A Comparative In Vitro Study of the Effects of Separate and Combined Products of Citrus e fructibus and Cydonia e fructibus on Immunological Parameters of Seasonal Allergic Rhiniti... by E. W. Baars, M. C. Jong, I. Boers, A. F. M. Nierop, H. F. J. Savelkoul

“…Peripheral blood mononuclear cells (PBMCs) from five healthy and five grass pollen-allergic donors were isolated and analyzed in vitro after polyclonal and allergen-specific stimulation of T cells in the presence of the three extracts. …”
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Pyrroloquinoline Quinone Administration Alleviates Allergic Airway Inflammation in Mice by Regulating the JAK-STAT Signaling Pathway by Zhihui Min, Jiebai Zhou, Ruolin Mao, Bo Cui, Yunfeng Cheng, Zhihong Chen

“…In vitro, the effects of PQQ on the secretion of epithelial-derived cytokines by house dust mite- (HDM-) incubated 16-HBE cells and on the differentiation potential of CD4+ T cells were investigated. In vivo, PQQ was administered to mice with ovalbumin- (OVA-) induced asthma, and lung pathology and inflammatory cell infiltration were assessed. …”
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Exploring the mechanisms by which common inhalational anesthetics influence malignant tumor metastasis: A data mining study based on comparative toxicogenomic databases by Yiyu Chen, Wenlan Ouyang, Hu Lv, Wei Chen

“…Functional enrichment analysis revealed that these anesthetics could influence tumor cell migration by activating signaling pathways such as the IL-17 and tumor necrosis factor signaling pathways, thereby potentially inducing tumor metastasis. …”
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Triptolide Inhibits Th17 Response by Upregulating microRNA-204-5p and Suppressing STAT3 Phosphorylation in Psoriasis by Qi He, Xingyue Wu, Quan Shi

“…Enzyme-linked immunosorbent assay was conducted to examine interleukin (IL)-17 and interferon-γ (IFN-γ) levels using corresponding kits. …”
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Examining the Effect of Consuming C8 Medium-Chain Triglyceride Oil for 14 Days on Markers of NLRP3 Activation in Healthy Humans by Helena Neudorf, Garett Jackson, Jonathan P. Little

“…The ketone body beta-hydroxybutyrate (βHB) suppresses the NLRP3 inflammasome and alters intracellular signalling pathways in vitro and in animal models; however, this effect has not yet been shown in vivo in humans. The purpose of this single-arm pilot trial was to determine if consuming 15 mL of C8 medium-chain triglyceride (trioctanoin; MCT) oil, which induces mild elevation of βHB, twice daily (30 mL total) for 14 days would suppress markers of NLRP3 inflammasome activation in young, healthy humans while following their habitual diet. …”
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Network Pharmacology Analysis of the Therapeutic Potential of Colchicine in Acute Lung Injury by Fei Sun, Lijuan Zhang, Lulu Shen, Chunman Wang

“…ALI-related genes were curated using databases such as DisGeNET, Therapeutic Target, and Comparative Toxicogenomics Database to curate ALI-related genes. …”
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Pyroptosis-Related Signature Predicts the Progression of Ulcerative Colitis and Colitis-Associated Colorectal Cancer as well as the Anti-TNF Therapeutic Response by Yumei Ning, Kun Lin, Jun Fang, Xiaojia Chen, Xinyi Hu, Lan Liu, Qiu Zhao, Haizhou Wang, Fan Wang

“…By intersecting with the differentially expressed PRGs, CASP5, GBP1, GZMB, IL1B, and IRF1 were selected as key PRGs to construct a pyroptosis-related signature (PR-signature). …”
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DSA e EMFA: speciale responsabilità delle piattaforme online e tutela della libertà dei media by Liliana Ciliberti

“…Il margine di discrezionalità che viene lasciato alle piattaforme online di dimensioni molto grandi nei confronti dei servizi di media presenti sui loro servizi è troppo ampio e solleva preoccupazioni. …”
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Arginase-1-specific T cells target and modulate tumor-associated macrophages by Mads Hald Andersen, Inés Lecoq, Ayako Wakatsuki Pedersen, Evelina Martinenaite, Shamaila Munir Ahmad, Maria Perez-Penco, Lucia Lara de la Torre, Marion Chapellier, Lars Rønn Olsen, Mia Aaboe-Jørgensen, Hannah Jorinde Glöckner, Anne Mette Askehøj Rømer

“…Furthermore, murine CD4+Arg1-specific T cells were able to target TAMs and effectively reprogram their phenotype ex vivo by secreting IL2 and IFNγ. Next, we established that human Arg1+TAMs present Arg1-derived peptides and are directly recognized by proinflammatory CD4+Arg1-specific T cell clones. …”
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miR-26a-5p Attenuates Oxidative Stress and Inflammation in Diabetic Retinopathy through the USP14/NF-κB Signaling Pathway by Jie Bian, Weizhong Ge, Zhengmei Jiang

“…The concentration of proinflammatory factors (TNF-α, IL-1β, and IL-6) was evaluated by ELISA. Hematoxylin-eosin staining for murine retinal tissues was performed for histopathological analysis. …”
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Exploring the Anti-PANoptosis Mechanism of Dachaihu Decoction Against Sepsis-Induced Acute Lung Injury: Network Pharmacology, Bioinformatics, and Experimental Validation by Yang Z, Kao X, Zhang L, Huang N, Chen J, He M

