Integrating pharmacogenomics and cheminformatics with diverse disease phenotypes for cell type-guided drug discovery by Arda Halu, Sarvesh Chelvanambi, Julius L. Decano, Joan T. Matamalas, Mary Whelan, Takaharu Asano, Namitra Kalicharran, Sasha A. Singh, Joseph Loscalzo, Masanori Aikawa

Get full text

Progress in the structural modification and pharmacological activity of isosteviol by Tao Wang, Bowen Pan, Lijuan Liu, Zhangchao Dong, Wenhui Zhang, Xiongwei Liu, Ying Zhou, Yang Shi

“…This article briefly reviews the novel derivatives obtained through structural modification of isosteviol, including their pharmacological activities, to provide a reference for the development of new synthetic strategies and the construction of new isosteviol derivatives, and to guide preclinical studies and development of new drugs with greater pharmacological efficacy.…”
Get full text

Teaching materials to improve the teaching of Clinical Pharmacology by Liset Jiménez Fernández, Zoila Armada Esmoris, Laura Adalys Guillen León, Juan Miguel Chala Tandrón, Melba Zayas González, Alianys Izaguirre Artiles

“…Conclusions: to improve the teaching of Clinical Pharmacology in the medical profession, teaching materials have been developed which have been satisfactorily evaluated by the specialists in guiding the students in their learning activity.…”
Get full text

The bioguided fractionation and pharmacological activity of an endemic Salix canariensis species by Gutiérrez Sandra Dévora, Kuri Susana Abdala, Martín-Herrera Domingo

“…The active compounds were identified. Pharmacological activities were explored in experimental animals by acetic acid-induced writhing, formalin and Levy’s tests, and bioactive compounds were identified after a bio-guided fractionation of the most active organic extract. …”
Get full text

Phytochemical and pharmacological review of Erica Genus (L.) Ericaceae plants by Francis Adu-Amankwaah, Hleziphi V. Mpundu, Kudakwashe Nyambo, Paula Strauss, Kudzanai Ian Tapfuma, Ndivhuwo Tshililo, Motunrayo Victoria Badejo, Lawrence Mabasa, Vuyo Mavumengwana, Lucinda Baatjies

“…Conclusion: This review provides a comprehensive reference for researchers, offering insights into the therapeutic potential of Erica species and guiding future investigations into their pharmacological benefits.…”
Get full text

A comprehensive review on the plant sources, pharmacological activities and pharmacokinetic characteristics of Syringaresinol by Lei Zhang, Yuqing Tian, Lingling Zhang, Huanyu Zhang, Jinghua Yang, Yi Wang, Na Lu, Wei Guo, Liang Wang

“…Thus, a comprehensive review on Syringaresinol is essential to advance scientific understanding, assess its therapeutic applications, ensure safety, and guide future research efforts. This will ultimately contribute to its potential integration into clinical practice and public health. …”
Get full text

Psychosocial and pharmacologic interventions for problematic methamphetamine use: Findings from a scoping review of the literature. by Mona Hersi, Kim Corace, Candyce Hamel, Leila Esmaeilisaraji, Danielle Rice, Nicole Dryburgh, Becky Skidmore, Gary Garber, Amy Porath, Melanie Willows, Paul MacPherson, Beth Sproule, Jorge Flores-Aranda, Chandlee Dickey, Brian Hutton

“…We conducted a scoping review of recent systematic reviews (SR), clinical practice guidelines (CPG), and primary controlled studies of psychosocial and pharmacologic treatments for MUD/PMU.<h4>Methods</h4>Guided by an a priori protocol, electronic database search updates (e.g., MEDLINE, Embase) were performed in February 2022. …”
Get full text

Cannabis sativa subsp. sativa's pharmacological properties and health effects: A scoping review of current evidence. by Xin Yi Lim, Terence Yew Chin Tan, Siti Hajar Muhd Rosli, Muhammad Nor Farhan Sa'at, Syazwani Sirdar Ali, Ami Fazlin Syed Mohamed

“…As popularity of hemp research and claims of beneficial effects rises, a systematic collection of current scientific evidence on hemp's health effects and pharmacological properties is needed to guide future research, clinical, and policy decision making.…”
Get full text

NMR, Novel Pharmacological and In Silico Docking Studies of Oxyacanthine and Tetrandrine: Bisbenzylisoquinoline Alkaloids Isolated from Berberis glaucocarpa Roots by Muhammad Alamzeb, Muhammad Omer, Mamoon Ur-Rashid, Muslim Raza, Saqib Ali, Behramand Khan, Asad Ullah

Get full text

MDTR: a knowledge-guided interpretable representation for quantifying liver toxicity at transcriptomic level by Inyoung Sung, Sangseon Lee, Dongmin Bang, Dongmin Bang, Jungseob Yi, Sunho Lee, Sun Kim, Sun Kim, Sun Kim, Sun Kim

Get full text

Ultrasound-Guided Genicular Nerve Thermal Radiofrequency Ablation for Chronic Knee Pain by Joshua Wong, Nicholas Bremer, Paul D. Weyker, Christopher A. J. Webb

“…Following successful ultrasound guided diagnostic genicular nerve blocks, she proceeded to RFA using the same ultrasound guided technique. …”
Get full text

The impact of community-based non-pharmacological interventions on cardiovascular and kidney disease outcomes in remote dwelling Indigenous communities: A scoping review protocol. by Ikechi G Okpechi, Vinash Kumar Hariramani, Naima Sultana, Anukul Ghimire, Deenaz Zaidi, Shezel Muneer, Mohammed M Tinwala, Feng Ye, Megan Sebastianski, Abdullah Abdulrahman, Branko Braam, Kailash Jindal, Maryam Khan, Scott Klarenbach, Soroush Shojai, Stephanie Thompson, Aminu K Bello, Aminu K Bello

“…<h4>Materials and methods</h4>This scoping review will be guided by the methodological framework for conducting scoping studies developed by Arksey and O'Malley. …”
Get full text

Contextual Vulnerability Should Guide Fair Subject Selection in Xenotransplantation Clinical Trials by Gianna Strand

Get full text

Nonapoptotic caspase-3 guides C1q-dependent synaptic phagocytosis by microglia by Megumi Andoh, Natsuki Shinoda, Yusuke Taira, Tasuku Araki, Yuka Kasahara, Haruki Takeuchi, Masayuki Miura, Yuji Ikegaya, Ryuta Koyama

Get full text

Structural basis for RNA-guided DNA degradation by Cas5-HNH/Cascade complex by Yanan Liu, Lin Wang, Qian Zhang, Pengyu Fu, Lingling Zhang, Ying Yu, Heng Zhang, Hongtao Zhu

Get full text

Comparative effectiveness of manual therapy, pharmacological treatment, exercise therapy, and education for neck pain (COMPETE study): protocol of a systematic review with network... by Ana Izabela Sobral de Oliveira-Souza, Jordana Barbosa-Silva, Douglas P. Gross, Bruno R. da Costa, Nikolaus Ballenberger, Tiago V. Pereira, Liz Dennett, Susan Armijo-Olivo

“…The information gathered in this project will inform decision-making and guide personalized care of individual patients in the future.…”
Get full text

Antiplasmodial Properties and Bioassay-Guided Fractionation of Ethyl Acetate Extracts from Carica papaya Leaves by Paula Melariri, William Campbell, Paschal Etusim, Peter Smith

Get full text