Genetic Insights Into Lipid Traits and Lipid-Modifying Drug Targets in Pregnancy Complications: A Two-Sample Mendelian Randomization Study by Shao H, Xu C, Zhang C, Li L, Wu P, Chen Z, Guan R

“…Huijing Shao,1,* Chang Xu,2,* Caihong Zhang,2 Lirong Li,3 Pengfei Wu,4 Zixi Chen,5 Rui Guan2 1Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, People’s Republic of China; 2Department of Obstetrics and Gynecology, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, People’s Republic of China; 3Department of Traditional Chinese Gynecology, China-Japan Friendship Hospital, Beijing, 100029, People’s Republic of China; 4Department of Obstetrics and Gynecology, Hospital of Obstetrics and Gynecology, Shanghai Medical School, Fudan University, Shanghai, 200080, People’s Republic of China; 5Department of Laboratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, People’s Republic of China*These authors contributed equally to this workCorrespondence: Rui Guan, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Naval Medical University, No. 168 Changhai Road, Yangpu District, Shanghai, 200433, People’s Republic of China, Email cngreen785@163.comBackground: Dyslipidemia is linked to pregnancy complications, but its causal role remains uncertain. This two-sample Mendelian Randomization (MR) study investigated the causal relationship between lipid traits and pregnancy complications and evaluated the impact of lipid-modifying drug targets.Methods: Genetic instruments for lipid traits and targets for lipid-modifying drugs were obtained from the Global Lipids Genetics Consortium. …”
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Unveiling <i>DENND2D</i> as a Novel Prognostic Biomarker for Prostate Cancer Recurrence: From Gene to Prognosis by Chi-Fen Chang, Lih-Chyang Chen, Yei-Tsung Chen, Chao-Yuan Huang, Chia-Cheng Yu, Victor C. Lin, Te-Ling Lu, Shu-Pin Huang, Bo-Ying Bao

“…Furthermore, the elevated <i>DENND2D</i> expression promotes immune infiltration in prostate cancer, supporting its role in immune modulation. <b>Conclusions:</b> <i>DENND2D</i> is a prognostic biomarker for BCR in prostate cancer and offers new avenues for personalized treatment strategies.…”
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Integral Equations Approach in Complex-Valued Generalized b-Metric Spaces by Shahid Mehmood, Saif Ur Rehman, Ihsan Ullah, Rashad A. R. Bantan, Mohammed Elgarhy

“…In this paper, we study a rational type common fixed-point theorem (CFP theorem) in complex-valued generalized b-metric spaces (Gb-metric spaces) by using three self-mappings under the generalized contraction conditions. We find CFP and prove its uniqueness. To justify our result, we provide an illustrative example. …”
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Analysis of the influence internal and external factors on the performance of IDXV30 by Tumpal Samosir, Pardomuan Sihombing

“…While the contributing factors are the IDXV30 itself while macroeconomics and global stock exchanges do not contribute.…”
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Features of Administrative Liability of Minors by O. M. Reznik

“…The procedural peculiarities of juvenile administrative liability are related to its judicial application, the possibility of applying administrative and coercive measures to the parents of a minor, the participation of legal representatives and representatives in the representation of their interests, the obligation to notify the parents or persons who replace them, about minor’s detention, and with impossibility to apply administrative penalties as a substitute for criminal liability. …”
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Differences and analogies in thyroid cancer discovered incidentally or by thyroid-related screening: a multicenter study by Laura Croce, Rosaria Maddalena Ruggeri, Camilla Virili, Carlo Cappelli, Marsida Teliti, Pietro Costa, Spyridon Chytiris, Antonio Nicocia, Francesca Coperchini, Maria Flavia Bagaglini, Flavia Magri, Alfredo Campennì, Mario Rotondi

“…Design: We performed a retrospective cohort study in three high-volume hospital-based centers for thyroid diseases (Pavia, Latina and Messina) in Italy. Patients: Consecutive patients with TC were included. …”
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Hérodias, portraits choisis by Sylvie Giraud

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Le « socle », matériau du projet de paysage by Hervé Davodeau

“…Reduced to the site, to its physical ground, the geography is constituted by landscape potentialities to be revealed. …”
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Metazoan diversity in Chilean hypersaline lakes unveiled by environmental DNA by Mattia Saccò, Mattia Saccò, Mattia Saccò, Matthew A. Campbell, Pablo Aguilar, Pablo Aguilar, Pablo Aguilar, Gonzalo Salazar, Gonzalo Salazar, Gonzalo Salazar, Tina E. Berry, Tina E. Berry, Matthew J. Heydenrych, Angus Lawrie, Nicole E. White, Chris Harrod, Chris Harrod, Chris Harrod, Morten E. Allentoft, Morten E. Allentoft

