Quantifying LAGA mutated mouse IgG2a monoclonal antibody with a rapid pepsin digestion enabled immunoaffinity LC/MS/MS assay by Linlin Dong, Susan Chen, Konstantin Piatkov, Dong Wei, Mark G. Qian

“…The successful implementation of this novel approach in discovery PK studies eliminates the need for tedious and costly generation of specific immunocapturing reagents for the LAGA mutants. …”
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Retracing the Cold Plasma Dispersion Law in Pulsar B0329+54: New Insights into Frequency-dependent Dispersion Measures by Shyam S. Sharma, Tetsuya Hashimoto, Tomotsugu Goto, Shotaro Yamasaki, Simon C.-C. Ho

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The Association Between IL‐8 Gene Polymorphisms and the Risk of Several Types of Cancer, Especially in Gastric Cancer by Bin Xu, Yidan Yan

“…Nowadays, the association between polymorphisms in the interleukin‐8 (IL‐8) gene and the susceptibility of cancer risk have been investigated in many studies, however, above relationships remain unclear. …”
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In Vitro Mechanism of Action of Acanthospermum hispidum in Trypanosoma brucei by Aboagye Kwarteng Dofuor, Temitayo Samson Ademolue, Karen Nana Akua Kuampah, Frederick Ayertey, Theresa Manful Gwira

“…The in vitro efficacies and mechanisms of antitrypanosomal activities of A. hispidum were investigated using a panel of cell biological approaches. …”
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Synthesis and kinetic evaluation of analogs of (E)-4-amino-3-methylbut-2-en-1-yl diphosphate, a potent inhibitor of the IspH metalloenzyme by Petit, Benoît Eric, Jobelius, Hannah, Bianchino, Gabriella Ines, Guérin, Mélina, Borel, Franck, Chaignon, Philippe, Seemann, Myriam

“…AMBPP has substantial limitations for drug development due to its poor metabolic stability. Here, we investigate the replacement of the diphosphate moiety of AMBPP by more stable mimics: sulfonate, phosphonate or phosphinophosphonate. …”
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Manipulation of 2D and 3D Magnetic Solitons Under the Influence of DMI Gradients by Rayan Moukhader, Davi Rodrigues, Eleonora Raimondo, Vito Puliafito, Bruno Azzerboni, Mario Carpentieri, Abbass Hamadeh, Giovanni Finocchio, Riccardo Tomasello

“…In this work, we present a comprehensive study using numerical and analytical methods to investigate the stability and motion of various magnetic textures under the influence of DMI gradients. …”
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Taurine inhibits acute ammonia-induced oxidative stress, immune response, and apoptosis of large yellow croaker (Larimichthys crocea) during keep-live transport by Xin Zhao, Zhenkun Xu, Jun Mei, Jing Xie

“…Taurine has antioxidant properties. This research investigated the oxidative stress, immune response, and apoptosis of large yellow croaker (Larimichthys crocea) during keep-live transport, and the alleviation effect of taurine. …”
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An amplification mechanism for weak ELF magnetic fields quantum-bio effects in cancer cells by Amirali Zandieh, Seyed Peyman Shariatpanahi, Amir Abas Ravassipour, Javad Azadipour, Maryam Sadat Nezamtaheri, Zahra Habibi-Kelishomi, Mojtaba Ghanizadeh, Ali Same-Majandeh, Keivan Majidzadeh-A, Amir Taheri, Alireza Madjid Ansari, Mohammad Amin Javidi, Mohammad Mehdi Pirnia, Bahram Goliaei

“…Abstract Observing quantum mechanical characteristics in biological processes is a surprising and important discovery. One example, which is gaining more experimental evidence and practical applications, is the effect of weak magnetic fields with extremely low frequencies on cells, especially cancerous ones. …”
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In Vitro Antibacterial and Antioxidant Activities, Pharmacokinetics, and In Silico Molecular Docking Study of Phytochemicals from the Roots of Ziziphus spina-christi by Hadush Gebrehiwot, Urgessa Ensermu, Aman Dekebo, Milkyas Endale, Tariku Nefo Duke

“…Conversely, the in silico molecular docking studies were attained via a Biovia Discovery Studio Visualizer 2021 in combination with the AutoDock Vina software. …”
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The curvilinear relationship between Framingham Steatosis Index and depression: insights from a nationwide study by Chunqi Jiang, Bo Wang, Ning Wang, Jun Wang, Yinuo Qu, Guang Zhao, Xin Zhang, Xin Zhang

“…We employed the PHQ-9 questionnaire for the evaluation of depressive symptoms. We investigated the association between FSI and depression using a weighted multiple logistic regression model and stratified analysis. …”
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Achievements and prospects of applying high-throughput sequencing techniques to potato genetics and breeding by I. V. Bykova, N. A. Shmakov, D. A. Afonnikov, A. V. Kochetov, E. K. Khlestkina

