Structure-guided identification of mitogen-activated protein kinase-1 inhibitors towards anticancer therapeutics. by Md Nayab Sulaimani, Shazia Ahmed, Farah Anjum, Taj Mohammad, Anas Shamsi, Ravins Dohare, Md Imtaiyaz Hassan

“…This pathway plays a crucial role in various cellular processes, including cell proliferation, differentiation, adhesion, migration, and survival. Besides, many chemotherapeutic drugs targeting the MAPK pathway are used in clinical practice, and novel inhibitors of MAPK1 with improved specificity and efficacy are required. …”
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Lactobacillus reuteri LR1 Improved Expression of Genes of Tight Junction Proteins via the MLCK Pathway in IPEC-1 Cells during Infection with Enterotoxigenic Escherichia coli K88 by Hongbo Yi, Li Wang, Yunxia Xiong, Zhilin Wang, Yueqin Qiu, Xiaolu Wen, Zongyong Jiang, Xuefen Yang, Xianyong Ma

“…It was found that L. reuteri LR1, in large part, offset the ETEC K88-induced increase in permeability of IPEC-1 cell monolayers and decreased the adhesion and invasion of the coliform in IPEC-1 cells. …”
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Effects of Tert-Butylhydroquinone on Intestinal Inflammatory Response and Apoptosis following Traumatic Brain Injury in Mice by Wei Jin, Hongbin Ni, Yuxiang Dai, Handong Wang, Tianyu Lu, Jun Wu, Jian Jiang, Weibang Liang

“…Intestinal mucosa apoptosis and inflammatory-related factors, such as nuclear factor kappa B (NF-κB), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and intercellular adhesion molecule-1 (ICAM-1), were investigated at 24 h after TBI. …”
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Fibrothorax and Severe Lung Restriction Secondary to Lupus Pleuritis and Its Successful Treatment by Pleurectomy by Sat Sharma, Robert Smith, Fahad Al-Hameed

“…On pathology, pleuritis with vascular pleural adhesions was found. No lupus pneumonitis was noted. …”
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Analysis and Verification of a Slope Steering Model of TRVs in Hilly and Mountainous Environments by Luojia Duan, Kaibo Kang, Shiying Chen, Zixing Du, Longhai Zhang, Zhijie Liu, Fuzeng Yang, Zheng Wang

“…Compared to wheeled vehicles, tracked robotic vehicles have less ground pressure, greater traction adhesion, and stronger climbing and obstacle crossing capabilities, making them suitable for agricultural production in hilly areas. …”
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Two Novel CYP11B1 Gene Mutations in Patients from Two Croatian Families with 11β-Hydroxylase Deficiency by Katja Dumic, Tony Yuen, Zorana Grubic, Vesna Kusec, Ingeborg Barisic, Maria I. New

“…Steroid 11β-hydroxylase deficiency (11β-OHD) is the second most common cause of congenital adrenal hyperplasia. Mutations in the CYP11B1 gene, which encodes steroid 11β-hydroxylase, are responsible for this autosomal recessive disorder. …”
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Nomograms for predicting recurrence of HER2‐positive breast cancer with different HR status based on ultrasound and clinicopathological characteristics by Xudong Zhang, Hanqing Kong, Xiaoxue Liu, Qingxiang Li, Xinran Fang, Junjia Wang, Zihao Qin, Nana Hu, Jiawei Tian, Hao Cui, Lei Zhang

“…The predictive accuracy was calculated using Harrell's C‐index and calibration curves. Results Three informative characteristics (axillary nodal status, calcification, and Adler degree) were identified in HR−/HER2+ patients, and another three (histological grade, axillary nodal status, and echogenic halo) in HR+/HER2+ patients. …”
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Experimental and modeled analysis of contaminant mobility in coal fly ash landfills under continuous rainfall regimes by Shuyuan Xu, Yongbo Zhang, Jiangbo Guo, Aijing Wu, Xinghua Xiang, Haodong Sun

“…Laboratory-scale long-term soil column leaching tests and long-term ash column leaching tests were conducted using compacted soil and compacted CFA, respectively, to simulate contaminant migration patterns from CFA during the early and later stages of landfill operation. Hydrus-1D simulation software was used to calculate contaminant transport from the CFA landfill. …”
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“Holding on to Hope”: follow up qualitative findings of a tobacco treatment intervention for people experiencing mental health conditions by Tessa-May Zirnsak, Kristen McCarter, Melissa L. McKinlay, Ashleigh Guillaumier, Nadine Cocks, Catherine Brasier, Laura Hayes, Amanda L. Baker, Donita E. Baird, Billie Bonevski, Ron Borland, Ron Borland, David Castle, Erin Forbes, Peter J. Kelly, Catherine Segan, Catherine Segan, Rohan Sweeney, Alyna Turner, Alyna Turner, Jill M. Williams, Lisa Brophy, Lisa Brophy

“…Quitting tobacco can be harder for people experiencing SMI due to higher levels of nicotine dependence, more severe withdrawal, and many other complex factors. …”
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Phase 1, open-label, dose-escalation study on the safety, pharmacokinetics, and preliminary efficacy of intravenous Coxsackievirus A21 (V937), with or without pembrolizumab, in pat... by Christy Ralph, Sumati Gupta, Matthew Zibelman, Brendan D Curti, Kevin J Harrington, Steven J O'Day, Andrew G Hill, David C Campbell, Gavin M Wright, David E Gerber, Jonathan E Rosenberg, Jaime R Merchan, Charles M Rudin, Hardev S Pandha, Wallace L Akerley, Daphne Day, Timothy D Clay, Ross R Jennens, Yixin Ren, Emmett V Schmidt, Lisa Guttman

