Showing 21 - 40 results of 437 for search 'Investigation Discovery', query time: 0.05s Refine Results
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    A microscale thermophoresis-based enzymatic RNA methyltransferase assay enables the discovery of DNMT2 inhibitors by Zarina Nidoieva, Mark O. Sabin, Tristan Dewald, Annabelle C. Weldert, Sabrina N. Hoba, Mark Helm, Fabian Barthels

    Published 2025-02-01
    “…Abstract RNA methyltransferases (MTases) have recently become increasingly important in drug discovery. Yet, most frequently utilized RNA MTase assays are limited in their throughput and hamper this rapidly evolving field of medicinal chemistry. …”
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    The impact of futures trade on the informational efficiency of the U.S. REIT market by Kwangwon Ahn, Hanwool Jang, Minhyuk Jeong, Sungbin Sohn

    Published 2025-01-01
    “…REIT spot market following the introduction of futures trading. To investigate the interplay between spot and futures markets, we analyze their respective roles in price discovery and find that, unlike in stock and bond markets, the spot market predominantly exhibits price leadership in the U.S. …”
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    Molecular dynamics-guided reaction discovery reveals endoperoxide-to-alkoxy radical isomerization as key branching point in α-pinene ozonolysis by Huan Yang, Umberto Raucci, Siddharth Iyer, Galib Hasan, Thomas Golin Almeida, Shawon Barua, Anni Savolainen, Juha Kangasluoma, Matti Rissanen, Hanna Vehkamäki, Theo Kurtén

    Published 2025-01-01
    “…A major challenge is navigating the complex chemical landscape of these transformations, which traditional hypothesis-driven methods fail to thoroughly investigate. Here, we explore the oxidation of α-pinene, a critical atmospheric biogenic VOC, using a novel reaction discovery approach based on molecular dynamics and state-of-the-art enhanced sampling techniques. …”
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