Nanostructured lipid carriers based mRNA vaccine leads to a T cell–inflamed tumour microenvironment favourable for improving PD-1/PD-L1 blocking therapy and long-term immunity in a... by Carole Fournier, Marion Mercey-Ressejac, Valentin Derangère, Amal Al Kadi, David Rageot, Christine Charrat, Alexis Leroy, Julien Vollaire, Véronique Josserand, Marie Escudé, Séverine Escaich, François Ghiringhelli, Thomas Decaens, Fabrice P. Navarro, Evelyne Jouvin-Marche, Patrice N. Marche

“…We tested the anti-tumoral impact of Ova mRNA vaccine in B16-OVA and E.G7-OVA cold tumour-bearing C57Bl6 female mice as well as its synergy effect with an anti-PD-1 therapy by following the tumour growth and performing immunophenotyping of innate and adaptive immune cells. …”
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Indigenous Knowledge on Shifting Cultivation and Sustainable Agriculture by Krisnawati Krisnawati, Alia Bihrajihant Raya

“…In 2021, agricultural sector contributed 33.61% to growth Arfak Mountains Gross Regional Domestic Product. …”
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Experimental research on mechanical and impact properties of ceramsite prepared from secondary aluminum dross and municipal solid waste incineration ash by Wangze He, Yufei Yang, Xinghan Zhu, Jinzhong Yang, Yingjie Sun, Qifei Huang

“…Abstract With the growth of the industrial aluminum smelting sector, and the increasing proportion of incineration treatment in the field of waste management and disposal, there has been a corresponding increase in the production of secondary aluminum dross (SAD) and municipal solid waste incineration fly ash (MSWIFA) annually. …”
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Modelling the Transmission Dynamics of Meningitis among High and Low-Risk People in Ghana with Cost-Effectiveness Analysis by Nicholas Kwasi-Do Ohene Opoku, Reindorf Nartey Borkor, Andrews Frimpong Adu, Hannah Nyarkoah Nyarko, Albert Doughan, Edwin Moses Appiah, Biigba Yakubu, Isabel Mensah, Samson Pandam Salifu

“…The effective reproductive number estimated in real time using the exponential growth method affirmed that the number of secondary meningitis infections will continue to increase without any intervention or policies. …”
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Urinary Microbiota of Healthy Prepubescent Girls and Boys—A Pilot Study by Yulia L. Naboka, Mikhail I. Kogan, Johannes M. Mayr, Irina A. Gudima, Elizaveta M. Koliva, Violetta M. Kotieva, Marina L. Chernytskaya, Vladimir V. Sizonov

“…We collected the mean portion of morning urine during natural micturition and determined aerobic and anaerobic microbiota using HiCrome™ chromogenic growth media. We identified microorganisms on the basis of morphotinctural properties and analyzed α- and β-diversity of microorganisms isolated from the urine of boys and girls. …”
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Effects of Antarctic Krill Meal in Diet on Reproductive Performance and Embryo Quality of Eriocheir sinensis by Xiaorong Huang, Ru Tan, Zhi Geng, Tao Zhang, Guangpeng Feng, Gang Yang, Feng Zhao, Ping Zhuang

“…The results revealed no significant differences in weight gain rate, specific growth rate, and survival rate. However, the hepatopancreatic weight and hepatopancreas index of female crabs in each group decreased, while gonadal weight and gonadosomatic index increased significantly after 60 days, with Diet K20 showing the highest values. …”
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Morphological, Physiological and Biochemical Changes in the Grape Variety “Hotan Red” Caused by the Occurrence of Stress Under the Influence of Saline–Alkaline Growing Conditions... by Yan Song, Ruxue Li, Long Zhou, Lili Jiang, Xiong Wang

“…The results showed that the growth of plant height and shoot thickness of Hotan Red was inhibited, chlorophyll content decreased and the salinity damage index increased with increasing saline–alkali stress. …”
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Copy number variations at the Rhg1 locus and their relationship with resistance to soybean cyst nematode (Heterodera glycines) by Dinesh Poudel, Guiping Yan, Carrie Miranda, Gustavo Fernando Kreutz, Intiaz Amin Chowdhury

“…One line, ND20-16996(GT) was resistant (FI<10%) to S2 in both runs, while none were resistant to S1. Copy number among the breeding lines ranged from 1 to 11, with higher copy numbers correlating negatively with female index, indicating greater resistance. …”
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Youth inclusion in value chain development: a case of the aquaculture in Nigeria by Likimyelesh Nigussie, Thai Thi Minh, Sonali Senaratna Sellamuttu

“…This is aimed at overcoming social, technical, and institutional obstacles and providing fair and significant opportunities for the growth of young people. Inclusive agricultural value chain development (VCD) is being used to address youth unemployment in the region. …”
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The Anticancer Activity of Lycium barbarum Polysaccharide by Inhibiting Autophagy in Human Skin Squamous Cell Carcinoma Cells In Vitro and In Vivo by Meihua Zeng, Qingtao Kong, Fang Liu, Jun Chen, Hong Sang

