Il rapporto tra cybersicurezza e tutela dei dati personali: sinergie, bilanciamenti e parallelismi by Benedetto Ponti

“…Il saggio si propone anche di dare corpo a questa premessa, corroborando la tesi di un rapporto molto meno diretto e scontato di quanto non si possa ritenere prima facie, ciò che implica un livello maggiore di consapevolezza non solo tra gli studiosi e gli addetti ai lavori, ma da parte di tutti gli utenti dei servizi che l’ordinamento appresta a tutela dei dati personali, per un verso, e a tutela della sicurezza cibernetica, per l’altro.…”
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Expression of lipocortins in human bronchial epithelial cells: effects of IL-1β , TNF-α, LPS and dexamethasone by M. M. Verheggen, H. I. M. de Bont, P. W. C. Adriaansen-Soeting, B. J. A. Goense, C. J. A. M. Tak, H. C. Hoogsteden, P. Th. W. van Hal, M. A. Versnel

“…Stimulation of bronchial epithelial cells with IL-1β, TNF-α or LPS for 24 h did not affect the lipocortin I or II mRNA or protein expression, although PGE2 and 6-keto-PGF1α production was significantly increased. …”
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Splenic Stromal Cells from Aged Mice Produce Higher Levels of IL-6 Compared to Young Mice by Jihyun Park, Takuya Miyakawa, Aya Shiokawa, Haruyo Nakajima-Adachi, Masaru Tanokura, Satoshi Hachimura

“…Furthermore, stromal cells of aged mice highly expressed IL-6 mRNA after LPS injection in vivo. These results suggest that stromal cells play a role in producing IL-6 in aged mice and imply that they contribute to the chronic inflammatory condition in the elderly.…”
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Suppressive Effects of GSS on Lipopolysaccharide-Induced Endothelial Cell Injury and ALI via TNF-α and IL-6 by Lei Yi, Zengding Zhou, Yijuan Zheng, Mengling Chang, Xiaoqin Huang, Feng Guo, Quanming Zhao, Jingning Huan

“…In this study, we found that GSS not only downregulated the levels of TNF-α and IL-6 in the lung and serum of mice in vivo but also inhibited the expression and secretion of TNF-α and IL-6 in ECs. …”
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IL-6–174 G/C transversion might decrease male infertility risk: A case-control study by Tayyebeh Zamani-Badi, Mohammad Karimian, Javad Amini Mahabadi, Atieh Rafatmanesh, Hossein Nikzad

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Hei-Gu-Teng Zhuifenghuoluo Granule Modulates IL-12 Signal Pathway to Inhibit the Inflammatory Response in Rheumatoid Arthritis by Kang Zheng, Zexu Chen, Wen Sun, Bin Liu, Danping Fan, Qingqing Guo, Hui Luo, Jiawen Shen, Li Li, Xiaojuan He, Shuang Kou, Xiaoya Li, Guoming Pang, Hongchuan Zhao, Cheng Lu

“…After that, we use experimental validation such as collagen-induced arthritis (CIA) mice model in vivo and U937 cell model in vitro. The bioinformatics results suggested that HGT may have anti-inflammatory characteristic on RA and IL-12 signaling pathway could be the potential key trigger. …”
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Combinatorial immunotherapy with anti-ROR1 CAR NK cells and an IL-21 secreting oncolytic virus against neuroblastoma by Yaya Chu, Meijuan Tian, Uksha Saini, Jessica Ayala-Cuesta, Kayleigh Klose, Alyssa S. Mendelowitz, Keira Foley, Mehmet F. Ozkaynak, Wen Luo, Timothy P. Cripe, Dean A. Lee, Kevin A. Cassady, Mitchell S. Cairo

