Uncovering the Mechanism of Action of Antiprotozoal Agents: A Survey on Photoaffinity Labeling Strategy by Alessandro Giraudo, Cristiano Bolchi, Marco Pallavicini, Roberto Di Santo, Roberta Costi, Francesco Saccoliti

“…The lack of robustly validated targets and the complexity of parasite’s diseases have made phenotypic screening a preferential drug discovery strategy for the identification of new chemical entities. …”
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SOD1 Transcriptional and Posttranscriptional Regulation and Its Potential Implications in ALS by Pamela Milani, Stella Gagliardi, Emanuela Cova, Cristina Cereda

“…Copper-zinc superoxide dismutase (SOD1) is a detoxifying enzyme localized in the cytosol, nucleus, peroxisomes, and mitochondria. The discovery that mutations in SOD1 gene cause a subset of familial amyotrophic lateral sclerosis (FALS) has attracted great attention, and studies to date have been mainly focused on discovering mutations in the coding region and investigation at protein level. …”
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Senyawa Fucodiphlorethol Dan Phloroglucinol Alga Coklat Sebagai Inhibitor Lipase Secara In Silico by Yohanes Bare, Dewi Ratih Tirto Sari, Marsiana Coo Mogi, Maria Marcelina Dua Nurak

“…Molecular dynamic are needed for further investigation.…”
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Antioxidant and cytotoxic potentials of Streptomyces gilvigriseus MUSC 26T isolated from mangrove soil in Malaysia by Hooi-Leng Ser, Wai-Fong Yin, Kok-Gan Chan, Tahir Mehmood Khan, Bey-Hing Goh, Learn-Han Lee

“…Microorganisms play an important role in natural product discovery, particularly the member of genus Streptomyces. …”
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«The Mechanism of Mendelian Heredity» (The 100th anniversary of the first publication of the book by the group of T.H. Morgan) by E. B. Muzrukova

“…Construction of chromosome maps and investigation of chromosome rearrangements stem from Morgan’s school. …”
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Distinct Redox Signalling following Macrophage Activation Influences Profibrotic Activity by Caitlin V. Lewis, Antony Vinh, Henry Diep, Chrishan S. Samuel, Grant R. Drummond, Barbara K. Kemp-Harper

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Glutamine and cancer: metabolism, immune microenvironment, and therapeutic targets by Ding Nan, Weiping Yao, Luanluan Huang, Ruiqi Liu, Xiaoyan Chen, Wenjie Xia, Hailong Sheng, Haibo Zhang, Xiaodong Liang, Yanwei Lu

“…With the encouraging results of cancer immunotherapy in recent years, more investigation into the impact of glutamine metabolism on immune cell function in the cancer microenvironment could lead to the discovery of new targets and therapeutic approaches. …”
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Revisiting the Metabolism of Donepezil in Rats Using Non-Targeted Metabolomics and Molecular Networking by Eun-Ji Park, Eui-Hyeon Kim, Ki-Young Kim, Ji-Hyeon Jeon, Im-Sook Song, So-Young Park, Kwang-Hyeon Liu

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Increased FGF-19 levels following explantation in women with breast implant illness by S. Azahaf, K. A. Spit, C. J. M. de Blok, P. W. B. Nanayakkara

“…While symptom improvement is frequently observed following implant removal, the underlying mechanisms remain poorly understood, and the absence of reliable biomarkers complicates clinical decision-making. Here, we investigate inflammatory protein profiles in 43 women with BII, comparing pre- and post-explantation levels using the Olink Target 96 Inflammation panel and Meso Scale Discovery technology for absolute quantification. …”
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Establishing endotoxin limits to enhance the reliability of in vitro immunogenicity risk assessments by Yun Hee Jeong, Gillian Lennon, Geertruida Veldman, Daniel M. Serna, Alexander Ibrahimov

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Whole genome sequence of Streptomyces colonosanans strain MUSC 93JT isolated from mangrove forest in Malaysia by Hooi-Leng Ser, Jodi Woan-Fei Law, Wen-Si Tan, Wai-Fong Yin, Kok-Gan Chan

