Hyperactive Behavior Screening and Its Influencing Factors in Preschool Children Based on a Computer Cloud Platform by YIN Xiaona, SHEN Longbin, WANG Nan, ZHANG Jinyu, WU Jianbo, QIU Shuangyan, LEI Haiyan, CHEN Zhuoming

“…The marital status of the children's parents as widowed (95% <italic>CI</italic> 3.154-19.646) and unmarried (95% <italic>CI</italic> 1.027-5.268), and the children's kindergartens located in Longhua Street (95% <italic>CI</italic> 1.138-2.508), in Dalang Street (95% <italic>CI</italic> 1.384-2.971), and in Guanlan Street (95% <italic>CI</italic> 1.470-3.509) were risk factors for hyperactive behavior in preschool children.ConclusionThe active screening through the computer cloud platform can easily and effectively screen preschool children with hyperactive behavior, as well as analyze and obtain the relevant protective or risk factors affecting hyperactive behavior in preschool children, which is recommended for early screening in a large area.…”
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基于RNA-Seq技术的野生和圈养塔里木马鹿皮肤组织转录组比较分析 by 布威海丽且姆·阿巴拜科日, 单文娟, 马合木提·哈力克, 钟林强

“…为探寻野生和圈养塔里木马鹿（<italic>Cervus elaphus yarkandensis</italic>）的基因表达谱是否存在差异，并进一步筛选该物种适应干旱环境的相关基因，利用RNA-Seq技术对野生和圈养塔里木马鹿的皮肤组织进行转录组测序，对测序数据质控后比对参考基因组，筛选差异表达基因并对其进行功能注释和富集分析，利用qRT-PCR方法对转录组测序结果进行可靠性检测。…”
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Expression and Function of Synthetic Dimeric Exercise-Induced Cytokine Irisin-Irisin by LIU Fengying, HUANG Yide, LIN Jia, CHEN Xuequn, WANG Qingshui, LIN Yao

“…ObjectiveStudies have shown that the exercise-induced cytokine Irisin functions were as a dimer, so tandem Irisin-Irisin mock dimers were designed to explore the similarities and differences between recombinant Irisin-Irisin expressed by <italic>Escherichia coli </italic>and commercial Irisin in activity and function on tumor cells.Methods<italic>Escherichia coli</italic> strain BL21 (DE3) and pET-30a expression vectors were selected to obtain recombinant Irisin-Irisin by isopropyl β-D-1-thiogalactopyranoside (IPTG) induction. …”
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Hippocampal Anti-inflammatory Effect of Electroacupuncture at Baihui and Shenting on Cognitive Dysfunction Induced by Systemic Inflammation by CHEN Xiaomei, PANG Lina, WANG Zhifu

“…After the behavioral experiment, immunofluorescence and ELISA were used to detect the changes of hippocampal Iba-1, TNF-α and serum TNF-α.Results1) Compared with the control group, the learning and memory time related to "what-where-when" in the model group was decreased (<italic>P</italic>&lt;0.01), and serum TNF-α (3 h after LPS) and hippocampal TNF-α (24 h) were significantly increased (<italic>P</italic>&lt;0.01); immunofluorescence and ELISA detection showed that hippocampal Iba-1 was significantly increased (<italic>P</italic>&lt;0.01) in the model group. 2) Compared with the model group, "what" and "when" learning time in the EA group increased (<italic>P</italic>&lt;0.01); the serum and hippocampal TNF-α were obviously decreased (<italic>P</italic>&lt;0.01 and <italic>P</italic>&lt;0.05); hippocampal Iba-1 in the EA group was decreased (<italic>P</italic>&lt;0.05).ConclusionElectroacupuncture at Baihui and Shenting may improve the cognitive dysfunction caused by systemic inflammation via inhibiting the activation of hippocampal microglia and reducing the release of inflammatory factor TNF-α in the peripheral blood and hippocampal regions.…”
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NAD⁺激活SIRT3/IDH2信号通路改善高血压血管内皮功能障碍 by 丘雨旻, 陈曦, 张建宁, 刘张弛, 朱秋霞, 张美信, 陶军, 吴杏

“…采用迁移实验和划痕实验评估体外内皮细胞功能；采用免疫荧光染色法检测mtROS水平；采用RT-PCR检测mtDNA、SIRT3、异柠檬酸脱氢酶2（IDH2）的mRNA表达；采用酶联免疫吸附法检测8-羟基-2'-脱氧鸟苷的水平；采用Western blot法检测p-eNOS、eNOS、SIRT3、IDH2蛋白表达水平。结果补充NMN降低了高血压小鼠血压（<italic>P</italic>&lt;0.001），改善内皮功能和动脉僵硬度（<italic>P</italic>&lt;0.001）；体外实验中，NMN可改善Ang Ⅱ刺激所致的内皮细胞舒张功能下降（<italic>P</italic>&lt;0.05）和减轻线粒体氧化应激水平（<italic>P</italic>&lt;0.001）。…”
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Clinical Observation of Different Acupuncture Measures on Restoration of Ischemic Stroke Patients'Hand Function by Zheng JIANG, Liping ZHUO, Shaoqin LIAO, Sai'e HUANG