“…We found that C021-infected NB cells secreted hIL-21 in vitro and in vivo. Compared to the non-cytokine-secreting parental virus C134, C021 significantly enhanced the in vitro cytotoxicity (p < 0.05) of anti-ROR1-CAR-NK cells with increased interferon (IFN)-γ (p < 0.05), granzyme B (p < 0.05), and perforin (p < 0.05) secretion against NB cells. …”
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Carbon Monoxide Inhibits Tenascin-C Mediated Inflammation via IL-10 Expression in a Septic Mouse Model by Md. Jamal Uddin, Chun-shi Li, Yeonsoo Joe, Yingqing Chen, Qinggao Zhang, Stefan W. Ryter, Hun Taeg Chung

“…TN-C siRNA did not affect the CORM-2-dependent increase of IL-10 expression. …”
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Cromolyn sodium reduces LPS-induced pulmonary fibrosis by inhibiting the EMT process enhanced by MC-derived IL-13 by Cheng Tan, Hang Zhou, Qiangfei Xiong, Xian Xian, Qiyuan Liu, Zexin Zhang, Jingjing Xu, Hao Yao

“…Cromolyn sodium and mast cell knockout decreased the expression of EMT-related protein and IL-13, alleviated the symptoms of pulmonary fibrosis in vivo and in vitro. …”
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Genetic variation in IL-4 activated tissue resident macrophages determines strain-specific synergistic responses to LPS epigenetically by Mingming Zhao, Dragana Jankovic, Verena M. Link, Camila Oliveira Silva Souza, Katherine M. Hornick, Oyebola Oyesola, Yasmine Belkaid, Justin Lack, Png Loke

“…Abstract How macrophages in the tissue environment integrate multiple stimuli depends on the genetic background of the host, but this is still poorly understood. We investigate IL-4 activation of male C57BL/6 and BALB/c strain specific in vivo tissue-resident macrophages (TRMs) from the peritoneal cavity. …”
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Engineered GM-CSF polarizes protumorigenic tumor-associated macrophages to an antitumorigenic phenotype and potently synergizes with IL-12 immunotherapy by Yue Wang, Kevin Chang, Aslan Mansurov, Jun Ishihara, Seounghun Kang, Trevin Kurtanich, Hye Rin Chun, Anna J Slezak, Lisa R Volpatti, Thomas Wang, Aaron T Alpar, Kirsten C Refvik, O Isabella Hansen, Gustavo J Borjas, Brendan T K Berg, Ha-Na Shim, Kevin T Hultgren, Suzana Gomes, Ani Solanki, Melody A Swartz, Jeffrey A Hubbell

“…We further investigated the potentiation of DC response to IL-12 by GM-CSF stimulation ex vivo.Results Engineered GM-CSF restored an antitumorigenic tumor myeloid microenvironment otherwise suppressed by TAMs, while engineered IL-12 provided effector signals to T cells, thereby boosting both tumor-resident antitumor macrophage and CD8+ T cell populations. …”
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Fusobacterium nucleatum promotes colorectal cancer liver metastasis via miR-5692a/IL-8 axis by inducing epithelial-mesenchymal transition by Yulong Yu, Han Yin, Bili Wu, Weiheng Zhao, Yuan Wang, Aifeina Aili, Mu Yang, Qianqian Yu, Xianglin Yuan

“…Mechanistically, F. nucleatum infection increased the expression of IL-8 by downregulated the level of miR-5692a, a regulatory microRNA of IL-8. …”
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Effect of Platelet-activating Factor on in vitro and in vivo Interleukin-6 Production by B. Pignol, T. Maisonnet, P. Guinot, J. M. Mencia-Huertac, P. Braquet

“…The in vivo effect of PAF on IL-6 production was also investigated in the rat. …”
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Lycium barbarum polysaccharide inhibits retinal neovascularization and inflammation in vitro and in vivo by Bin Wu, Xue Wang, Wei Zhang, Xin Wang, Qi-Miao Wang, Ya-Ju Pang, Yi-Chun Kong

