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Characteristics, Incidence, and Management of Immune Checkpoint Inhibitors Related Cardiovascular Adverse Events in Real-World Practice-A Retrospective Study in Chinese Han Populat...
Published 2025-02-01“…Rong-Hua Wang,1 Yin Chen,1 Ya-Ling Lou,1 Yu-Liang Lu,2 Hui-Min Xu3 1Department of Pharmacy, HuZhou Central Hospital (The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University), Huzhou, People’s Republic of China; 2Department of Cardiology, HuZhou Central Hospital (The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University), Huzhou, People’s Republic of China; 3Department of Pharmacy, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of ChinaCorrespondence: Rong-Hua Wang, Department of Pharmacy HuZhou Central Hospital (The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University), No. 1558 Sanhuan North Road, Wuxing District, Huzhou, Zhejiang, 313000, People’s Republic of China, Email legend.blue@163.com Hui-Min Xu, Department of Pharmacy Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88 Jiefang Road, Shangcheng District, Hangzhou, Zhejiang, 310009, People’s Republic of China, Email xuhuimin78@zju.edu.cnPurpose: This study aimed to elaborate on the incidence, clinical features, and management of immune checkpoint inhibitors (ICIs) related cardiovascular adverse events (CVAEs) in real-world practice.Patients and Methods: We performed a retrospective chart review study on patients receiving at least one dose of ICI therapy at a Chinese tertiary hospital from March 2020 to March 2021. …”
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242
Nanoparticles Modulating the Immune Microenvironment in Breast Cancer Treatment
Published 2025-02-01“…Li-Juan Guo,1 Jinsheng Wu,1 Weifeng Lu,2 Jing Li,1 Yeling Wang,1 Hui Yang,1 Tian-Zhu Wang3 1Department of Radiotherapy, The First Affiliated Hospital of Hainan Medical University, Haikou, 570102, People’s Republic of China; 2Institute of Oncology, The First Affiliated Hospital of Hainan Medical College Institute of Oncology, Haikou, 570102, People’s Republic of China; 3Department of Radiation Oncology, Hainan Cancer Hospital, Haikou, 570311, People’s Republic of ChinaCorrespondence: Tian-Zhu Wang, Department of Radiation Oncology, Hainan Cancer Hospital, Haikou, 570311, People’s Republic of China, Email pillarsky@126.comAbstract: Breast cancer remains a significant therapeutic challenge, with the immune microenvironment playing a crucial role in its progression and treatment response. …”
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Drug Clues for the Treatment of Fungal Catheter-Related Bloodstream Infection With Antifungal Lock Therapy
Published 2025-01-01“…Xiuyun Li,1 Bing Yu,2 Hui Li,3 Zhirui Liu,4 Xiaohan Fu,1 Ping Jiao,5 Lei Wang6 1Infection and Microbiology Research Laboratory for Women and Children, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, 250014, People’s Republic of China; 2Medical Affairs Department, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, 250014, People’s Republic of China; 3Pediatric Department, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, 250014, People’s Republic of China; 4Faculty of Medicine and Health, The University of Sydney, Camperdown NSW, 2050, Australia; 5Department of Pharmacy, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, 250012, People’s Republic of China; 6School of Pharmaceutical Science @ Institute of Materia Medica. …”
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245
Causal Association Between Obstructive Sleep Apnea and Migraine: A Bidirectional Mendelian Randomization Study
