Editorial: The role of dietary interventions in the regulation of host-microbe interactions, volume II by Xinyi Zhang, Xinyi Zhang, Xinyi Zhang, Yujie Cai, Xia He, Tingtao Chen, Tingtao Chen

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Metabolic features of patients with repeated Omicron infections highlight new targets for therapeutic intervention by Jiaying Zhang, Sin Man Lam, Shan Ji, Longyu Zhang, Jiming Yin, Haiqing Sun, Danlei Mou, Lianchun Liang, Qinghua Meng, Guanghou Shui, Yingmei Feng

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Dual-species proteomics and targeted intervention of animal-pathogen interactions by Yang Sylvia Liu, Chengqian Zhang, Bee Luan Khoo, Piliang Hao, Song Lin Chua

“…Introduction: Host-microbe interactions are important to human health and ecosystems globally, so elucidating the complex host-microbe interactions and associated protein expressions drives the need to develop sensitive and accurate biochemical techniques. …”
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The use of stem cells and organoids for modeling host-microbe interactions in low-biomass tissues by Claire A. Shaw, Claire A. Shaw, Margo Verstrate, Kinga Graniczkowska, Katie R. Risoen, Katie R. Risoen, Pouya Dini, Bart C. Weimer, Bart C. Weimer

“…Additionally, this work describes the pivotal role of cell culture models in advancing host–microbe interaction studies in understudied low-biomass organs such as the stomach and reproductive tract. …”
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Circadian rhythms of gut microbiota and plaque vulnerability: mechanisms and chrono-microbiota modulation interventions by Taiyu Zhai, Xueyang Zou, Zichen Zhang, Yifei Wang, Lin Shi, Wenbo Ren, Jing Huang

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Comparative analysis of goat and bovine milk proteins in the improvement of sarcopenia based on host-microbial interactions by Ruoyu Wang, Yuxin Ma, Meng Sun, Lutong Li, Zhaofeng Zhang

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Facilitating a high-quality dietary pattern induces shared microbial responses linking diet quality, blood pressure, and microbial sterol metabolism in caregiver-child dyads by Emily B. Hill, Li Chen, Michael T. Bailey, Amrik Singh Khalsa, Ross Maltz, Kelly Kelleher, Colleen K. Spees, Jiangjiang Zhu, Brett R. Loman

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Multi-omics analysis reveals the efficacy of two probiotic strains in managing feline chronic kidney disease through gut microbiome and host metabolome by Hsiao-Wen Huang, Tzu-Chien Kuo, Tzu-Chien Kuo, Ya-Jane Lee, Ya-Jane Lee, Ming-Ju Chen, Ming-Ju Chen

“…Overall, our findings suggest that Lm intervention may influence the gut-kidney axis in cats with CKD. …”
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Biomarker Research in ADHD: the Impact of Nutrition (BRAIN) - study protocol of an open-label trial to investigate the mechanisms underlying the effects of a few-foods diet on ADHD... by Esther Aarts, Tim Stobernack, Stefan P W de Vries, Rob Rodrigues Pereira, Lidy M Pelsser, Cajo J F ter Braak, Peter van Baarlen, Michiel Kleerebezem, Klaas Frankena, Saartje Hontelez

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Diet, Gastric Microbiota, and Metabolites in Gastric Tumorigenesis by Lanping Jiang, Harry Cheuk-Hay Lau, Ruijie Zeng, Jun Yu

“…We also explore microbial metabolites and host–microbe interactions in gastric tumorigenesis, alongside dietary interventions targeting the microbiota for the prevention and management against GC.…”
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Gut Microbiota Dysbiosis and Its Impact on Type 2 Diabetes: From Pathogenesis to Therapeutic Strategies by Yonghua Yu, Yilan Ding, Shuangyuan Wang, Lei Jiang

“…Additionally, we explore potential therapeutic strategies, including probiotics and dietary interventions, to modulate the gut microbiota and its metabolites, providing insights for future clinical research and the development of novel treatments for T2DM.…”
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Disentangling the impact of obesity, diet, host factors, and microbiota on small intestinal antimicrobial peptide expression by Fabiola Puértolas-Balint, Vishnu Prasoodanan P K, Sandra M. Holmberg, Bjoern O. Schroeder