“…Objective:To assess the differences in brain functional connectivity among transcutaneous nerve stimulation (TS), electroacupuncture (EA), manual acupuncture (MA) and sham acupuncture (SA) in ischemic stroke (IS) patients with upper limb dysfunction using resting-state functional magnetic resonance imaging (rsfMRI).Methods:148 IS patients with upper limb dysfunction were randomly assigned to TS group (<italic>n</italic>=37), EA group (<italic>n</italic>=36), MA group (<italic>n</italic>=38) and SA group (<italic>n</italic>=37). …”
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Protective Mechanism of Electroacupuncture Combined with Enriched Rehabilitative Training on Hippocampal Neurons in Rats with Cerebral Ischemia-Reperfusion Injury by Li GONG, Wei TANG, Zhen QIU, Mengxing LI

“…Compared with the EA group and RT group, the EA+RT group showed stronger learning and memory ability (<italic>P</italic>&lt; 0.01), lower cerebral infarction volume, apoptosis index, protein expression of PERK, CHOP and Bax (<italic>P</italic>&lt; 0.05), higher Bcl-2 protein expression and p-Akt level (<italic>P</italic>&lt; 0.01). …”
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CFTR通过调控二磷酸腺苷受体P2Y₁₂影响血小板活化 by 李俊, 杨涵滟, 韩慧, 李梅, 王冠蕾

“…目的二磷酸腺苷受体P2Y₁₂介导的血小板活化是血小板活化及血栓形成的核心机制，本研究探讨囊性纤维化跨膜转导调节子（CFTR）对P2Y₁₂介导的血小板活化的影响。方法应用8~16周龄<italic>CFTR</italic>全基因敲除（<italic>Cftr</italic>^-/-）小鼠及野生型（<italic>Cftr</italic>^+/+）小鼠，分别制备胶原蛋白和肾上腺素诱导的肺栓塞小鼠模型。…”
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威胁视力的2型糖尿病视网膜病变风险预测模型的建立与验证 by 罗瑾, 黄文勇, 黎宇婷, 张健, 陈敏瑜, 陈淑惠, 刘嘉慧, 黄圣松

“…结果建模集共纳入患者2 161例，并发VTDR者135例（6.25%）。年龄（<italic>P</italic>＜0.001，OR=0.927，95%CI：0.898~0.957）、体质量指数（<italic>P</italic>＜0.001，OR =0.845，95%CI：0.821~0.932）与VTDR负相关，糖尿病病程（<italic>P</italic>＜0.001，OR=1.064，95%CI：1.035~1.094）、是否使用胰岛素（<italic>P</italic> =0.045，OR =1.534，95%CI：1.010~2.332）、收缩压（<italic>P</italic>＜0.001，OR =1.019，95%CI：1.008~1.029）、糖化血红蛋白（<italic>P</italic>＜0.001，OR =1.484，95%CI：1.341~1.643）和血清肌酐（<italic>P</italic>＜0.001，OR =1.017，95%CI：1.010~1.023）与VTDR正相关，均被纳入模型。…”
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红景天苷通过抑制TLR4/NF-κB通路抑制高磷诱导的血管平滑肌细胞钙化 by 刘芳, 李明熹, 颜建云

“…结果茜素红染色及钙离子浓度定量结果提示不同浓度的红景天苷改善高磷诱导的人血管平滑肌细胞的钙化（<italic>P</italic>&lt;0.05）。与高磷模型组相比，红景天苷（250 μmol/L、500 μmol/L）下调成骨样分化蛋白RUNX2（<italic>P</italic>&lt;0.05）和BMP2（<italic>P</italic>&lt;0.05）； 250 μmol/L、500 μmol/L浓度的红景天苷还下调高磷诱导的TLR4（<italic>P</italic>&lt;0.05）和p-NF-κB p65（<italic>P</italic>&lt;0.05）的表达，而对NF-κB p65影响无显著差异（<italic>P</italic>&gt;0.05）；红景天苷（250 μmol/L、500 μmol/L）抑制炎症因子IL-1β（<italic>P</italic>&lt;0.05）、IL-6（<italic>P</italic>&lt;0.05）的蛋白水平。…”
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Efficacy of MCU-based and 3D-FEA for Improving Cervical Spondylosis by Meigui KE, Ruixu XU, Ningying HUANG, Hai GUO, Xinghui YAN, Nanxi WU, Sidong DOU