Published 2025-01-01“…Yu-Pei Wang,1,* Hui-Xia Wei,2,* Yuan-Yuan Hu,3 Chao Zhang,4 Yu-Ming Niu3– 5 1Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, People’s Republic of China; 2Department of Anesthesiology, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, People’s Republic of China; 3Department of Stomatology, Gongli Hospital of Shanghai Pudong New Area, Shanghai, People’s Republic of China; 4Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, People’s Republic of China; 5Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei Provincial Clinical Research Center for Umbilical Cord Blood Hematopoietic Stem Cells, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yu-Ming Niu, Department of Stomatology, Gongli Hospital of Shanghai Pudong New Area, Shanghai, People’s Republic of China, Tel +86 13581370999, Email niuyuming@yeah.net Chao Zhang, Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, People’s Republic of China, Email zhangchao0803@126.comObjective: Patients with obstructive sleep apnea (OSA) frequently suffer from migraine, however the causal relationship between OSA and migraine is unknown. …”
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246
Asiaticoside Attenuates Chronic Restraint Stress-Induced Hippocampal CA1 Neuronal Ferroptosis via Activating BDNF/Nrf2/GPX4 Signaling Pathway
Published 2025-02-01“…An Zhou,1– 3 Hao-Yinghua Feng,4 Chu-Ning Fan,3 Jun Wang,3 Zhong-Yu Yuan,3 Guang-Hui Xu,5 Cheng-Fu Li,6 Wei-Feng Huang,1 Li-Tao Yi3,7,8 1Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian Province, 361003, People’s Republic of China; 2School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen, Fujian Province, 361102, People’s Republic of China; 3Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen, Fujian Province, 361021, People’s Republic of China; 4College of Pharmacy, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong province, 510006, People’s Republic of China; 5Xiamen Medicine Research Institute, Xiamen, Fujian Province, 361008, People’s Republic of China; 6Xiamen Hospital of Traditional Chinese Medicine, Xiamen, Fujian Province, 361009, People’s Republic of China; 7Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen, Fujian Province, 361021, People’s Republic of China; 8Fujian Provincial Key Laboratory of Biochemical Technology, Huaqiao University, Xiamen, Fujian Province, 361021, People’s Republic of ChinaCorrespondence: Li-Tao Yi, Department of Chemical and Pharmaceutical Engineering, Huaqiao University, 668 Jimei Avenue, Xiamen, Fujian Province, 361021, People’s Republic of China, Email litaoyi@hqu.edu.cn Wei-Feng Huang, Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, 55 Zhenhai Road, Xiamen, Fujian Province, 361003, People’s Republic of China, Email hwf0625@xmu.edu.cnPurpose: Ferroptosis, characterized by iron-dependent lipid reactive oxygen species accumulation, plays a critical role in the pathophysiology of depression. …”
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247
Association Between Diurnal Temperature Range and Risk of Cardiomyopathy-Induced Hospitalisation in Henan, China: A Time-Series Study
Published 2025-01-01“…Zhaolin Zhang,1,* Yongbin Wang,2,* Yifeng Zhou,1 Jiachao Pei,1 Guoan Zhao,1,3 Pingshuan Dong,4 Kan Yang,5 Hui Liu,6 Na Xie,7 Xuefang Li,3 Xiayan Zang,3 Fei Lin,1,3 Zhigang Chen1 1Department of Cardiology,The First Affiliated Hospital of Xinxiang Medical University, Weihui, 453100, People’s Republic of China; 2Department of Epidemiology and Health Statistics, Xinxiang Medical University, Xinxiang, 453003, People’s Republic of China; 3Henan Engineering Technology Research Center of Environmental Meteorological Medicine, The First Affiliated Hospital of Xinxiang Medical University, Weihui, 453100, People’s Republic of China; 4Department of Cardiology,The First Affiliated Hospital of Henan University of Science and Technology, Luoyan, 471000, People’s Republic of China; 5Department of Cardiology,Nanyang Central Hospital, Nanyang, 473005, People’s Republic of China; 6Department of Cardiology,Anyang District Hospital, Anyang, 455000, People’s Republic of China; 7Department of Cardiology,The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453003, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fei Lin; Zhigang Chen, Department of Cardiology,The First Affiliated Hospital of Xinxiang Medical University, No. 88 Jiankang Road, Weihui, Henan, People’s Republic of China, Tel +86 18567557937, Email 1fy2000129@xxmu.edu.cn; 1fy2015157@xxmu.edu.cnPurpose: The effect of the diurnal temperature range (DTR) on human health in diverse geographic areas and the potential confounding factors are not fully understood. …”
