Factors associated with having a steady homosexual partner among men who have sex with men, based on internet recruitment by Peng Zhang, Weiyong Chen, Jing Li, Yun Fu, Fang Wang, Xing Wang, Zhongrong Yang

“…Multivariate logistic regression analysis showed that older participants having a steady HP (adjusted odds ratio [aOR]: 1.04; 95% confidence interval [CI]: 1.01–1.07)was associated with an average monthly income >6,000 Chinese yuan (aOR: 1.47; 95% CI: 1.01–2.16), a belief that using enhancers such as Rush Popper increases the human immunodeficiency virus (HIV) infection risk (aOR: 1.56; 95% CI: 1.02–2.41), identification as purely homosexual (aOR: 2.02; 95% CI: 1.37–2.99), having engaged in anal sex with a HP in the previous 6 months (aOR: 4.13; 95% CI:2.51–6.90), and knowing the HIV status of their HP (aOR: 1.88; 95% CI: 1.17–3.06). …”
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First-in-human dose escalation trial to evaluate the clinical safety and efficacy of an anti-MAGEA1 autologous TCR-transgenic T cell therapy in relapsed and refractory solid tumors by Ignacio I Wistuba, Mamta Kalra, Linus Backert, Martin Wermke, Edwin R Parra, Jason John Luke, Apostolia M Tsimberidou, Sebastian Bunk, Mohammad B Hossain, Andrea Mayer-Mokler, Arun Satelli, Norbert Hilf, Steffen Walter, Cedrik M Britten, Van K Morris, Tobias A W Holderried, Winfried H Alsdorf, Katrin Wetzko, Borje S Andersson, Sandra Grund-Gröschke, Katrin Aslan, Anantha Marisetty, Swapna Satam, Jens Hukelmann, M Alper Kursunel, Karine Pozo, Andreas Acs, Melissa Baumeister, Claudia Wagner, Oliver Schoor, Ali S Mohamed, Delfi Krishna

“…Eligible patients underwent leukapheresis, T cells were isolated, transduced with lentiviral vector carrying MAGEA1-specific TCR and following lymphodepletion (fludarabine/cyclophosphamide), infused with a median of 1.4×109 specific T cells (range, 0.086×109–2.57×109) followed by interleukin 2.Safety of IMA202 No DLT was observed. …”
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Rapamycin-resistant polyclonal Th1/Tc1 cell therapy (RAPA-201) safely induces disease remissions in relapsed, refractory multiple myeloma by Lawrence G Lum, Parameswaran Hari, Aniko Szabo, Michele Donato, Jee Hyun Park, Daniel H Fowler, Binod Dhakal, Saurabh Chhabra, Deborah D Glass, David S Siegel, Tania C Felizardo

“…Rapamycin-resistant T cells polarized for a type II cytokine phenotype were previously evaluated in the allogeneic transplantation context.Methods The clinical trial (NCT04176380) evaluated RAPA-201 therapy in combination with fludarabine-sparing low-dose host conditioning for the treatment of patients with relapsed, refractory multiple myeloma (RRMM).Results From December 2020 to December 2022, 14 patients with RRMM received a median of three RAPA-201 infusions (median dose, 80×106 cells). RAPA-201 drug products (DPs) were: polyclonal; enriched for TCM cells; reduced for immune checkpoint expression, including PD1, CD73, and LAIR1; and preferentially secreted Th1 cytokines. …”
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CT-based skeletal muscle loss predicts long term prognosis in patients with distal cholangiocarcinoma undergone pancreaticoduodenectomy by Guangzhen Qu, Shao-Cheng Lyu, Yong Zhang, Kun Gao, Chuanguo Zhou

“…Demographic, laboratory and follow-up information was obtained. The cross-sectional images of skeletal muscle area at the level of the third lumbar spine was obtained based on computed tomography (CT), and the SMI was calculated by skeletal muscle mass through height squared normalization. …”
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Age modulates, religious coping mediates: the role of attitude to self in cancer patients’ quality of life by Maria-Chidi C. Onyedibe, Runcie C.W. Chidebe, Runcie C.W. Chidebe, Runcie C.W. Chidebe, Barbara L. Andersen, Uzoamaka F. Ugwoke, Lawrence Ejike Ugwu, Lawrence Ejike Ugwu

