Effect of Spine Nerves Muscle Stimulation Combined with Scalp Acupuncture on Shoulder-hand Syndrome after Early Stroke by Huazhong YANG, Yongsheng ZHOU, Haipeng JIA, Qingjun YANG, Lingjuan RAO

“…Fugl-Meyer(FMA)of the upper limb motor function, visual analogue scale(VAS)for pain and modified Barthel index(MBI)scores were recorded and compared before and after treatment.Results:There were no significant differences in FMA, VAS and MBI scores between the two groups before treatment(<italic>P</italic>&gt;0.05).In the control group, the FMA score(27.41±6.82 <italic>vs</italic> 34.36±8.38, <italic>P</italic>&lt;0.05), the VAS score(4.27±0.94 <italic>vs</italic> 2.23±1.23, <italic>P</italic>&lt;0.05)and the MBI score(29.23±8.21 <italic>vs</italic> 39.55±9.90, <italic>P</italic>&lt;0.05)were improved than those at baseline after 4 weeks'treatment. …”
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基因多态性对先天性心脏病儿童舒芬太尼药代动力学的影响 by 李碧莲, 王思怡, 白雪, 刘瑶, 魏伟, 管宴萍, 钟国平, 宋兴荣

“…结果共纳入可能影响SUF药代动力学和药效学相关的靶点、代谢酶、转运体及通路相关的9个基因中30个单核苷酸多态性位点。发现基因<italic>ABCG2 </italic>rs2054576和<italic>OPRM1 </italic>rs4870266与SUF药物暴露量相关<italic>（P</italic>&lt;0.05）；<italic> OPRM1 </italic>rs2236257与SUF表观分布容积相关<italic>（P</italic>&lt;0.05）；<italic>CYP3A4 </italic>rs2246709和<italic>OPRM1 </italic>rs2236257，rs4870266与SUF药物清除率相关<italic>（P</italic>&lt;0.05）。…”
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Effect of Electroacupuncture at Baihui and Shenting on Cognitive Function in Cerebral Ischemia-reperfusion Injured Rats by Yongmei YOU, Yijing JIANG, Zhicheng LIN, Zengtu ZHAN, Jun WANG, Wei WEI, Shanli YANG

“…Objective:To observe the effect of electroacupuncture (EA) at Baihui and Shenting on cognitive function in rats after cerebral ischmeia-reperfusion (IR) injury, and explore the possible mechanism.Methods:A total of 111 male adult SD rats weighting (300±20) g were selected and randomly divided into the sham operation group (<italic>n</italic>=36) and the operation group (<italic>n</italic>=75). …”
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一种基于搭扣设计的可拆卸小鼠光学离焦性近视模型 by 唐湘华, 李周越, 许晟嵩, 杨晓

“…于实验开始前，干预后第1、2、3和4周，复方托吡卡胺散瞳后检影检测屈光度，光学相干断层扫描在体测量眼轴。各组内，左右眼进行配对<italic>t</italic>检验。3组间比较，采用Welch's ANOVA，差异有统计学意义时，采用Dunnett's T3法校正<italic>P</italic>值进行两两比较。…”
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体外受精周期获卵不多于三枚胚胎移植策略 by 李婷婷, 陈攀宇, 王艳芳, 方丛

“…结果3组患者年龄、基础FSH、AMH无明显差别，<italic>t</italic>检验结果均<italic>P</italic>&gt;0.05，即两组数据总体一般资料无差异。…”
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Effect of Acupuncture Combined with Enriched Rehabilitation Training on Neural Function, Nogo Protein and Its Receptor in Cerebral Ischemia Rats by Mengxing LI, Zhaohui CHEN, Qi LIU, Fang LIU, Wei TANG

“…The scores of neural function deficit, sensation and motor ability were recorded, and the expression of Nogo-A and NgR proteins in hippocampal tissues were detected by immunohistochemistry staining.Results:At the 7 d, 14 d after treatment, the neural function deficit score, sensation and motor ability score in the acupuncture group, the enriched rehabilitation training group and the acupuncture combined with enriched rehabilitation training group were lower respectively than those of the model group (<italic>P</italic>&lt;0.01 or <italic>P</italic>&lt;0.05), and the scores in the acupuncture combined with enriched rehabilitation training group were lower respectively than those of the acupuncture group and the enriched rehabilitation training group (<italic>P</italic>&lt;0.01 or <italic>P</italic>&lt;0.05). …”
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Clinical Observation of Sling Exercise Therapy and Meridian Plucking Manipulation on Lumbar Disc Herniation by LI Li, Ziyun FENG, Jinglong SUN

