Evaluation of immunomodulatory effects of lamotrigine in BALB/c mice by Abu-Rish Eman Y., Elhayek Shada Y., Mohamed Yehia S., Hamad Islam, Bustanji Yasser

“…These included the in vivo effects of lamotrigine on delayed-type hypersensitivity (DTH) response to sheep red blood cell (SRBC) antigens, hemagglutination titer assays and hematological changes. …”
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Regulation of the IgE response by T follicular regulatory cells by Alexander L. Dent

“…T follicular helper (TFH) cells expressing IL-4 are required for the development of IgE expressing B cells in the germinal center (GC). …”
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Intelligenza artificiale in medicina: alcune risposte – significative, ma parziali – offerte dal codice di deontologia medica (in materia di non discriminazione, consenso informato... by Paolo Zuddas

“…In particolare, si intende evidenziare come il ricorso a sistemi di AI medica: aumenti il rischio di operare discriminazioni nell’erogazione delle prestazioni sanitarie, in conseguenza dell’impiego, nell’addestramento dei sistemi di machine learning, di dati distorti e di dati incompleti; ponga in crisi l’istituto del consenso informato, stante la necessità di fornire informazioni complete concernenti anche le logiche di funzionamento dei sistemi informatici eventualmente coinvolti nell’attività diagnostica o terapeutica, a fronte delle note forme di opacità dei sistemi di AI; trasformi progressivamente il rapporto di cura, con ricadute destinate ad incidere sia sulla natura delle valutazioni cliniche sia sul ruolo del medico, chiamato ad operare sempre più come intermediario tra il paziente e il sistema informatico. …”
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Metaverso, Digital Twins e diritti fondamentali by Antonio Iannuzzi

“…Il diritto deve affrontare la regolazione del metaverso, essendo alle porte la diffusione del web 4.0: la quarta generazione del World Wide Web che, utilizzando l'intelligenza artificiale e ambientale avanzata, l’Internet delle cose, le transazioni blockchain affidabili, i mondi virtuali e le funzionalità XR, permette agli oggetti e agli ambienti digitali e reali di integrarsi completamente e di comunicare tra loro; promette di consentire esperienze realmente intuitive e immersive, fondendo senza soluzione di continuità il mondo fisico e quello digitale. …”
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Amantadine modulates novel macrophage phenotypes to enhance neural repair following spinal cord injury by Shijie Yang, Beibei Yu, Qing Zhang, Yongfeng Zhang, Longhui Fu, Bisheng Zhou, Haining Wu, Jianzhong Li, Shouping Gong

“…Subsequent in vitro and in vivo experiments demonstrated that amantadine reduces Il-1b+ IMs and facilitates the transition to Mrc1+ BAMs and Arg1+ CIMs, likely through modulation of the HIF-1α and NF-κB pathways. …”
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Pharmacological Effects of Antioxidant Mycosporine-Glycine in Alleviating Ultraviolet B-Induced Skin Photodamage: Insights from Metabolomic and Transcriptomic Analyses by Kai Wang, Ling Qin, Huan Lin, Mengke Yao, Junhan Cao, Qing Zhang, Changfeng Qu, Yingying He, Jinlai Miao, Ming Liu

“…Furthermore, M-Gly reduced inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and IL-1β, typically upregulated after UVB exposure. …”
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Nanoparticles transfected with plasmid-encoded lncRNA-OIP5-AS1 inhibit renal ischemia-reperfusion injury in mice via the miR-410-3p/Nrf2 axis by Rongjie Zhang, Xin Zhang, Xuhui Zhu, Tao Li, Yansheng Li, Peng Zhang, Yuanhao Chen, Gao Li, Xiuwu Han

“…RI/R or OGD/R models were established in mice and HK-2 cells, respectively. In vivo, vector or POP-NPs were administered (10 nmol, IV) 48 h after RI/R treatment. …”
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New bitongling regulates gut microbiota to predict angiogenesis in rheumatoid arthritis via the gut-joint axis: a deep neural network approach by Yin Guan, Xiaoqian Zhao, Yun Lu, Yue Zhang, Yan Lu, Yue Wang

“…The findings were further validated through analysis with deep neural network models and in vivo/in vitro experiments, including western blot, immunofluorescence, and miRNA analysis.ResultsNBTL treatment markedly diminished inflammation in RA rats, evidenced by the reduced expression of TNF-α, IL-17, IL-6, and ASC in synovial tissues. …”
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La tutela dei minori nel prisma della protezione dei dati personali. I sistemi di verifica dell’età tra personalismo ed esigenze di bilanciamento fra diritti by Simonetta Trozzi

“…Il saggio analizza il rapporto tra i sistemi di controllo dell’età degli utenti dei servizi online e la disciplina della protezione dei dati personali. …”
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Quale nozione di pluralismo nell’EMFA? by Ottavio Grandinetti

