerve fibers in corpus callosum and hippocampus; luxol fast blue (LFB) staining was used to observe demyelination in corpus callosum; Western blot was used to detect the expression of myelin basic protein (MBP) and pericyte marker platelet-derived growth factor receptor β (PDGFR-β) in corpus callosum and hippocampus.Results(1) Learning and memory ability: compared with the sham operation group, the escape latency prolonged significantly from day 2 to day 4 after operation in the 28 days after operation group and on the 3rd day in the 56 days after operation group (<italic>P</italic>&lt;0.05). Compared with the sham operation group, the times of crossings of the platform and the proportion of target quadrant time in the 28 days after operation group and the 56 days after operation group were significantly lower (<italic>P</italic>&lt;0.05). (2) Changes of white matter nerve fibers in corpus callosum and hippocampus: compared with the sham operation group, the MD values of white matter nerve fibers in the left and right corpus callosum and the left and right hippocampus in the 28 days after operation group and the 56 days after operation group were significantly lower (<italic>P</italic>&lt;0.05). (3) Correlation analysis between learning and memory ability and MD values of corpus callosum or hippocampus: there was a positive correlation between the times of crossings of the platform and MD values of corpus callosum or hippocampus (<italic>r</italic>=0.832, <italic>P</italic>&lt;0.01; <italic>r</italic>=0.777, <italic>P</italic>&lt;0.01). (4) Morphology of nerve fibers in the corpus callosum: compared with the sham operation group, the structure disorder and loss of myelin sheath occurred in the corpus callosum after chronic cerebral ischemia. …”
Get full text

Clinical Observation of Auricular Acupressure Combined with Transcranial Direct Current Stimulation for Nicotine Dependence by KUANG Hongjun, FU Shanshan, HUANG Qian, YANG Layuan, YUAN Yangyang, YUAN Nan, LIU Minquan, TANG Jian, FANG Chuang, ZHONG Feng

“…Compared with before treatment, FTND score, MNWS score and QSU score in each group decreased after 4 weeks of treatment (<italic>P</italic>&lt;0.05); the FTND score of the combination group was (1.46±1.41), which was better than that of the tDCS group (2.70±2.03) and the auricular acupressure group (2.83±1.23) (<italic>P</italic>&lt;0.05); the MNWS score of the combination group was (4.73±3.16), which was better than that of the tDCS group (6.33±3.38) and the auricular acupressure group (6.96±2.09) (<italic>P</italic>&lt;0.05); the QSU score of the combination group was (12.70±3.15), which was better than the tDCS group (15.86±5.34) and the auricular acupressure group (16.60±6.71) (<italic>P</italic>&lt;0.05). …”
Get full text

⁶⁸Ga-PSMA-11 PET/CT双时相SUVmax与前列腺癌临床病理特征的相关性 by 李建芳, 万麒昌, 秦露平, 谢良骏, 李锦萍, 伍清宇, 梁子超, 程木华

“…收集所有病人的临床、病理资料。采用Mann-Whitney <italic>U</italic>检验、受试者工作特征（ROC）曲线分析SUVmax值与患者临床病理特点的关系，以<italic>P</italic>&lt;0.05标准为差异有统计学意义。…”
Get full text

Experimental Study of Modified Videman Method to Replicate Knee Osteoarthritis in Rabbits by Jing LIU, Qiaoxuan LIN, Liming LU, Zexing GUO, Hong LIU, Liangzhi ZHANG, Zhongbiao XIU

“…The success rate of the improved group was higher than that of the traditional group (<italic>P</italic>&lt;0.05).2) Comparison of behavioral outcomes: in the comparison with the normal group, Lequesne MG knee joint evaluation method in the traditional group and the improved group were risen (<italic>P</italic>&lt;0.05). …”
Get full text

Characteristics of Static Balance Function in Elderly Patients with Type 2 Diabetes Mellitus in Different Blood Pressure States by Shuai GUO, Zhizhen LIU, Jiawei QIN, Lianhua YIN, Jia HUANG, Jing TAO

“….; compared the difference of health-related indicators in three groups, such as blood pressure (BP) and pulse rate per minute; compared the difference of static balance function parameters in three groups, such as track length (LNG), surface of the statokine-sigram (SSKG), LNG/area, track length-X(LNG-X), track length-Y(LNG-Y), romberg quotient (RQ) and deviation amplitude (DA).Results:①Blood biochemical indexes: compared with the control group, FBG, GHbA1c, TG, TC and LDL in the T2DM group and T2DM-HTN group were higher (<italic>P</italic>&lt; 0.05); compared with T2DM group, FBG in the T2DM-HTN group was higher (<italic>P</italic>&lt; 0.05). ②Health-related indicators: compared with the control group, BMI, pulse rate per minute and systolic and diastolic blood pressure in the T2DM group and T2DM-HTN group were higher (<italic>P</italic>&lt; 0.05); compared with the T2DM group, BMI, pulse rate per minute and systolic and diastolic blood pressure in the T2DM-HTN group were higher (<italic>P</italic>&lt; 0.05). ③Static balance function parameters: At open eyes state, compared with the control group, LNG/area in the T2DM group was higher (<italic>P</italic>&lt; 0.05), LNG, SSKG, LNG/area, LNG-X and LNG-Y in the T2DM group were higher (<italic>P</italic>&lt; 0.05); Compared with the T2DM group, LNG, LNG/area, LNG-X and LNG-Y in the T2DM-HTN group were higher (<italic>P</italic>&lt; 0.05). …”
Get full text

