The Role of Dopamine in Impulsivity and Substance Abuse: A Narrative Review by Connor J Plaisance, Lloyd F Ledet III, Nicholas J Slusher, Charles P Daniel, Zachary Lee, Bradley Dorius, Sonnah Barrie, Tomasina Q Parker-Actlis, Shahab Ahmadzadeh, Sahar Shekoohi, Alan D Kaye

“…The focus of the present investigation is to delve into the current literature regarding dopamine and its clinical implications in substance use disorder and impulsive behavior.…”
Get full text

In Vitro and In Silico Analysis of Bergenia ciliata and Mimosa pudica for Inhibition of α-Amylase by Mahesh Bohara, Sajani Ghaju, Kabita Sharma, Surya Kant Kalauni, Karan Khadayat

“…The discovery of antidiabetic natural products is a flourishing field of opportunity in the sector of drug discovery. …”
Get full text

Noi cercetări arheologice la cetatea Saschiz I. Incinta exterioară by Marcu Istrate, D., Dobrotă, S., Rezi, B., Gál, S.

“…Due to the amount of data and materials collected during the 2023 investigation, the research results will be published gradually, as they are being processed. …”

Navigating from cellular phenotypic screen to clinical candidate: selective targeting of the NLRP3 inflammasome by Rosalie Matico, Karolien Grauwen, Dhruv Chauhan, Xiaodi Yu, Irini Abdiaj, Suraj Adhikary, Ine Adriaensen, Garcia Molina Aranzazu, Jesus Alcázar, Michela Bassi, Ellen Brisse, Santiago Cañellas, Shubhra Chaudhuri, Francisca Delgado, Alejandro Diéguez-Vázquez, Marc Du Jardin, Victoria Eastham, Michael Finley, Tom Jacobs, Ken Keustermans, Robert Kuhn, Josep Llaveria, Jos Leenaerts, Maria Lourdes Linares, Maria Luz Martín, Rosa Martín-Pérez, Carlos Martínez, Robyn Miller, Frances M Muñoz, Michael E Muratore, Amber Nooyens, Laura Perez-Benito, Mathieu Perrier, Beth Pietrak, Jef Serré, Sujata Sharma, Marijke Somers, Javier Suarez, Gary Tresadern, Andres A Trabanco, Dries Van den Bulck, Michiel Van Gool, Filip Van Hauwermeiren, Teena Varghese, Juan Antonio Vega, Sameh A Youssef, Matthew J Edwards, Daniel Oehlrich, Nina Van Opdenbosch

Get full text

Unlocking the potential of collagen: A comprehensive review on its dermocosmetic benefits and applications by Felicia Andrei, Ana Toma, Ștefania Avram, Valentin Popa, Ioana Gencia, Patricia Cristodor

“…An analysis of the published studies on the subject was carried out, comparing the effectiveness of using collagen in different ways to improve skin conditions. The investigation included a literature review on collagen’s role in enhancing skin properties, covering its discovery, structure, chemical composition, systemic and topical applications, diverse sources, and skin penetration mechanisms. …”
Get full text

Multiple fusiform and saccular aneurysms in a person living with Human Immunodeficiency Virus by Talia Unice, Poobalan Naidoo, Pranav Hiralal, Yeshkhir Naidoo, Somasundram Pillay

“…Subsequently, a non-urgent computerized tomography angiogram of the cerebral vasculature corroborated the existence of multiple cerebral aneurysms. Despite investigation, no secondary etiological factors for the aneurysmal condition were identified. …”
Get full text

Bioactivity-guided isolation and molecular modeling of the anti-inflammatory constituents from the leaves of Duranta erecta Linn. by Marina Sobhy, Farid N. Kirollos, Sameh F. AbouZid, Nasser S. M. Ismail, Riham A. El-Shiekh, Essam Abdel-Sattar

“…Overall, the data reported in this study add to our understanding of the pharmacological properties of the examined plant and Duranterectoside A (1) and pave the way for future research and investigation in inflammation and drug discovery.…”
Get full text

THE DEVELOPMENT OF SCIENCE AND THE FATE OF A SCIENTIST (FOLLOWING GENETICS) by Jonas Rubikas

“… In the development of genetics it is possible to see definite levels of investigation. Every level has its characteristic methodology, which includes a set of methods, a subject of investigation, an evaluation, and an interpretation of the results obtained. …”
Get full text