“…Altogether, the current project clearly highlights the importance of under-explored environment like mangrove in natural product discovery. The availability of whole genome sequence MUSC 93JT warrants subsequent in-depth investigation and optimization for the production of bioactive compounds which can be exploited for the health and wellbeing of mankind.…”
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From Lab to Clinic: Effect of Academia–Industry Collaboration Characteristics on Oncology Phase 1 Trial Entry by Wonseok Yang, Sang‐Won Lee

“…ABSTRACT This study investigated the success rate of Phase 1 clinical trial entry and the factors influencing it in oncology projects involving academia–industry collaboration during the discovery and preclinical stages. …”
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A high fat, high sugar diet exacerbates persistent post-surgical pain and modifies the brain-microbiota-gut axis in adolescent rats by Sabrina Salberg, Matthew Macowan, Angela Doshen, Glenn R. Yamakawa, Marissa Sgro, Benjamin Marsland, Luke A. Henderson, Richelle Mychasiuk

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Phytochemical screening and neuro-pharmacological activity of Mimosa pudica flowers: Integrating in vitro, in silico and in vivo approaches by Fahmida Alam, Rashedul Alam, A.T.M. Yusuf, Joya Datta Ripa, Raktim Das Nithin, Sourav Barua, Mohammed Fazlul Kabir, Seong-Tshool Hong, Hea-Jong Chung

“…Throughout millennia, medicinal plants have been crucial in preserving human well-being and enhancing the whole human experience.Mimosa pudica, sometimes referred to as the ''sensitive plant,'' possesses considerable promise in the discovery of innovative herbal remedies. The objective of our research is to examine the various pharmacological uses of this mysterious plant by undertaking a thorough investigation of its methanolic extract. …”
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Intricate interplay of CRISPR-Cas systems, anti-CRISPR proteins, and antimicrobial resistance genes in a globally successful multi-drug resistant Klebsiella pneumoniae clone by Jianping Jiang, Astrid V. Cienfuegos-Galletd, Tengfei Long, Gisele Peirano, Tingyu Chu, Johann D. D. Pitout, Barry N. Kreiswirth, Liang Chen

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Novel mitochondrial-targeted alkyl chains act as fungal specific inhibitors of C. neoformans by Elizabeth S. M. Edrich, Luke Young, John Spencer, Andrew McGown, Anthony L. Moore, Campbell W. Gourlay

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Old and Recent Advances in Life Cycle, Pathogenesis, Diagnosis, Prevention, and Treatment of Malaria Including Perspectives in Ethiopia by Dejen Nureye, Solomon Assefa

“…Antiadhesion adjunctive therapies are also under investigation in the laboratory. In addition to previously known targets for diagnostic tool, vaccine and drug discovery scientists from all corner of the world are in search of new targets and chemical entities.…”
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Caractéristiques rythmiques du chant de l'indri et nouvelles perspectives pour une évaluation comparative du rythme chez les primates non humains by Marco Gamba, Valeria Torti, Chiara De Gregorio, Teresa Raimondi, Longondraza Miaretsoa, Filippo Carugati, Walter Cristiano, Rose M. Randrianarison, Giovanna Bonadonna, Anna Zanoli, Olivier Friard, Daria Valente, Andrea Ravignani, Cristina Giacoma

“…Since the discovery that rhythmic abilities are universal in humans, temporal features of vocal communication have greatly interested researchers studying animal communication. …”
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Analysis of International Competitiveness of Multinational Corporations Based on Rough Sets by Jing Zhao, Ning Qi

“…Modern business judgment is mostly faced with complex, unclear nature, and not fully confirmed research objects and needs a lot of relevant data investigation, inherent contradiction retrieval, and the discovery and extraction of potential laws. …”
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From TORTORA to MegaTORTORA—Results and Prospects of Search for Fast Optical Transients by Grigory Beskin, Sergey Bondar, Sergey Karpov, Vladimir Plokhotnichenko, Adriano Guarnieri, Corrado Bartolini, Giuseppe Greco, Adalberto Piccioni, Andrew Shearer

“…Some results of its operation, including first high time resolution study of optical transient accompanying GRB and discovery of its fine time structure, are presented. …”
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