Lunasin protease inhibitor concentrate decreases pro-inflammatory cytokines and improves histopathological markers in dextran sodium sulfate-induced ulcerative colitis by Andrea Nieto-Veloza, Zhihong Wang, Qixin Zhong, Doris D’Souza, Hari B. Krishnan, Vermont P. Dia

“…In vivo, LPIC increased colonic bleeding and did not improve macroscopic markers of the disease, but reduced colonic IL-1β and IL-6, decreased systemic circulation of TNF-α, attenuated neutrophils infiltration and iNOS expression in colonic tissue, and diminished the damage in colonic architecture. …”
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Lack of Proinflammatory Cytokine Interleukin-6 or Tumor Necrosis Factor Receptor-1 Results in a Failure of the Innate Immune Response after Bacterial Meningitis by Lea-Jessica Albrecht, Simone C. Tauber, Julika Merres, Eugenia Kress, Matthias B. Stope, Sandra Jansen, Thomas Pufe, Lars-Ove Brandenburg

“…The goal of the current study was to examine the interaction between IL-6 and TNFR1 as receptor for TNF-α and the innate immune response in vivo in a model of Streptococcus pneumoniae-induced meningitis. …”
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The MicroRNA-106a/20b Strongly Enhances the Antitumour Immune Responses of Dendritic Cells Pulsed with Glioma Stem Cells by Targeting STAT3 by Hui Zhou, Chengmei Sun, Cong Li, Shiting Hua, Feng Li, Ruichun Li, Dongpeng Cai, Yuxi Zou, Yingqian Cai, Xiaodan Jiang

“…The production and secretion of the cytokines IL-6, IL-12, TNF-α, and IL-10 in DCs induced by GSCs were determined by enzyme-linked immunosorbent assay. …”
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Regulation of NK cell development, maturation, and antitumor responses by the nuclear receptor NR2F6 by Johannes Woelk, Florian Hornsteiner, Stephanie Aschauer-Wallner, Patrizia Stoitzner, Gottfried Baier, Natascha Hermann-Kleiter

“…Consequently, Nr2f6-deficient IL-15 complex-treated NK cells raise enhanced effector responses of IFNγ, Perforin, and Granzyme B upon ex vivo activation. …”
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Ruxolitinib synergizes with regulatory T cells to improve inflammation but has no added benefits in decreasing albuminuria in SLE by Mi-Ae Lyu, Ximing Tang, Maria Gabriela Raso, Meixian Huang, Ke Zeng, Tara Sadeghi, Christopher R. Flowers, Simrit Parmar

“…UCB-Treg and ruxolitinib combination also downregulates the soluble form of inflammatory cytokines including IFN-γ, IP-10, TNF-α, IL-6, sCD40L, IL-17A, IL-17F, IL-1α, and LIF in cocultures. …”
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Jiaweishaoyao Decoction Alleviates DSS-Induced Ulcerative Colitis via Inhibiting Inflammation by Huixia Qiao, Yahui Huang, Xiaoyan Chen, Long Yang, Yue Wang, Rongrong Xu

“…The levels of TNF-α, IL-1β, and IL-6 were analyzed by ELISA and qRT-PCR. …”
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Diagnostic approach to limbal stem cell deficiency by Daniella Lent-Schochet, Mizna Akbar, Joshua H. Hou, Asim V. Farooq

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Interleukin-29 Enhances Synovial Inflammation and Cartilage Degradation in Osteoarthritis by Lingxiao Xu, Qiuyue Peng, Wenhua Xuan, Xiaoke Feng, Xiangqing Kong, Miaojia Zhang, Wenfeng Tan, Meilang Xue, Fang Wang

“…Furthermore, recombinant IL-29 augmented the mRNA expression of IL-1β, IL-6, IL-8, and matrix-metalloproteinase-3 (MMP-3) in OA FLS and increased cartilage degradation when ex vivo OA cartilage explant was coincubated with OA FLS. …”
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Genetically Modified Lactococcus lactis for Delivery of Human Interleukin-10 to Dendritic Cells by Inge L. Huibregtse, Sebatian A. Zaat, Martien L. Kapsenberg, Maria A. Sartori da Silva, Maikel P. Peppelenbosch, Sander J. H. van Deventer, Henri Braat

“…The spatially restricted delivery of IL-10 by food-grade bacteria is a promising strategy to induce suppressor Th-cells in vivo and to treat inflammatory diseases.…”
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CD22 modulation alleviates amyloid β-induced neuroinflammation by Yu Dong Mai, Qingqing Zhang, Cheuk Lim Fung, Shui On Leung, Chi Ho Chong

“…Here we reported that sCD22 promotes neuroinflammation both in vivo and in vitro. sCD22 activated microglia via both p38 and ERK1/2 signaling pathway for the secretion of TNFα, IL-6 and CCL3. …”
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Terminal complement complex deposition on chondrocytes promotes premature senescence in age- and trauma-related osteoarthritis by Leonie Ruths, Jana Hengge, Graciosa Q. Teixeira, Melanie Haffner-Luntzer, Anita Ignatius, Jana Riegger