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Potential use of agroindustrial waste as a source of phenolic compounds with biological activity by Anahí Belén Bonilla Rodríguez, Mary Mishell Pintag Fuertes, Gerardo Emilio Medina Ramírez

“…Agroindustrial waste has a high potential as a novel source of phenolic compounds with biological activity, which can be used in the pharmaceutical, food and cosmetic industries. Among its applications are antioxidant, anti-inflammatory, antimicrobial and antiproliferative activity. …”
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Propofol Reduces Lipopolysaccharide-Induced, NADPH Oxidase (NOX2) Mediated TNF-α and IL-6 Production in Macrophages by Tao Meng, Jingya Yu, Zhen Lei, Jianbo Wu, Shuqin Wang, Qiyu Bo, Xinyu Zhang, Zhiyong Ma, Jingui Yu

“…While the immunomodulatory activity of propofol is highly documented, its effect on the LPS-induced NOX2/ROS/NF-κB signaling pathway in macrophages has not been addressed. …”
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ALIGNING PRAXIS OF FAITH AND THEOLOGICAL THEORY IN THEOLOGICAL EDUCATION THROUGH AN EVALUATION OF CHRISTIANITY IN SOUTH AFRICA by E. Oliver

“…Christianity is also in need of a revolution back to its origin of an un-institutionalised, non-hierarchical, living faith that is changing the lives of people both in the present and eternally. …”
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Prolactinoma: A Massive Effect on Bone Mineral Density in a Young Patient by Scott Sperling, Harikrashna Bhatt

“…This case highlights a prolactinoma in a young male, and its impact on bone health. Osteoporosis has been noted to be an issue in postmenopausal women with prolactinomas. …”
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Bone-Immune Cell Crosstalk: Bone Diseases by Giorgio Mori, Patrizia D’Amelio, Roberta Faccio, Giacomina Brunetti

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The panel threshold analysis of digitalization on manufacturing industry’s green total factor productivity by Lu Liu, Yulong Xin, Bei Liu, Yuankui Pang, Weiran Kong

“…The empirical results show that: (1) Digitalization has a significant threshold impact on IGTFP, and the research results are still robust according to changing the threshold variable algorithm and carrying on a Winsorize test. (2) Industry technological innovation (ITI) plays a threshold role in the process of digitalization impact on IGTFP. (3) Heterogeneity analysis shows that the impact mechanism varies depending on differentiated industry factor intensity and industry pollution degree. …”
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Extracellular matrix turnover in severe COVID-19 is reduced by corticosteroids by Janesh Pillay, Antine W. Flikweert, Matijs van Meurs, Marco J. Grootenboers, Simone van der Sar-van der Brugge, Peter H. J. van der Voort, Morten A. Karsdal, Jannie M. B. Sand, Diana J. Leeming, Janette K. Burgess, Jill Moser

“…Dexamethasone (DEX) has been shown to improve outcomes in critically ill patients; however, its effect on tissue remodeling, particularly collagen turnover, remains unclear. …”
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Specific surface area changes and functional potential exploration of Pleurotus pulmonarius under ultrasonic frequency control by Hangyu Fan, Jinlin Jiang, Huaihai Dong, Jinqing Hu, Wenjun Chen, Yingjie Pan, Yong Zhao, Haiquan Liu

“…This article explores the changes in the specific surface area of Pleurotus pulmonarius under the control of different ultrasonic frequencies, analyzes the changes in flavor substances of P. pulmonarius and explores its functional nutritional potential. The results show that within a certain range, the specific surface area and pore size increase with the increase of ultrasonic waves, which has a significant effect on the release of flavor substances of P. pulmonarius and also affects its ability to adsorb and release substances. …”
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Characterization of <i>Clostridium perfringens</i> Phage Endolysin PlyDolk21 by Suyoung Seo, Bokyung Son, Minsuk Kong

“…The lytic activity of PlyDolk21 was assessed in comparison to its catalytic domain alone. Both PlyDolk21 and its cell wall binding domain (CBD) were evaluated in beef and milk for their antimicrobial activity and cell wall binding activity, respectively. …”
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The impact of long-term exposure to NO2, O3, and their oxidative potential on adolescents’ mental health, and the protective role of school-based greenness by Jiajia Dang, Yaqi Wang, Ning Ma, Shan Cai, Jianhui Guo, Yunfei Liu, Haoyu Zhou, Xinyao Lian, Di Shi, Ziyue Chen, Yihang Zhang, Jiaxin Li, Tianyu Huang, Guangrong Zhu, Jing Li, Jun Ma, Yi Song

“…Greenness around schools, measured by the Normalized Difference Vegetation Index (NDVI), was examined for its potential effect modification on the association between NO2, O3, OX, and mental health. …”
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Regolith-Rich PEEK Composite Bricks: Steps Towards Space-Ready Lunar Construction Materials by Roberto Torre, Carlo Giovanni Ferro, Lorenzo Bono, Aidan Cowley

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