“…In vivo, DCHD improved lung histopathological injury, reduced inflammatory factor expression, and alleviated oxidative stress injury in lung tissues. …”
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Exosomes secreted by ATF3/Nrf2-mediated ferroptotic renal tubular epithelial cells promote M1/M2 ratio imbalance inducing renal interstitial fibrosis following ischemia and reperfu... by Qiao Tang, Jiatao Xie, Yifei Wang, Chong Dong, Chong Dong, Qian Sun

“…Therefore, we aimed to explore the mechanisms by which ferrotosis occurs in renal tubular epithelial cells (RTECs) and ferroptotic cell-derived exosomes induce macrophage polarization in IRI-related RIF model.MethodsIn vivo, C57BL/6J mice were randomly divided into four groups: sham group, ischemia and reperfusion (IR) group, IR + Ferrostatin-1 (Fer-1) group, and IR +ATF3 knockdown (ATFKD) group. …”
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Anti-inflammatory treatment using alpha melanocyte stimulating hormone (α-MSH) does not alter osteoblasts differentiation and fracture healing by Johanna Graue, Melanie Timmen, Katharina Schmitz, Daniel Kronenberg, Markus Böhm, Kishor K. Sivaraj, M. Gabriele Bixel, Richard Stange

“…Therefore, we evaluated the impact of α-MSH-treatment on bone forming cells in an inflammatory setting in vitro and as a treatment approach in a murine fracture healing model in vivo. Methods The influence of α-MSH treatment and melanocortin-receptor expression patterns was investigated in vitro in the presence of either IL-1β or/and TNF-α as an inflammatory stimulus. …”
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Adipose-Derived Mesenchymal Stem Cells Migrate and Rescue RPE in the Setting of Oxidative Stress by Aya Barzelay, Shira Weisthal Algor, Anat Niztan, Sebastian Katz, Moshe Benhamou, Itay Nakdimon, Noam Azmon, Sandy Gozlan, Daphna Mezad-Koursh, Meira Neudorfer, Michaella Goldstein, Benjamin Meilik, Anat Loewenstein, Adiel Barak

“…In vivo, mice received systemic injection of NaIO3, and 72 h later, ASCs were transplanted in the subretinal space. …”
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AI Act e consulenza legale online: problemi in tema di accesso alla giustizia by Paolo Comoglio

“…Il saggio esamina l'impatto dell'intelligenza artificiale generativa sul modello tradizionale di avvocatura, evidenziando i rischi per il monopolio degli avvocati nella consulenza legale. …”
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Diritto di difesa, accesso a Internet e rimozione degli “ostacoli di ordine economico e sociale” by Simone Cafiero

“…Muovendo da una ricostruzione del principio di eguaglianza sostanziale come principio che impone la rimozione delle diseguaglianze che attengono alla distribuzione delle “utilità fondamentali”, a ciascuna delle quali corrisponde la previsione di un diritto sociale costituzionalmente garantito, il presente lavoro si misura con il tema della costituzionalizzazione espressa di un diritto all’accesso alla Rete, in un contesto nel quale la possibilità di accedere efficacemente al cyberspazio rappresenta una condizione necessaria al pieno esercizio di un ampio insieme di diritti costituzionali. …”
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Nuove prassi e norme per un sistema sanitario “smart”: ricadute dell’AI Act sulla relazione di cura by Tonino Cantelmi, Luisa Lodevole

“…L’articolo si propone di esplorare lo stato dell’arte dell'utilizzo dei sistemi di IA nel settore sanitario, in particolare sotto forma di software per il processo decisionale clinico e di dispositivi medici. …”
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Dalla legalità algoritmica alla legalità (dell’amministrazione) artificiale. Premesse ad uno studio by Enrico Carloni

“…L’avvento delle intelligenze artificiali, ora nella forma delle AI generative, come ChatGPT, pone problemi formidabili ed al tempo stesso offre straordinarie opportunità di miglioramento dell’azione pubblica. La questione, dal punto di vista del diritto amministrativo, è quella di comprendere il fenomeno e quindi riflettere su quali regole possano continuare a garantire l’individuo nel rapporto con il nuovo potere digitale. …”
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Cryopreserved Umbilical Cord Mesenchymal Stem Cells Show Comparable Effects to Un-Cryopreserved Cells in Treating Osteoarthritis by Bo Yan, Huixin Chen, Li Yan, Qiang Yuan, Le Guo

“…In vitro, C-CFM and UC-CM promoted the proliferation of chondrocytes, improved the expression of anabolism-related molecules ( Col2 , COL2, and SOX9), and decreased the expression of catabolism-related molecules ( Adamts5 , Mmp13 , Il6 , COL10, and MMP13). These results indicated that UC-MSCs and C-MSCs had comparable anti-OA effects, and cryopreservation did not alter the anti-OA capability of hucMSCs, which provides further support for clinical use of C-MSCs in treating OA.…”
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Peroxisome Proliferator-Activated Receptor γ Induces the Expression of Tissue Factor Pathway Inhibitor-1 (TFPI-1) in Human Macrophages by G. Chinetti-Gbaguidi, C. Copin, B. Derudas, N. Marx, J. Eechkoute, B. Staels

“…Here we report that PPARγ activation increases the expression of TFPI-1 in human macrophages in vitro as well as in vivo in circulating peripheral blood mononuclear cells. …”
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