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1521
Virgin coconut oil lessens trichloroacetic acid assault on the stomach and intestine of rats via enhancement of Nrf2 but inhibition of TNF-α, IL1β/NF-kB signalling pathway
Published 2025-02-01“…Results: TCA's intoxication which caused a decrease in the activity of SOD, CAT, GPx, and Nrf2 in the stomach and colon, and an increase in MDA, MPO, TNF-α, IL-1β, and NF-kB levels were all reversed by VCO, either alone or in combination with 5-FU. …”
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1522
ALKBH3-mediated m1A demethylation promotes the malignant progression of acute myeloid leukemia by regulating ferroptosis through the upregulation of ATF4 expression
Published 2025-12-01“…Studies have shown that ALKBH3 is upregulated in most tumors, but the role of ALKBH3 in AML remains unclear.Methods: In this study, we investigated the function of ALKBH3 in AML cells (KG-1) by immunofluorescence, ELISA, flow cytometry, HE staining, and Western blotting.Results: Our results revealed that ALKBH3 is upregulated in AML and that the downregulation of ALKBH3 inhibited KG-1 cell proliferation and promoted cell apoptosis; at the same time, ALKBH3 upregulated ATF4 expression through m1A demethylation, and the knockdown of ATF4 resulted in increased ferrous iron content; TFR1, ACSL4, and PTGS2 expression; and ROS and MDA levels, whereas SOD and GSH levels and the expression levels of ATF4, SLC7A11, GPX4, and FTH1 decreased in KG-1 cells, thereby promoting ferroptosis. …”
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1523
Genome-Wide Association Analysis of Boar Semen Traits Based on Computer-Assisted Semen Analysis and Flow Cytometry
Published 2024-12-01“…A total of 1183 Duroc boars were genotyped using the GeneSeek GGP Porcine 50 K SNP BeadChip. The GWAS was performed using three different models: GLM, MLM, and FarmCPU. …”
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1524
Anti-Inflammatory Property of the Ethanol Extract of the Root and Rhizome of Pogostemon cablin (Blanco) Benth
Published 2013-01-01“…Preliminary mechanism studies demonstrated that ERP decreased the level of MPO and MDA, increased the activities of anti-oxidant enzymes (SOD, GPx, and GRd), attenuated the productions of TNF-α, IL-1β, IL-6, PGE2 and NO, and suppressed the activities of COX-2 and iNOS. …”
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1525
Efficient hydrogen peroxide reduction in glutathione peroxidase cycle using cost-effective FeSe2 nanospheres
Published 2025-01-01“…These nanospheres (termed Nanozymes) mimic the enzymatic action of natural antioxidants, such as the glutathione peroxidase (GPx) enzyme, in biological systems. Their exceptional efficiency makes them a strong candidate for practical applications in mitigating early browning caused by melanogenesis.ConclusionsFeSe2 nanozymes exhibit great promise as a biocatalyst for enhancing the shelf life of fruits and vegetables by reducing damage due to early melanogenesis. …”
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1526
Research note: Increased lipid accumulation within broiler preadipocytes during differentiation in vitro at atmospheric oxygen tension
Published 2025-01-01“…Abundance of glutathione peroxidase 4 (GPX4) was increased in all the differentiation cultures compared to the controls, regardless of oxygen tension; however, differences in the abundance of other antioxidant enzymes were not observed. …”
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1527
The AMPK–mTOR Pathway Is Inhibited by Chaihu Shugan Powder, Which Relieves Nonalcoholic Steatohepatitis by Suppressing Autophagic Ferroptosis
Published 2024-01-01“…The liver protein levels of Adenosine monophosphate-activated protein kinase–mammalian target of rapamycin (AMPK–mTOR)-mediated autophagy and ferroptosis markers, such as p-AMPKα/AMPKα, p-mTOR/mTOR, Beclin-1, microtubule associated protein 1 light chain 3 gamma (LC3), p62 (sequestosome 1 [SQSTM1/p62]), Kelch-like ECH-associated protein 1 (KEAP1), nuclear factor erythroid 2-related factor 2 (Nrf-2), ferritin heavy chain 1 (FTH1), and glutathione peroxidase 4 (GPX4), were restored by CSP. Furthermore, our findings indicated that the suppression of autophagy had a repressive impact on the occurrence of ferroptosis in the mouse model, indicating that autophagy activation likely plays a role in mediating ferroptosis in NASH.…”
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1528
Research note: Protective effects of compound mycotoxin detoxifier in broiler chicken fed aflatoxins-contaminated diets
Published 2025-02-01“…Although total antioxidant capacity, GPx, and SOD activities were not affected by treatments (P > 0.05), the lowest catalase levels were found in HCTB (P < 0.05). …”
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1529
Proteomic analysis reveals the roles of silicon in mitigating glyphosate-induced toxicity in Brassica napus L.
