β-谷甾醇靶向CDC25B抑制肝癌细胞增殖 by 王凯, 李卫, 李志芳, 纪会琼, 郭志伟, 曹俊秋

“…结果CDC25B表达水平，肝癌组织高于其癌旁组织（<italic>P</italic>&lt;0.05），TNM分期（T2-4）高于TNM分期（T1）（<italic>P</italic>&lt;0.05），肝癌临床分期Ⅱ-Ⅳ高于临床分期I（<italic>P</italic>&lt;0.05），肝癌G3-4分化高于G1-2分化（<italic>P</italic>&lt;0.05），复发患者高于未复发者（<italic>P</italic>&lt;0.05），预后不良者高于预后良好者（<italic>P</italic>&lt;0.05）；CDC25B高表达组患者的总生存率低于CDC25B低表达组（<italic>P</italic>&lt;0.05）。…”
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Protective Mechanism of Alisol A 24-Acetate on Brain Microvascular Endothelial Cells in Mice with Cerebral Ischemia-Reperfusion Injury by TRPM2/Akt/GSK3β Pathway by LI Huihong, DENG Yunfei, WEI Wei, ZHAN Zengtu, LIN Libin, XUE Xiehua

“…Compared with the model group, CD31 fluorescence expression in 24A group significantly increased (<italic>P</italic>&lt;0.05). Compared with the sham group, ZO-1, Occludin and Claudin-5 protein expression levels in the model group significantly decreased (<italic>P</italic>&lt;0.05). …”
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全数字化乳腺摄影、数字乳腺断层摄影与DCE-MRI对乳腺肿物诊断效能的比较 by 王智慧, 卢国雄, 颜卓恒, 毛家骥, 曹明慧, 胡辉军

“…结果在全部乳腺腺体中，MRI诊断（<italic>kappa </italic>= 0.66）与病理诊断一致性高于DBT（<italic>kappa </italic>= 0.44），而FFDM诊断与病理无显著一致性（<italic>kappa </italic>= 0.14），在非致密型乳腺中，MRI诊断（<italic>kappa </italic>= 0.88）与病理诊断一致性高于DBT（<italic>kappa </italic>= 0.51），而FFDM诊断与病理无显著一致性（<italic>kappa </italic>= 0.18）。…”
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NLRP3炎症小体在甲型流感病毒H1N1预感染降低小鼠巨噬细胞抗MRSA免疫中的作用 by 师小函, 石云锋, 巴俊慧, 罗进梅, 胡佳佳, 吴本权

“…结果MRSA组NLRP3、Caspase-1的mRNA表达水平与空白对照组比无统计学差异（<italic>P</italic>均&gt;0.05），NLRP3的蛋白表达水平与空白对照组比无统计学差异（<italic>P</italic>&gt;0.05），MRSA组IL-1β的mRNA表达及上清液浓度均明显高于空白对照组（<italic>P</italic>均&lt;0.01）。…”
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右美托咪定缓解三叉神经痛小鼠动态痛觉超敏反应 by 戚智慧, 李静, 王钟兴, 胡榕

“…结果与Sham组相比，CCI-ION组小鼠在术后3 d或7 d可引起同侧和对侧V2、V3区域的DA反应（<italic>P</italic>=0.004 8；<italic>P</italic>＜0.000 1），同时双侧大脑mPFC区域c-Fos（神经元兴奋性标记物）阳性神经元数量均显著上升（<italic>P</italic>=0.044 1；<italic>P</italic>=0.044 4）。…”
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整合素β4调控脑血管发育 by 邓昭华, 董影影, 李颍雯, 何欢欢

“…目的探讨整合素β4（ITGB4）对脑血管生长发育的调控作用。方法通过逆转录PCR（RT-PCR）检测靶向<italic>itgb4</italic> mRNA序列的吗啉环（MO）在斑马鱼胚胎中的敲低效果。…”
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Effect of Suspension Massage Exercise Technique on Cervicogenic Insomnia and Vertebrobasilar Artery Hemodynamics by ZHANG Tianyu, LIU Li, DING Yi, SUN Jie, WANG Shurui, LI Zewen, WANG Jinghua, LI Li

“…After treatment, PSQI and NPQ scores were significantly lower in both groups, and the above scores in the observation group were lower than those in the control group, and the differences were statistically significant (<italic>P</italic>&lt;0.01); after treatment, the scores of each factor of PSQI of the observation group were reduced (<italic>P</italic>&lt;0.05), and the scores of sleepiness of the control group were reduced (<italic>P</italic>&lt;0.05). and the scores of sleep quality, sleep disorder, and daytime dysfunction in the control group decreased (<italic>P</italic>&lt;0.05), and the sleep quality, sleep onset, and sleep duration in the observation group were lower than those in the control group (<italic>P</italic>&lt;0.05); The Vm values of LVA, RVA and BA increased in both groups after treatment, and the above indexes in the observation group were higher than those in the control group, and the differences were statistically significant (<italic>P</italic>&lt;0.05). …”
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Effect of Auditory Recognition on the Vocabulary Knowledge of Children with Functional Articulation Disorder by YAN Jiajian, WANG Chengdong, LU Jianliang, LI Yuchang, SHEN Longbin, OU Jianlin, CHEN Zhuoming

