Identification of Potential miRNA-mRNA Regulatory Network Contributing to Parkinson’s Disease by Xi Yin, Miao Wang, Wei Wang, Tong Chen, Ge Song, Yixuan Niu, Ziying Jiang, Zhongbao Gao, Zhenfu Wang

“…We further investigated the expression of genes in the miRNA-mRNA regulatory network in blood samples collected from PD patients and healthy donors via qRT-PCR. …”
Get full text

Evaluating the association between lipidome and female reproductive diseases through comprehensive Mendelian randomization analyses by Ye Ma, Fang Wu, Zeming Yu, Lu Yang

“…The two-sample MR (TSMR) approach was employed to investigate the causal relationships, with further validation using false discovery rate (FDR) and multivariable MR (MVMR) methods. …”
Get full text

Marigold: a machine learning-based web app for zebrafish pose tracking by Gregory Teicher, R. Madison Riffe, Wayne Barnaby, Gabrielle Martin, Benjamin E. Clayton, Josef G. Trapani, Gerald B. Downes

“…Abstract Background High-throughput behavioral analysis is important for drug discovery, toxicological studies, and the modeling of neurological disorders such as autism and epilepsy. …”
Get full text

Beyond immortality: Epstein–Barr virus and the intricate dance of programmed cell death in cancer development by Arezoo Esmaeili, Prankur Awasthi, Samira Tabaee

“…Innovatively, the review synthesizes recent discoveries on the multifaceted roles of non-coding RNAs and cellular signaling pathways in modulating cell death within the context of EBV infection. …”
Get full text

Atlantic mackerel population structure does not support genetically distinct spawning components [version 2; peer review: 1 approved, 2 approved with reservations] by Imanol Aguirre-Sarabia, Alice Manuzzi, Dorte Bekkevold, Natalia Díaz-Arce, Jessica Gomez-Garrido, Teunis Jansen, Marta Gut, Tyler S. Alioto, Sonia Sanchez-Maroño, Martin Castonguay, Naiara Rodriguez-Ezpeleta, Paula Álvarez

“…Such reference genome was used to map Restriction-site-associated sequencing (RAD-seq) reads for SNP discovery and genotyping in more than 500 samples distributed along the species range. …”
Get full text

Sand body architecture of braided river deltas in the Upper Triassic Xujiahe Formation, Sichuan Basin by Yanqing Huang, Meizhou Deng, Nan Duan, Wujun Jin, Junlong Liu, Na Niu, Ai Wang, Xiaolin Lu

“…The recent discovery of natural gas within the fifth member of the Xujiahe Formation (T3x5) in the Dongfeng area within the Sichuan Basin highlights the significant exploration potential of this member. …”
Get full text

Identity Construction and Transformation of Zen Tourists by Xu Haichao, Liang Zengxian

“…Using qualitative methods, this study investigated how non-religious tourists construct and transform their identities through Zen tourism. …”
Get full text

Insights Into Causal Effects of Genetically Proxied Lipids and Lipid‐Modifying Drug Targets on Cardiometabolic Diseases by Liwan Fu, Qin Liu, Hong Cheng, Xiaoyuan Zhao, Jingfan Xiong, Jie Mi

“…This study used Mendelian randomization to investigate the causal relationships and underlying mechanisms. …”
Get full text

Gut Microbiota Composition and Structure of the Ob/Ob and Db/Db Mice by Mingsheng Yang, Yixin Liu, Hengchang Xie, Zhengzheng Wen, Yunxia Zhang, Changjing Wu, Li Huang, Jie Wu, Chensheng Xie, Tao Wang, Weifeng Peng, Shangqi Liu, Long Chen, Xiaomeng Liu

“…The data on gut microbiota in ob/ob and db/db mice investigated herein has broad implications for the pathogenesis study and drug discovery on obesity and related complications.…”
Get full text

METTL16 controls airway inflammations in smoking-induced COPD via regulating glutamine metabolism by Xinyu Jia, Shan Liu, Chunan Sun, Manni Zhu, Qi Yuan, Min Wang, Tingting Xu, Zhengxia Wang, Zhongqi Chen, Mao Huang, Ningfei Ji, Mingshun Zhang

“…However, its exact role in smoking-induced COPD remains to be investigated. In this study, we found that the level of METTL16 was aberrantly decreased in lung tissues of COPD smokers. …”
Get full text

Synergistic removal of organic and nutrients from landfill leachate using photobioreactor-cultivated microalgae-bacteria consortium by N. Emalya, Y. Yunardi, E. Munawar, S. Suhendrayatna, T. Tarmizi