“…The JOA score and back extensor muscle strength in three groups were significantly increased, but the degree of improvement in SET and meridian plucking manipulation group was higher than that of other two groups (<italic>P</italic>&lt;0.05).Conclusion:The SET and meridian plucking manipulation has good effect on LDH, and its effect is better than that of SET, meridian plucking manipulation respectively. …”
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Kinematics Analysis and Scale Synthesis of a Novel Spherical Parallel Mechanism by Zhen Chang, Chengbo Wang, Gaofeng Wang, Jianshe Gao

“…The mechanism has a 3-DOF to rotate around the <italic>X </italic>axis，<italic>Y </italic>axis，<italic>Z</italic> axis，and the rotation around the <italic>Z</italic> axis is controlled by only one branch，while the other two branches jointly control the mechanism to move around the <italic>X </italic>axis，<italic>Y </italic>axis. …”
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Correlation of the Changes of Gray Matter Volume with Aβ Deposition and Learning and Memory Abilities in APP/PS1 Mice at Different Periods by Yuhao ZHANG, Hao JIN, Xiufeng ZHANG, Shengxiang LIANG, Weilin LIU, Jing TAO, Lidian CHEN

“…The brain paraffin sections of two groups of mice of different months were separated and prepared, and the Aβ deposition in bilateral entorhinal cortex and hippocampus of the two groups was detected by Thioflavine-s fluorescence staining, and the correlation between the changes of gray matter volume and memory learning ability and Aβ deposition in the corresponding brain area of the two groups was analyzed by Pearson correlation analysis.Results:①The results of Morris water maze test: compared with the WT group, there was no significant difference in the behavioral results of the 2-month-old mice in the APP/PS1 group, and the difference was not statistically significant (<italic>P</italic>&gt;0.05); the escape latency of mice of the APP/PS1 group at the 6 and 12 month-old increased significantly, the number of crossing platforms of the APP/PS1 group at the 6 and 12 month-old decreased significantly, and the difference was statistically significant (<italic>P</italic>&lt;0.05).②The results of MRI T2WI scan: compared with the WT group, there was no significant change in the gray matter volume of the APP/PS1 group at 2-month-old, and the difference was not statistically significant (<italic>P</italic>&gt;0.05); the volume of the entorhinal cortex of the APP/PS1 group at 6-month-old decreased significantly, and the volume of the entorhinal cortex and hippocampus of the APP/PS1 group at 12-month-old mice decreased significantly, the difference was statistically significant (<italic>P</italic>&lt;0.05).③The results of Th-s fluorescence staining test: Aβ deposition was not detected in WT group and APP/PS1 group at 2-month-old; compared with the WT group, a small amount of Aβ deposition could be detected in the entorhinal cortex and hippocampus of the APP/PS1 group at 6-month-old, while a large number of dense Aβ plaques can be detected in the entorhinal cortex and hippocampus of the APP/PS1 group at 12-month-old.④Correlation analysis results: APP/PS1 group mice's entorhinal cortex and hippocampus volume changes were significantly negatively correlated with escape latency (<italic>r</italic>=-0.729, <italic>P</italic>&lt;0.001; <italic>r</italic>=-0.643, <italic>P</italic>&lt;0.001); the volume changes of the entorhinal cortex and hippocampus in the APP/PS1 group showed a positive correlation with the number of crossing platforms (<italic>r</italic>=0.705, <italic>P</italic>&lt;0.001; <italic>r</italic>=0.719, <italic>P</italic>&lt;0.001); the volume changes of the entorhinal cortex and hippocampus in the APP/PS1 group were significantly negatively correlated with Aβ deposition (<italic>r</italic>=-0.865, <italic>P</italic>&lt;0.001; <italic>r</italic>=-0.885, <italic>P</italic>&lt;0.001).Conclusion:APP/PS1 transgenic mice may have learning and memory dysfunction at 6-month-old, and it gradually worsen with time; the learning and memory dysfunction may be related to the atrophy of the entorhinal cortex and hippocampus in the brain of mice, and excessive Aβ deposition may be the one of the factors that cause the brain gray matter volume to shrink.…”
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Correlation between Cortical Excitability and Hand Function in Patients with Subacute Cerebral Infarction by Ling CHEN, Junling WANG, Dongfeng HUANG