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Editorial by Daniel Halliday

“…Inequalities of this sort may be harder to justify than those owed to differences in the life choices or levels of effort, such as the sorts of inequalities that might arise in a properly meritocratic labour market. …”
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Neurotrophin-3 as a mediator in the link between PM2.5 exposure and psychiatric disorders: A Mendelian randomization study by Yuan Zhang, Wei Wang, Xuening Zhang, Ran Jing, Xin Wen, Peng Xiao, Xinjie Liu, Zengle Zhao, Tongmin Chang, Yufei Li, Wen Liu, Chenxi Sun, Xiaorong Yang, Lejin Yang, Ming Lu

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Soluble and cell-based markers of immune checkpoint inhibitor-associated nephritis by Sandra M Herrmann, Riley Fadden, Ryan J Sullivan, Kerry L Reynolds, Harish Seethapathy, Meghan E Sise, Shruti Gupta, Alexandra-Chloe Villani, Qiyu Wang, Daiana Moreno, Destiny Harden, R Neal Smith, Ivy A Rosales, Robert B Colvin, Sarah Chute, Lynn D Cornell, Nancy J Yang, Sara Barmettler, Sophia Wells, Jocelyn Farmer

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Cross-Gendering the Racial Memory by Marlon B. Ross

“…In European-American iconography, there is a drive to materialize this gigantic feminine figure not only by super-sizing her but also by casting her in the hardest stones—again the Statue of Liberty providing a perfect instance. …”
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Binderless MDF from Hydroxymethylated Kenaf Pulp by Nyoman J Wistara, Wulan Starini, Fauzi Febrianto, Gustan Pari

“…Modified lignin with improved reactivity can be a potential alternative for synthetic phenol formaldehyde resin for the adhesive of wood composite. Direct hydroxymethylation of kenaf in the present experiments was intended to increase lignin reactivity, and therefore was expected to result in satisfying properties of binderless MDF. …”
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Comparison of Two Synthesis Methods for 3D PLA-Ibuprofen Nanofibrillar Scaffolds by Esteban Mena-Porras, Annaby Contreras-Aleman, María Francinie Guevara-Hidalgo, Esteban Avendaño Soto, Diego Batista Menezes, Marco Antonio Alvarez-Perez, Daniel Chavarría-Bolaños

“…The drug release profile was assessed by ultraviolet-visible spectrophotometry (UV-Vis), and cell adhesion and viability were evaluated using fibroblast culture assays. …”
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Association between Neutrophilic Granulocyte Percentage and Diabetes Mellitus in Cushing’s Syndrome Patients: A Cross-Sectional Study by Baomin Wang, Yumei Yang, Haoyue Yuan, Xiaomu Li

“…The demographic data, clinical data, and blood samples (lipids, adrenal, glucose, and inflammatory blood cell parameters) were recorded. …”
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Genetic Determinants and Biofilm Properties Useful in Estimation of UTI Pathogenicity of the <i>Escherichia coli</i> Strains Isolated from Free-Living Birds by Bartosz Rybak, Tomasz Jarzembowski, Agnieszka Daca, Beata Krawczyk, Lidia Piechowicz

“…The estimation of the ability to form biofilms was tested using crystal violet, and the pathogenic potential of strains by monocyte activation assay including changes in morphology, adhesion and cytotoxicity. <b>Conclusions</b>: In conclusion, the virulence of <i>E. coli</i> strains isolated from free-living birds is significant, and they can be considered environmental reservoirs of pathogenic strains. …”
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Restoring Teeth with an Advanced Lithium Disilicate Ceramic: A Case Report and 1-Year Follow-Up by Felicitas Hölken, Helmut Dietrich

“…The monolithic restorations were placed adhesively. The rehabilitation with the ALD blocks resulted in an aesthetically pleasing, functional outcome that improved overall treatment time and increased patient and practitioner satisfaction, which remained stable over a one-year follow-up period.…”
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Numerical study of ice crystal movement and melting in rotating blade channels by ZHANG Lifen, ZHAO Jianhui, YU Bangtuo, LYU Yaguo, LIU Zhenxia

“…The results show: ① the collection coefficient of ice crystal at the leading edge of the blade is the highest, the trailing edge of the pressure surface is also the area where the ice crystal may impact, while the root of the blade is less affected by centrifugal force; ② the larger the ice crystal content, the larger the collection rate of ice crystal at the same position on the blade surface; the larger the ice crystal diameter, the larger the collection rate of ice crystal at the suction surface, the smaller the collection rate of ice crystal at the pressure surface; the higher the non-spherical degree of ice crystal, the more likely the ice crystal will impact on the pressure surface; the higher the non-sphericity of ice crystals, the easier it is for the ice crystals to impact on the pressure surface; when the rotational speed decreases, the ice crystals are more likely to impact on the suction surface, and the impact area is also larger and closer to the blade root; ③ The melting ice crystals impacting on the pressure surface are more widely distributed, and the pressure surface is more prone to ice crystal adhesion and freezing than the suction surface; while, there are also melted ice crystals on the suction surface near the trailing edge, where ice crystals may also adhere; the larger the ice crystal content, the larger the diameter, the larger the non-sphericity, and when the rotational speed increases, the melting rate of ice crystals decreases.…”
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