Combined extracts of Syzygium aromaticum (Clove) and Xylopia aethiopica (Negro pepper) seeds inhibit testosterone propionate-induced benign prostatic hyperplasia in Wistar rats by Emmanuel Nnaemeka Uhuo, Simeon Ikechukwu Egba, Chiemeziem Adnma Obike, Paul Ndubuisi Anyiam, Prince Ogochukwu Alaebo, Pryanka Munachiso Okeke, Emmanuella Chinaza Obinali

“…Catalase and glutathione peroxidase (GPx) activities decreased significantly (p < 0.05) in the TP group compared to those in the NC, TP-200, and TP-400 groups. …”
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Improvement of Post‐Thaw Quality and In Vivo Fertility of Simmental Bull Spermatozoa Using Ferulic Acid by Mobin Afsar, Ali Soleimanzadeh, Amir Khaki, Esmail Ayen

“…After the samples were frozen and thawed, the samples were tested for malondialdehyde (MDA), total antioxidant capacity (TAC), superoxide dismutase (SOD), glutathione peroxidase (GPx), total motility, progressive motility, motility characteristics, and plasma membrane functionality. …”
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A pH-responsive PROTAC-based nanosystem triggers tumor-specific ferroptosis to construct in situ tumor vaccines by Linghong Huang, Xinyuan Sun, Qinhua Zuo, Ting Song, Ning Liu, Zonghua Liu, Wei Xue

“…Degradation of BRD4 can downregulate the expression of ferroptosis-related genes such as GPX4, thereby promoting tumor-specific ferroptosis. …”
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Fatty acid metabolism-related signature suggests an oncogenic role of TEKT1 in endometrial cancer by Zhikai Xiahou, Hong Xiao, Yafeng Song, Xin Xu

“…Results: A prognostic signature based on 10 FAMRGs (ACACB, PTGIS, BMPR1B, DHCR24, FAAH, GPX1, GPX4, INMT, PON3, PPT2) was generated using Lasso Cox hazards regression analysis in TCGA. …”
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miR-432-5p Inhibits the Ferroptosis in Cardiomyocytes Induced by Hypoxia/Reoxygenation via Activating Nrf2/SLC7A11 Axis by Degrading Keap1 by Wei Geng, Shaohua Yan, Xinyue Li, Qiumei Liu, Xuefei Zhang, Xinshun Gu, Xiang Tian, Yunfa Jiang

“…Upregulation of miR-432-5p inhibited ferroptosis of cardiomyocytes induced by RAS-selective lethal 3 (RSL3), an inhibitor of GPX4 and ferroptosis inducer through decreasing the binding protein of Nrf2, Keap1, which was confirmed by bioinformatics and mutation assay. …”
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丙烯醛体内外诱导神经元铁死亡的初步研究 by 彭伟嘉, 朱泽宇, 杨扬, 侯加卫, 皮荣标

“…此外，在细胞水平丙烯醛促进环氧化酶2（COX-2）、铁蛋白重链1（FTH1）表达上升，谷胱甘肽过氧化物酶4（GPX4）表达减少；在动物水平丙烯醛促进COX-2表达上升，GPX4、FTH1表达减少。结论丙烯醛可在体内外诱导神经元发生铁死亡现象，提示铁死亡抑制剂可以用来缓解与丙烯醛有关的中枢神经系统疾病，如阿尔兹海默病。…”
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Empagliflozin-Metformin Combination Has Antioxidative and Anti-Inflammatory Properties that Correlate with Vascular Protection in Adults with Type 1 Diabetes by Miodrag Janić, Matej Cankar, Jan Šmid, Alenka France Štiglic, Aleš Jerin, Mišo Šabovič, Andrej Janež, Mojca Lunder

