Discovery of amino acid substitutions in penicillin-binding proteins associated with adaptation to D-Ala-D-Lac in vancomycin-resistant Enterococcus faecalis by Nese Caglayan, Banu Sancak, Zeynep Kanlidere, Tanil Kocagoz, Tanil Kocagoz

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RNA Virus Discovery Sheds Light on the Virome of a Major Vineyard Pest, the European Grapevine Moth (<i>Lobesia botrana</i>) by Humberto Debat, Sebastian Gomez-Talquenca, Nicolas Bejerman

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Molecular Assessment of Domain I of Apical Membrane Antigen I Gene in Plasmodium falciparum: Implications in Plasmodium Invasion, Taxonomy, Vaccine Development, and Drug Discovery by Che Roland Achungu, Damian Nota Anong, Robert Adamu Shey, Cevie Jesenta Tabe

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Barlow Twins deep neural network for advanced 1D drug–target interaction prediction by Maximilian G. Schuh, Davide Boldini, Annkathrin I. Bohne, Stephan A. Sieber

“…Abstract Accurate prediction of drug–target interactions is critical for advancing drug discovery. By reducing time and cost, machine learning and deep learning can accelerate this laborious discovery process. …”
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Investigation of non-alcoholic steatohepatitis in labidochromis caeruleus and xiphophorus hellerii by Mustafa Ünal Boyraz, Muhammet Yaşar Dörtbudak, Muhammet Bahıttin Dörtbudak

“…The aim of this study, upon the discovery that these species died by showing various clinical signs in optimum conditions and standard feding conditions, was to investigate the causes of death and to determine the problems that may be encountered in the field.…”
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Experts Participation in Crime Scene Search while Investigating Murders by A. H. Vuima

“…The reasons why investigators do not examine the corpse at the place of its discovery have been established. …”
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Discovery of a New Cyanobacterial Genus (<em>Paludothrix</em> gen. nov.) from the Sanyang Wetland in Eastern China, Reflecting the Latest Taxonomic Status in Coleofasciculaceae by Yangyang Wu, Yao Cheng, He Zhang, Ruozhen Geng, Peng Xiao, Baiyu Cui, Renhui Li

“…The findings from morphological analysis, 16S rRNA gene sequencing, and the identification of the 16S-23S ITS rRNA region have led to the discovery of a new genus, <i>Paludothrix</i>, which is categorized within the family <i>Coleofasciculaceae</i>. …”
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Discovery of mutated oncodriver genes associated with glioblastoma originated from stem cells of subventricular zone through whole exome sequence profile analysis, and drug repurpo... by Arnob Sarker, Burhan Uddin, Reaz Ahmmed, Sabkat Mahmud, Alvira Ajadee, Md. Al Amin Pappu, Md. Abdul Aziz, Md. Nurul Haque Mollah

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A split intein and split luciferase-coupled system for detecting protein-protein interactions by Zhong Yao, Jiyoon Kim, Betty Geng, Jinkun Chen, Victoria Wong, Anna Lyakisheva, Jamie Snider, Marina Rudan Dimlić, Sanda Raić, Igor Stagljar

“…Recently, PPIs have started to be exploited for drug discovery purposes and have thus attracted much attention from both the academic and pharmaceutical sectors. …”
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Benchmarking the identification of a single degraded protein to explore optimal search strategies for ancient proteins by Rodriguez Palomo, Ismael, Nair, Bharath, Chiang, Yun, Dekker, Joannes, Dartigues, Benjamin, Mackie, Meaghan, Evans, Miranda, Macleod, Ruairidh, Olsen, Jesper V., Collins, Matthew J.

“…However, there is a lack of a systematic exploration of how these affect the identification of peptides, post-translational modifications (PTMs), proteins and their significance (through the False Discovery Rate) and correctness. We systematically investigated the performance of a wide range of sequencing tools and search engines in a controlled system: the experimental degradation of the single purified bovine β-lactoglobulin (BLG), heated at 95°C and pH 7 for 0, 4 and 128 days. …”
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Investigation of Equivalent Unsprung Mass and Nonlinear Features of Electromagnetic Actuated Active Suspension by Jun Yin, Xinbo Chen, Jianqin Li, Lixin Wu

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An Experimental Investigation on Transpiration Cooling Part II: Comparison of Cooling Methods and Media by J. H. Wang, J. Messner, H. Stetter

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Investigation of catechin’s anti-inflammatory activity: A bioinformatics and molecular docking study by Nisa Yulianti Suprahman, Bulan Rosita Sari, Riri Fauziyya, Fatimah

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Discovery of New Ligand with Quinoline Scaffold as Potent Allosteric Inhibitor of HIV-1 and Its Copper Complexes as a Powerful Catalyst for the Synthesis of Chiral Benzimidazole De... by Sabikeh G. Azimi, Ghodsieh Bagherzade, Mohammad Reza Saberi, Zeinab Amiri Tehranizadeh

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Topographical investigation and magnetometer prospection of the Agighiol tumulus, Tulcea County (4th century BC) by Zickgraf, B., Riese, T., Teleaga, E.

“…The Agighiol tumulus was investigated in 1931 after the unprofessional dismantling of the funerary construction. …”

Direct Analysis in Real Time Mass Spectrometry for the Nondestructive Investigation of Conservation Treatments of Cultural Heritage by Marcello Manfredi, Elisa Robotti, Greg Bearman, Fenella France, Elettra Barberis, Pnina Shor, Emilio Marengo

“…The method has been developed for the noninvasive analysis of the Dead Sea Scrolls, one of the most important archaeological discoveries of the 20th century. In this study castor oil and glycerol parchment treatments, prepared on new parchment specimens, were investigated in order to evaluate two different types of operations. …”
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A Computational Approach to the Perimeter-Area Inequality in a Triangle by Tomás Recio, Carlos Ueno, María Pilar Vélez

“…This paper explores the application of automated reasoning tools, specifically those implemented in GeoGebra Discovery, to the perimeter-area inequality in triangles. …”
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Exploring therapeutic strategies for androgen-independent prostate cancer using a magnetic coculture platform by Anjani Chavali, Giles Fitzwilliams, Adam Germain, Sandra Khuon, Young-tae Kim

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Structural bioinformatics for rational drug design by Soroush Mozaffari, Agnethe Moen, Che Yee Ng, Gerry A.F. Nicolaes, Kanin Wichapong

“…However, the landscape of drug discovery has been transformed by the recent advancements in bioinformatics and cheminformatics. …”
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A strategy for selective screening of dual-target bioactive compounds against hypertrophic scar through inhibiting angiotensin II type 1 receptor while stimulating type 2 receptor... by Lejing Qu, Meizhi Jiao, Zilong Zhang, Yuanyuan Ou, Xue Zhao, Yajun Zhang, Xinfeng Zhao

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