“…In response to this challenge, a research study was undertaken to investigate the potential of utilizing a consortium comprising microalgae and bacteria in the treatment of landfill leachate.METHODS: The microalgae, bacteria, and leachate utilized in this study were sourced from a leachate treatment facility located at the Aceh regional domestic waste management unit in Blang Bintang, Aceh Besar, Indonesia. …”
Get full text

Lewy body diseases and the gut by Timothy R. Sampson, Malú Gámez Tansey, Andrew B. West, Rodger A. Liddle

“…The cellular and mechanistic origins of ⍺-syn propagation in disease are under intense investigation. Experimental LBD models have implicated important contributions from the intrinsic gut microbiome, the intestinal immune system, and environmental toxicants, acting as triggers and modifiers to GI pathologies. …”
Get full text

Prediction model for type 2 diabetes mellitus and its association with mortality using machine learning in three independent cohorts from South Korea, Japan, and the UK: a model de... by Hayeon Lee, Seung Ha Hwang, Seoyoung Park, Yunjeong Choi, Sooji Lee, Jaeyu Park, Yejun Son, Hyeon Jin Kim, Soeun Kim, Jiyeon Oh, Lee Smith, Damiano Pizzol, Sang Youl Rhee, Hyunji Sang, Jinseok Lee, Dong Keon Yon

“…To ensure the robustness of our ML-based prediction model, we investigated the potential association between the model probability divided into tertiles and the risk of mortality following the onset of T2DM. …”
Get full text

Deciphering the role of IL17RA in psoriasis and chronic mucocutaneous candidiasis: shared pathways and distinct manifestations by Ayat Kadhi, Ayat Kadhi, Ayat Kadhi, Edward Eid, Michel J. Massaad, Inaam El-Rassy, Dana Maria Khoury, Yutaka Shimomura, Nelly Rubeiz, Mazen Kurban, Mazen Kurban, Mazen Kurban, Georges Nemer, Georges Nemer

“…Despite the truncation, our investigations revealed that this variant produces a fully functional IL17RA protein. …”
Get full text

End-to-End Stroke Imaging Analysis Using Effective Connectivity and Interpretable Artificial Intelligence by Wojciech Ciezobka, Joan Falco-Roget, Cemal Koba, Alessandro Crimi

“…This allows directed graph network representations that have not been fully investigated so far by graph convolutional network classifiers. …”
Get full text

Case report: Novel multi-exon homozygous deletion of ZBTB24 causes immunodeficiency, centromeric instability, and facial anomalies syndrome 2 by Yan Long, Chenghan Wang, Jie Xiao, Yunhua Huang, Xiaoting Ling, Chaoyu Huang, Ying Chen, Jiaqi Luo, Rongheng Tang, Faquan Lin, Yifang Huang

“…This study aimed to investigate the phenotype and immune function of a girl with ICF2, identify her genetic defect, and explore the potential pathogenic mechanisms of the disease. …”
Get full text

Omics-Based Comparison of Fungal Virulence Genes, Biosynthetic Gene Clusters, and Small Molecules in <i>Penicillium expansum</i> and <i>Penicillium chrysogenum</i> by Holly P. Bartholomew, Christopher Gottschalk, Bret Cooper, Michael R. Bukowski, Ronghui Yang, Verneta L. Gaskins, Dianiris Luciano-Rosario, Jorge M. Fonseca, Wayne M. Jurick

“…While these two fungi have been investigated individually, a recent discovery revealed that <i>P. chrysogenum</i> can block <i>P. expansum-</i>mediated decay of apple fruit. …”
Get full text

UHPLC-QTOF-MS/MS profiling, molecular networking, and molecular docking analysis of Gliricidia sepium (Jacq.) Kunth. ex. Walp. stem ethanolic extract and its gastroprotective effec... by Aya A. Wafaey, Seham S. El-Hawary, Osama G. Mohamed, Sahar S. Abdelrahman, Alaa M. Ali, Ahmed A. El-Rashedy, Mohamed F. Abdelhameed, Farid N. Kirollos

Get full text

Smoking cessation is a protective factor for lung cancer onset and mortality: a population-based prospective cohort study by Wei Yin, Zhuochen Lin, Wei-Jie Gong, Wen-Xuan Wang, Ying-Ying Zhu, Yi-Lin Fu, Han Yang, Jin-Xin Zhang, Peng Lin, Ji-Bin Li

“…We aimed to comprehensively investigate the association of smoking cessation-related behaviors on the AAO of LC, LC-specific and all-cause mortality. …”
Get full text

Small open reading frames (sORFs): Driving big improvements in plant development and quality by Kui Dong, Chaofan Shan, Dongyu Wen, Zifan Cui, Jun Cao

“…With the advent of sophisticated technologies such as bioinformatics, ribosome profiling, and mass spectrometry, the investigation of sORFs has experienced a transformative shift and significant expansion. …”
Get full text