The power of dialogue and discovery by Kalina Jastrzębowska

“…The aim of this action research was to investigate the relationship between a classroom environment that allows for dialogue and discovery and young children’s input into problem solving. …”
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The New Stage in the Archeology of Kaliningrad Region (On the Conference Archeology of the Baltic Region: New Discoveries and Investigations, Kaliningrad, November 17-19, 2010 by Linas Tamulynas

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New strategies to enhance the efficiency and precision of drug discovery by Qi An, Liang Huang, Chuan Wang, Dongmei Wang, Yalan Tu

“…Drug discovery plays a crucial role in medicinal chemistry, serving as the cornerstone for developing new treatments to address a wide range of diseases. …”
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E-guided discovery module for cartesian coordinates topic in junior high school by Dian Permatasari, Tatang Herman

“…Guided Discovery learning is an approach that actively engages students by allowing them to discover and investigate concepts independently. …”
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Biomarker discovery and phytochemical interventions in Alzheimer's disease: A path to therapeutic advances by Mithila Debnath, Mahir Azmal, Rashid Taqui, Moshiul Alam Mishu, Ajit Ghosh

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Discovery of the bacterial HslV protease activators as lead molecules with novel mode of action by Aurangzeb Sana, Aurongzeb Muhammad, Shamim Shahbaz, Rashid Yasmeen, Khan Khalid Mohammed, Aziz Tariq, Alharbi Metab, Alasmari Abdullah F.

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Discovery and Detailed Study of the M31 Classical Nova AT 2023tkw: Evidence for Internal Shocks by Judhajeet Basu, Ravi Kumar, G.C. Anupama, Sudhanshu Barway, Peter H. Hauschildt, Shatakshi Chamoli, Vishwajeet Swain, Varun Bhalero, Viraj Karambelkar, Mansi Kasliwal, Kaustav K. Das, Igor Andreoni, Avinash Singh, Rishabh Singh Teja

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First detection and phylogenetic analysis of Trypanosoma species in European wolves and bears: discovery of novel haplotypes by Blanka Orłowska, Magdalena Świsłocka-Cutter, Katarzyna Filip-Hutsch, Daniel Młocicki, Adam Olszewski, Marek Asman, Krzysztof Anusz, Joanna Werszko

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A microscale thermophoresis-based enzymatic RNA methyltransferase assay enables the discovery of DNMT2 inhibitors by Zarina Nidoieva, Mark O. Sabin, Tristan Dewald, Annabelle C. Weldert, Sabrina N. Hoba, Mark Helm, Fabian Barthels

“…Abstract RNA methyltransferases (MTases) have recently become increasingly important in drug discovery. Yet, most frequently utilized RNA MTase assays are limited in their throughput and hamper this rapidly evolving field of medicinal chemistry. …”
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Virulence factor discovery identifies associations between the Fic gene family and Fap2+ fusobacteria in colorectal cancer microbiomes by Geicho Nakatsu, Duhyun Ko, Monia Michaud, Eric A. Franzosa, Xochitl C. Morgan, Curtis Huttenhower, Wendy S. Garrett

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Discovery of amino acid substitutions in penicillin-binding proteins associated with adaptation to D-Ala-D-Lac in vancomycin-resistant Enterococcus faecalis by Nese Caglayan, Banu Sancak, Zeynep Kanlidere, Tanil Kocagoz, Tanil Kocagoz

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Investigation of catechin’s anti-inflammatory activity: A bioinformatics and molecular docking study by Nisa Yulianti Suprahman, Bulan Rosita Sari, Riri Fauziyya, Fatimah

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Barlow Twins deep neural network for advanced 1D drug–target interaction prediction by Maximilian G. Schuh, Davide Boldini, Annkathrin I. Bohne, Stephan A. Sieber

“…Abstract Accurate prediction of drug–target interactions is critical for advancing drug discovery. By reducing time and cost, machine learning and deep learning can accelerate this laborious discovery process. …”
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Topographical investigation and magnetometer prospection of the Agighiol tumulus, Tulcea County (4th century BC) by Zickgraf, B., Riese, T., Teleaga, E.

“…The Agighiol tumulus was investigated in 1931 after the unprofessional dismantling of the funerary construction. …”

A split intein and split luciferase-coupled system for detecting protein-protein interactions by Zhong Yao, Jiyoon Kim, Betty Geng, Jinkun Chen, Victoria Wong, Anna Lyakisheva, Jamie Snider, Marina Rudan Dimlić, Sanda Raić, Igor Stagljar

“…Recently, PPIs have started to be exploited for drug discovery purposes and have thus attracted much attention from both the academic and pharmaceutical sectors. …”
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Benchmarking the identification of a single degraded protein to explore optimal search strategies for ancient proteins by Rodriguez Palomo, Ismael, Nair, Bharath, Chiang, Yun, Dekker, Joannes, Dartigues, Benjamin, Mackie, Meaghan, Evans, Miranda, Macleod, Ruairidh, Olsen, Jesper V., Collins, Matthew J.

“…However, there is a lack of a systematic exploration of how these affect the identification of peptides, post-translational modifications (PTMs), proteins and their significance (through the False Discovery Rate) and correctness. We systematically investigated the performance of a wide range of sequencing tools and search engines in a controlled system: the experimental degradation of the single purified bovine β-lactoglobulin (BLG), heated at 95°C and pH 7 for 0, 4 and 128 days. …”
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Structural bioinformatics for rational drug design by Soroush Mozaffari, Agnethe Moen, Che Yee Ng, Gerry A.F. Nicolaes, Kanin Wichapong

“…However, the landscape of drug discovery has been transformed by the recent advancements in bioinformatics and cheminformatics. …”
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Cardio-metabolic-related plasma proteins reveal biological links between cardiovascular diseases and fragility fractures: a cohort and Mendelian randomisation investigationResearch... by Karl Michaëlsson, Rui Zheng, John A. Baron, Tove Fall, Alicja Wolk, Lars Lind, Jonas Höijer, Carl Brunius, Eva Warensjö Lemming, Olga E. Titova, Bodil Svennblad, Susanna C. Larsson, Shuai Yuan, Håkan Melhus, Liisa Byberg, Hannah L. Brooke

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Foundational contributions of Svetlana Mojsov to the GLP-1 field by George Barany, Michael J. Barany

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TMEM45A enhances palbociclib resistance and cellular glycolysis by activating AKT/mTOR signaling pathway in HR+ breast cancer by Cui Chen, Zehong Chen, Jinze Zhao, Xinyun Wen, Hanming Yao, Zijin Weng, Huiping Xiong, Zongheng Zheng, Juekun Wu

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