“…LBP can induce apoptosis of A431 cells by inhibiting autophagy and can inhibit tumor growth in vivo.…”
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The effectiveness analysis of traditional and new landscape indexes in indicating flood risk of watersheds from the perspective of source-sink landscapes: A case study of Changsha,... by Lingxuan Zhang, Sheng Jiao, Jie Lu

“…The source landscapes expanded by 680.84 km2, with significant growth and aggregation, primarily in low-lying areas near watershed outlets, while the sink landscapes evolved in the opposite direction. …”
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HGF-Modified Dental Pulp Stem Cells Mitigate the Inflammatory and Fibrotic Responses in Paraquat-Induced Acute Respiratory Distress Syndrome by Panpan Geng, Yuning Zhang, Huan Zhang, Xiwen Dong, Yuefeng Yang, XiaoNa Zhu, Chu-Tse Wu, Hua Wang

“…Mesenchymal stem cells (MSCs) and hepatocyte growth factor (HGF) have been shown to partially reverse this damage. …”
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Short-term impact of low air pressure on plants' functional traits. by Silvia Lembo, Georg Niedrist, Bouchra El Omari, Paul Illmer, Nadine Praeg, Andreas Meul, Matteo Dainese

“…This might impact plant photosynthetic activity, resource allocation, water relations, and growth. However, the direct impact of low air pressure on plant physiology is largely unknown. …”
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Impaired ARID1A expression attenuated the immune response in gastric cancer via histone acetylation by Yu Tang, Ruizhi Zhang, Gan Mao, Chong Li, Yisong Gao, Xuebing Zhou, Wenxiang Nie, Tianyu Song, Suao Liu, Kaixiong Tao, Peng Zhang, Wei Li

“…Additionally, ARID1A depletion was associated with enhanced tumor growth and the absence of CD8+ T cells within the tumor microenvironment. …”
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Episcleral spread of ciliochoroidal melanoma following surgeries: a case report by E.E. Grishina, I.D. Kim, E.N. Izotova

“…The disrupted eye globe integrity caused by the glaucoma surgery and cataract extraction contributed to the extrascleral tumor growth. The inadequate therapy and delayed anti-tumor treatment of uveal melanoma necessitated to increase the scope of the surgical excision — the left orbital exenteration and, potentially, could deteriorate the survival prognosis. …”
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HER-SAFE study design: an open-label, randomised controlled trial to investigate the safety of withdrawal of pharmacological treatment for recovered HER2-targeted therapy-related c... by Robin Chung, James C Moon, Alexander R Lyon, Charlotte H Manisty, Muhummad Sohaib Nazir, Malcolm Walker, Peter Kellman, Benjamin Dowsing, Daniel Chen, Jessica Artico, Mark Westwood, Hakim-Moulay Dehbi, Rebecca Roylance, Tom Crake, Peter Schmid, Arjun Ghosh, Maria Sol Andres, Joanna Pedra, Orla Worn

“…Introduction A quarter of breast cancers show human epidermal growth factor-2 (HER2) overexpression, where targeted therapy dramatically improves survival. …”
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O2-self-supplying and glutathione-depleting scaffold for synergistic cancer therapy by Jiajia Zeng, Chongxian He, Xinna Bai, Cijun Shuai, Hao Pan

“…Therefore, the Ti3C2 nano-sheet loaded with CeO2 could combine the dual enzyme activities, photodynamic and photothermal effect to enhance the tumor therapy with a tumor growth inhibitory effect of approximately 88.8 %. …”
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An Analysis of the Spatial Characteristics of Jin Ancestral Temple Based on Space Syntax by Chuanjin Hu, Yuanbo Qi, Chongen Wang

“…Visual Graph Analysis (VGA) shows that the central axis area has the unique characteristics of a “visual center” and a “transportation hub”. The plaza on the north side of the reflecting pool forms the core area of visual connectivity, while Jinren Terrace becomes the transportation node with the highest accessibility. …”
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CircTRRAP Knockdown Has Cardioprotective Function in Cardiomyocytes via the Signal Regulation of miR-370-3p/PAWR Axis by Yuan Zhang, Zhenggong Li, Jiao Wang, Hao Chen, Rui He, Hongkun Wu

“…Downregulation of circTRRAP promoted cell growth but inhibited apoptosis, inflammation, and oxidative stress in hypoxic cells. …”
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Green synthesis of iron nanoparticles to promote seed germination of Zea mays under salinity condition by Hiba Fouad Abdulfatah, May Fahmi Abdulrahman, Enas Fahd Naji

“…The synthesized Fe NPs were spherical and have around 12 nm in size, with a 5.5 mV value, the synthesized Fe NPs were stable.The effects of these (Fe NPs) on the germination of maize (Zea mays L.) labeled Z1(Buhooth 5018), Z2(Baghdad-3) and Z3 (Fajr-1) seeds and the growth of their roots were assessed under conditions of salinity at different levels (0, 8, 12 ds m−1) in a laboratory-scale system. …”
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