A novel Alteromonas phage with tail fiber containing six potential iron-binding domains by Chen Yu, Meishun Yu, Ruijie Ma, Shuzhen Wei, Min Jin, Nianzhi Jiao, Qiang Zheng, Rui Zhang, Xuejin Feng

“…Our isolation and characterization of R22Y complements the Trojan Horse hypothesis, proposes the possible role of alterophages for marine iron biogeochemical cycling, and provides new insights into phage-host interactions in the iron-limited ocean.IMPORTANCEIron (Fe), as an essential micronutrient, is often a limiting factor for microbial growth in marine ecosystems. The Trojan Horse hypothesis suggests that iron in the phage tail fibers is recognized by the host’s siderophore-bound iron receptor, enabling the phage to attach and initiate infection. …”
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Future climate change impacts on common bean (Phaseolus vulgaris L.) phenology and yield with crop management options in Amhara Region, Ethiopia by Adem Mohammed, Estifanos Feleke

“…The impact analysis showed that both days to flowering and days to maturity may decrease in 2030s and 2050s at both sites and under both RCP4.5 and RCP8.5 scenarios as compared to the simulated values for the baseline period (1981–2010) but the decrease is not statistically significant. …”
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Contradictory Effect of Lymphocyte Therapy and Prednisolone Therapy on CD3+CD8+CD56+ Natural Killer T Population in Women with Recurrent Spontaneous Abortion by Fatemeh Rezayat, Nafiseh Esmaeil, Abbas Rezaei, Roya Sherkat

“…Furthermore, the concentration of interferon-gamma (IFN-γ), transforming growth factor-beta (TGF-β) and interleukin-10 (IL-10) was measured quantitatively using the enzyme-linked immunosorbent assay technique. …”
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Determinants of school-going adolescent girls’ health and nutritional status in district Malir, Karachi: a baseline cross-sectional study by Saira Zafar, Babar Tasneem Shaikh, Zoha Imtiaz Malik, Abdul Momin Rizwan Ahmad

“…IntroductionAdolescence is a phase of life marked by rapid growth. Adequate nutrition is essential during this developmental stage, leading to significant physical performance, improved cognitive ability, and productivity. …”
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Morphological variation of Ficus johannis subsp. afghanistanica (Warb.) Browicz in Sistan-va-Baluchestan province, Iran by Ali Khadivi, Farhad Mirheidari, Abdolvahid Saeidifar, Younes Moradi, Yazgan Tunç

“…The study highlights significant morphological diversity of F. johannis subsp. afghanistanica, with key traits, including erect growth habits (25 accessions), intermediate and high vigor (21 accessions), and varied fruit ripening times (35 early, 12 late). …”
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Mfsd2a suppresses colorectal cancer progression and liver metastasis via the S100A14/STAT3 axis by Linfeng Sun, Xiangdong Li, Yuhao Xiao, Wenjie Yu, Xuyang Chen, Ziyi Wang, Nan Xia, Xuejiao Chen, Minhao Chen, Haoliang Zhu, Jie Li, Jie Wei, Sheng Han, Liyong Pu

“…The biological function of Mfsd2a in CRLM was confirmed by a series of experiments conducted both in vitro and in vivo. Additionally, we investigated downstream molecular pathways using western blot, Co-immunoprecipitation, immunofluorescence, and mass spectrometry techniques. …”
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Anti-Inflammatory and Anti-Migratory Effects of Morin on Non-Small-Cell Lung Cancer Metastasis via Inhibition of NLRP3/MAPK Signaling Pathway by Punnida Arjsri, Kamonwan Srisawad, Sonthaya Umsumarng, Pilaiporn Thippraphan, Songyot Anuchapreeda, Pornngarm Dejkriengkraikul

“…High rates of metastasis contribute significantly to the poor prognosis of NSCLC, in which inflammation plays an important role by enhancing tumor growth, angiogenesis, and metastasis. Targeting inflammatory pathways within cancer cells may thus represent a promising strategy for inhibiting NSCLC metastasis. …”
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Biological characteristics of bream (Abramis brama Linnaeus, 1758) of the Kremenchuk Reservoir as an object of commercial fishery by N. Rudyk-Leuska, O. Buzevych, M. Leuskyi, I. Burjak

“…The parameters of the von Bertalanffy equation, which characterize the growth rate for bream of the Kremenchuk Reservoir in the period 2021-2023, were: K = 0.119 (year-1), L∞ = 57.9 (cm) to = -0.77 (year), which is fully consistent with the values obtained in previous studies. …”
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Oncometabolite D-2HG drives tumor metastasis and protumoral macrophage polarization by targeting FTO/m6A/ANGPTL4/integrin axis in triple-negative breast cancer by Siyue Zhang, Ning Zhang, Tong Wan, Yinqiao He, Jie Hao, Yiwei Liu, Yidong Liu, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Chao Gao, Qifeng Yang

“…Results We found that D-2HG accumulated in triple-negative breast cancer (TNBC), exerting oncogenic effects both in vitro and in vivo by promoting TNBC cell growth and metastasis. …”
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Multi-target gene therapy AUP1602-C to improve healing and quality of life for diabetic foot ulcer patients: a phase I, open-label, dose-finding study by Christoph Schindler, Jacek Mikosiński, Pawel Mikosiński, Hanna-Riikka Kärkkäinen, Mirka Sanio, Jere Kurkipuro, Igor Mierau, Wesley Smith, Aki Vartiainen, Laurent Décory, Dirk Weber, Thomas Wirth, Juha Yrjänheikki, Sebastian Schellong, Haritha Samaranayake

