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Machine learning analysis of pathological images to predict 1-year progression-free survival of immunotherapy in patients with small-cell lung cancer
Published 2024-02-01“…The machine learning analysis of the TIME had better accuracy than the human count evaluations (AUC of human count, CD8-positive lymphocyte: 0.681, FoxP3-positive lymphocytes: 0.626, PD-L1 score: 0.567).Conclusions The spatial analysis of the TIME using machine learning predicted the immunotherapy efficacy in patients with SCLC, thus supporting its role as an immunotherapy biomarker.…”
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Decrease in platelet count in patients with AKI and its association with major adverse kidney events
Published 2024-12-01Get full text
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A concept of natural genome reconstruction. Part 2. Effect of extracellular double-stranded DNA fragments on hematopoietic stem cells
Published 2025-01-01“…Extracellular fragments delivered to hematopoietic stem cells initiate division of the original hematopoietic stem cell in such a way that one of the daughter cells becomes committed to terminal differentiation, and the second retains its low-differentiated status. After treatment of bone marrow cells with hDNAgr, the number of CD34+ cells in the colonies increases to 3 % (humans as the model organism). …”
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14990
Th1/Th2 Cells and Associated Cytokines in Acute Hepatitis E and Related Acute Liver Failure
Published 2020-01-01Get full text
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14991
Assessing Mental Illness Referral Request Acceptance: A Nationwide E-Referral Data From Saudi Arabia
Published 2025-02-01“…The system’s selective acceptance patterns reflect its capability to prioritize care based on clinical urgency and resource availability. …”
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What all physicians should know about women’s health: a Delphi study
Published 2025-01-01“…Participants voted IN/OUT on each statement based on its perceived relevance and feasibility for general physician knowledge, regardless of specialty. …”
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Eye Collateral Channel Characteristic Analysis and Identification Model Construction of Mild Cognitive Impairment
Published 2024-02-01“…By comparing the model performance, the optimal model was selected to achieve early clinical recognition.ResultsThe important eye collateral channel characteristics of the MCI group were red dots, dull brown spots, dull yellow fog diffusion, mounds, red blood veins, and tortuous blood veins (<italic>P</italic><0.05), their distribution frequency was higher than that of the normal cognition group (<italic>P</italic><0.05), but the distribution frequency of dull pink spots was lower than that of the normal cognition group (<italic>P</italic><0.05). …”
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High-Resolution Mapping of Concentrated Solar Power Site Suitability in Ghardaïa, Algeria: A GIS-Based Fuzzy Logic and Multi-Criteria Decision Analysis
Published 2025-01-01“…Algeria primarily relies on fossil fuels to meet its growing electricity demand, significantly contributing to climate change and the depletion of non-renewable resources. …”
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Serine/threonine protein kinase mediates rifampicin resistance in Brucella melitensis through interacting with ribosomal protein RpsD and affecting antioxidant capacity
Published 2025-01-01“…., and the identified STPK or its pathway can serve as a potential target for new drug development against rifampicin-resistant Brucella spp.IMPORTANCENew rifampicin resistance gene in Brucella melitensis is identified via bioinformatics predictions and a whole-genome transposon mutant library, new mechanisms of rifampicin resistance in B. melitensis, and new function of serine/threonine protein kinase gene and its interaction proteins.…”
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Trial protocol of an open-label pilot study of oral naltrexone–bupropion combination pharmacotherapy for the treatment of methamphetamine use disorder (the NABU trial)
Published 2025-02-01“…Introduction Methamphetamine use disorder is a global public health concern with no approved pharmacotherapies for its treatment. One recent randomised controlled trial conducted in the USA examined a combination of bupropion and naltrexone not readily available globally. …”
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Social determinants of mental health in asthma: an exploratory study
Published 2025-02-01Get full text
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