Prioritization of potential pharmacological targets for the development of anti-hepatocarcinoma drugs modulating the extrinsic apoptosis pathway: the reconstruction and analysis... by P. S. Demenkov, E. A. Antropova, A. V. Adamovskaya, E. I. Mishchenko, T. M. Khlebodarova, T. V. Ivanisenko, N. V. Ivanisenko, A. S. Venzel, I. N. Lavrik, V. A. Ivanisenko

“…The reconstruction of gene networks describing the molecular mechanisms of interaction of aberrantly methylated genes with key participants of the extrinsic apoptosis pathway and their regulation by HCV proteins can provide important information when searching for pharmacological targets. …”
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Archeohandi: protocol for a national disabilities database in archaeology in France by Rozenn Colleter, Valérie Delattre, Cyrille Le Forestier, Alex Baiet, Philippe Blanchard, Fanny Chenal, Anne-Sophie Coupey, Stéphanie Desbrosse-Degobertière, Sylvie Duchesne, Cécile Durin, Jean-Luc Gisclon, Noémie Gryspeirt, Fanny La Rocca, Raphaëlle Lefebvre, Jérôme Livet, Cécile Paresys, Mikaël Rouzic, Isabelle Souquet, Florence Tane, Aminte Thomann, Ivy Thomson, Émilie Trébuchet, Marie-Cécile Truc, Jean-Baptiste Barreau

“…Our database is hosted on the Huma-Num platform, with a management interface and quick access based on multiple tabs. The data includes information about archaeological operations, subjects, and pathologies; it is complemented by pictorial data stored on the Nakala platform. …”
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Epidemiological features and risk factors of human psittacosis in Hangzhou City, eastern China by Zhou Sun, Ke Xu, Liangliang Huo, Xingliang Zhang, Yi Wang, Yonghui Gong, Bingbing Chen

“…ObjectivesThis study aimed to investigate the epidemiological characteristics and risk factors associated with human psittacosis in Hangzhou city, eastern China.MethodsThe human psittacosis data from 2021 to 2024 were obtained from the China information system for diseases control and prevention infectious disease surveillance system. …”
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The association between Chlamydia pneumoniae infection and prognosis in lung cancer patients: a prospective study by Maolin Liu, Hailing Ye, Tao Lin, Zishan Chen, Xinying Xu, Jinman Zhuang, Yongsheng Yang, Xuezhen Chen, Chunting Chen, Mengxin Lin, Fei He

“…Chlamydia pneumoniae IgG and IgA antibodies were detected using a micro-immunofluorescence kit and a unified questionnaire was used to collect demographic and clinical information. Follow-up was conducted every six months until August 25, 2022, or death. …”
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Pembrolizumab plus Pemetrexed and Platinum in Metastatic Non-Squamous Non-Small Cell Lung Cancer: A Real-Life Study at a Portuguese Centre by Maria João Santos, Filipa Ferro, Andrea Machado, Ana Sofia Vilariça, Direndra Hasmucrai, Paula Alves

“…With median progression-free survival and overall survival of 6.7 and 12.2 months, respectively, and no new safety signals, these results complement data from clinical trials, providing information from a real-world setting. …”
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Predictors of missed hospital appointments in patients with posterior compartment pelvic floor disorders in a tertiary referral centre by Tanzeela Gala, Mehak Saini, Abigail Fernandes, Carlotta Sarzo, Noman Shahzad, Carlene Igbedioh, Alexis Schizas, Linda Ferrari, Alison Hainsworth

“…Methods:: This is a cross-sectional single-institution study from a tertiary pelvic floor unit (PFU) with data collected from a prospectively maintained database.A missed appointment was marked if patients did not​ attend two consecutive appointments without informing or asking to re-schedule and were recorded for Telephone Triage Assessment Clinic (TTAC), Specialist-nurse, face-to-face bowel function clinic (BFC), Investigations including endoanal (EAUS) and pelvic floor ultrasound (PFUS) and defaecating proctogram (DP). …”
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Household needs among wildfire survivors in the 2017 Northern California wildfires by Mitchell Snyder, Mira Miles, Irva Hertz-Picciotto, Kathryn C Conlon