“…By using different dietary interventions in mice, we here show that prolonged intake of an obesogenic Western-style diet had a stronger impact on AMP expression than diet-independent obesity. …”
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Heat stress in chickens induces temporal changes in the cecal microbiome concomitant with host enteric serotonin responses by Joshua M. Lyte, Xinglin Jia, Valentina Caputi, Danyang Zhang, Karrie M. Daniels, Gregory J. Phillips, Mark Lyte

“…As these findings demonstrate that heat stress can alter serotonin concentrations in the chicken intestinal tract, with distinct outcomes depending on duration of the stressor, serotonergic signaling may serve as potential leverageable point of intervention in host-microbe interactions including foodborne pathogen colonization in the chicken gut. …”
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The dynamic distribution of the rectal microbiota in Holstein dairy calves provides a framework for understanding early-life gut health by Qi Huang, Fengtao Ma, Yuhang Jin, Duo Gao, Meinan Chang, Peng Sun

“…This study provides a framework for understanding early-life gut health and offers theoretical guidance for future research on host–microbe interactions and early nutritional interventions. …”
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Gut microbiome in gastrointestinal neoplasms: from mechanisms to precision therapeutic strategies by Jiaqian Song, Wei Zhang, Deqiang Wang

“…This review aims to systematically analyze the core molecular mechanism of GM affecting tumor development and explore the precise intervention strategies guided by clinical translation. …”
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Gut-lung axis in allergic asthma: microbiota-driven immune dysregulation and therapeutic strategies by Jian Lv, Yu Zhang, Shuang Liu, Ruoyu Wang, Jianan Zhao

“…Clinically, diminished SCFA levels correlate with impaired immune tolerance and airway remodeling, while probiotics (Lactobacillus, Bifidobacterium), prebiotics, and high-fiber diets restore microbial equilibrium, attenuating asthma severity.ConclusionFuture research must integrate multi-omics data to delineate strain-specific functions, host-microbe interactions, and individualized responses influenced by genetics, diet, and environmental factors. …”
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Culture dependent and independent approaches reveal the role of specific bacteria in human skin aging by Jing‐jing Xia, Qian Zhong, Zhi‐ming Li, Qing‐zhen Wei, Liu‐yi‐qi Jiang, Cheng Duan, Hui‐jue Jia, Yi‐mei Tan, Lian‐yi Han, Jean Krutmann, Jiucun Wang, Xiao Liu

“…We also validated the biological functions of the host‐microbe interactions in vitro. Moraxella osloensis isolated from healthy skin regulates collagen metabolism and extracellular matrix assembly, and promotes cell senescence in human keratinocytes and fibroblasts, making it potentially applicable in the development of antiaging interventions.…”
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A Global Comparative Genomic Analysis of Major Bacterial Pathogens in Bovine Mastitis and Lameness by Szilvia Kusza, Zoltán Bagi

“…Our findings provide crucial insights into pathogen adaptation and host–microbe interactions, suggesting the need for region-specific intervention strategies. …”
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Microbiota, chronic inflammation, and health: The promise of inflammatome and inflammatomics for precision medicine and health care by Huan Zhang, Bing Jun Yang Lee, Tong Wang, Xuesong Xiang, Yafang Tan, Yanping Han, Yujing Bi, Fachao Zhi, Xin Wang, Fang He, Seppo J. Salminen, Baoli Zhu, Ruifu Yang

“…This discipline transcends traditional inflammation paradigms by dissecting molecular pathways connecting dysbiosis to systemic inflammation, enabling early detection and precision interventions. It integrates evolutionary perspectives on host–microbe interactions, emphasizing the human body as a stress-sensitive “organ”. …”
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Complex system modeling reveals oxalate homeostasis is driven by diverse oxalate-degrading bacteria by Sromona D Mukherjee, Carlos Batagello, Ava Adler, Jose Agudelo, Anna Zampini, Mangesh Suryavanshi, Andrew Nguyen, Terry Orr, Denise Dearing, Manoj Monga, Aaron W Miller

“…Importantly, the administration of the oxalate-degrading specialist, Oxalobacter formigenes, was only effective against a poor oxalate-degrading microbiota background and gives critical new insights into why clinical intervention trials with this species exhibit variable outcomes. …”
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