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Sakuranetin Prevents Acetaminophen-Induced Liver Injury via Nrf2-Induced Inhibition of Hepatocyte Ferroptosis
Published 2025-01-01“…Serum transaminase levels, histological changes, inflammatory mediators, oxidative stress, ferroptosis-related markers and Nrf2 signaling pathway proteins were analyzed.Results: Sakuranetin significantly reduced serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), as well as inflammatory factor; increased HepG2 activity and decreased cell death; inhibited ROS production, increased glutathione (GSH) content, expression of Glutathione Peroxidase 4 (GPX4) and Solute Carrier Family 7 Member 11 (SLC7A11), and decreased malondialdehyde and Acyl-CoA Synthetase Long Chain Family Member 4 (ACSL4) expression in mice and HepG2 cells after APAP treatment. …”
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CAPE activates AMPK and Foxo3 signaling to induce growth inhibition and ferroptosis in triple-negative breast cancer.
Published 2024-01-01“…ROS, MDA, SOD, GSH, C11-bodipy staining, along with measurements of GPX4 and Ferritin levels, were utilized for ferroptosis detection. …”
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Rutin attenuates zearalenone-induced ferroptosis of endometrial stromal cells in piglets through the p53 signaling pathway
Published 2025-01-01“…Additionally Rutin lowered the expression of p53, ALOX12, and ACSL4 while significantly improving cytokinesis, antioxidant enzyme activity, and SLC7A11, GPX4, Nrf2, FTH1, thereby inhibiting cellular ferroptosis. …”
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Tra stratificazione sociale e razzializzazione
Published 2025-01-01“…Lo strumento utilizzato, tipico dei modelli regolativi, è l’adesione ai disciplinari, che fa corrispondere la “qualità” ad uno standard di produzione o di provenienza territoriale che è, a sua volta, esito del funzionamento di dinamiche di potere e di lobbying tipicamente operanti nelle sedi delle istituzioni europee, come testimoniano i processi decisionali relativi al riconoscimento delle certificazioni (DOP, IGP, ecc.). L’origine dell’idea del cibo “perfetto”, corrispondente ad uno standard, che svolge al contempo una funzione che può risultare inclusiva delle classi sociali, come mostra per esempio la rilevanza dell’alimentazione nei processi educativi, o, viceversa, escludente, risale all’Inghilterra vittoriana: un’epoca in cui la costruzione dell’impianto normativo della qualità degli alimenti, strumento individuato come idoneo a risolvere le numerose questioni legate all’insicurezza alimentare, per lo più ereditate dal secolo precedente, si colloca sullo sfondo di importanti questioni sociopolitiche. …”
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Radiative Impact of Fireworks at a Tropical Indian Location: A Case Study
Published 2014-01-01“…Weeklong intensive observational campaign for aerosol study was carried out at a representative urban location in the eastern Indo-Gangetic Plain (IGP), Varanasi (25.3°N, 83.0°E), from October 29 to November 04, 2005 (Diwali on November 01, 2005), to investigate behavioral change of aerosol properties and radiative forcing between firework affected and nonaffected periods. …”
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Improvement of Fish Growth and Metabolism by Oligosaccharide Prebiotic Supplement
Published 2022-01-01“…The application of XOS and GOS also elevated the production of glutathione-related enzymes and the enzymatic activity of glutathione peroxidase (GPX), indicating the enhancement of antioxidation processes in fish. …”
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Liraglutide Attenuates Hepatic Oxidative Stress, Inflammation, and Apoptosis in Streptozotocin-Induced Diabetic Mice by Modulating the Wnt/β-Catenin Signaling Pathway
Published 2023-01-01“…Furthermore, a significant increase in the levels of malondialdehyde and inflammatory markers such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin 1β (IL-1β) and the proapoptotic proteins caspase-3 and Bax were observed in the livers of diabetic mice, together with marked increases in antioxidants superoxide dismutase (SOD) and glutathione peroxidase (GPX) as well as antiapoptotic protein Bcl-2, all of which were significantly mitigated by treatment with liraglutide, insulin, and their combinations. …”
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Molecular subtype of gastric cancer based on apoptosis-related genes reveals differential immune microenvironment and intratumoral microorganisms distribution
Published 2025-01-01“…Subsequently, significant differences were found in the tumor immune microenvironment, intratumoral microorganisms, gene expression, signaling pathways, and protein interaction networks between the two subtypes. GPX3, PLAT, and CAV1 were identified as key prognostic genes related to apoptosis in GC, with a focus on their impact on disease progression-related pathways. …”
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Extreme Air Pollution Events Spiking Ionic Levels at Urban and Rural Sites of Indo-Gangetic Plain
Published 2020-04-01“…Abstract The present study is a modest attempt to quantify the water-soluble inorganic ions (WSIIs) in the early morning (fog-forming) ambient air on the central Indo-Gangetic Plain (IGP) during winter via dissolution using a low-cost refluxing mist chamber. …”
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Effects of different Lys/Met ratios on the antioxidant capacity, tissue morphology, and fatty acid composition of subcutaneous fat in Tibetan sheep on low-protein diets: a lipidomi...
Published 2025-01-01“…The expression of genes associated with adipogenesis, antioxidant capacity, and fatty acid metabolism was also examined.ResultsThe results indicated that the 1:1 Lys/Met group exhibited significantly higher antioxidant capacity (glutathione peroxidase, GSH-Px), with more orderly adipocyte arrangement, uniform cell size, and a general increase in unsaturated fatty acid levels. …”
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1471
Targeting Ferroptosis Attenuates Inflammation, Fibrosis, and Mast Cell Activation in Chronic Prostatitis
Published 2022-01-01“…Meanwhile, we discovered significant biological performances associated with ferroptosis in CP/CPPS, including the downregulation of the system Xc-/GPX4 axis and the upregulation of the ACSL4/LPCAT3 axis. …”
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Anticolitic Effect of Berberine in Rat Experimental Model: Impact of PGE2/p38 MAPK Pathways
Published 2020-01-01“…In addition, BER restored colonic antioxidant capacity through elevation of GSH level and antioxidant enzymatic activities (SOD, CAT, GPx, and GR) together with reductions of both MDA and NO levels. …”
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1473
Two-Dimensional Rotating Stall Analysis in a Wide Vaneless Diffuser
Published 2006-01-01Get full text
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AN INVESTIGATION INTO LEXICAL CONTENTS IN ENGLISH STANDARDIZED TESTS
Published 2024-12-01Get full text
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