Clinical Symptoms and Types of Samples Are Critical Factors for the Molecular Diagnosis of Symptomatic COVID-19 Patients: A Systematic Literature Review by Milad Zandi, Abbas Farahani, Armin Zakeri, Sara Akhavan Rezayat, Ramin Mohammadi, Umashankar Das, Jonathan R. Dimmock, Shervin Afzali, Mohammadvala Ashtar Nakhaei, Alireza Doroudi, Yousef Erfani, Saber Soltani

Get full text

Innovative IOP-Independent Neuroprotection and Neuroregeneration Strategies in the Pipeline for Glaucoma by James C. Tsai

“…These innovative strategies in the pipeline include investigation of neurotrophic factors, gene therapy, immune system modulation, and novel neuroregeneration pathways. …”
Get full text

Livogrit mitigates ANIT-induced cholestasis-like symptoms in an in vivo model by curbing hepatic inflammation and regulating BAX, TGF-β, MMP-9 and α-SMA gene expression by Acharya Balkrishna, Ritu Paliwal, Surjeet Singh, Rani Singh, Vivek Gohel, Rishabh Dev, Kunal Bhattacharya, Sandeep Sinha, Anurag Varshney

Get full text

Revisiting the age of the Florisbad hominin material by Lee R. Berger, John Hawks

“…The site’s complex stratigraphy and the details about the tooth’s discovery also pose challenges for the previous ESR age estimate. …”
Get full text

The Integral Field View of the Orion Nebula by Adal Mesa-Delgado

“…Since the early work of Vasconcelos and collaborators in 2005, this technique has facilitated the investigation of global properties of the nebula and its morphology, providing new clues to better constrain its 3D structure. …”
Get full text

BAFF and APRIL immunotherapy following Bacille Calmette-Guérin vaccination enhances protection against pulmonary tuberculosis in mice by Min Xie, Chen-Yu Tsai, Joshua Woo, Frank Nuritdinov, Melissa Cristaldo, Narineh M. Odjourian, Rosleine Antilus-Sainte, Maureen Dougher, Martin Gengenbacher, Martin Gengenbacher

Get full text

A Quantitative Trait Locus on Chromosome 5p Influences D-Dimer Levels in the San Antonio Family Heart Study by V. P. Diego, L. Almasy, D. L. Rainwater, M. C. Mahaney, A. G. Comuzzie, S. A. Cole, R. P. Tracy, M. P. Stern, J. W. MacCluer, J. Blangero

“…These results warrant further investigation.…”
Get full text

The Binding of BF-227-Like Benzoxazoles to Human α-Synuclein and Amyloid β Peptide Fibrils by Lee Josephson PhD, Nancy Stratman MS, YuTing Liu MS, Fang Qian MS, Steven H. Liang PhD, Neil Vasdev PhD, Shil Patel PhD

Get full text

Asymmetric multi-component trifunctionalization reactions with α-Halo Rh-carbenes by Xiaoyan Yang, Xiaoyu Zhou, Wenhao Hu, Yu Qian

Get full text

Slow Metabolism–Driven Amplification of Hepatic PPARγ Agonism Mediates Benzbromarone‐Induced Obesity‐Specific Liver Injury by Guanting Li, Yourong Hu, Han Zhao, Ziyu Peng, Xin Shang, Jia Zhang, Kunxin Xie, Meiwei Li, Xiaohang Zhou, Qinyao Zhou, Kai Li, Fang Zhou, Heyao Wang, Zhijian Xu, Jiali Liu, Peng Sun

“…Given the significance of BBR and its analogs in anti‐gout/hyperuricemia drug discovery, elucidating the mechanism by which BBR exacerbates obesity‐specific DILI warrants further investigation. …”
Get full text

Therapeutic implications for the PD-1 axis in cerebrovascular injury by James Feghali, Christopher M. Jackson

“…Since the discovery and characterization of the PD-1/PD-L pathway, mounting evidence has emerged regarding its role in regulating neuroinflammation following cerebrovascular injury. …”
Get full text

Mechanisms of blaIMP-4 dissemination across diverse carbapenem-resistant clinical isolates by Ying Fu, Faye C. Morris, Stephanie C. Pereira, Xenia Kostoulias, Yan Jiang, Callum Vidor, Galain Williams, Yogi Srikhanta, Nenad Macesic, Yunsong Yu, Dena Lyras, Anton Y. Peleg

Get full text