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248
Abnormal Expression of Peripheral Blood Leukocyte Surface Markers in Retinopathy of Prematurity Patients
Published 2025-02-01“…Rui Guo,1 Fang Cheng,1 Xiang-Jie Meng,2,3 Jun-Mei Fan,4 Ya-Ling Lu,5 Xiao-Hui Ma,6 Xin Qiao,6 Jun-Hong Li7 1Department of Ophthalmology, Children’s Hospital of Shanxi and Women Health Center of Shanxi, Affiliated to Shanxi Medical University, Taiyuan, 030000, People’s Republic of China; 2Department of Pediatric Stomatology, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, People’s Republic of China; 3Department of Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, People’s Republic of China; 4Department of Reproductive Medicine Center, Children’s Hospital of Shanxi and Women Health Center of Shanxi, Affiliated to Shanxi Medical University, Taiyuan, 030000, People’s Republic of China; 5School of Basic Medicine, Shanxi Medical University, Taiyuan, 030001, People’s Republic of China; 6Department of Shanxi Province Key Laboratory of Ophthalmology, Shanxi Eye Hospital Affiliated to Shanxi Medical University, Taiyuan, 030002, People’s Republic of China; 7Department of Strabismus and Pediatric Ophthalmology, Shanxi Eye Hospital, Affiliated to Shanxi Medical University, Taiyuan, 030002, People’s Republic of ChinaCorrespondence: Jun-Hong Li, Department of Strabismus and Pediatric Ophthalmology, Shanxi Eye Hospital Affiliated to Shanxi Medical University, No. 100 Fudong Street, Taiyuan, 030002, People’s Republic of China, Tel +8613834131099, Email junhongliljh@126.comObjective: Our study compares immune cell profiles in preterm infants with and without severe ROP, identifying risk factors for its development to explore both immunological aspects and determinants of ROP in preterm infants.Methods: Infants born between January 2023 to December 2023 at the Children’s Hospital of Shanxi were enrolled in this study according to the inclusion criteria. …”
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249
Shipwreck Architecture
Published 2025-02-01“…An academic introduction will connect the tragic aspects of Yuk Hui’s cosmotechnics, to the tragic pairings created by figurative surrealists Rene Magritte and Salvador Dalí, to the ontographic project of shipwreck hauntography. …”
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250
Application of the 2021 AAPOS Guidelines in Clinics with Revision and Validation of SPOT Referral Criteria
Published 2025-01-01“…Rui Li,1,* Qi Yan,2,* Xiao Lin,3,* Zhujian Wu,4 Hui Zhu,4 Wei Guo,4 Peibin Zhang,4 Feidi Zuo,5 Ziyan Wu,5 Hu Liu,4 Dan Huang4 1Department of Ophthalmology, Nanjing First Hospital, Nanjing Medical University, Nanjing, People’s Republic of China; 2Department of Ophthalmology, Children’s Hospital of Soochow University, Suzhou, People’s Republic of China; 3Department of Ophthalmology, Baylor College of Medicine, Houston, TX, USA; 4Department of Ophthalmology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, People’s Republic of China; 5The Fourth School of Clinical Medicine of Nanjing Medical University, Nanjing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hu Liu; Dan Huang, Department of Ophthalmology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, People’s Republic of China, Tel +86 (25) 68136470, Fax +86 (25) 83275171, Email liuhu@njmu.edu.cn; huangdan@njmu.edu.cnPurpose: This study aims to validate and revise the Spot Vision Screener referral criteria for detecting amblyopia risk factors (ARFs), visually significant refractive error (VSRE), and amblyopia.Methods: In clinics, we gathered data from children aged 12 months to 7 years. …”
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251
Progress in the Study of Intratumoral Microorganisms in Hepatocellular Carcinoma