“…After 12 weeks of treatment, VAS scores were lower in the experimental group and in all subgroups than in the control group(<italic>P</italic>&lt;0.05 and <italic>P</italic>&lt;0.017, respectively);and there was a statistical difference in the degree of pain relief in each age subgroup(<italic>P</italic>&lt;0.05), suggesting that young patients had better pain relief than middle-aged and elderly patients. …”
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术中血浆输注剂量对心脏外科手术患者临床预后的影响 by 李丹丹, 黄国栋, 马伟, 刘怡伶

“…方法收集中山大学孙逸仙纪念医院2014年1月至2022年12月期间术中输注新鲜冰冻血浆的305例心脏外科手术患者的临床资料，并根据术中血浆输注剂量分为低剂量组（血浆输注剂量&lt;15 mL/kg，<italic>n</italic>=214）和高剂量组（血浆输注剂量≥15 mL/kg，<italic>n</italic>=91）， 并通过单因素，相关性以及Logistic多因素回归分析，探讨血浆输注量，血浆输注前后INR的变化情况与心脏外科手术患者临床预后之间的关系。…”
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Dynamics Modeling and Analysis of a 5-DOF Parallel Manipulator Arm with Closed Loop Branch Chain by Zhang Dianfan, Zhang Xingchao, Yu Jin, Dai Shijie, Zhang Shijun

“…The mapping of the velocity of the branch drive，the velocity of the swing angle of the branch and the generalized velocity <italic>V</italic><italic>_o</italic> of the moving platform is derived. …”
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Validation of a Finite Element Simulation for Predicting Individual Knee Joint Kinematics by Elin Theilen, Anna Rorich, Thomas Lange, Sebastian Bendak, Cora Huber, Hagen Schmal, Kaywan Izadpanah, Joachim Georgii

“…<italic>Goal:</italic> We introduce an in-vivo validated finite element (FE) simulation approach for predicting individual knee joint kinematics. …”
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Characterization of Sleep Structure and Autonomic Dysfunction in REM Sleep Behavior Disorder by Nicla Mandas, Maximiliano Mollura, Giulia Baldazzi, Parisa Sattar, Maria Mura, Elisa Casaglia, Michela Figorilli, Laura Giorgetti, Pietro Mattioli, Francesco Calizzano, Francesco Fama, Dario Arnaldi, Monica Puligheddu, Danilo Pani, Riccardo Barbieri

“…<italic>Goal:</italic> REM Sleep Behavior Disorder (RBD) is a REM parasomnia that is associated to high risk of developing &#x03B1;-synucleinopathies, as Parkinson&#x0027;s disease (PD) or dementia with Lewy bodies, over time. …”
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Reliability and Validity of the Pain Self-efficacy Questionnaire in Simplified Chinese Version by Zhongfei BAI, Mengjian QU, Enqi DING, Qinghe ZHAO, Weili XIA, Tian SHU, Jiani LU

“…Appropriate adjustment for its items may reduce the extent of ceiling effect.…”
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Usability Assessment of Technologies for Remote Monitoring of Knee Osteoarthritis by Andrea Cafarelli, Angela Sorriento, Giorgia Marola, Denise Amram, Fabien Rabusseau, Herve Locteau, Paolo Cabras, Erik Dumont, Sam Nakhaei, Ake Jernberger, Par Bergsten, Paolo Spinnato, Alessandro Russo, Leonardo Ricotti

“…<italic>Goal</italic>: To evaluate the usability of different technologies designed for a remote assessment of knee osteoarthritis. …”
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Bayesian Inference of Hidden Cognitive Performance and Arousal States in Presence of Music by Saman Khazaei, Md Rafiul Amin, Maryam Tahir, Rose T. Faghih

“…<italic>Goal:</italic> Poor arousal management may lead to reduced cognitive performance. …”
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On the Evaluation of the Hyperthermic Efficiency of Magnetic Scaffolds by Matteo B. Lodi, Antonios Makridis, Konstantina Kazeli, Theodoros Samaras, Makis Angelakeris, Giuseppe Mazzarella, Alessandro Fanti

“…<italic>Goal:</italic> Deep-seated tumors (DST) can be treated using thermoseeds exposed to a radiofrequency magnetic field for performing local interstitial hyperthermia treatment (HT). …”
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Research on Stability of the High-order System Based on the Routh Criterion and Dominant Pole Method by Lin Xianxin, Su Qian, Ye Chengbao, Li Guojin, Liang Lin

“…The force model of the omnidirectional robot moving on the slope is constructed, the system function of the model is calculated, and the influence on the system due to load, slope <italic>θ</italic>, inertia and other disturbances is analyzed. …”
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