Hsp90α promotes lipogenesis by stabilizing FASN and promoting FASN transcription via LXRα in hepatocellular carcinoma by Zihao Deng, Lixia Liu, Guantai Xie, Zhenming Zheng, Jieyou Li, Wenchong Tan, Yaotang Deng, Jinxin Zhang, Manfeng Liang, Yingxia Wu, Zhifeng Zhou, Yan Li, Yukui Chen, Yaling Huang, Hairou Su, Guibing Wu, Xiongjie Shi, Shengpei Cen, Yandan Liao, Yilin Liu, Fei Zou, Xuemei Chen

“…Excessive lipid accumulation promotes the occurrence and progression of hepatocellular carcinoma (HCC), accompanied by high levels of fatty acid synthetase (FASN) and more active lipogenesis. Heat shock protein 90 (Hsp90) acts as a chaperone to maintain the stability and activity of the client proteins. …”
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Pirfenidone Inhibits Hypoxic Pulmonary Hypertension through the NADPH/ROS/p38 Pathway in Adventitial Fibroblasts in the Pulmonary Artery by Song Zhang, ZongXiu Yin, WeiDong Qin, XiaoLi Ma, Yao Zhang, EnXiu Liu, YanBiao Chu

“…Migration of HPAAFs was assessed by a wound healing assay. The expression levels of smooth muscle alpha-actin (a-SMA) and procollagen I (COL1A1) were assessed by RT-PCR and western blot analysis. …”
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Machine learning approach for predicting tramp elements in the basic oxygen furnace based on the compiled steel scrap mix by Michael Schäfer, Ulrike Faltings, Björn Glaser

“…Data from around 115000 heats were analyzed and a model was developed to better predict the content of the tramp elements copper, chromium, molybdenum, phosphorus, nickel, tin and sulphur at the end of the basic oxygen furnace process. …”
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Osseointegrated Transcutaneous Device for Amputees: A Pilot Large Animal Model by Brian T. Grisez, Andrew E. Hanselman, Karim W. Boukhemis, Trapper A. J. Lalli, Brock A. Lindsey

“…Periprosthetic fractures occurred in the two animals that received the longer internal prosthesis; one healed with splinting and the other animal underwent a second surgical procedure to advance the amputation site more proximal. …”
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The effect of tube orientation on thermal characteristics in flow boiling of a hybrid nanofluid – A numerical study by Babak Safari Chukami, Mohammad Mahdi Heyhat

“…Additionally, for the hybrid nanofluid, the heat transfer coefficient (HTC) increased up to 5.59 % in vertical tube but decreased up to 17.69 % in horizontal tube, compared to pure water. …”
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Histone Deacetylation Regulated by KDM1A to Suppress DACT1 in Proliferation and Migration of Cervical Cancer by Lingjuan Zeng, Chunyan Chen, Chanjiao Yao

“…Meanwhile, the downregulation of KDM1A or overexpression of DACT1 could suppress the cell proliferation and migration ability in HeLa and SiHa cells. Cotransfection of KDM1A and DACT1 overexpression could reverse the increased cell proliferation and migration ability induced by KDM1A overexpression. …”
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Two Unrelated Iranian Patients with Adenosine Deaminase 2 Deficiency: A Case Report and Review of Treatment by Parvaneh Karimzade, Aziz Eghbali, Mohammad Keramatipour, Reza Shiari, Zahra Golchehre, Mahdieh Taghizadeh, Mazdak Fallahi, Shahrzad Fallah, Nasrin Khakbazan Fard, Narges Eslami, Narges Bazgir, Mahnaz Jamee, Zahra Chavoshzadeh

“…The first patient was a 7-year-old female who experienced recurrent neurological symptoms such as vertigo, tinnitus, hearing loss, and right-sided hemiparesis. Her brain magnetic resonance imaging (MRI) revealed a left-sided stroke, and she responded well to antitumor necrosis factor alpha agents and plasmapheresis. …”
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Anticancer effect of the antirheumatic drug leflunomide on oral squamous cell carcinoma by the inhibition of tumor angiogenesis by Chieko Niwata, Takayuki Nakagawa, Takako Naruse, Miyuki Sakuma, Nao Yamakado, Misaki Akagi, Shigehiro Ono, Kei Tobiume, Jing Gao, Eijiro Jimi, Kouji Ohta, Tomonao Aikawa

“…Methods To evaluate the inhibitory effect of LEF on OSCC, cell proliferation and wound-healing assays using human OSCC cell lines were performed. …”
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Network Design Mode of In-Seam Gas Extraction Parameters Using Mathematical Modelling—Take Tangan Colliery as an Example by Tong-qiang Xia, Ke Gao, Hong-yun Ren, Jiao-fei He, Zi-long Li

“…In this work, taking our previous gas-coal and gas-coal-heat coupling models of gas extraction as the theoretical basis, a new communication and design concept—an engineering design platform for gas extraction—is proposed using the network mode. …”
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The Cytokine and Bone Protein Expression by Ellagic Acid-Hydroxyapatite in Bone Remodelling Model by Dyah Noviana Primasari, Intan Nirwana, Hendrik Setia Budi, Agung Satria Wardhana, Annisa Fitria Sari, Novita Novita, Andika Putri Setyawan, Meircurius Dwi Condro Surboyo, Khairul Anuar Shariff