“…Objective:To observe the cortical activation characteristics of cerebral motor prediction in patients with subacute cerebral infarction in the palm grasping task, and to explore the correlation between cortical excitability and hand function in patients with cerebral infarction.Methods:A total of twenty-five patients with subacute cerebral infarction who were hospitalized in the first affiliated hospital of Sun Yat-sen University from January 2017 to March 2018 were selected as the experimental group, and twenty-five healthy individuals matched with the gender and age of the experimental group were selected as the control group.Event related potentials were used to collect the electroencephalogram signals of the two groups in the palm grasping task, and then analyzed the latencies and amplitudes of the contingent negative variation(CNV)in the cerebral cortex before motor activation.Action Research Arm Test(ARAT)was used to assess the function of hand, and the correlation between CNV amplitude and ARAT score was analyzed.Results:Compared with the control group, the CNV latencies in the midline region of the experimental group were significantly shorter during the left hand grasp and right hand grasp, and the CNV amplitude were statistically significantly increased in the midline, bilateral frontal lobe and primary motor area(M1)(<italic>P</italic>&lt;0.05).There was no significant difference in CNV latency between left hand grasp and right hand grasp in the experimental group(<italic>P</italic>&gt;0.05), with the CNV amplitude of Cz electrode in midline statistically significantly greater than that of C4 electrode in contralateral M1(<italic>P</italic>&lt;0.05).There was moderate correlation between the CNV amplitude and ARAT in the non-lesioned frontal lobe, M1 and midline during right hand grasp in the experimental group(F4: <italic>r</italic>=0.510; C4: <italic>r</italic>=0.442; Fz: <italic>r</italic>=0.428).There was moderate correlation between the CNV amplitude and ARAT in the non-lesioned frontal lobe, M1 and midline during left hand grasp in the experimental group(F4: <italic>r</italic>=0.422; C4: <italic>r</italic>=0.496; Fz: <italic>r</italic>=0.446).Conclusion:The neural mechanism of motor anticipation in patients with subacute cerebral infarction is abnormal, the time of brain motor preparation is prolonged, and the non-lesioned frontal lobe and M1 are hyperactivity compensatory during motor anticipation.There was moderate correlation between the cortical excitability and hand dysfunction.Therefore, CNV may be a neural indicator of the severity of hand dysfunction in patients with cerebral infarction.…”
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Study of Brain Default Network Changes in Patients with Amnestic Mild Cognitive Impairment Based on rs-fMRI by HU Saiqin, Zhao Xv, Li Yaxue, Ji Yahong, LI Sha, LV Jing, ZHANG Yi, WANG Feng

“…The correlation analysis showed that the zFC value in left middle frontal gyrus（<italic>r=0. 439，P=0. 005</italic>），rightmiddle temporal gyrus（<italic>r</italic>=0. 422，<italic>P</italic>=0. 007），right parahippocampal gyrus（<italic>r</italic>=0. 468，<italic>P</italic>=0. 002） and left precuneus（<italic>r=0. 482，P=0. 002</italic>）were positively correlated with MMSE score，and the zFC value in right anterior cingulate gyruswere positively correlated with AVLT-delayed recall score（<italic>r=0. 362，P=0. 022</italic>）and DST-forward score（<italic>r=0. 503，P=0. 001</italic>），while the zFC value in right precentral gyrus was negatively correlated with TMT-B score（<italic>r=-0. 450，P=0. 004</italic>）.ConclusionThe abnormal FC within DMN of patients with aMCI are associated with cognitive defect in memory，attention，executive functionand audio-visual function. …”
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动物园禽源奇异变形杆菌对第三代头孢菌素的耐药分子机制 by 梁玉蕾, 李垠树, 陈秋如, 董焱斌, 丁爱萍, 苑丽

“…为研究观赏禽类中分离的奇异变形杆菌（<italic>Proteus mirabilis</italic>）对第三代头孢菌素的耐药机制，于2019年从河南省某动物园禽类养殖区绿孔雀（<italic>Pavo muticus</italic>）、红绿金刚鹦鹉（<italic>Ara chloroptera</italic>）、火鸡（<italic>Meleagris gallopavo</italic>）、帽子鸡（polish chicken）和非洲鸵鸟（<italic>Struthio camelus</italic>）5种观赏禽类中分离17株奇异变形杆菌，经药物敏感性试验、<italic>bla</italic>_CTX-M基因检测、全基因组测序、PFGE和RT-qPCR等探明受试菌对第三代头孢菌素的耐药机制。…”
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择期剖宫产术中应用ERAS对GDM孕妇及其新生儿的疗效及安全性探讨 by 周瑾, 张培珍, 谭章敏, 李婥, 姚琳, 何田田, 尹玉竹

