Kajian Farmakoinformatika Senyawa Alkaloid Anggur Laut (Caulerpa racemose) Sebagai Inhibitor Collagenase Dalam Mekanisme Antiaging by Dewi Ratih Tirto Sari, M.Eko Pranoto, Siti Zamilatul Azkiyah

“…Further in vivo analysis were required for further investigation.…”
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Study of miRNA Based Gene Regulation, Involved in Solid Cancer, by the Assistance of Argonaute Protein by Surya Narayan Rath, Debasrita Das, V Badireenath Konkimalla, Sukanta Kumar Pradhan

“…The residual interaction and hydrogen bonding are inspected in Discovery Studio 3.5 suites. The current investigation throws light on understanding miRNAs based gene silencing mechanism in solid cancer.…”
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Exploration Degree Bias: The Hidden Influence of Node Degree in Graph Neural Network-Based Reinforcement Learning by Peter Tarabek, David Matis

“…This phenomenon impacts exploration in RL, skewing it away from mid-degree nodes, potentially hindering the discovery of optimal policies. We provide a systematic investigation of EDB across widely used GNN architectures—GCN, GraphSAGE, GAT, and GIN—by quantifying correlations between node degrees and logits. …”
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Synthesis, antibacterial evaluation and in silico studies of novel 2-(benzo[d]thiazol-2-yl)-N-arylacetamides and their derivatives as potential DHFR inhibitors by Nadia Hanafy Metwally, Galal Hamza Elgemeie, Aya Ragab Abdelrazek, Salwa Magdy Eldaly

“…Additionally, compounds 2c and 4m showed enzyme inhibition against dihydrofolate reductase in Escherichia coli with greater potency (IC50 for 2c = 3.796 µM, IC50 for 4m = 2.442 µM) than the standard antibiotic trimethoprim (IC50 = 8.706 µM). Investigation of the physicochemical properties of the newly compounds exhibited their better ADME properties that can be developed for the discovery of new antibacterial agents. …”
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A Knowledge Concept Map: Structured Concept Analysis from Systematic Literature Review by Philip Sisson, Julie J.C.H. Ryan

“…The purpose of this article is to present a mental model of knowledge as a concept map as an input to knowledge management (KM) investigations. This article’s extended knowledge concept map can serve as a resource where the investigation, development, or application of knowledge would be served with a broad mental model of knowledge. …”
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Exploring the antimicrobial potential of two haloarchaeal strains belonging to the genera Halopiger and Natrialba isolated from the Algerian Sahara by Inès Quadri, Imene Ikram Hassani, Hocine Hacène

“…Conclusion: This investigation confirms that Algerian saline soils are a promising source of interesting antimicrobial compounds. …”
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PRELIMINARY FINDINGS AND AWARENESS FROM THE C6-1 ARCHAEOLOGICAL EXPLORATION IN KRONGNO, DAKNONG PROVINCE by Lê Xuân Hưng, La Thế Phúc, Phạm Thị Phương Thảo, Vũ Tiến Đức, Nguyễn Trung Minh

“…This paper presents the preliminary findings regarding the discovery of dwellings and stone tool processing of prehistoric people living around 6,000 – 4,000 years ago obtained from the investigation of 10 caves and the excavation of the C6-1 volcanic cave in Krongno in 2017. …”
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Beyond the Trends: Evolution and Future Directions in Music Recommender Systems Research by Babak Amiri, Nikan Shahverdi, Amirali Haddadi, Yalda Ghahremani

“…Ultimately, it improves the music discovery experience for people globally.…”
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RATIONAL DRUG DESIGN OF POTENT V600E-BRAF KINASE INHIBITORS THROUGH MOLECULAR DOCKING SIMULATION by Bello Abdullahi Umar, Adamu Uzairu, Gideion Adamu Shallangwa, Sani Uba

“…V600E-BRAF protein has lot potential for scientific investigation as the therapeutic target owing to its participation in melanoma cancer and is the molecular target of many anticancer compounds like quinolinylaminopyrimidines (QAP) derivatives. …”
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Designing of an innovative conserved multiepitope subunit vaccine targeting SARS-CoV-2 glycoprotein and nucleoprotein through immunoinformatic by Temitope Isaac Adelusi, Abdeen Tunde Ogunlana, Moyosoluwa Precious Oyewole, Taiwo Ooreoluwa Ojo, Olamide Tosin Olaoba, Elijah Kolawole Oladipo, Shopnil Akash, Samir Ibenmoussa, Mohammed Bourhia, Yousef A. Bin Jardan, Baye Sitotaw