“…Explants were additionally treated with clusterin (CLU, TCC inhibitor), N-acetylcysteine (NAC, antioxidant), Sarilumab (IL-6 receptor inhibitor), STAT3-IN-1 (STAT3 inhibitor), or IL-1 receptor antagonist (IL-1RA) in order to investigate the consequences of TCC deposition. …”
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Interleukin-7 Resensitizes Non-Small-Cell Lung Cancer to Cisplatin via Inhibition of ABCG2 by Bin Ke, Ting Wei, Yuanyuan Huang, Yuxin Gong, Gang Wu, Junfang Liu, Xiaoting Chen, Lin Shi

“…In vivo results also confirmed that IL-7 only in combination with DDP could remarkably induce tumor regression with reduced levels of ABCG2 in tumorous tissues. …”
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Evidence for Transfer of Membranes from Mesenchymal Stem Cells to HL-1 Cardiac Cells by Robert A. Boomsma, David L. Geenen

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Functionalization of collagen fiber with nano-islands of silver via atomic layer deposition to promote bone healing by Sarah Hashemi Astaneh, Leonardo P. Faverani, Harshdeep Bhatia, Eduardo Dallazen, Monique Gonçalves Costa, Edilson Ervolino, Valentim A.R. Barão, Cortino Sukotjo, Christos G. Takoudis

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Cellular Anti-Inflammatory and Antioxidant Activities of Bamboo Sasa albomarginata Leaf Extract and Its Constituent Coumaric Acid Methyl Ester by Shiori Kojima, Masatoshi Hakamata, Toshimichi Asanuma, Rie Suzuki, Jun-ichi Tsuruda, Takeshi Nonoyama, Yinzhi Lin, Hitomi Fukatsu, Naoki Koide, Kazuo Umezawa

“…It also inhibited iNOS, IL-6, and IL-1β expressions. Moreover, it inhibited LPS-induced IL-6 expression and production in human monocyte leukemia THP-1 cells differentiated into macrophages. …”
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Inflammatory Mediator Profiling Reveals Immune Properties of Chemotactic Gradients and Macrophage Mediator Production Inhibition during Thioglycollate Elicited Peritoneal Inflammat... by Derek Lam, Devon Harris, Zhenyu Qin

“…Here, we used murine thioglycollate elicited peritonitis to determine concentrations of 23 inflammatory mediators in peritoneal exudates and plasma before (day 0) and after (days 1 and 3) thioglycollate administration to peritoneal cavities; these mediators included TNF-α, FGF-9, IFN-γ, IP-10, RANTES, IL-1α, IL-6, IL-7, IL-10, IL-11, IL-12p70, IL-17A, lymphotactin, OSM, KC/GRO, SCF, MIP-1β, MIP-2, TIMP-1, VEGF-A, MCP-1, MCP-3, and MCP-5. …”
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ABIN1 Inhibits Inflammation through Necroptosis-Dependent Pathway in Ulcerative Colitis by Jing Bao, Bin Ye, Yuhan Ren

“…Upon TNF-α stimulation in the intestinal epithelia cell line, overexpression of ABIN1 significantly inhibits necroptosis in the intestinal inflammation model along with the reduction expression of pro-inflammatory cytokines such as IL1B, IL6, IL8, and TNF-α. Blocking RIPK1 by Nec-1s in vivo and in vitro dramatically alleviated the colitis and cell death which shares the same phenotype with ABIN1 overexpression. …”
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Deletion of AMP-activated protein kinase impairs metastasis and is rescued by ROS scavenging or ectopic CD36 expression by Gopalakrishnan Ramakrishnan, Alexander R. Terry, Veronique Nogueira, Ahmed Magdy, Nissim Hay

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Proinflammatory Mediators of Toxic Shock and Their Correlation to Lethality by Teresa Krakauer, Marilyn J. Buckley, Diana Fisher

“…This study examines the cytokine response and lethality of mice exposed to varying doses of staphylococcal enterotoxin B (SEB) or lipopolysaccharide (LPS) and their combinations. In vivo, SEB alone induced moderate levels of IL-2 and MCP-1 and all mice survived even with a high dose of SEB (100 μg/mouse). …”
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PreS1 deletions in genotype C HBV leads to severe hepatic inflammation and hepatocarcinogenesis via the IRE1-JNK axis by Yu-Min Choi, Junghwa Jang, Dong Hyun Kim, Ziyun Kim, Eunseo Kim, Won Hyeok Choe, Bum-Joon Kim

“…We found that the preS1Del variant selectively activates the IRE1 pathway, primarily through enhanced IRE1-JNK-IL6 signaling. Inhibition of either the IRE1-JNK pathway or IL6 reduced HBV replication and tumor load in in vivo HCC models. …”
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