“…It was found that there was a significant positive correlation between total average accuracy of the minimum difference phoneme contrast test and digit memory span test (<italic>P</italic>&lt;0.001); there was a significant positive correlation between total average accuracy of the minimum difference phoneme contrast test and performance of spatial memory span task (<italic>P</italic>&lt;0.001); there was a significant positive correlation between total average accuracy of minimum difference phoneme contrast test and PPVT score (<italic>P</italic>&lt;0.001). …”
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三阴性乳腺癌化疗后骨髓抑制与其预后的相关性分析 by 夏坤健, 王琳, 孙振华

“…</italic> 85.7%，<italic>P</italic>=0.027），5年OS率的差异无统计学意义（88.8% <italic>vs.…”
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Effect of Auditory Integration Training on Children with Autism Spectrum Disorder and Auditory Attention Disorder by HUANG Qijun, ZHOU Kun, LIU Zhenhuan, YANG Jie

“…The scores of communication and behavior skills of PEP-3 scale of the observation group were statistically higher than those of the control group after treatment (<italic>P</italic>&lt;0.05). 4) Typical symptoms of autism: compared with those before treatment, the scores of ABC and CARS of the observation group after treatment decreased significantly (<italic>P</italic>&lt;0.05). …”
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Effect of Extracorporeal Diaphragmatic Pacing Combined with Four-Point Kneeling Position Training on Pulmonary Function in Patients with Ischemic Stroke by LU Wei, DONG Pengxia, XIE Tianpei, FAN Yingjie, QIU Hao, LIU Haoyu, SU Min

“…After 8 weeks of continuous treatment, the patients were evaluated for changes of clam endexpiratory diaphragmatic thickness (CEEDT), maximum end-inspiratory diaphragm thickness (MEIDT), quiet breathing diaphragm mobility (QBDM), deep breathing diaphragm mobility (DBDM), forced vital capacity (FVC), forced expiratory volume in 1 second (FEV₁), FEV₁/FVC, peak expiratory flow (PEF), 6-minute walking distance (6MWD) and Borg score of patients were detected and evaluated in both groups.ResultsThere were no significant differences in the pre-treatment general data and baseline evaluation results at baseline, before treatment between the two groups (<italic>P</italic>&gt;0.05). Compared with the pre-treatment, CEEDT of the unaffected side increased after 8 weeks of treatment in the control group (<italic>P</italic>&lt;0.05), and CEEDT on the affected side significantly increased after 4 and 8 weeks of treatment (<italic>P</italic>&lt;0.05); in the treatment group, CEEDT of both the unaffected and affected sides significantly increased after 4 and 8 weeks of treatment (<italic>P</italic>&lt;0.05). …”
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紫云英苷诱导自噬减轻APP/PS1转基因小鼠皮质内神经元损伤及老年斑沉积 by 杨翠珠, 张润恒, 王姝涵, 蒋裕芸, 刘靖, 李国营, 马宇昕

“…结果免疫荧光染色法表明，20、40 mg/kg AST均可减少APP/PS1转基因小鼠脑皮质内Aβ斑块沉积（<italic>P </italic>&lt; 0.000 1； <italic>P </italic>&lt; 0.000 1）。…”
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活体情况下评价载脂蛋白A1对小鼠视网膜血管生成的影响 by 苏焜仪, 胡安娣娜, 陈珠婷, 连玉, 吕林, 胡洁

“…目的用眼底照相及荧光造影探讨载脂蛋白A1（apoA1）正常生理状态下及缺氧状态下对小鼠视网膜血管生长情况的影响。方法在正常生理条件（常氧）下，通过<italic>apoA1^+/+</italic>鼠、<italic>apoA1 ^-/-</italic>鼠与C57/BL6J小鼠对比，分别在第17天末（幼年期）、8 周龄（成年期）、20周龄（中老年期），进行体内实验：①小鼠眼底照相（观察血管形态）及②荧光造影（FFA）（观察血管渗漏情况，分析视网膜平均血管密度、孔隙率及连接点个数）；并分别制备它们缺氧条件下的氧诱导的视网膜病变（OIR）模型进行实验：①眼底照相；②荧光眼底血管造影。…”
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高龄经产妇剖宫产术中出血风险因素分析 by 陈小俊, 廖冰野, 林梦伊, 欧阳秋怡, 林文金, 李惠敏, 龚凤球, 金宇

“…结果Logistic回归分析显示，手术时间［OR=1.069，95% CI为（1.050， 1.089），<italic>P</italic>&lt;0.001］、胎盘娩出方式［OR=3.131，95%CI为（1.259， 7.782）， <italic>P</italic>=0.014］、胎儿窘迫［OR=4.727，95%CI为（1.191， 18.763），<italic>P</italic>=0.027］、手术级别［OR=21.494，95%CI为（6.031， 76.611），<italic>P</italic>&lt;0.001］、麻醉方式［OR=2.904，95%CI为（1.158， 7.281），<italic>P</italic>=0.023］和宫缩乏力［OR=7.255，95%CI为（4.413， 11.927），<italic>P</italic>&lt;0.001］为术中出血独立风险因素。…”
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中国两栖类物种新纪录——德氏棘蛙 by 贺艳红, 艾仁达, 黄镇杨, 张洋, 刘小龙, 袁智勇