“…Four major themes were identified: physical, health, air, and information, each representing an array of varied specific needs or impacts. …”
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Human Papillomavirus, Human Immunodeficiency Virus, and Oral Microbiota Interplay in Nigerian Youth (HOMINY): A Prospective Cohort Study Protocol by Jia Liu, Esosa Osagie, Paul Akhigbe, Nosakhare Idemudia, Ozoemene Obuekwe, Ruxton Adebiyi, Nicolas Schlecht, Yana Bromberg, Fidelis E Eki-Udoko, Nosayaba Osazuwa-Peters, Modupe Oluseun Coker

“…Multiple comparisons will be adjusted using the False Discovery Rate (FDR) correction to control for Type I error.Ethics and dissemination The study was approved by Rutgers State University (Pro2022000949) and the UBTH (ADM/E22/A/VOL. VII/14813674). Informed consent was obtained from all parents/guardians.…”
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Support for, and perceived effectiveness of, the UK soft drinks industry levy among UK adults: cross-sectional analysis of the International Food Policy Study by David Hammond, Jean Adams, Martin White, David Pell, Tarra Penney, Lana Vanderlee

“…Design Cross-sectional online survey.Setting UK.Participants UK respondents to the 2017 International Food Policy Study aged 18–64 years who provided information on all variables of interest (n=3104).Outcome measures Self-reported perceived effectiveness of, and support for, the SDIL.Results Most participants supported the SDIL (70%), believed it would be effective (71%), had a positive attitude to SSBs (62%), had knowledge of the link between SSBs and obesity (90%), and trusted messages from health experts (61%), but not those from the food and beverage industry (73%). …”
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Cohort profile: maternal and child health and parenting practices during the COVID-19 pandemic in Ceará, Brazil: birth cohort study (Iracema-COVID) by Marcia C Castro, Márcia Maria Tavares Machado, Simone Farías-Antúnez, David Augusto Batista Sá Araújo, Ana Luiza Penna, Francisco Ariclene Oliveira, Camila Machado de Aquino, Antônio Silva Lima Neto, Geziel dos Santos de Sousa

“…Data were collected through standardised questionnaires that, in addition to sociodemographic and economic data, collected information on breast feeding, mental health status and COVID-19.Findings to date Results from the first wave show that the majority of participants have 9–11 years of schooling (54.4%; 95% CI 61.0 to 70.9) and are of mixed race (71.5%; 95% CI 66.5 to 76.0). …”
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Incremental long-term benefit of drug therapies for chronic obstructive pulmonary disease in quality of life but not mortality: a network meta-analysis by Qiong Pan, Jiongzhou Sun, Shiyuan Gao, Zian Liu, Yiwen Huang, Yixin Lian

“…Material and methods This study retrieved randomised clinical trials (RCTs) with follow-up ≥ 48 weeks on long-acting β-agonists (LABAs), long-acting muscarinic receptor antagonists (LAMAs), inhaled corticosteroids (ICSs), and dupilumab in the PubMed, EMBASE, and Cochrane Central Register of Controlled Trials databases. The information on eligible studies was extracted after the screening. …”
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#emergencymedicine: A TikTok Content Analysis of Emergency Medicine-related Content by Madison Stolly, Erika Wilt, Nathan Gembreska, Mohamad Nawras, Emily Moore, Kelly Walker, Rhonda Hercher, Mohamad Moussa

“…Our study offers insight into how EM professionals can effectively use characteristics associated with higher engagement rates to relay information to a wider audience on TikTok.…”
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Enhancing patient engagement: the influence of an in-consult patient decision aid on shared decision-making for lung tumour radiation – protocol for the randomised trial ‘SDM Lung... by Karina Dahl Steffensen, Signe Timm, Torben Frøstrup Hansen, Thomas Leth Fink, Charlotte Kristiansen, Torben Schjødt Hansen, Rune Slot Thing

“…Secondary outcomes are patient-reported outcomes, quality of life and side effects following treatment.Ethics and dissemination All patients give informed consent to participate. According to Danish legislation, ethical approval is not required for this study as studies using questionnaires, observations or other non-biological studies are not considered interventions according to the Committee Act. …”
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Level of Awareness, Screening Practices, and Self-Detection Among Breast Cancer Patients by Ahmed Nawzad Hassan, Mustafa Saber Al-Attar