Published 2025-01-01“…Protein-protein interactome analyses confirmed the involvement of six key proteins, including L-ascorbate peroxidase, superoxide dismutase, glutaredoxin-C2, peroxidase, glutathione peroxidase (GPX) 2, and peptide methionine sulfoxide reductase A3 which involved in antioxidant activity, sulfur assimilation, and herbicide tolerance, contributing to the resilience of B. napus against Gly toxicity. …”
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1530
Comprehensive analysis of differential mRNA and circRNA profiles in primary and metastatic pancreatic neuroendocrine tumors
Published 2025-03-01“…Our analysis of differentially expressed RNA and circRNA genes revealed that tumor cell adhesion and integrin activation, regulated by genes like PIEZO1, IFT74, SKAP1, GPX1, F7, VTN, and OMG, are strongly linked to pNET metastasis. …”
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1531
Protective Effect of Melatonin on Acute Pancreatitis
Published 2012-01-01“…The beneficial effect of melatonin on acute pancreatitis, which has been reported in many experimental studies and supported by clinical observations, is related to: (1) enhancement of antioxidant defense of the pancreatic tissue, through direct scavenging of toxic radical oxygen (ROS) and nitrogen (RNS) species, (2) preservation of the activity of antioxidant enzymes; such as superoxide dismutase (SOD), catalase (CAT), or glutathione peroxidase (GPx), (3) the decline of pro-inflammatory cytokine tumor necrosis α (TNFα) production, accompanied by stimulation of an anti-inflammatory IL-10, (4) improvement of pancreatic blood flow and decrease of neutrophil infiltration, (5) reduction of apoptosis and necrosis in the inflamed pancreatic tissue, (6) increased production of chaperon protein (HSP60), and (7) promotion of regenerative process in the pancreas. …”
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1532
Impact of COVID-19 Control Measures on Trace Gases (NO2, HCHO and SO2) and Aerosols over India during Pre-monsoon of 2020
Published 2020-10-01“…In April, the decrease occurred primarily over the Indo-Gangetic-Plains (IGP) and eastern India, while in May a marked homogeneous reduction was noted over entire India. …”
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1533
Bredemolic Acid Ameliorates Selected Liver Function Biomarkers in a Diet-Induced Prediabetic Rat Model
Published 2020-01-01“…However, the administration of BA decreased liver enzyme concentrations, decreased hepatic oxidative stress, and improved antioxidant enzymes such as SOD and GPx. Conclusion. BA administration improved liver function in diet-induced prediabetic rats in the presence or absence of dietary intervention.…”
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1534
Ferrostatin-1 inhibits osteoclast differentiation and prevents osteoporosis by suppressing lipid peroxidation
Published 2025-01-01“…Results During osteoclastogenesis, the levels of ROS, MDA, ACSL4 and LPCAT3 increased with increasing duration of RANKL stimulation, while there were no significant changes in the levels of GSH or GPX4. Fer-1 inhibited osteoclast differentiation and decreased the level of lipid peroxides. …”
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1535
Lipid peroxidation and sarcopenia: molecular mechanisms and potential therapeutic approaches
Published 2025-02-01“…In addition, we discuss the protective role of antioxidant factors such as GPX4 (glutathione peroxidase 4) and antioxidant peptides like SS peptides in mitigating lipid peroxidation and delaying the progression of sarcopenia. …”
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1536
Silica Nanoparticles Loaded With Selenium Quantum Dots Reduce Myocardial Ischemia-Reperfusion Injury by Alleviating Ferroptosis and Mitochondrial Dysfunction
Published 2025-02-01“…The Se@PSN treatment increased GPX4 levels, effectively inhibiting ferroptosis in cardiomyocytes. …”
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1537
Bibliometric analysis of ferroptosis: a comprehensive evaluation of its contribution to lung cancer
Published 2025-01-01“…Therapeutic targets like GPX4, SLC7A11, P53, FSP1, Nrf2, LSH, STYK1/NOK, and ACSL4 are prominent. …”
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1538
Evaluación del expeller de soja en dietas de cerdos en recría y engorde
Published 2020-01-01“…Se obtuvieron en promedio un 40% de AGS, 46% de AGMI y 14% AGPI y un 42% AGS, 37,21% AGMI y un 19,79% AGPI para la grasa intramuscular del LD y la grasa subcutánea, respectivamente. …”
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1539
Mass testing and characterization of 20-inch PMTs for JUNO
Published 2022-12-01Get full text
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1540