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Effect of titin phosphorylation on degradation of titin from skeletal muscles
Published 2023-07-01“…This study aimed to investigate effect of phosphorylation on titin degradation. …”
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322
A Comprehensive Review of the Diversity of Fungal Secondary Metabolites and Their Emerging Applications in Healthcare and Environment
Published 2024-11-01“…Advancement in fermentation techniques, bioprocessing, and co-cultivation approaches for large-scale production of SMs. Investigators further highlighted the importance of omics technologies in understanding the regulation and biosynthesis of SMs, which offers an understanding of novel applications in drug discovery and sustainable agriculture. …”
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323
The Influence Mechanism of Deformation on the Precipitation Behavior and Mechanical Properties of 7075 Aluminum Alloy During Hot Forming-Quenching Integrated Process
Published 2024-12-01“…In terms of industrial applications, this discovery offers significant advantages for shortening the production cycle of the hot stamping process and reducing production costs.…”
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324
Structural properties and recrystallization effects in ion beam modified B20-type FeGe films
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Harmonizing multisite neonatal diffusion-weighted brain MRI data for developmental neuroscience
Published 2025-01-01“…ComBat could enable unprecedented sample sizes in developmental neuroscience, offering new horizons for biomarker discovery and validation, understanding typical and atypical brain development, and assessing neuroprotective therapies.…”
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329
Anthelmintic activity of 1,10-phenanthroline-5,6-dione-based metallodrugs
Published 2025-02-01“…Additionally, the compounds were tested on Caenorhabditis elegans, a model organism for drug discovery. All compounds exhibited strong antiparasitic activity, with Cu-phendione showing the greatest potency (EC50 = 2.3 µM for S. mansoni and 6.4 µM for A. cantonensis). …”
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330
Exploration of the shared diagnostic genes and molecular mechanism between obesity and atherosclerosis via bioinformatic analysis
Published 2025-01-01“…Furthermore, Gene set enrichment analysis (GSEA) was used to investigate molecular pathways and immune infiltration related to the diagnostic genes. …”
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331
Characterization of a Novel Male Pheromone Compound in <i>Leucoptera sinuella</i> (Lepidoptera: Lyonetiidae) and Its Role in Courtship Behavior
Published 2024-12-01“…To our knowledge, (<i>Z</i>)-3-decenyl hexanoate has not been previously reported as a sex pheromone component in any insect species, making this discovery an intriguing addition to the diversity of chemical communication in insects.…”
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332
A novel ubiquitination-related gene signature for overall survival prediction in patients with liver hepatocellular carcinoma
Published 2025-01-01“…Abstract Liver hepatocellular carcinoma (LIHC) is a highly heterogeneous disease, necessitating the discovery of novel biomarkers to enhance individualized treatment approaches. …”
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333
Causal relationship between immune cells and risk of heart failure: evidence from a Mendelian randomization study
Published 2025-01-01“…BackgroundHeart failure (HF) is a clinical syndrome resulting from structural damage or dysfunction of the heart. Previous investigations have highlighted the critical involvement of immune cells in the progression of heart failure, with distinct roles attributed to different types of immune cells. …”
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The Global Secondary Metabolite Regulator <i>AcLaeA</i> Modulates <i>Aspergillus carbonarius</i> Virulence, Ochratoxin Biosynthesis, and the Mode of Action of Biopesticides and Ess...
Published 2024-12-01“…The goal of this study was to investigate the role of the regulatory gene <i>AclaeA</i> in physiology, virulence, and ochratoxin A (OTA) production by deleting this gene from the genome of a wild-type <i>A. carbonarius</i> strain. …”
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335
Blood molecular subtypes to guide precision treatment strategies in systemic juvenile idiopathic arthritis
Published 2025-02-01“…A comprehensive understanding of molecular signatures at the systems level and the discovery of molecular subtypes are the initial steps toward personalized medicine in sJIA. …”
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336
Causal association between circulating α-Klotho levels and venous thromboembolism: a two-sample Mendelian randomization study
Published 2025-01-01“…The effect size was expressed as odds ratios (ORs) and 95% confidence intervals (CIs), and the False Discovery Rate (FDR) test was used for correction. …”
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Advances and trends of modern and contemporary research on the geology of coal-measure minerals in China
Published 2025-01-01“…Advances Based on textual research and the analysis of logical relations, this study generalized the advances in research on the geology of CMMs in China into four aspects. (1) Increasingly improved geological theory system of CMMs: China’s classic theoretical system of coal field geology was formed in the second half of the 20th century, and the geological theory system focusing on coals, coal-measure gas, and coal-measure critical metals has been gradually developed since the 21st century. (2) Research on the origin and genesis of coals, advancing the international coal geology: The advancements include the development of the new coal metamorphism theory, the discovery of the world's youngest soft lignite, the reveal of late-stage coalification jumps, the establishment of the ordinary organic petrology, and the comprehensive ascertainment of the formation and evolutionary mechanisms of coals. (3) The unique CMM accumulation, distribution, and metallogenic theory: The specific outcomes include the establishment of multiple sedimentary and structural coal-controlling patterns, the reveal of the fundamental framework of coal accumulation in sea areas, the identification of deposits of various coal-measure critical metals, and the determination of the division schemes for coal-controlling geotectonic units and the metallogenic zones of coal-measure critical metals, and the development of a geological theory system for coalbed methane. (4) Significant achievements in the geological surveys and assessment of special coal resources: Specifically, the methodological system for the geological prediction and assessment of special coal types and high-quality, eco-friendly, and clean coal resources has been developed, the methodological system for the resource potential assessment of tar-rich coals and underground coal gasification has been formed, and the coal resources for related purposes have been preliminarily investigated. …”
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338
Deaths during Sexual Activity
Published 2024-05-01“…It is important to rule out homicide or suicide as the cause of death when investigating sexual deaths. Determining the cause of death requires a comprehensive assessment of the evidence and circumstances and should not be based solely on autopsy findings. …”
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The divergent histories of Bose-Einstein statistics and the forgotten achievements of Władysław Natanson (1864–1937)
Published 2019-11-01“… This article investigates the forgotten achievements of Władysław Natanson (1864–1937) related to the creation of Bose-Einstein statistics. …”
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