“…An important outcome of the genome sequencing was further identification of more than 8 thousand SNPs and approbation of the Genotyping-by-sequencing (GBS) method on potato, which is the basis for potato genomic selection and for discovery of economically important genes using genome wide association studies (GWAS). …”
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Record Keeping Systems and Service Delivery in Uganda: Case Of Kabale District Local Government by Turyasingura John Bosco, agaba moses, Kabagambe Jesse David, Barigye Godfrey

“…The study's end variable was the provision of services, and its predictor factors were the efficiency with which the records management systems function. Prior to the investigation, a cross-sectional survey was conducted. …”
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Ethanol Extracts of Solanum lyratum Thunb Regulate Ovarian Cancer Cell Proliferation, Apoptosis, and Epithelial-to-Mesenchymal Transition (EMT) via the ROS-Mediated p53 Pathway by Chen Zhang, Zheming Li, Jie Wang, Xuelu Jiang, Mengting Xia, Jianfen Wang, Shenyi Lu, Shouye Li, Hanmei Wang

“…The current study is aimed at investigating the effect of SLT on ovarian cancer cells. …”
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PLGA confers upon conventional nonfluorescent molecules luminescent properties to trigger 1O2-induced pyroptosis and immune response in tumors by Lan Zou, Rujing Wang, Mengnan Zhao, Yuke Li, Chen Sun, Jinjin Xie, Yan Chen, Qian Jing, Dandan Mi, Sanjun Shi

“…Remarkably, these new luminophores, composed of two non-inherently luminous components, exhibit a remarkable synergistic boost in photoluminescence through a “0 + 0 > 2” phenomenon. In-depth investigations uncovered that these luminous PLGA-NPs, capable of generating 1O2, induce pyroptosis under photoexcitation conditions through the caspase-3/gasdermin E (GSDME) pathway. …”
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Characterization of a chemically induced osteoarthritis model in zebrafish by Gongyi Xiao, Jin Qin, Huiping Yang, Qizhi Song, Ruobin Zhang, Junlan Huang, Yuexi Mou, Wen Liu, Xianding Sun, Mao Nie

“…Consequently, this offers a fresh avenue for investigating the pathogenesis, prevention, and potential therapeutic approaches for human OA.…”
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Human Papillomavirus, Human Immunodeficiency Virus, and Oral Microbiota Interplay in Nigerian Youth (HOMINY): A Prospective Cohort Study Protocol by Jia Liu, Esosa Osagie, Paul Akhigbe, Nosakhare Idemudia, Ozoemene Obuekwe, Ruxton Adebiyi, Nicolas Schlecht, Yana Bromberg, Fidelis E Eki-Udoko, Nosayaba Osazuwa-Peters, Modupe Oluseun Coker

“…Multiple comparisons will be adjusted using the False Discovery Rate (FDR) correction to control for Type I error.Ethics and dissemination The study was approved by Rutgers State University (Pro2022000949) and the UBTH (ADM/E22/A/VOL. …”
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Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities by Ammara Riaz, Azhar Rasul, Ghulam Hussain, Muhammad Kashif Zahoor, Farhat Jabeen, Zinayyera Subhani, Tahira Younis, Muhammad Ali, Iqra Sarfraz, Zeliha Selamoglu

“…Although researchers have reported multiple pharmacological applications of astragalin in various diseased conditions, further experimental investigations are still mandatory to fully understand its mechanism of action. …”
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Identification of Five m6A-Related lncRNA Genes as Prognostic Markers for Endometrial Cancer Based on TCGA Database by Li Shan, Ye Lu, Cheng-Cheng Xiang, Xiaoli Zhu, Er-Dong Zuo, Xu Cheng

“…A risk score model was established, and Kaplan–Meier analysis was conducted for investigating overall survival (OS) across two patient groups (high risk and low risk). …”
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Vix (Côte-d’Or) et l’émergence des principautés celtiques : l’hypothèse portuaire et le concept de port of trade by Bruno Chaume

“…This discovery once again draws attention to the synergy that existed between the Hallstatt princely seats and the rivers on which they were often located. …”
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Assessing the impact of sewage and wastewater on antimicrobial resistance in nearshore Antarctic biofilms and sediments by Melody S Clark, Benjamin H Gregson, Carla Greco, Harisree Paramel Nair, Marlon Clark, Claire Evans, Kevin A. Hughes, Kudzai Hwengwere, Marcus Leung, Lloyd S Peck, Caray A. Walker, William Chow

“…This study takes a sequencing discovery-led approach to investigate levels and extent of AMR around the Rothera Research Station (operated by the UK) on the Antarctic Peninsula. …”
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