“…The empagliflozin-metformin combination increased levels of the antioxidants (TAS, SOD, and GPx up to 1.1-fold; P<0.01), decreased the levels of prooxidants (AOPP and isoprostanes up to 1.2-fold, P<0.01; AGE up to 1.5-fold, P<0.01), and decreased inflammatory parameters (up to 1.5-fold, CRP P<0.01; IL-6 P<0.001). …”
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Crop residue degradation by fungi isolated from conservation agriculture fields under riceâwheat system of North-West India by Madhu Choudhary, Parbodh C. Sharma, Hanuman S. Jat, Vibha Nehra, Andrew J. McDonald, Neelam Garg

“…Purpose In North West-Indo Gangetic Plains (NW-IGP) of India in situ burning of crop residues is practiced by majority of farmersâ which deteriorates soil and environmental quality. …”
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The Impact of Silymarin on Inflammation and Oxidative Stress: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Mahdi Vajdi, Shaghayegh Adeli, Arash Karimi, Vahid Asghariazar, Arezoo Moini Jazani, Ramin Nasimidoost Azgomi

“…Furthermore, silymarin significantly increases IL-10 (WMD: 2.03 pg/mL; 95% CI: 1.04, 3.01, p<0.001), superoxide dismutase (SOD) (SMD: 3.39, 95% CI: 1.42, 5.37, p=0.001), and glutathione peroxidase (GPx) (SMD: 1.94; 95% CI, 0.89 to 2.99; p<0.001) level. …”
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Quantification of Eosinophilic Granule Protein Deposition in Biopsies of Inflammatory Skin Diseases by Automated Image Analysis of Highly Sensitive Immunostaining by Peter Kiehl, Katrin Falkenberg, Markus Vogelbruch, Alexander Kapp

“…Extracellular deposition of toxic eosinophilic granule proteins (EGPs), but not the presence of intact eosinophils, is crucial for their functional effect in situ. …”
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Successful Use of Plasma Exchange in the Treatment of Corticosteroid-Refractory Eosinophilic Granulomatosis with Polyangiitis Associated with Gastrointestinal Manifestations by Kohei Tsujimoto, Masato Yagita, Masashi Taniguchi, Masaaki Fujita

“…We describe the case of a 33-year-old woman having corticosteroid-refractory eosinophilic granulomatosis with polyangiitis (EGPA) who presented with abdominal pain and responded dramatically to plasma exchange. …”
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Power Control Algorithm Based on a Cooperative Game in User-Centric Unmanned Aerial Vehicle Group by Yuexia Zhang, Pengfei Zhang

“…This shows that the CGPC algorithm can effectively reduce the transmission power of the cooperative UAV and enhance the capacity of the entire system, ensuring communication quality.…”
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Study on segment routing network and its application in traffic engineering by Xiaoming HE, Quan LU, Liang XING

“…Segment routing network is the inheritance and innovation of IP routing technology，which has many unique advantages in the realization of network virtualization，fast re-routing，network programming，load balancing and traffic engineering，and so on.Segment routing mechanism was studied in depth，and the protocol extensions of interior gateway protocols （IGP）and border gateway protocol （BGP）for segment routing were introduced and analyzed in detail.Furthermore，the realization of traffic engineering for segment routing in typical application scenarios of the operator networks was explored.With the maturity of technology and standardization，segment routing network will promise to have broad application prospects.…”
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Dynamics of soil nitrogen availability indices in a sandy clay loam soil amended with animal manures by Habeebah Adewunmi Saka, Jamiu Oladipupo Azeez, Joy Nwakaego Odedina, Shade John Akinsete

“…Results The results showed N release peaked at 10 WAI with highest NH4 +–N (830, 400, 253 mg kg−1) and NO3 −–N (316, 398, 250 mg kg−1) at 150, 60 and 60 t ha−1 for CGPM, respectively. Initial rapid N release phase occurred at 0–4 WAI, NH4 +–N and NO3 −–N increased averagely by 182, 183, 139% and 131, 175, 144% for CGPM, respectively. …”
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Haplotype Analysis of Candidate Genes Involved in Inflammation and Oxidative Stress and the Susceptibility to Preeclampsia by Aiping Chen, Huifang Zhao, Jingli Wang, Ru Zhang, Jingjing Liu, Xin Zhao, Congying Li, Xuewen Jia, Xueying Li, Yan Lin, Mingzhen Guo, Sai Li, Chao Liu, Yuan Li, Shiguo Liu

