Addition of PARP1-inhibition enhances chemoradiotherapy and thermoradiotherapy when treating cervical cancer in an in vivo mouse model by Marloes IJff, Xionge Mei, Enzo M. Scutigliani, Hans M. Rodermond, Gregor G. W. van Bochove, Przemek M. Krawczyk, Nicolaas A. P. Franken, Lukas J. A. Stalpers, Johannes Crezee, Arlene L. Oei

“…The aim of our present study was to test efficacy of different combinations of treatment modalities radiotherapy, cisplatin, hyperthermia and PARP1-inhibitors using in vitro tumor models, ex vivo treated patient samples and in vivo tumor models.Materials and Methods: In vitro clonogenic survival curves (0–6 Gy) show that PARP1-i (4–5 M Olaparib) enhances both chemoradiotherapy (0.3–0.5 µM cisplatin) and thermoradiotherapy (42 °C for 1 h) in SiHa, CaSki and HeLa cells. A cervical cancer mouse model and freshly obtained in-house developed patient-derived organoids were used to examine the effects of different treatment combinations. …”
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Application of S-100 absorbable hemostatic patch in endonasal endoscopic dacryocystorhinostomy: A randomized controlled trial by Hai-Sheng Zheng, Xing-Wu Zhong, Jia-Yao Xu, Hai-Yan Chen, Li-Na Liu, Bo-Wen Ou-Yang

“…Conclusion: S-100 absorbable hemostatic patch cover can reduce the risk of postoperative bleeding and improve the success rate of EN-DCR treatment of CD by promoting healing of the anastomotic mucosa and preventing wound scar and granuloma formation after EN-DCR.…”
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Economic Valuation of Ecosystem Services and Its Association with Socioeconomic Factors in the Wof-Washa Natural State Forest, North Shewa Zone, Ethiopia by Abere Wondimu Kassie, Admasu Moges, Tilahun Alelign, Gojam Bayeh

“…The study also revealed that male-headed households, larger families, and those having limited farmland and off-farm income depended more heavily on the forest. …”
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Effect of variation in gridded cattle diet composition on estimated enteric methane emissions in data sparse tropical regions by J.Y. Mutua, A.J. Duncan, T.P. Robinson, S. Fraval, A.M.O. Notenbaert, G.R. Watmough

“…Estimated enteric methane emissions from cattle varied between and within livestock production systems (37.1 – 72.8 kg CH4/head per year), with significant differences between mixed rainfed humid and temperate production systems (P < 0.05). …”
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NIR-triggered programmable nanomotor with H2S and NO generation for cascading oncotherapy by three-pronged reinforcing ICD by Jinlong Zhang, Quan Jing, Longlong Yuan, Xianhui Zhou, Duolong Di, Jinyao Li, Dong Pei, Zhongxiong Fan, Jun Hai

“…Meanwhile, the unique protective mechanism of H2S is utilized to induce tumor thermal ablation by reducing the overexpression of heat shock protein 90 (HSP 90) and minimize the unnecessary damage toward normal tissues. …”
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Study on Factors Affecting Estrus Synchronization in Smallholder Dairy Farming Systems of Tigray, Northern Ethiopia by Dagmawit Kibre, Gebregiorgis Ashebir, Berihu Gebrekidan, Haben Fesseha

“…AI technicians and farm owners need continuous training to improve their heat detection skills, increase their knowledge, and obtain a successful program.…”
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Swallowing-related muscle inflammation and fibrosis induced by a single dose of radiation exposure in mice by Shuntaro Soejima, Chia-Hsien Wu, Haruna Matsuse, Mariko Terakado, Shinji Okano, Tsuyoshi Inoue, Yoshihiko Kumai

“…Abstract Background Although radiotherapy is commonly used to treat head and neck cancer, it may lead to radiation-associated dysphagia (RAD). …”
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Alpha-linolenic acid-mediated epigenetic reprogramming of cervical cancer cell lines by Amrita Ulhe, Prerna Raina, Amol Chaudhary, Ruchika Kaul-Ghanekar

“…RT-PCR was utilized to assess the expression of tumor regulatory genes (hTERT, DAPK, RARβ, and CDH1) and their promoter methylation in HeLa (HPV18-positive), SiHa (HPV16-positive) and C33a (HPV-negative) cervical cancer cell lines. …”
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circ-SIRT1 Promotes Colorectal Cancer Proliferation and EMT by Recruiting and Binding to eIF4A3 by Xiangjie Wang, Shuang Liu, Bin Xu, Yabin Liu, Peng Kong, Changlin Li, Binghui Li

“…Colony formation and Cell Counting Kit-8 assays were used to evaluate the effect of circ-SIRT1 knockdown on the proliferative ability of CRC cells. Wound healing and Transwell assays were used to assess the effect of circ-SIRT1 knockdown on the migratory and invasive capacity of CRC cells. …”
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HIF-3α-Induced miR-630 Expression Promotes Cancer Hallmarks in Cervical Cancer Cells by Forming a Positive Feedback Loop by Qiaohui Gao, Zhenghua Ren, Shengyuan Jiao, Juan Guo, Xia Miao, Jin Wang, Junye Liu