Published 2025-01-01“…Yagang Song,1,2 Shuo Tian,1,2 Zhanzhan Li,1,2 Jinxin Miao,1,2 Mingming Wu,1,2 Tingli Xu,1,2 Xiangxiang Wu,1,2 Jingyi Qiao,1,2 Xialei Zhang,1,3 Hui Zhao,1,2 Le Kang,1,3 Lihua Cao,1,2 Pingsheng Zhu,4 Mingsan Miao1 1Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan, 450046, People’s Republic of China; 2Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan University of Chinese Medicine, Zhengzhou, Henan, 450046, People’s Republic of China; 3School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, 450046, People’s Republic of China; 4College of Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou, Henan, 450046, People’s Republic of ChinaCorrespondence: Mingsan Miao, Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan, 450046, People’s Republic of China, Tel/Fax +86-371-65962546, Email miaomingsan@163.comAbstract: The intratumoral microbiota, an integral part of liver tumors, has garnered significant attention from researchers due to its role in tumor development regulation and impact on cancer treatment. …”
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252
Clinical Characteristics and Risk Factors for Multidrug-Resistant Enterobacter cloacae Complex Bacteremia in a Chinese Tertiary Hospital: A Decade Review (2013–2022)
Published 2025-01-01“…Mei Han,1,2,* Miaomiao Hua,3,* Hui Xie,1 Jia Li,1 Yijun Wang,2,4 Han Shen,1 Xiaoli Cao1 1Department of Laboratory Medicine, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, People’s Republic of China; 2Nanjing Field Epidemiology Training Program, Nanjing Municipal Center for Disease Control and Prevention, Nanjing, Jiangsu, People’s Republic of China; 3Department of Laboratory Medicine, The Affiliated Fuyang Hospital of Anhui Medical University, Fuyang, Anhui, People’s Republic of China; 4Nanjing Jiangning District Center for Disease Control and Prevention, Nanjing, Jiangsu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaoli Cao; Han Shen, Email cao-xiao-li@163.com; shenhan10366@sina.comObjective: This study aimed to analyze the antimicrobial resistance profiles, clinical characteristics and risk factors of bacteremia caused by Enterobacter cloacae complex (ECC) strains.Methods: We retrospectively collected clinical data from patients diagnosed with ECC bacteremia between 2013 and 2022 in a tertiary hospital in Jiangsu. …”
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253
Utilizing Targeted Next-Generation Sequencing for Rapid, Accurate, and Cost-Effective Pathogen Detection in Lower Respiratory Tract Infections
Published 2025-01-01“…Lisha Qin,1,* Mengyuan Liang,1,2,* Jianping Song,1,* Ping Chen,1,* Shujing Zhang,3,* Yaya Zhou,1 Hui Li,1 Jian Tang,1 Yanling Ma,1 Bohan Yang,1 Juanjuan Xu,1 Jianchu Zhang1 1Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, Zhengzhou University People’s Hospital, Henan Provincial People’s Hospital, Zhengzhou, People’s Republic of China; 3Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jianchu Zhang, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China, Tel +86-13971445469, Email zsn0928@163.comObjective: To evaluate the diagnostic performance and clinical impact of targeted next-generation sequencing (tNGS) in patients with suspected lower respiratory tract infections.Methods: Following propensity score matching, we compared the diagnostic performances of tNGS and metagenomic next-generation sequencing (mNGS). …”
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254
Cucurbitacin IIa Alleviates Colitis via Promoting the Release of Host-Derived Extracellular Vesicles Encapsulating microRNA-30b-5p
Published 2025-01-01“…Yinyin Zhao,1 Binyuan Jiang,2 Shengnan Zuo3 1Ningbo Institute of Innovation for Combined Medicine and Engineering (NIIME), The Affiliated LiHuiLi Hospital of Ningbo University, Ningbo, People’s Republic of China; 2Medical Research Center of the Affiliated Changsha Central Hospital of Hengyang Medical School, University of South China, Changsha, People’s Republic of China; 3Clinical Laboratory Department, Hunan Guangxiu Hospital, Changsha, People’s Republic of ChinaCorrespondence: Binyuan Jiang; Shengnan Zuo, Email 2018050871@usc.edu.cn; shengnanzuo123@sina.comPurpose: Cucurbitacins have demonstrated anti-inflammatory effects and show promise for inflammatory bowel diseases. …”
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Prominence of Microbiota to Predict Fibrous Stenosis in Crohn’s Disease