Effect of Mirror Therapy Combined with Task-Oriented Training on Hemiplegic Upper Limb Functions after Stroke by HE Aiqun, WANG Yang, NIE Tiancui, YING Qixing, YE Simei, SONG Qiushuang, XU Hui, HE Maoli

“…The upper limb motor functions were assessed by the Fugl-Meyer assessment-upper extremity (FMA-UE) and action research arm test (ARAT), occupational performance was assessed by the functional test of hemiplegic upper extremity-Hong Kong (FTHUE-HK).ResultsThere were no significant differences in FMA-UE scores, ARAT scores and FTHUE-HK grade between the two groups before treatment (<italic>P</italic>&gt;0.05). After 4 weeks of treatment, the FMA-UE scores, ARAT scores of the two groups showed significant improvement compared with those before treatment (<italic>P</italic>&lt;0.001), FTHUE-HK grade of the two groups showed significant improvement compared with that before treatment (<italic>P</italic>&lt;0.05). …”
Get full text

长托宁于全麻无抽搐电休克治疗中安全性及有效性的分析 by 李晓月, 臧向阳, 胡静萍, 周少丽

“…结果两组患者的收缩压（SBP）、舒张压（DBP）、平均动脉压（MAP）及心率（HR）在电刺激后显著升高（<italic>P</italic>&lt;0.05），长托宁组药物注射前后血流动力学指标无明显差异（<italic>P</italic>&gt;0.05），阿托品组药物注射后心率显著升高（<italic>P</italic>&lt;0.05），组间比较阿托品组在药物注射后及电刺激后心率显著高于长托宁组（<italic>P</italic>&lt;0.05），血压无明显差异（<italic>P</italic>&gt;0.05）；两组口腔分泌物含量及术后48 h内不良反应发生情况差异无统计学意义（<italic>P</italic>&gt;0.05）。…”
Get full text

椭圆钢管混凝土压弯扭复合受力性能及承载力计算方法研究 by 王静峰, 陶书庆, 沈奇罕, 盛鸣宇

“…为研究椭圆钢管混凝土构件在压弯扭共同作用下的受力性能，基于椭圆钢管核心混凝土等效本构模型，通过ABAQUS有限元软件建立了椭圆钢管混凝土构件在压弯扭复合受力作用下的有限元分析模型，并利用已有的试验数据验证了模型的准确性和可行性；系统分析了约束效应系数、轴压比、弯矩比和扭矩比等关键参数对其<italic>T</italic>/<italic>T</italic>_u-<italic>M</italic>/<italic>M</italic>_u曲线、<italic>T</italic>-<italic>θ</italic>曲线和破坏模式的影响规律，最终提出了椭圆钢管混凝土构件在压弯扭复合受力作用下的承载力计算公式。…”
Get full text

Neurobehavioral Mechanism of Cross-Education Phenomenon in the Upper Limb Based on Functional Near-Infrared Spectroscopy by PAN Yingying, WANG Menghuan, WANG Yixiu, XIE Min, JIANG Zhongli, LIN Feng

“…Purdue pegboard training with the contralateral upper limb of unilateral limb was taken as the contralateral training, and the number of Purdue pegboard plug-ins completed within a limited time as the task performance. fNIRS was used to collect the cerebral hemodynamic changes of healthy right-handed individuals after contralateral training when the left and right hand performed operational activities and record the behavioral data, and compare the cerebral cortex activation and behavioral performance of the left and right hands before and after contralateral training.ResultsAfter contralateral training, the performance of the left hand was significantly better than that before training (<italic>t</italic>=-8.865, <italic>P</italic>&lt;0.010), while the performance of the right hand did not change after training (<italic>t</italic>=-1.689, <italic>P</italic>=0.606). …”
Get full text

基于肝脏转录组测序对不同海拔喜马拉雅旱獭的低氧适应性研究 by 赵坤钰, 李优, 南新营, 李耀东

“…为探究低、中、高3个不同海拔梯度下喜马拉雅旱獭（<italic>Marmota</italic> <italic>himalayana</italic>）基因表达是否存在差异，筛选该物种与高原低氧及强紫外辐射环境适应的相关候选基因，采用Illumina HiSeq 2500高通量测序平台对喜马拉雅旱獭肝脏组织进行无参转录组学分析，通过对质控后测序数据与参考基因组的比较分析，筛选差异表达基因后进行GO功能注释和KEGG富集分析。…”
Get full text

近视患者近距离用眼后黄斑血流的变化 by 张汝婷, 滕月, 李君慧, 廉丽华

“…结果近距离用眼后的黄斑区浅层视网膜微循环指标普遍较用眼前低，除了FAZ-A及FAZ-P以外（<italic>P </italic>= 0.148、<italic>P </italic>= 0.975），差异均具有统计学意义，VLD中以中心VLD（差异1.00）及内层VLD（差异0.80）的差异最大（<italic>P </italic>= 0.001、<italic>P </italic>= 0.008），VPD中以中心VPD（差异0.02）及内层VPD（差异0.02）最大（<italic>P </italic>= 0.001、<italic>P </italic>= 0.008），不同屈光度及眼轴的青年变化程度无差异。…”
Get full text