“…Compared with those in the hypoxic groups, Western blotting of HRECs and retinal tissues revealed that the expression of EGFR, PI3K, p-mTOR, p-AKT, IL-1β, iNOS, and TNF-α decreased in the LBP group but was still greater than that in control group. …”
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Early mucosal sensing of SIV infection by paneth cells induces IL-1β production and initiates gut epithelial disruption. by Lauren A Hirao, Irina Grishina, Olivier Bourry, William K Hu, Monsicha Somrit, Sumathi Sankaran-Walters, Chris A Gaulke, Anne N Fenton, Jay A Li, Robert W Crawford, Frank Chuang, Ross Tarara, Maria L Marco, Andreas J Bäumler, Holland Cheng, Satya Dandekar

“…An intestinal loop model was used to interrogate the effects of SIV infection on gut mucosal immune sensing and response to pathogens and commensal bacteria in vivo. …”
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Inhibition of NF-κB/IL-33/ST2 Axis Ameliorates Acute Bronchiolitis Induced by Respiratory Syncytial Virus by Liwen Zhang, Yu Wan, Liang Ma, Kaihong Xu, Baojin Cheng

“…In vivo study, we found that NF-κB/IL-33/ST2 axis is mediated the Th2 cytokine levels and BAL cell number induced by RSV. …”
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In Vivo Exposure of Deltamethrin Dysregulates the NFAT Signalling Pathway and Induces Lung Damage by Prakriti Sharma, R. S. Sethi

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Navigating from cellular phenotypic screen to clinical candidate: selective targeting of the NLRP3 inflammasome by Rosalie Matico, Karolien Grauwen, Dhruv Chauhan, Xiaodi Yu, Irini Abdiaj, Suraj Adhikary, Ine Adriaensen, Garcia Molina Aranzazu, Jesus Alcázar, Michela Bassi, Ellen Brisse, Santiago Cañellas, Shubhra Chaudhuri, Francisca Delgado, Alejandro Diéguez-Vázquez, Marc Du Jardin, Victoria Eastham, Michael Finley, Tom Jacobs, Ken Keustermans, Robert Kuhn, Josep Llaveria, Jos Leenaerts, Maria Lourdes Linares, Maria Luz Martín, Rosa Martín-Pérez, Carlos Martínez, Robyn Miller, Frances M Muñoz, Michael E Muratore, Amber Nooyens, Laura Perez-Benito, Mathieu Perrier, Beth Pietrak, Jef Serré, Sujata Sharma, Marijke Somers, Javier Suarez, Gary Tresadern, Andres A Trabanco, Dries Van den Bulck, Michiel Van Gool, Filip Van Hauwermeiren, Teena Varghese, Juan Antonio Vega, Sameh A Youssef, Matthew J Edwards, Daniel Oehlrich, Nina Van Opdenbosch

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cAMP analogues downregulate the expression of granulocyte macrophage colony-stimulating factor (GM-CSF) in human bone marrow stromal cells in vitro by G. Bug, J. Aman, C. Huber, C. Peschel, H. G. Derigs

“…The stimulation of granulocyte macrophage-colony stimulating factor (GM-CSF) by interleukin-1 (IL-1) has been shown to be counteracted in different mesenchymal cell systems by cyclic adenosine monophosphate (cAMP) agonists. …”
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Investigation of calonysterone and 20-hydroxyecdysone effects in high-fat, high-sugar diet-induced obesity rat model by Alaa AM. Osman, Dávid Laczkó, Máté Vágvölgyi, Adrienn Seres-Bokor, Anita Sztojkov-Ivanov, Kata Kira Kemény, Attila Hunyadi, Eszter Ducza

“…Our ongoing research examines the impacts of 20E and calonysterone (CAL) in an animal model with a diet high in fats and sugars (HFHSD).Glucose tolerance tests assessed prediabetic status and RT-PCR and Western blot analysis determined interleukin-6 (IL6) expression. …”
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