“…This is particularly evident in low and middle-income countries (LMICs) where healthcare disparities exacerbate distress. …”
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Evaluating the impact, implementation experience and political economy of primary care networks in Kenya: protocol for a mixed methods study by Beatrice Amboko, Jacinta Nzinga, Benjamin Tsofa, Peter Mugo, Anita Musiega, Beryl Maritim, Ethan Wong, Caitlin Mazzilli, Wangari Ng’ang’a, Brittany Hagedorn, Gillian Turner, Anne Musuva, Felix Murira, Nirmala Ravishankar, Salim Hussein, Edwine Barasa

“…Abstract Background Primary care networks (PCNs) are increasingly being adopted in low- and middle-income countries (LMICs) to improve the delivery of primary health care (PHC). …”
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Detection of CRISPR‒Cas and type I R–M systems in Klebsiella pneumoniae of human and animal origins and their relationship to antibiotic resistance and virulence by Xue Li, Ling Wang, Jinghuan Lin, Yingjuan Gu, Zhihua Liu, Jing Hu

“…ABSTRACT The clustered regularly interspaced short palindromic repeats (CRISPR)‒CRISPR-associated protein (Cas) and restriction‒modification (R–M) systems are important immune systems in bacteria. Information about the distributions of these two systems in Klebsiella pneumoniae from different hosts and their mutual effect on antibiotic resistance and virulence is still limited. …”
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Optimization of industrial symbiosis in coffee-based eco-industrial park design by N. Laili, T. Djatna, N.S. Indrasti, M. Yani

“…The utilization of data integration enhances the transparency and efficiency of information exchange among eco-industrial park participants, promoting predictability and reliability in material exchange. …”
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践行数智化健康管理理念，提升我国卒中患者管理质量和效率 Implementing the Concept of Digital Intelligent Health Management to Enhance the Quality and Efficiency of Stroke Patient Management in China... by 李星明1，宋西方2，武剑3，4，邱月4，杨宇彤1，过君君1，高雨润1，周立涵1 (LI Xingming1, SONG Xifang2, WU Jian3,4, QIU Yue4, YANG Yutong1, GUO Junjun1, GAO Yurun1, ZHOU Lihan1)

“…Currently, with the rapid development of information technology and mobile internet, digital intelligent health technology has begun to play a significant role in stroke management, providing patients with more efficient and real-time medical services and showing good cost-effectiveness. …”
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Incidence and survival of skin melanoma in Puglia: A comparison with the rest of Italy by Anna Maria Nannavecchia, Danila Bruno, Antonino Ardizzone, Enrico Caputo, Anna Melcarne, Antonia Mincuzzi, Fernando Palma, Lucia Bisceglia, Ida Galise, Francesco Cuccaro

“…Materials and methods: We collected accurate information about clinical and pathological variables, and measured crude and age-adjusted incidence and mortality rates, and estimated relative and net survival according to Ederer II and Pohar-Perme methods, respectively. …”
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Detection of atrial fibrillation in primary care with radial pulse palpation, electronic blood pressure measurement and handheld single-lead electrocardiography: a diagnostic accur... by Wim A M Lucassen, Henk C P M van Weert, Bjorn Winkens, Henri E J H Stoffers, J André Knottnerus, Steven B Uittenbogaart, Nicole Verbiest-van Gurp, Petra M G Erkens

“…Exclusion criteria were terminal illness, inability to give informed consent or visit the practice or having a pacemaker or an implantable cardioverter-defibrillator.Outcomes Diagnostic accuracy of individual tests and test combinations to detect unknown AF.Results We included 4339 patients; 0.8% showed new AF. …”
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Geriatric nutritional risk index as a predictor of 30-day and 365-day mortality in patients with acute myocardial infarction: a retrospective cohort study using the MIMIC-IV databa... by Xiaolong Zheng, Xiaolong Zheng, Xin Zheng, Xin Zheng, Changgui Zhang, Minghua Liu

“…This study aims to explore the correlation between the GNRI and the overall mortality within 30 days and 365 days in those with acute myocardial infarction (AMI).MethodsA retrospective analysis was performed utilizing the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. …”
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Implementation strategies: lessons learned during an e-learning intervention to improve dietary behaviors and feeding practices in early childhood education and care by Henrik Lian, Nina Cecilie Øverby, Frøydis Nordgård Vik, Anine Christine Medin, Natalie Garzon Osorio, Christine Helle, Tormod Bjørkkjær, Penelope Love, Harry Rutter, Mary Elizabeth Barker, Elisabet Rudjord Hillesund, Sissel Heidi Helland

