The Upregulation of IL-1β Induced by Cisplatin Triggers PI3K/AKT/MMP9 Pathway in Pericytes Mediating the Leakage of the Blood Labyrinth Barrier by Yu M, Jiang WJ, Yu M, Zhou Z, Wang M, Li L

“…Keywords: cisplatin, BLB, IL-1β, MMP9, PI3K/AKT pathway…”
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In vivo interspecies dissemination of IncM2-type blaNDM-1 carrying plasmid by Mor N. Lurie-Weinberger, Darya Bychenko-Banyas, Meirav Mor, Sivan Laviad-Shitrit, Ella Kaplan, Nadya Rakovitsky, Alona Keren-Paz, Chaim Ben-Zvi, Yehuda Carmeli

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GM-CSF and IL-21-armed oncolytic vaccinia virus significantly enhances anti-tumor activity and synergizes with anti-PD1 immunotherapy in pancreatic cancer by Yujing Xuan, Wenyi Yan, Ruimin Wang, Xibin Wang, Yu Guo, Huilin Dun, Ziyan Huan, Lihua Xu, Ruxia Han, Xianlei Sun, Lingling Si, Nicholas R. Lemoine, Nicholas R. Lemoine, Yaohe Wang, Yaohe Wang, Pengju Wang

“…VVL-DD exhibited significant tumor selectivity in vitro and anti-tumor potency in vivo in a murine pancreatic cancer model. Then, VVL-DD was armed with an optimal combination of immunomodulatory molecules, granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-21 (IL-21), to produce VVL-GL21. …”
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Herbal Extract SH003 Suppresses Tumor Growth and Metastasis of MDA-MB-231 Breast Cancer Cells by Inhibiting STAT3-IL-6 Signaling by Youn Kyung Choi, Sung-Gook Cho, Sang-Mi Woo, Yee Jin Yun, Sunju Park, Yong Cheol Shin, Seong-Gyu Ko

“…Here, we demonstrate that our new herbal extract, SH003, suppresses both tumor growth and metastasis of MDA-MB-231 breast cancer cells via inhibiting STAT3-IL-6 signaling path. Our new herbal formula, SH003, mixed extract from Astragalus membranaceus, Angelica gigas, and Trichosanthes kirilowii Maximowicz, suppressed MDA-MB-231 tumor growth and lung metastasis in vivo and reduced the viability and metastatic abilities of MDA-MB-231 cells in vitro. …”
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Moscatilin inhibits vascular calcification by activating IL13RA2-dependent inhibition of STAT3 and attenuating the WNT3/β-catenin signalling pathway by Tingting Zhang, Mengmeng Zhu, Jialing Ma, Zhenghong Liu, Zhidan Zhang, Meijie Chen, Yaping Zhao, Huaxin Li, Shengnan Wang, Xiaoning Wei, Wenwen Zhang, Xiaoxiao Yang, Peter J. Little, Danielle Kamato, Hao Hu, Yajun Duan, Baotong Zhang, Jianbo Xiao, Suowen Xu, Yuanli Chen

“…Objectives: This study was designed to test the therapeutic effects and mechanism of Moscatilin (also known as dendrophenol) from Dendrobium huoshanense (an eminent traditional Chinese medicine) in suppressing vascular calcification in vitro, ex vivo and in vivo. Methods: Male C57BL/6J mice (25-week-old) were subjected to nicotine and vitamin D3 (VD3) treatment to induce vascular calcification. …”
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DMAV in Drinking Water Activated NF-κB Signal Pathway and Increased TGF-β and IL-1β Expressions in Bladder Epithelial Cells of Rats by Siqi Cao, Shengnan Liu, Fei Wang, Jieyu Liu, Mengdan Li, Chen Wang, Shuhua Xi

“…Dimethylarsinic acid (DMAV) is the main product of arsenic methylation metabolism in vivo and is rat bladder carcinogen and tumor promoting agent. …”
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Repurposing of phosphodiesterase-5 inhibitor sildenafil as a therapeutic agent to prevent gastric cancer growth through suppressing c-MYC stability for IL-6 transcription by Zhenzhan Zhang, Wuqing Huang, Donghua Huang, Zhou Xu, Qingfeng Xie, Xin Tan, Wenjun He, Weihao Yang, Guoxin Li, Jianguang Ji, Hao Liu