“…AUP1602-C, a topical four-in-one gene therapy medicinal product (GTMP), consisting of a Lactococcus cremoris strain that produces fibroblast growth factor-2, interleukin-4, and colony-stimulating factor-1, is a promising novel treatment for DFU. …”
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The Influence of Digital Talent Development and Green Innovation and The Use of Green Innovation As Mediation To Measure Data Centre Performance by Rifa Herdian, Mohammad Syamsul Maarif, Anggraini Sukmawati, Irman Hermandi

“…Background: Data Centre industry activity in Asia Pacific is experiencing significant growth, driven by the increasing adoption of cloud technology and data-driven solutions. …”
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Natural and Migration Balance of the Population in Sibiu County Between 1992 and 2021 by Raularian RUSU, Ciprian MOLDOVAN, Titus MAN, Elena-Manuela BÎRSĂNUC, Cosmina-Daniela URSU

“…However, the steep decline of the natural balance rate during the pandemic also affected the total balance rate, which became negative in both 2020 and 2021. Nevertheless, the total balance rate is expected to reverse back to positive values after the end of the pandemic. …”
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Exploring the role of circulating proteins in multiple myeloma risk: a Mendelian randomization study by Matthew A. Lee, Kate L. Burley, Emma L. Hazelwood, Sally Moore, Sarah J. Lewis, Lucy J. Goudswaard

“…Seven proteins had 95% confidence intervals (CIs) that did not overlap the null in both forward MR analyses and did not have evidence for an effect in the reverse direction: higher levels of dermatopontin (DPT), beta-crystallin B1 (CRYBB1), interleukin-18-binding protein (IL18BP) and vascular endothelial growth factor receptor 2 (KDR) and lower levels of odorant-binding protein 2b (OBP2B), glutamate-cysteine ligase regulatory subunit (GCLM) and gamma-crystallin D (CRYGD) were implicated in increasing MM risk. …”
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Effects of Food on the Pharmacokinetics and Safety of HA121-28 Tablet, a Novel Multi-Targeting Tyrosine Kinase Inhibitor, in Healthy Chinese Subjects: A Phase I Clinical Trial by Liu Y, Li X, Zhang M, Men Y, Wang Y, Zhu X, Zheng L

“…The clinical application of HA121-28 tablet can be recommended for use in both fasted and postprandial states.Keywords: HA121-28, ##Food effects, pharmacokinetics, safety, tyrosine kinase inhibitor…”
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Anemia and Associated Factors among Public Elementary School Children in Asella Town, Southeast Ethiopia: A Facility-Based Cross-Sectional Study by Ararso Hordofa Guye, Kasim Hansa, Kasahun Ketema, Meseret Moroda, Dame Banti Shambi

“…Anemia has a negative impact on school children, including poor physical growth and reduced mental performance. Children show poor attentiveness, behavior, and memory and reduced school performance. …”
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Predictive Value of Initial 18F-FDG PET/CT for Identifying EGFR and KRAS Mutations in Patients with Non-small-cell Lung Cancer by Ozge Vural Topuz, Nur Buyukpinarbasili

“…Aim: Since the importance of epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene homolog gene (KRAS) mutation status in predicting treatment response in non-small cell lung cancer (NSCLC) patients is well known, we aimed to evaluate whether initial fluorine-18-fluorodeoxyglucose (18F-FDG) positron emission tomography-computed tomography (PET/CT) imaging could non-invasively predict EGFR or KRAS mutation states in this patient group. …”
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Current regenerative approaches to the treatment of generalized periodontitis in young people (literature review) by O.V Kopchak, I.V. Kovach, Y.V. Litvinova, K.A. Yanishevsky, N.S. Marchenko

“…The use of stem cells and growth factors, which contains platelet-rich plasma, allows you to significantly increase the effectiveness of periodontal disease treatment.…”
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Severe pregnancy-associated atypical hemolytic uremia syndrome in the context of the COVID-19 pandemic: a novel survival case report by Yan Yang, Xiao-jin Li, Hua-Yan Yuan, Jing-Jing Xiong, Peng-Fei Li, Zhen Wang

“…Case presentation A 26-year-old patient with a history of four pregnancies and one delivery (P4G1) presented at 30 weeks and 2 days of gestation with vaginal fluid leakage and fetal growth restriction detected by ultrasound at a different hospital. …”
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Kinesiotherapy for Post-stroke Rehabilitation： Analysis of Characteristics of Clinical Trials in the Past 20 Years Based on Clinical Trials Registry Platform by WANG Hui, FENG Yuting, YU Yongpei, HU Chenhua, TAO Liyuan

“…The main intervention measure with the highest proportion was robot-assisted rehabilitation (15.43%), followed by integrative treatment (13.73%), virtual reality (6.93%), and the main evaluation indexes were scores of motor function scales (42.53%) and motor function test (23.69%).ConclusionThe clinical trials related to kinesiotherapy of post-stroke rehabilitation are in a period of rapid growth, which is related to current trends with emphasis on the early rapid recovery of sensory and motor abilities and activities of daily living in the medical field, which will greatly improve the quality of life of patients after stroke. …”
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Anaemia prevalence in children newly registered at UNRWA schools: a cross-sectional study by Yassir Turki, Wafaa Zeidan, Akihiro Seita, Majed Hababeh, Nada AbuKishk, Suha Saleh, Shatha Albaik, Zoheir el-Khatib, Nimer Kassim, Hasan Arab, Khawalah Abu-Diab

“…Underweight (weight-for-age z-score <−2 SD), stunting (height-for-age z-score <−2 SD), thinness (body mass index-for-age z-score <−2 SD) and obesity (body mass index-for-age z-score >+2 SD) were examined according to WHO growth indicators (5–10 years).Results 2419 students (1278 girls and 1141 boys) aged 6.1±0.4 years were examined. …”
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