“…The GT and GC haplotypes of rs4807542 and rs713041 in GPX4 may increase the risk of PE in the Chinese Han population.…”
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Mulberry leaf extract reduces damage by regulating the oxidative response, immune response and intestinal flora of largemouth bass (Micropterus salmoides) under chronic heat stress by Bing Fu, Donglai Zhou, Xiaotong Qiu, Xiaotong Qiu, Jieqiu Zheng, Jieqiu Zheng, Qiong Yang, Yang Xiao, Sentai Liao, Qingrong Li, Dongxu Xing

“…Dietary MLE also significantly up-regulated the mRNA expressions of gpx, tgf-β, il-10, jnk2, and bcl-2, but down-regulated the mRNA expressions of il-8, tnf-α, caspase-3, atf4, chop, ire1, traf2, jnk1, TRPV, MCU, and VDAC in liver. …”
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Endoscopic retrograde cholangiopancreatography combined with extracorporeal shock wave lithotripsy for the removal of large gallbladder stones: a pilot study by Liang Zhu, Jinli He, Zhenzhen Yang, Xi Huang, Junbo Hong, Xiaojiang Zhou, Youxiang Chen, Guohua Li

“…Abstract Background Endoscopic gallbladder-preserving cholecystolithotomy (EGPC) has become an alternative option for treating cholecystolithiasis. …”
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Combined Effects of Chrysin Supplementation and Exercise Training on Diabetes-Induced Oxidative Stress and Apoptosis in Rat Testicular Tissue by Shiva Cheraghi Abajlou, Asghar Tofighi, Javad Tolouei Azar, Amir Afshin Khaki, Mazdak Razi

“…Following 8 weeks, the histopathological changes (Johnson’s score, epithelial height,and tubular diameter), testicular malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase(GPX), and the mRNA levels of anti-apoptotic gene Bcl-2 and pro-apoptotic gene Bax was analyzed.Results: Chrysin solely and simultaneous with MIRET could remarkably (P=0.001) improve the DM-induced histopathologicaldamages, increase the testicular SOD and GPx levels, and decline the DM-increased MDA content.Moreover, our results showed that Chrysin solely and more simultaneously with MIRET could significantly (P=0.001)decrease the mRNA expression of Bax and improve the Bcl-2 expression and rebalance the Bax/Bcl-2 balance.Conclusion: Our findings showed that co-administration of Chrysin along with MIRET can significantly amelioratethe DM-induced histopathological, and biochemical impairments and reduce the pro-apoptotic impact of DMon testicular tissue.…”
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Impact of Feeding Frequency on Growth Performance and Antioxidant Capacity of <i>Litopenaeus vannamei</i> in Recirculating Aquaculture Systems by Qinlang Liang, Gang Liu, Yazhi Luan, Jiangbo Niu, Yasong Li, Huwei Chen, Ying Liu, Songming Zhu

“…Pearson’s correlation confirmed a positive relationship between SOD and GPx. Economically, the A8 group achieved the highest profitability. …”
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siRNA-mediated inhibition of hTERT enhances the effects of curcumin in promoting cell death in precursor-B acute lymphoblastic leukemia cells: an in silico and in vitro study by Muhammad Hossein Ashoub, Ali Afgar, Alireza Farsinejad, Razieh Razavi, Samira Anvari, Ahmad Fatemi

“…This was characterized by the upregulation of ferroptosis promoters (lipid-ROS, Fe²⁺, ACSL4) and suppression of inhibitors (GSH, GPx, SLC7A11, GPx4). The response showed cell-line specificity, with Nalm-6 cells exhibiting enhanced ferroptotic sensitivity while REH cells underwent apoptotic cell death. …”
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