“…Most of the participants (80%) had no previous knowledge regarding causes, signs and symptoms, or detection methods, while only 20% had little information. Among the participants, most (87.3%) did not undergo any pre-tests before the time of diagnosis, while only 12.7% did pre-test at least once. …”
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A review of vegetable waste bio-processing techniques in rural areas by Noorafizah Murshid, Junidah Lamaming, Sariah Saalah, Mariani Rajin, Abu Zahrim Yaser

“…By reviewing and synthesizing 173 articles (with 162 from 2019–2023), this paper summarizes and illustrates the information collected. Results: In a systematic search, AD and composting easily surpassed 2000 publications (from 2013 to January 2023). …”
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Comparing the efficacy of different methods in assessing cervical stromal invasion in endometrial carcinoma: a retrospective study of 2,020 patients by Ying Yang, Ying Yang, Zhijun Ye, Zhijun Ye, Yifei Zhao, Yifei Zhao, Zhengyu Li, Zhengyu Li

“…PurposeThis study aimed to assess the preoperative diagnostic efficacy of magnetic resonance imaging (MRI), computed tomography (CT), and endometrial biopsy for cervical stromal invasion (CSI) in endometrial carcinoma (EC) and to discuss the influencing factors of CSI.Material and methodsA total of 2,020 patients with EC were retrospectively analyzed in a tertiary hospital. Basic patient information, clinical pathology, and laboratory indicators were collected and analyzed. …”
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RELATIONSHIP BETWEEN CERVICAL SAGITTAL ALIGNMENT AND CURVE PATTERN IN IDIOPATHIC SCOLIOSIS by Mauricio Coelho Lima, Marcelo Italo Risso Neto, Paulo Tadeu Maia Cavali, Samuel Henrique Jakoski Gehhlen, André Frazão Rosa, Sylvio Mistro Neto, Rafael Magalhães Grana, Alexander Junqueira Rossato, Maurício Antonelli Lehoczki, Alberto Cliquet Junior

“…Method: This was a cross-sectional, descriptive and retrospective study. Information was collected from medical records and lateral panoramic radiographs of 49 patients with idiopathic scoliosis were analyzed. …”
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Genome variability of domestic tomato varieties: data from AFLP analysis by A. V. Kulakova, E. A. Dyachenko, A. V. Shchennikova, O. N. Pyshnaya, E. A. Dzhos

“…According to the AFLP analysis, four combinations of primers E32/M59, E32/M57, E38/M57, and E41/M59, which had the highest PIC (polymorphism information content) values, were selected. In the process of genotyping a collection of 59 cultivars/lines of S. lycopersicum and 11 wild tomato accessions, the selected primers revealed 391 fragments ranging in size from 80 to 450 bp, of which 114 fragments turned out to be polymorphic and 25 were unique. …”
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The association of lifestyle with cardiovascular and all-cause mortality based on machine learning: a prospective study from the NHANES by Xinghong Guo, Mingze Ma, Lipei Zhao, Jian Wu, Yan Lin, Fengyi Fei, Clifford Silver Tarimo, Saiyi Wang, Jingyi Zhang, Xinya Cheng, Beizhu Ye

“…It applies to individuals, healthcare professionals, and policymakers to make informed decisions.…”
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Validation of a paediatric sepsis screening tool to identify children with sepsis in the emergency department: a statewide prospective cohort study in Queensland, Australia by Paula Lister, Kristen Gibbons, Luregn J Schlapbach, Adam Irwin, Michael Rice, Sainath Raman, Amanda Harley, Patricia Gilholm

“…We assessed the performance of the paediatric sepsis screening tool using stepwise multiple logistic regression analyses with 10-fold cross-validation and evaluated the final model at defined risk thresholds.Setting Twelve emergency departments (EDs) in Queensland, Australia.Participants 3473 children screened for sepsis, of which 523 (15.1%) were diagnosed with sepsis.Interventions A 32-item paediatric sepsis screening tool including rapidly available information from triage, risk factors and targeted physical examination.Primary outcome measure Senior medical officer-diagnosed sepsis combined with the administration of intravenous antibiotics in the ED.Results The 32-item paediatric sepsis screening tool had good predictive performance (area under the receiver operating characteristic curve (AUC) 0.80, 95% CI 0.78 to 0.82). …”
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