“…Consequently, stable overexpression of miR-630 in HeLa cells promotes cancer hallmarks, including radioresistance, inhibition of apoptosis, increased migration and invasion, and EMT-mediated metastasis. …”
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Nevoid basal cell carcinoma syndrome (Gorlin syndrome): a case report by Noura Abdul Rahman, Fatima Breim, Joud Zakour, Zainab Srouji, Silva Ishkhanian

“…The patient showed positive responses to the treatment, with most lesions healing completely and others showing ongoing improvement. …”
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An Improved Solar Cooling System for Date Safety and Storage under Climate of the Maghreb by Benameur Afif, Boualem Merabet, Mustafa Inc, Younes Menni, Sameer Alsharif, Ahmed Althobaiti, Ayman A. Aly

“…By optimizing the storage parameters and cooling gas with less energy consumption, R152a has been confirmed as a reliable refrigerant to own high critical temperature, sufficient specific heat capacity, and potential cost-effectiveness of compression. …”
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Growth and Productivity Assessment of Short-Duration Rice (Oryza sativa L. and Upland NERICA) Genotypes in Semiarid North-Central Namibia by Simon K. Awala, Kudakwashe Hove, Vistorina Shivute, Johanna S. Valombola, Pamwenafye I. Nanhapo, Yoshihiro Hirooka, Osmund D. Mwandemele, Morio Iijima

“…The results showed significant genotype by year interaction for days to heading, plant height, the number of tillers per m2, shoot biomass, the number of panicles per m2, 1000-grain weight, harvest index, and grain yield. …”
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A depth-controlled and energy-efficient routing protocol for underwater wireless sensor networks by Umesh Kumar Lilhore, Osamah Ibrahim Khalaf, Sarita Simaiya, Carlos Andrés Tavera Romero, Ghaida Muttashar Abdulsahib, Poongodi M, Dinesh Kumar

“…In the proposed energy-efficient routing protocol, an enhanced cluster head node is used to select a strategy that can analyze the remaining energy and directions of each participating node. …”
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The Impact of Tillage and Weed Control Methods on Physical Properties of Sandy Clay Loam Forest Ochrosol in Cassava Cultivation by Maxwell Budu, Thomas Atta-Darkwa, Harrison Amaglo, Nicholas Kyei-Baffour, Isaac Albert Aidoo, Samuel Kojo Ahorsu, Enoch Bessah

“…Given similar weather and soil conditions, the study recommends that farms and farmers in the Ho Municipality and the Volta Region adopt conservative tillage methods such as heaping with machete or hoe weeding and use the savings to expand their farm sizes. …”
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MOG associated autoimmune encephalomyelitis with active disease dynamic in imaging examinations and minimal clinical manifestation by E. Tilindytė, I. Muliuolis, R. Samaitienė

“…The diagnosis was confirmed by magnetic resonance imaging (MRI) of the head and neck as well as by serum MOG antibody testing. …”
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A Cross-Stage Focused Small Object Detection Network for Unmanned Aerial Vehicle Assisted Maritime Applications by Gege Ding, Jiayue Liu, Dongsheng Li, Xiaming Fu, Yucheng Zhou, Mingrui Zhang, Wantong Li, Yanjuan Wang, Chunxu Li, Xiongfei Geng

“…At the same time, in each detection layer, a lightweight CRE module was integrated, leveraging attention mechanisms and detection heads to enhance precision for small object detection. …”
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Spatiotemporal Variation of Abattoir Operation on Soil Quality Dynamics in Umuahia South, Abia State, Nigeria by M.U. Chikwendu, U.I. Uchendu, N.O. Ochor

“… Heaps of abattoir wastes are commonly sighted in most abattoirs in Nigeria which constitute serious environmental and public health hazards. …”
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GJB6-D13S1830 and GJB6-D13S1854 Deletions in Patients with non-Syndromic Prelingual Deafness by Mercedes Arceo Álvarez, Estela Morales Peralta, Yuledmi Perdomo Chacón, Teresa Collazo Mesa

“…These deletions have been found associated with pathogenic variants of the GJB2 gene in individuals with hearing loss. <br /><strong>Objective:</strong> to describe the presence of GJB6-D13S1830 and GJB6-D13S1854 deletions in patients with autosomal recessive non-syndromic deafness. …”
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Neuromuscular Excitation Pattern in Expert Indoor Skydivers by Susanna Rampichini, Eloisa Limonta, Irene Di Giulio, Marta Borrelli, Emiliano Cè, Giuseppe Coratella, Johnny Padulo, Stefano Longo, Fabio Esposito

“…The surface electromyographic signal was recorded on the anterior deltoid, AD; posterior deltoid, PD; pectoralis major, PM; latissimus dorsi, LD; rectus abdominis, Rabd; erector spinae, ES; rectus femoris, RF; and biceps femoris, BF for each position: PRONE, SUPINE, SIT, and head-down (HD). A synchronous heart rate was recorded to assess the cardiac engagement. …”
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