“…Mechanistically, sildenafil restrained GC growth by directly activating PKG through PDE5 inhibition for regulating c-MYC expression via its phosphorylation and ubiquitination degradation, thereby suppressing c-MYC stability for IL-6 transcription within the downstream IL-6/JAK/STAT3 signalling pathway. …”
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P2Y2 Receptor Induces L. amazonensis Infection Control in a Mechanism Dependent on Caspase-1 Activation and IL-1β Secretion by Maria Luiza Thorstenberg, Monique Daiane Andrade Martins, Vanessa Figliuolo, Claudia Lucia Martins Silva, Luiz Eduardo Baggio Savio, Robson Coutinho-Silva

“…Infected cells pretreated with IL-1R antagonist did not show reduced parasitic load after UTP and ATP treatment. …”
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Effet de l'illumination proche infra-rouge intracérébrale chez des primates MPTP by Fannie Darlot, Cécile Moro, Napoléon Torres‑Martinez, Claude Chabrol, Florian Reinhart, Diane Agay, Thomas Costecalde, John Mitrofanis, Alim‑Louis Benabid

“…Les traitements actuels sont tous des traitements symptomatiques, à ce jour il n’existe pas de traitement curatif de la MP. …”
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Partie 1 : Existe-t-il une corrélation entre le diamètre de la plaie de taille et la profondeur du cône de dessèchement ? by Emilie Bruez, Céline Cholet, Massimo Guidici, Marco Simonit, Mathilde Boisseau, Xavier Poitou, Patrice Coll, Laurence Gény-Denis

“… Alors que la taille est une pratique ancestrale et obligatoire pour la gestion du rendement et pour garder le plus longtemps possible la vigne en production, de nombreuses questions restent en suspens quant à son rôle sur la physiologie de la vigne, notamment en ce qui concerne la formation du cône de dessèchement qui est la résultante de la plaie de taille. Les tailles dites « respectueuses des flux de sèves » préconisent de ne pas tailler ras et de laisser un « chicot » c’est-à-dire une zone de bois entre la coupe et la base du rameau supprimé. …”
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Missing Trader Ontology (MTO): un’ontologia per il rilevamento delle società cartiere e la prevenzione delle frodi all’IVA intracomunitaria by Matteo Longo

“…Lo sviluppo di ontologie applicative, oltre a dotare gli Organi di controllo di una definizione unitaria del fenomeno fraudolento, fornisce l’elemento processabile dagli strumenti di ragionamento automatico per il rilevamento delle società “cartiere” e la prevenzione delle frodi all’IVA intracomunitaria.…”
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Effects of ALA-PDT on the murine footpad model of Fonsecaea monophora infection and its related mechanisms in vivo by Xuelin Wu, Wenyi Chen, Muhammad Danish Yaqoob, Kangxing Liu, Yanqing Hu, Yan Lu, Yongxuan Hu

“…Serum cytokines TNF-α, GM-CSF, IL-4, and IL-10 were measured using enzyme-linked immunosorbent assay to indicate changes in the immune microenvironment after PDT. …”
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Prolyl 4‐hydroxylase α‐subunit family regulation of type I collagen deposition and IL17RB/c‐Jun activation synergistically mediate choline dehydrogenase promotion of colorectal can... by Xiaowen Yang, Yifei Li, Xinzhuang Shen, Shuying Wang, Zhuqing Zhang, Wenfei Du, Chenglong Yang, Xinyu Jiang, Xiaoyuan Zhang, Yongming Huang, Wenzhi Shen

“…Together, P4HA and IL17RB promote CRC cell metastasis. P4HA and c‐Jun inhibitors abolished CHDH‐mediated CRC cell metastasis in vitro and in vivo. …”
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Gualou Guizhi Granule inhibits microglia-mediated neuroinflammation to protect against neuronal apoptosis in vitro and in vivo by Xuezhen Li, Han Huang, Yanan Li, Yi Feng, Jinxuan Wang, Shuping Luo, Yaping Chen, Yuqin Zhang, Guohong Yan, Lihong Nan