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Electrochemical Behavior of Biologically Important Indole Derivatives by Cigdem Karaaslan, Sibel Suzen

“…Voltammetric techniques are most suitable to investigate the redox properties of a new drug. Use of electrochemistry is an important approach in drug discovery and research as well as quality control, drug stability, and determination of physiological activity. …”
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Scoping review of the applications of peptide microarrays on the fight against human infections. by Arthur Vengesai, Maritha Kasambala, Hamlet Mutandadzi, Tariro L Mduluza-Jokonya, Takafira Mduluza, Thajasvarie Naicker

“…The findings were from the investigation of viral (45.6%), bacterial (32. 0%), parasitic (23.3%) and fungal (2. 0%) infections. …”
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Quality Evaluation of Traditional Chinese Medicine Prescription in Naolingsu Capsule Based on Combinative Method of Fingerprint, Quantitative Determination, and Chemometrics by Lili Xu, Yang Jiao, Weiliang Cui, Bing Wang, Dongxiao Guo, Fei Xue, Xiangrong Mu, Huifen Li, Yongqiang Lin, Huibin Lin

“…We first established the nontargeted investigation based on fingerprinting coupled with UHPLC-Q/TOF-MS/MS. …”
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Fish-derived hepcidins in cancer treatment: a scoping review by Wan-Atirah Azemin, Syarifah Ab Rashid, Noraini Philip, Abdul Manaf Ali, Mohd Shahir Shamsir

“…Abstract Background The discovery of hepcidin, a peptide hormone primarily known for iron homeostasis regulation, has revealed promising anticancer properties. …”
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cGAS-STING targeting offers therapy choice in lung diseases by Yu Wang, Xuan Zhang, Weixue Wang, Yi Zhang, Joshua S. Fleishman, Hongquan Wang

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Development and Validation of New High Performance Liquid Chromatography Analytical Technique For Separation of Diclofenac Sodium and Lidocaine Hydrochloride From Ampoule Injection by Mohammed Ali Salih, Dlivan Fattah Aziz, Salar Ibrahim Ali

“…In the current investigation, a number of chromatographic methods with the accurate, precise and specific criteria have been developed and validated for diclofenac sodium and lidocaine hydrochloride Commitment of their large quantities ampule of pharmaceutical dosage form. …”
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Antimalarial Activity of Piperine by Artitaya Thiengsusuk, Phunuch Muhamad, Wanna Chaijaroenkul, Kesara Na-Bangchang

“…Resistance of Plasmodium falciparum to artemisinins in Southeast Asia is a great concern for disease control and research on discovery and development of new alternative antimalarial drugs is urgently required. …”
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Impact of antibody architecture and paratope valency on effector functions of bispecific NKp30 x EGFR natural killer cell engagers by Ammelie Svea Boje, Lukas Pekar, Katharina Koep, Britta Lipinski, Brian Rabinovich, Andreas Evers, Carina Lynn Gehlert, Steffen Krohn, Yanping Xiao, Simon Krah, Rinat Zaynagetdinov, Lars Toleikis, Sven Poetzsch, Matthias Peipp, Stefan Zielonka, Katja Klausz

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Death trends for 2010 - 2022 for members of a large private medical scheme in South Africa by L Steenkamp, S Collie, T A Moultrie, H Moultrie, G Gray

“…This analysis sheds light on the health profile of this specific demographic. Objective. To investigate trends in Discovery Health Medical Scheme (DHMS) members’ death rates and underlying cause of death patterns between 2010 and 2022. …”
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A Comprehensive Review on Pharmacotherapeutics of Herbal Bioenhancers by Ghanshyam B. Dudhatra, Shailesh K. Mody, Madhavi M. Awale, Hitesh B. Patel, Chirag M. Modi, Avinash Kumar, Divyesh R. Kamani, Bhavesh N. Chauhan

“…In India, Ayurveda has made a major contribution to the drug discovery process with new means of identifying active compounds. …”
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