“…I prefer when peers share experiences. 3) Newsletters were helpful and reminded me, but I do not always have enough time to read. 4) Evaluations have increased my awareness, and we do them informally and formally. 5) The regular phone calls reminded me I could receive support and express my opinion. …”
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The Predictive Value of Growth Differentiation Factor-15 in Recurrence of Atrial Fibrillation after Catheter Ablation by Ying Wei, Shuwang Liu, Haiyi Yu, Yuan Zhang, Wei Gao, Ming Cui, Lei Li

“…We prospectively included 150 consecutive AF patients who underwent RFCA. Clinical information about the patients was collected. Blood samples on the second morning of hospital admission and three months after RFCA were collected, and enzyme-linked immunosorbent assay (ELISA) was used to measure the concentration of GDF-15. …”
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Reconstruction and computer analysis of the structural and functional organization of the gene network regulating cholesterol biosynthesis in humans and the evolutionary characteri... by A. D. Mikhailova, S. A. Lashin, V. A. Ivanisenko, P. S. Demenkov, E. V. Ignatieva

“…Systematization of information about the molecular mechanisms controlling the activity of SREBP factors and cholesterol biosyn­thesis in the form of a gene network and building new knowledge about the gene network as a single object is extremely important for understanding the molecular mechanisms underlying the predisposition to diseases. …”
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Metabolic syndrome in type 1 diabetes: higher time above range and glycemic variability revealed by continuous glucose monitoring (CGM) by Yayu Fang, Wei Liu, Xiaoling Cai, Yu Zhu, Mingxia Zhang, Siqian Gong, Xiangqing Wang, Chu Lin, Rui Zhang, Sai Yin, Juan Li, Yongran Huo, Xiaodan Hu, Xiaoqi Xie, Linong Ji

“…Demographic data, anthropometric measurements, clinical information and continuous glucose monitoring (CGM) data were collected and compared between participants with metabolic syndrome and those without. …”
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From Acceptance to Dependence: Exploring Influences of Smart Healthcare on Continuous Use Intention of Mobile Health Services Among Older Adults with Chronic Illnesses in China by Jiacheng Luo, Kewei Zhang, Qianghong Huang, Shan Jiang, Younghwan Pan

“…With the acceleration of the aging process in China, chronic diseases have become one of the main health threats for older adults, creating significant pressure on society and the healthcare system. As information technology and artificial intelligence advance rapidly, smart health services have become readily accessible. …”
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Sex-related association between smoke exposure and gallstones in a US population: a cross-sectional study by Xingyong Huang, Xuanyu Hao, Tingting Wang, Xiaoyue Zhang, Peng Wu, Lufan Shen, Yuanyuan Yang, Wanchuan Zhang, Kai Zhang

“…The analysis was limited to individuals aged ≥ 20 years with complete information available. Self-reported smoking status, serum cotinine concentration, and self-reported gallstones conditions were combined to analyze the association of gallstones with smoking and cotinine concentration. …”
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Pharmacokinetic Characterisation and Comparison of Bioavailability of Intranasal Fentanyl, Transmucosal, and Intravenous Administration through a Three-Way Crossover Study in 24 He... by S. Nardi-Hiebl, J. W. Ndieyira, Y. Al Enzi, W. Al Akkad, T. Koch, G. Geldner, C. Reyher, L. H. J. Eberhart

“…The pharmacokinetics of one intranasal puff of fentanyl formulation (47 μg, 140 mL per puff), one short intravenous infusion of 50 μg fentanyl, and one lozenge with an integrated applicator (200 μg fentanyl) were studied, and bioavailability was calculated. …”
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No major impact of new grape varieties on Bordeaux wine typicity: expert assessments in blind and non-blind tastings by Marc Plantevin, Sophie Tempère, Cécile Thibon, Lucile Dijkstra, Julien Lecourt, Agnès Destrac-Irvine, Cornelis van Leeuwen

“…Assessing the wines through both blind and non-blind tastings (indication of the varieties present in the blend), the importance of the information on the typicity judgment was assessed. No significant differences were recorded between non-blind and blind tastings, showing that the perceptual judgement of the highly-experienced professionals was not influenced by the introduction of the new varieties to the classical blend. …”
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