“…结果本研究共收集孕妇150例，其中GDM组（<italic>n</italic>=75），非GDM组（<italic>n</italic>=75），两组孕妇手术当日空腹血糖无明显差异［（4.4 ± 0.5） mmol/L <italic>vs.…”
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Improving Accuracy and Calibration of Deep Image Classifiers With Agreement-Driven Dynamic Ensemble by Pedro Conde, Rui L. Lopes, Cristiano Premebida

“…As such, state-of-the-art DL models should be <italic>accurate</italic> and also <italic>calibrated</italic>, meaning that each prediction has to codify its confidence/uncertainty in a way that approximates the true likelihood of correctness. …”
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吉林省五种鸟类分布新纪录 by 杨雨佳, 张鹏

“…2018—2022年，在吉林省长春市伊通河流域进行鸟类资源调查，记录到欧亚鸲（<italic>Erithacus rubecula</italic>；43°52′34.76″ N，125°21′52.74″ E）、灰蓝山雀（<italic>Cyanistes cyanus</italic>；43°52′33.61″ N，125°21′53.08″ E；43°49′18.99″ N，125°21′19.65″ E）、三趾鸥（<italic>Rissa tridactyla</italic>；43°48′44.02″ N，125°20′56.08″ E）、中白鹭（<italic>Ardea intermedia</italic>；43°57′46.09″ N，125°22′5.71″ E）和赤嘴潜鸭（<italic>Netta rufina</italic>；43°58′2.72″ N，125°22′4.42″ E；43°48′27.18″ N，125°20′49.41″ E）5种鸟类，并拍摄到野外照片。…”
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二代测序在子宫内膜癌分子分型的临床应用 by 刘叶, 刘小云, 颜淑梅, 龙亚康, 王海云, 王芳

“…方法收集中山大学附属肿瘤医院经病理确诊的子宫内膜癌112例，均进行基于1 021个基因panel的杂交捕获二代测序检测，分析各分子亚型的分子变异谱及与临床病理特征之间的关系。结果DNA聚合酶<italic>ε</italic>（<italic>POLE</italic>）突变型8例（7.1%），错配修复功能缺陷型34例（30.4%），<italic>TP53</italic>突变型26例（23.2%），非特异性分子谱型44例（39.3%），4个亚型肿瘤突变负荷中位数分别为252.0、38.4、5.8及5.4 Muts/Mb。…”
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河南董寨再引入朱鹮的巢址选择 by 朱家贵, 黄治学, 王科, 蔡德靖, 祝文平, 席学博, 王代平

“…为有针对性地制定朱鹮（<italic>Nipponia nippon</italic>）保护计划，促进朱鹮再引入，壮大野外种群规模，2014—2019年7—11月，对河南董寨再引入朱鹮的35个巢址及其周边 3 m×3 m样方的22个生境特征进行观察、测量和记录。…”
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高强方钢管高强混凝土长柱偏压性能 by 李帼昌, 陈博文, 杨志坚, 邱增美, 李晓, 刘润泽

“…基于试验与数值模拟，采用《钢管混凝土结构技术规范》（GB 50936—2014）和人工神经网络模型对68个试件的极限荷载<italic>P</italic>_u及其弯矩<italic>M</italic>_p值进行预测。…”
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Effect of Repetitive Transcranial Magnetic Stimulation on Patients with Post-Stroke Cognitive Impairment by Zheyi YU, Weiming ZHANG

“…Objective:To observe the improvement of cognitive function and the changes of serum nerve influencing factors and cytokines in patients with stroke treated with repetitive transcranial magnetic stimulation (rTMS).Methods:A total of 100 patients with post-stroke congitive impairment (PSCI) were randomly divided into observation group (<italic>n</italic>=51) and control group (<italic>n</italic>=49) by SAS software. …”
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貂熊线粒体基因组全序列分析及其系统进化 by 张士芳, 魏丹, 郭媛, 刘应竹, 路平, 刘凤春, 朱世兵

“…为了更好地了解貂熊（<italic>Gulo gulo</italic>）的起源、进化等生物学信息，采用PCR方法克隆貂熊的线粒体基因组全序列，利用测序技术等常规分子生物学手段对其进行分析。…”
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