“…Additionally, we investigated the effects of GLGZG in combination with N-[N-[3,5-difluorophenacetyl]-L-alanyl]-S-phenylglycine t-butyl ester (DAPT) or siRNA-Notch1 to further elucidate the involvement of the Notch signaling pathway.ResultsGLGZG significantly inhibited microglia activation and reduced neuroinflammation by de-creasing the levels of pro-inflammatory cytokines IL-1β, IL-6, and TNF-α in both in vitro and in vivo models. …”
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HILARIA GŁÓWCZYŃSKA. MISTICA DELL’INTERCESSIONE by Zdzisław J. Kijas

“…Dopo una breve introduzione biografica, l’articolo descrive l’inizio delle esperienze mistiche di Suor Główczyńska e il “Diario spirituale” in cui registrava le comunicazioni interiori con Gesù. …”
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Lyophilized powder of calf bone marrow hydrolysate liposomes improved renal anemia: In vitro and in vivo evaluation. by Li Li, Shasha Zhao, Xiaodun Liu, Zhe Xu, Dong Li, Xiaoyu Dai

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Interleukin-1 Receptor-Associated Kinase-3 Aggravates Neuroinflammatory Injury After Intracerebral Hemorrhage via Activation NF-κB/IL-17A Pathway in Mice by Wang J, Li Y, Tan C, Shao J, Tang W, Kong Q, Sheng W, Ding Z, Li F, Piao J, Lv D, Hu L, Wang Q, Jiang X

“…The mechanisms of IRAK3 and neuroinflammation will be further investigated by Western blotting, qRT-PCR and immunofluorescence. Recombinant IL-17A was used to investigate the connection between IRAK3 and the NF-κB/IL-17A signaling pathway in vivo and in vitro experiments.Results: The expression of IRAK3 increased, peaking at 24 h, followed by a subsequent decrease after ICH. …”
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Identification and Verification of Novel Biomarkers Involving Rheumatoid Arthritis with Multimachine Learning Algorithms: An In Silicon and In Vivo Study by Fucun Liu, Juelan Ye, Shouli Wang, Yang Li, Yuhang Yang, Jianru Xiao, Aimin Jiang, Xuhua Lu, Yunli Zhu

“…CRTAM, PTTG1IP, ITGB2, and MMP13 were highly expressed in RA tissues and might function as pivotal diagnostic and treatment targets by deteriorating the immune dysfunction state. …”
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Matrine disturbs the eimeria necatrix-induced loop of tuft cell-intestinal stem cell-goblet cell by inactivating IL-13/JAK2/STAT3 signaling by Geng-xiu Zan, Hao-zhan Qu, Jia Meng, Xiao-fan Wang, Hui-chao Yan, Xiu-qi Wang, Jia-yi Zhou

“…In this study, we investigated the modulation effects of Matrine on the specific intestinal epithelial cell loop in EN-exposed chicks in vivo and intestinal organoids (IOs) ex vivo. The results showed that EN infection resulted in swelling and hemorrhage of the jejunum, accompanied by the increase in levels of sIgA and inflammatory cytokines (IL-6, IL-1β, and TNF-α). …”
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Chimeric cytokine receptor TGF-β RⅡ/IL-21R improves CAR-NK cell function by reversing the immunosuppressive tumor microenvironment of gastric cancer by Yaojun Ren, Min Xue, Xinhui Hui, Xiuyu Liu, Muhammad Asad Farooq, Yiran Chen, Yuzhou Ji, Yixin Duan, Iqra Ajmal, Jie Yao, Wenzheng Jiang

“…This study aims to tackle the challenge of TGF-β-mediated tumor immune evasion within the immunosuppressive tumor microenvironment by designing a novel chimeric cytokine receptor TRII/21 R, which consists of extracellular domains of TGF-β receptor II (TRII) and transmembrane and intracellular domains of IL-21 receptor (21 R) and can convert the immunosuppressive signal from TGF-β in the tumor microenvironment (TME) into an NK cell activation signal through the IL-21R-STAT3 pathway. …”
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