“…2022年7月，在中国云南省文山麻栗坡老山省级自然保护区采集到4号两栖纲（Amphibia）无尾目（Anura）叉舌蛙科（Dicroglossidae）棘胸蛙属（<italic>Quasipaa</italic>）标本。标本整体体型较大，成体雄性头体长76.2~77.3 mm。…”
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Study of Salidroside on Expression of Synaptophysin and Tau in Rats after Local Cerebral Ischemia-reperfusion Injury by Yanqing SU, Yingzheng WANG, Xuwen WANG, Baiying SONG, Yu LIN, Guizhu HONG

“…Objective:To investigate the effect of salidroside on the expression of synaptophysin (SYN) and Tau in rats after cerebral ischemia-reperfusion injury.Methods:A total of 36 healthy adult male Sprague-Dawley rats were randomly divided into sham group (<italic>n</italic>=12) and model group (<italic>n</italic>=24). …”
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弥可保预防长春新碱诱导的病理性疼痛的机制 by 黄睿臻, 徐劲, 魏绪红

“…方法SD大鼠随机进行如下分组：生理盐水组、生理盐水+弥可保组、长春新碱组、长春新碱+弥可保组，Up-down方法测定50%机械撤足阈值，在体电生理方法记录脊髓背角C纤维诱发电位的幅度，免疫组化检测脊髓背角 CGRP阳性纤维末梢的数量，免疫组化或Western blot 检测NF-κB信号p65及IL-10蛋白表达的情况。结果长春新碱可引起机械痛敏（<italic>P</italic>&lt;0.05），同时引起脊髓背角C纤维诱发电位幅度明显增大（<italic>P</italic>&lt;0.05）。…”
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Effects of Pressure Gloves Combined with Hand Training for Post-stroke Hand Edema by Hua LIN, Jing YUAN, Zhilan LIU, Nian WANG, Wen HE, Jing BU, Qianqian MA, Hongbing WANG

“…Pressure comfort was assessed with semantic differential method.Results:There were no differences of hand edema volume, range of joint motion and FMA scale of upper extremity between the two groups before treatment(<italic>P</italic>&gt;0.05).After four weeks of treatment, the hand edema volume in both groups were significantly lower than the volume before treatment(<italic>P</italic>&lt;0.05).The range of joint motion and FMA scale of upper extremity in both groups were significantly higher than those before treatment(<italic>P</italic>&lt;0.05).The hand edema volume after treament was significantly lower in the observation group than in the control group(<italic>P</italic>&lt;0.05).The range of joint motion and FMA scale of upper extremity after treatment were significantly higher in the observation group than in the control group(<italic>P</italic>&lt;0.05).The score of comfortable sensation was significantly higher in the observation group than in the control group(<italic>P</italic>&lt;0.05).Conclusion:Pressure gloves combined with hand training can reduce post-stroke hemiplegic hand edema. …”
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不同环境条件下川金丝猴的皮质醇和Klotho激素水平变化 by 王伟, 程铭昊, 赵思棋, 蒋军, 由玉岩, 孙冬婷, 黄天鹏, 吴锋, 刘连贵, 张于光, 刘学锋

“…为了探究川金丝猴（<italic>Rhinopithecus roxellana</italic>）在不同季节和环境中皮质醇和Klotho激素水平的变化规律，以神农架国家公园大龙潭野外补食群（WG）、神农架姊妹峰笼养群（ZCG）和北京动物园笼养群（BCG）的川金丝猴为研究对象，随机采集各种群4个季节的粪便样品，运用ELISA法测定激素水平。…”
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Mulligan Manipulation Combined with Mckenzie Mechanics Method in Treating 43 Cases of Cervical Spondylotic Radiculopathy by Fuchun WU, Jie CHEN, Wei XU, Guoqing MO

“…Some measurements including pain visual analog scale (VAS), clinical assessment scale for cervical spondylosis (CASCS), the MOS Item Short From Health Survey (SF-36) were recorded to evaluate the curative effects before and after the treatment.Results:The VAS scores in the two groups were decreased after the treatment (<italic>P</italic>&lt;0.01), and the decreasing amplitude of treatment group was higher significantly than that of the control group (<italic>P</italic>&lt;0.05); the scores of CASCS and SF-36 in the two groups were increased after the treatment (<italic>P</italic>&lt;0.01), and the increasing amplitude of treatment group was higher significantly than that of the control group (<italic>P</italic>&lt;0.05); there were significant differences in cure rate and total effective rate between the two groups (<italic>P</italic>&lt;0.01).Conclusion:On the basis of cervical traction and ultrashort wave therapy, Mulligan manipulation combined with Mckenzie function training has positive effects on the improvement of the symptoms, signs and functional status and the quality of life for CSR patients.…”
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