“…Ellagic acid, a phenolic compound with anti-inflammatory potential, can be used to accelerate the bone healing process and affect human health, while hydroxyapatite is the most commonly used bone graft material. …”
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ALGORITHM OF PREPARATION OF THE TRAINING SAMPLE USING 3D-FACE MODELING by D. I. Samal, I. I. Frolov

“…The age, emotional looks, turns of the head, various conditions of lighting, noise, and also some combinations of the listed parameters are chosen as the key considered parameters for modeling. …”
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The Yugoslav National Front: Attempt(s) to unify the Yugointegralists extreme right 1935-1939 by Dragosavljević Vasilije

“…There is a paradox in the fact that the concept of the Yugoslav National Front was ultimately implemented by Milan Stojadinović - a person against whose politics the idea itself was directed and who devoted most of the time he spent at the head of the Yugoslav government to the fight against the unification of the Yugoslav integralist forces. …”
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Effect of ZnO on the Thermal Properties of Tellurite Glass by H. A. A. Sidek, S. Rosmawati, B. Z. Azmi, A. H. Shaari

“…The thermal expansion coefficient of each zinc tellurite glasses was measured using L75D1250 dilatometer, while their glass transition temperature (Tg) was determined by the SETARAM Labsys DTA/6 differential thermogravimetric analysis at a heating rate of 20 K min−1. The acoustic Debye temperature and the softening temperature (Ts) were estimated based on the longitudinal (VL) and shear ultrasonic (Vs) wave velocities propagated in each glass sample. …”
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Recent Engineering Applications for Noise Reduction in an Automotive Industry by Berkay Uğur, Ender Pak, Ülge Taş

“…Especially noise is one of the most common causes of hearing disorders and one of the most common occupational diseases in the industry. …”
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[18F]FB(ePEG12)12-exendin-4 noninvasive imaging of insulinoma negative for insulin immunostaining on specimen from endoscopic ultrasonography-guided fine needle aspiration: a case... by Daisuke Otani, Takaaki Murakami, Saeko Murakami, Ikuko Hanaoka, Hiroyuki Fujimoto, Yoichi Shimizu, Kanae Kawai Miyake, Kentaro Sakaki, Yohei Ueda, Daisuke Tanaka, Tsuyoshi Ohno, Hironori Shimizu, Naoki Uyama, Norishige Iizuka, Daisuke Yabe, Yuji Nakamoto, Nobuya Inagaki

“…We report here a case of insulinoma in the pancreatic head in which an EUS-FNA specimen was negative on insulin immunostaining while precise preoperative localization and conclusive evidence for curative enucleation was provided by 18F-exendin-4 PET/CT (Japan Registry of Clinical Trials; jRCTs051200156).…”
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Clinical Manifestations, Diagnosis, and Surgery of Inferior Oblique Muscle Ectopia by Zhipeng Xue, Xiaoshan Min, Jieyue Wang, Ying Zhu, Sujun He, Kangcheng Liu, Yi Ding

“…They all presented with significant exotropia and unilateral (or bilateral) overelevation in adduction (OEA). No compensatory head position was detected. Some of them had vertical deviation, V pattern, or excyclotropia, which were indicated by fundus torsion. …”
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APOC1 knockdown induces apoptosis and decreases angiogenesis in diffuse large B-cell lymphoma cells through blocking the PI3K/AKT/mTOR pathway by Jing Gao, Xiaojuan Lu, Guanglei Wang, Tanling Huang, Zhongyu Tuo, Weiwei Meng

“…Using APOC1 gene knockdown, apoptosis, migration, and invasion were assessed through flow cytometry, the EDU assay, wound healing, and Transwell assays. Additionally, human umbilical vein endothelial cells (HUVEC) angiogenesis was evaluated. …”
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Driving Risk Analysis Based on Driving Experience at Hook-Turn Intersection Using the Emerging Virtual Reality Technology by Taeho Oh, Yanping Xu, Zhibin Li, Inhi Kim

“…The simulator in this research was developed by integrating Vissim and Unity3D embedded head-mounted display and driving devices to ensure a better driving experience. …”
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Comparison of speech intelligibility in a real and virtual living room using loudspeaker and headphone presentations by Schütze Julia, Kirsch Christoph, Kollmeier Birger, Ewert Stephan D.

“…Virtual acoustics enables hearing research and audiology in ecologically relevant and realistic acoustic environments, while offering experimental control and reproducibility of classical psychoacoustics and speech intelligibility tests. …”
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Legal Status of the Court Administration by V. I. Teremetskyi, K. D. Kutsenko

“…It has been proved that the legal status of the court administration is characterized by the following elements: performance of functions by the employees of the court administration on organizational, technical and information provision of the court; implementation of the court administration’s activity in accordance with the principles of legality, rule of law, professionalism, efficiency, political impartiality, transparency and others; selection of employees of the court administration on a competitive basis; performance of duties by the court administration in accordance with the established structure and staffing; the presence of a special legal status of the head of the local court administration, which consists in a special procedure for appointment and dismissal, a specific list of responsibilities. …”
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