Published 2025-02-01“…Xue Yang,* Yan Pan,* Cai-Ping Gao, Hang Li, Ying-Hui Zhang, Chun-Li Huang, Lu Cao, Shi-Yu Xiao, Zhou Zhou Department of Gastroenterology, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhou Zhou; Shi-Yu Xiao, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, People’s Republic of China, Email doublezhouu2006@163.com; xiaoshiyu57@163.comPurpose: Intestinal fibrous stenosis due to Crohn’s disease (CD) is highly prevalent. …”
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Compassionate Use of Omadacycline in a Down Syndrome Pre-Schooler With Critically Ill Atypical Pneumonia Caused by Macrolide-Resistant Mycoplasma Pneumoniae
Published 2025-01-01“…Di Wu,1,* Feng-Jie Xie,2,* Ya-Jun Wang,3,* Xiao-Hui Jiang,1,* Guo-Li Zhang,3,* Hong Zhang,2 Yu-Cheng Zhu,4 Yan Zhang,4 Yu-Jia Tang,1 Yi-Lu Lin,1 Jia-Xi Xu,5 Jia-Ning Zhang,5 Bo-Wen Liu,5 Kai Kang,5 Yang Gao1 1Department of Critical Care Medicine, The Sixth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, People’s Republic of China; 2Department of Critical Care Medicine, The Hongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang, Heilongjiang Province, People’s Republic of China; 3Department of Pediatrics, The Sixth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, People’s Republic of China; 4Department of Critical Care Medicine, The Hongxinglong Hospital of Beidahuang Group, Shuangyashan, Heilongjiang Province, People’s Republic of China; 5Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Kai Kang, Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin, Heilongjiang Province, 150001, People’s Republic of China, Tel +86-13904618016, Email janekk79@126.com Yang Gao, Department of Critical Care Medicine, The Sixth Affiliated Hospital of Harbin Medical University, 998 Aiying Road, Songbei District, Harbin, Heilongjiang Province, 150027, People’s Republic of China, Tel +86-13045160709, Email gaoyang0312@126.comBackground: Rapid and accurate identification of causative organisms and prompt initiation of pathogen-targeted antibiotics are crucial for managing atypical pneumonia. …”
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May Measurement Month 2020: An Analysis of Blood Pressure Screening Results From China
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Network Pharmacology and Experimental Validation of the Therapeutic Effect of Baji Capsule on LPS-Induced Osteoporosis
Published 2025-02-01“…Qian Li,1 Dinglin Li,1 Ciqiu Tian,2 Xiangjie Liu,1 Hui Wang,1 Hao Liu1 1Liyuan Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Tongji Medical College of Science and Technology, Wuhan, People’s Republic of China; 2Hubei University of Chinese Medicine, Wuhan, People’s Republic of ChinaCorrespondence: Hao Liu, Liyuan Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology, Tongji Medical College of Science and Technology, Wuhan, People’s Republic of China, Email 729481937@qq.comPurpose: Osteoporosis is a common skeletal disease characterized by impaired bone microarchitecture, decreased bone mineral density and increased bone fragility, leading to a heavy physical and economic burden due to its greatly increased risk of fracture. …”
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Development and Characterization of a Hydrogel Containing Chloramphenicol-Loaded Binary Ethosomes for Effective Transdermal Permeation and Treatment Acne in Rat Model
Published 2025-02-01“…Run jia Liu,1 Miao Li,1 Qian Zhu,1 Hui ying Liu,1 Xing xiu Zhang,1 Xiang yuan Han,1 Meng jun Yu,1 Jian wen Zhou,2 Cui yan Han1 1School of Pharmacy, Qiqihar Medical University, Qiqihar, People’s Republic of China; 2Institute of Medicine and Drug Research, Qiqihar Medical University, Qiqihar, People’s Republic of ChinaCorrespondence: Cui yan Han, School of Pharmacy, Qiqihar Medical University, Qiqihar, People’s Republic of China, Tel/Fax +86-24-2663822, Email hcymuphar@qmu.edu.cnPurpose: Acne is a serious disfiguring follicular sebaceous gland disorder that negatively affects patients’ quality of life and self-image. …”
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