Successful treatment of etanercept- and adalimumab-resistant pyoderma gangrenosum with spesolimab, moderate-dose corticosteroids, and minocycline by Hanlin Zhang, Chao Wu, Hongzhong Jin

“…After reviewing the screening results and discussing treatment options, the patient received two doses of spesolimab (900 mg intravenously) administered two weeks apart.Results Marked clinical improvement was observed after spesolimab initiation. Complete ulcer healing was achieved within six weeks of starting spesolimab, with no adverse effects reported.Conclusions This case demonstrates the potential efficacy of spesolimab for treating refractory PG, particularly in patients unresponsive to TNF-α inhibitors. …”
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Identification and Characterization of TEX101 in Bovine Epididymal Spermatozoa by Subir K. Nagdas, Eric L. McLean, Leeá P. Richardson, Samir Raychoudhury

“…Immunofluorescence staining of sperm with anti-TEX101 demonstrated that the polypeptide is localized at the head of cauda sperm. Our biochemical results provide evidence on the presence of TEX101 in bovine epididymal sperm plasma membranes and may have a potential role in sperm-egg interaction.…”
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Capability of biodentine and the mineral trioxide aggregate mta sealing in furcal perforation repair. Literature review by Silvana Benavides, Alejandra Guallo, Yecenia Carrillo

“…An ideal perforation repair material , should create an adequate seal, be biocompatible, not be affect by blood contamination, be a bactericide, radiopaque, induce bone formation and healing, induce mineralization, cementogenesis, facilite its manipulation and application. …”
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A systematic review on the impact of breastfeeding on cancer risk, weight loss, cardiovascular disease, type 2 diabetes mellitus in mothers, and the role of fathers, medical person... by Olga Krupa, Daria Rybak, Katarzyna Kamińska-Omasta, Bartosz Omasta, Kuba Borys Romańczuk, Magdalena Agata Czerska, Paulina Dorota Pietrukaniec, Szymon Przemysław Stolarczyk, Zofia Martyna Wójcik, Kinga Furtak

“…Aim of the study Assessing the impact of breastfeeding on the risk of cancer, cardiovascular disease, type 2 diabetes In the mother and the role of fathers, medical personnel and training in the breastfeeding process     Materials and Methods A review of the literature collected in the PubMed database was conducted to gather information under the headings: "breastfeeding and cancer," "health benefits for breastfeeding mothers," "breastfeeding and cardiovascular disease risk reduction," "impact of breastfeeding on type II diabetes risk," "role of fathers in breastfeeding," "role of medical personnel in breastfeeding," and "strategies affecting breastfeeding."         …”
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MLAS: Machine Learning-Based Approach for Predicting Abiotic Stress-Responsive Genes in Chinese Cabbage by Xiong You, Yiting Shu, Xingcheng Ni, Hengmin Lv, Jian Luo, Jianping Tao, Guanghui Bai, Shusu Feng

“…This study presents a computational model utilizing machine learning techniques to predict genes in Chinese cabbage that respond to four abiotic stresses: cold, heat, drought, and salt. To construct this model, data from relevant studies regarding responses to these abiotic stresses were compiled, and the protein sequences encoded by abiotic SRGs were converted into numerical representations for subsequent analysis. …”
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Radiation-Associated Fracture Nonunion of the Clavicle Treated with Locking Plate Fixation and Autologous Bone Grafting by Takahiro Niikura, Sang Yang Lee, Yoshitada Sakai, Kotaro Nishida, Ryosuke Kuroda, Masahiro Kurosaka

“…Our case suggests that a locking plate provides sufficient fixation and autologous bone grafting is effective in enhancing bone healing in a radiation-associated fracture nonunion of the clavicle in which it is difficult to achieve bony union.…”
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IEDSFAN: information enhancement and dynamic-static fusion attention network for traffic flow forecasting by Lianfei Yu, Ziling Wang, Wenxi Yang, Zhijian Qu, Chongguang Ren

“…Secondly, we construct a novel Gated Multi-head Self-Attention (GMHSA), which maps the input through the MGFG module to capture the complex spatial–temporal interactions in the features. …”
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Women’s understanding and experiences of menopause in low-income and middle-income countries in the Asia Pacific region: a scoping review protocol by Michelle Redman-MacLaren, Karen Cheer, Relmah Baritama Harrington, Dorothy Esau, Emmy Foroasi

“…MEDLINE, CINAHL, PsycINFO and Scopus databases will be systematically searched between February 2022 and May 2022 using subject headings and keywords. The title–abstract and full text of retrieved studies will be assessed against eligibility criteria. …”
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Herbal remedies as a potential alternative therapy for arthritis by Disha Trivedi, Riya Jayapal Roja, Eva Künnemann

“…Natural plant substances can influence these pathways and help to break out of the vicious cycle and to find a way for stopping the disease or even to regenerate and heal injured cartilage. In conclusion, rosehip, curcumin and other natural remedies are effective treatments and combinations are possible. …”
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Sex-Related Effects of Adrenergic Drugs on Conditioned Pain Modulation: A Randomized Controlled Cross-Over Double-Blind Trial by Marie-Philippe Harvey, Marie-Chantal Dubois, Philippe Chalaye, Yanick Sansoucy, Serge Marchand