“…L’articolo si propone, attraverso l’analisi del regolamento (UE) 2024/1083, da un lato di verificare quale nozione di pluralismo abbia tenuto presente il legislatore europeo nell’EMFA (European Media Freedom Act) e, dall’altro lato, di individuare le risposte che il legislatore europeo ha dato alle c.d. nuove sfide del pluralismo informativo. …”
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Exemestane Attenuates Hepatic Fibrosis in Rats by Inhibiting Activation of Hepatic Stellate Cells and Promoting the Secretion of Interleukin 10 by Ya-Hui Wang, Rong-Kun Li, Ying Fu, Jun Li, Xiao-Mei Yang, Yan-Li Zhang, Lei Zhu, Qin Yang, Jian-Ren Gu, Xin Xing, Zhi-Gang Zhang

“…Additionally, EXE promoted the secretion of antifibrotic and anti-inflammatory cytokine IL-10 in vivo and in HSC-T6 culture media. In conclusion, our findings reveal a new function of EXE on hepatic fibrosis and prompted its latent application in liver fibrotic-related disease.…”
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Shrimp White Spot Viral Infections Are Attenuated by Organic Acids by Regulating the Expression of HO-1 Oxygenase and β-1,3-Glucan-Binding Protein by Ioan Pet, Igori Balta, Nicolae Corcionivoschi, Tiberiu Iancu, Ducu Stef, Lavinia Stef, Iuliana Cretescu

“…With this exploratory study we aimed to test, both in vitro and in vivo, the efficacy of an organic acid mixture (Aq) against WSSV infections in shrimp. …”
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A data-driven approach to establishing cell motility patterns as predictors of macrophage subtypes and their relation to cell morphology. by Manasa Kesapragada, Yao-Hui Sun, Kan Zhu, Cynthia Recendez, Daniel Fregoso, Hsin-Ya Yang, Marco Rolandi, Rivkah Isseroff, Min Zhao, Marcella Gomez

“…We apply both morphology and motility-based image processing approaches to analyze live cell images consisting of macrophage phenotypes. …”
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Induced Pluripotent Stem Cell-Differentiated Chondrocytes Repair Cartilage Defect in a Rabbit Osteoarthritis Model by Yu-Hsun Chang, Kun-Chi Wu, Dah-Ching Ding

“…The transplanted cartilage expressed less IL-1β, TNF-α, and MMP13 than control cartilage. …”
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DPSCs Protect Architectural Integrity and Alleviate Intervertebral Disc Degeneration by Regulating Nucleus Pulposus Immune Status by Xiwen Dong, Fanqi Hu, Jing Yi, Yuning Zhang, Chao Liu, Panpan Geng, Han Duan, Chu-Tse Wu, Xuesong Zhang, Hua Wang

“…Intervertebral disc (IVD) degeneration is the primary cause for low back pain that has a high prevalence in modern society and poses enormous economic burden on patients. …”
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Protective mechanism of quercetin nanoliposomes on hydrogen peroxide-induced oxidative damage in 3D Caco-2 cell model by Xiaofeng Liu, Zhiyuan Zhou, Xiaoqin Lu, Hao Zhong, Rongjun He, Ziwei Feng, Rongfa Guan

“…Compared with 2D cell models, 3D cell models are more similar to the in vivo microenvironment and more sensitive to external stimuli. …”
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Soft Artificial Synapse Electronics by Md. Rayid Hasan Mojumder, Seongchan Kim, Cunjiang Yu

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Paraoxonase 2 Induces a Phenotypic Switch in Macrophage Polarization Favoring an M2 Anti-Inflammatory State by Marie Koren-Gluzer, Mira Rosenblat, Tony Hayek

“…Thus, the aim of our study was to analyze the direct effect of PON2 on macrophage inflammatory phenotypes. Ex vivo studies were performed with murine peritoneal macrophages (MPM) harvested from control C57BL/6 and PON2-deficient (PON2KO) mice. …”
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TRIM28 is an essential regulator of three-dimensional chromatin state underpinning CD8+ T cell activation by Kun Wei, Ruifeng Li, Xiaohong Zhao, Bowen Xie, Tian Xie, Qinli Sun, Yongzhen Chen, Peng Wei, Wei Xu, Xinyi Guo, Zixuan Zhao, Han Feng, Ling Ni, Chen Dong

“…We show that CD8+ T-cell-specific deletion of Trim28 in mice disrupts autocrine IL-2 production and leads to impaired CD8+ T cell activation in vitro and in vivo. …”
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LMW Heparin Prevents Increased Kidney Expression of Proinflammatory Mediators in (NZBxNZW)F1 Mice by Annica Hedberg, Premasany Kanapathippillai, Ole Petter Rekvig, Kristin Andreassen Fenton

“…Heparin treatment of B/W mice reduced the in vivo expression of CCR2, IL1β, and TLR7 compared to untreated B/W mice. …”
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