“…Pain intensity induced by using a contact heat stimulation thermode was compared before and after a cold-pressure conditioning stimulus to evaluate CPM effectiveness. …”
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Relationship between Metabolic Syndrome and Ocular Microcirculation Shown by Laser Speckle Flowgraphy in a Hospital Setting Devoted to Sleep Apnea Syndrome Diagnostics by Tomoaki Shiba, Mao Takahashi, Tadashi Matsumoto, Yuichi Hori

“…Blowout score (BOS) and blowout time (BOT), which are the pulse waveform analysis parameters, and mean blur rate (MBR) using LSFG in the optic nerve head (ONH) and choroid were evaluated. Throughout, the ONH was separated out from the vessels and tissue for analysis and MBRs in the ONH were divided into four sections (superior, temporal, inferior, and nasal). …”
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Effect of amniotic fluid on hair follicle growth by Gamze Tumentemur, Elif Ganime Aygun, Bulut Yurtsever, Didem Cakirsoy, Ercument Ovali

“…Purpose: Human amniotic fluid stem cells (hAFSCs) have shown significant regenerative potential in treating hair loss, wound healing, and tissue repair. This study aims to evaluate the effects of human amniotic fluid (hAF) on hair follicle (HF) regeneration and immune system modulation.Materials and Methods: The hAF used was pooled, acellular, and gamma-irradiated to standardize its contents and enhance its stability. …”
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Recovering Uniform Coverage in a 3D Survey: Case Study from Onshore Southern India by K. Shukla, P. Jaiswal, C. S. Singh

“…We present a case study on 3D seismic acquisition under inaccessible ground conditions and heavy head-loads. The novelty in this case study is designing novel shot recovery strategies. …”
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Distribution of the Highest Plantar Pressure Regions in Patients with Diabetes and Its Association with Peripheral Neuropathy, Gender, Age, and BMI: One Centre Study by Edyta Sutkowska, Krzysztof Sutkowski, Michał Sokołowski, Edward Franek, Szymon Dragan

“…The most frequent regions of the highest pressure on the sole in patients with diabetes were the central part of the forefoot (2-3 metatarsal heads) with no simple relationship to the assessed variables other than BMI<35. …”
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The experimental and numerical studies on the effects of the operating conditions on the performance of breastshot waterwheel by Agato Agato, Deendarlianto Deendarlianto, Indarto Indarto, Alfeus Sunarso

“…The wheel was installed on a channel with the weir head of 250 mm, the headrace length of 100 mm, and the water flow rate of 0.014 m3/sec. …”
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A Fast Testing Method to Objectively Quantify the Stiffness of Stability Boots by Simon Bürgi, Judith Roost, Marco R. Hitz, Peter Schwilch, William R. Taylor, Silvio Lorenzetti

“…Stability boots can protect the ankle ligaments from overloading after serious injury and facilitate protected movement in order to aid healing of the surrounding soft tissue structures. …”
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Laparoscopic Diagnosis and Treatment of Gossypiboma Postconventional Ovariohysterectomy in a Bitch by Maurício Veloso Brun, Paula Cristina Basso, Marília Teresa de Oliveira, Fabíola Dalmolin, Saulo Tadeu Lemos Pinto-Filho, Helen Fialho Hartmann, Stephanie Lanzarini Abati, Marco Augusto Machado-Silva, Daniel Curvello de Mendonça Müller, Francisco Miguel Sanchez-Margallo

“…The chronic wound showed first intention healing. The mass was composed of fibrous tissues surrounding one surgical gauze. …”
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Necroptotic Cell Death Signaling and Execution Pathway: Lessons from Knockout Mice by José Belizário, Luiz Vieira-Cordeiro, Sylvia Enns

“…Multiple extracellular (pH, heat, oxidants, and detergents) or intracellular (DNA damage and Ca2+ overload) stress conditions trigger various types of the nuclear, endoplasmic reticulum (ER), cytoplasmatic, and mitochondrion-centered signaling events that allow cells to preserve the DNA integrity, protein folding, energetic, ionic and redox homeostasis, thus escaping from injury. …”
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Photothermal inactivation of methicillin‐resistant Staphylococcus aureus : anti‐biofilm mediated by a polypyrrole–carbon nanocomposite by Niloufar Behzadpour, Neda Akbari, Naghmeh Sattarahmady

“…Antibacterial mechanisms of PPy‐C were assessed through temperature increment, reactive oxygen species production, and protein and DNA leakages. Photothermal heating assay showed that 26°C temperature increases in the presence of 1000 µg ml−1 PPy‐C led to >98% killing of MRSA. …”
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Age-Related Reduced Somatosensory Gating Is Associated with Altered Alpha Frequency Desynchronization by Chia-Hsiung Cheng, Pei-Ying S. Chan, Sylvain Baillet, Yung-Yang Lin

“…Thus, this study used whole-head magnetoencephalography to record responses to paired-pulse electrical stimulation to the left median nerve in healthy young and elderly participants to test whether insufficient stimulus 1- (S1-) induced event-related desynchronization (ERD) contributes to a less-suppressed stimulus 2- (S2-) evoked response. …”
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